Zhanxiang Zhou Search Results

New Approach To Treat Alcoholic Liver Disease Identified

Read the story on BioSpace. A new study found evidence of a pharmacological approach that reversed some of the effects of alcoholic liver disease. Kannapolis, NC- It’s sweet. It’s bitter. It’s tangy and even tart. The tastes and types of alcohol seem endless. Despite the variety, alcohol when metabolized becomes one thing: toxic. Through processes […]

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Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats, J Nutr. 2015 Oct 14, Zhong W1, Li Q1, Sun Q2, Zhang W1, Zhang J3, Sun X1, Yin X3, Zhang X3, Zhou Z4. 1Center for Translational Biomedical Research and. 2Center for Translational Biomedical Research and Department of Nutrition, University of […]

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Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats

Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats, 2015 Mar 26, Am J Physiol Gastrointest Liver Physiol., Song M1, Schuschke DA2, Zhou Z3, Zhong W3, Zhang J2, Zhang X2, Wang Y2, McClain CJ2. 1University of Louisville m0song03@louisville.edu. 2University of Louisville. 3University of North […]

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Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease, 2015 Mar 12, Am J Physiol Gastrointest Liver Physiol. Sun Q1, Zhong W2, Zhang W2, Li Q2, Sun X2, Tan X2, Sun X2, Dong D2, Zhou Z3. UNC greensboro. 2University of North Carolina at Greensboro. 3University of North Carolina at Greensboro z_zhou@uncg.edu. Abstract […]

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Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde

Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde, Alcohol Clin Exp Res. 2015 Feb 19, Zhang W1, Zhong W, Sun X, Sun Q, Tan X, Li Q, Sun X, Zhou Z. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina. Abstract BACKGROUND: Chronic alcohol exposure causes […]

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Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.  J Hepatol. 2014 Dec 24, Zhong W1, Zhang W1, Li Q1, Xie G2, Sun Q3, Sun X1, Tan X1, Sun X1, Jia W2, Zhou Z4. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA 28081. 2University of Hawaii Cancer Center, Honolulu, Hawaii, USA 96813. 3Center for Translational […]

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Effect of microfluidisation on antioxidant properties of corn bran

Effect of microfluidisation on antioxidant properties of corn bran. Food Chemistry. June 1, 2014 Wang T, Zhu Y, Sun X, Raddatz J, Zhou Z, Chen G. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, NC Research Campus; School of Food Science & Technology, Dalian Polytechnic University, Dalian, China; Center for Translational & Biomedical Research, The University of North […]

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Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats

Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats. Alcoholism Clinical and Experimental Research. May 21, 2014. Qiong Li1, Guoxiang Xie2, Wenliang Zhang1, Wei Zhong1, Xiuhua Sun1, Xiaobing Tan1, Xinguo Sun1, Wei Jia2,3and Zhanxiang Zhou1,4,* 1 Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina; 2 University of Hawaii Cancer Center, Honolulu, Hawaii; 3 Center for Translational […]

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A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential

A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential. Clinical Cancer Research: An Official Journal of the American Association of Cancer Research. March 25, 2014. Qiu Y, Cai G, Zhou B, Li D, Zhao A, Xie G, Li H, Cai S, Xie D, Huang C, Ge W, Zhou Z, Xu LX, Jia W, Zheng S, Yen Y, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth […]

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Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors.

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PlosOne. Oct 14, 2013. Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract Clinical studies have demonstrated that alcoholics have a […]

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Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.

Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. Cell Death & Disease. October 2013. Li H, Zhou Y, Zhao A, Qiu Y, Xie G, Jiang Q, Zheng X, Zhong W, Sun X, Zhou Z, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University, Affiliated Sixth People’s Hospital, Shanghai, […]

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Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites

Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites. Journal of Proteome Research. June 14, 2013. [Epub ahead of print] Xie G, Zhong W, Zheng X, Li Q, Qiu Y, Li H, Chen H, Zhou Z, Jia W. Center for Translational Biomedical Research, University of North Carolina at Greensboro , North Carolina Research Campus, Kannapolis Abstract […]

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Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB: Official Publication of the Federation of American Societies for Experimental Biology.  Epub May 14, 2013. Xie G, Zhong W, Li H, Li Q, Qiu Y, Zheng X, Chen H, Zhao X, Zhang S, Zhou Z, Zeisel SH, Jia W. Center for […]

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High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways. PLoS One. April 2013.  Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract High […]

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At NCRC, a year of milestones

By Hugh Fisherhfisher@salisburypost.com   Hugh Fisher/for the salisbury post John Shea, research technician at the N.C. Research Campus and UNC-Charlotte graduate student, compiles data from a recent study of nutrients in different varieties of blueberries. Shea said his NCRC experience will give him an advantage in his future career. KANNAPOLIS – The North Carolina Research […]

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NCRC Scientists Advance Nutritional Interventions for Fatty Liver Disease

NC Research Campus, Kannapolis, NC- January 3, 2013)- Alcohol-induced and non-alcoholic induced fatty liver disease are serious health conditions with few treatment options. Both conditions can lead to the inflammation, scarring and even cancer of the liver. Based on studies involving the essential nutrients zinc and choline, scientists at the North Carolina Research Campus are […]

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Zinc: A Potential Treatment for Alcohol-Induced Fatty Liver Disease

While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou is co-director of the UNC Greensboro Center forTranslational Biomedical Research and an expert on the disease. During his visit, Zhou counseled his friends on dietary changes that might help them. One day, […]

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Zinc A Potential Treatment for Alcohol-Induced Fatty Liver Disease

  While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou, who is co-director of the UNC Greensboro Center for Translational Biomedical Research at the North Carolina Research Campus (NCRC), is an expert on the disease. During his visit, Zhou counseled his […]

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Cancer Treatments Emerge From Modern Metabolomics, Traditional Chinese Medicine

Over 1,800 years ago healers in China mixed together a formulation called Huangqin Decoctin to relieve their patients’ aches and pains. Today, colorectal cancer patients in a Phase II Clinical Trial are receiving a therapeutic treatment made from this ancient formulation. The potential new drug is being tested for its effectiveness in reducing the harsh […]

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Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice.

Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice. The Journal of American Pathology, July 2012. Xiaobing Tan, Xiuhua Sun, Qiong Li, Yantao Zhao, Wei Zhong, Xinguo Sun, Wei Jia, Craig J. McClain, Zhanxiang Zhou. UNC Greensboro Center for Translational Biomedical Research. Abstract White adipose tissue (WAT) secretes adipokines, which critically regulate lipid […]

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