Xiaohe Yang Search Results

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells, PLOS One, Ming Zhao, Erin W. Howard, Zhiying Guo, Amanda B. Parris, Xiaohe Yang.  Department of Biological and Biomedical Sciences, Julius L. Chambers Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Kannapolis, North Carolina Abstract Alcohol consumption is associated with increased breast cancer risk; however, […]

0 comments

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

0 comments

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer, July 22, 2015, In Press Accepted Manuscript, Yujie Fu, Onat Kadioglu, Benjamin Wiench, Zuofu Wei, Wei Wang, Meng Luo, Xiaohe Yang, Chengbo Gu, Yuangang Zu, Thomas Efferth NC Central University <style>.requiresJS{display:none}.dartAd{display:block !important}</style> Abstract Anti-estrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established anti-hormones such as tamoxifen, novel […]

0 comments

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib, Journal of Cancer Research, April 22, 2015, Ming Zhao, Amanda Blackwelder, Harry Lee, and Xiaohe Yang Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC. Abstract 3557: Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib Abstract […]

0 comments

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice, 2015 Apr 7, Int J Mol Sci, Ma Z1, Blackwelder AJ2, Lee H3, Zhao M4, Yang X5. 1Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA. mzhao@nccu.edu. 2Julius L. Chambers Biomedical/Biotechnology […]

0 comments

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells, Phytomedicine, 11 March 2015,  Yujie Fua, b, 1, Onat Kadiogluc, 1, Benjamin Wienchc, Zuofu Weia, b, Chang Gaod, Meng Luoa, b, Xiaohe Yange, Chengbo Gua, b, Yuangang Zua, b, Thomas Efferth Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer […]

0 comments

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk.  Molecular Cancer Research. Nov 2014, Zhikun Ma, Amanda Blackwelder, and Xiaohe Yang North Carolina Central Unversity, Kannapolis, NC. Abstract A09: In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk Abstract The mammary […]

0 comments

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. The Journal of Endocrinology. Apr 16, 2014 [Epub ahead of print] Yang X1, Mei S, Gu H, Guo H, Zha L, Cai J, Li X, Liu Z, Cao W. 1X Yang, Nutrition, UNC at Chapel Hill, Kannapolis, United States. Abstract We have previously shown that insulin plays an essential role […]

0 comments

BRITE future for Kannapolis students

By Jennifer Woodford Link to original article in Business Today As a child, TinChung Leung, PhD, enjoyed raising fish. Today, he is a scientist with the NC Central University Nutrition Research Program at the NC Research Campus and an expert in the use of zebra fish as a model system for cancer and cardiovascular disease […]

0 comments

Catalyst Group’s 2013 Symposium Celebrates NCRC Research

 NCRC The NC Research Campus Catalyst Group hosted their second annual research symposium, Celebrating Research and Collaborations at the NCRC, on Monday, April 15, 2013 in the core lab event room. The Catalyst Group, which fosters personal and professional relationships between researchers on campus, hosted 100 attendees who benefited from a poster competition, faculty presentations, […]

0 comments

Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

NRCR News The impact of soy on breast cancer is puzzling to many consumers including women at risk for breast cancer. Numerous studies label the isoflavone genistein in soy as a natural compound that can prevent breast cancer. At the same time, increasing numbers of reports suggest that genistein may be a risk factor for […]

0 comments

Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

One of the most controversial and confusing questions surrounding breast cancer is the effect of eating soy. Some studies say soy and the isoflavone genistein that it contains prevents breast cancer. Other studies say genistein is a risk factor for developing breast cancer. Breast cancer researcher Xiaohe Yang, PhD, associate professor with the North Carolina Central […]

0 comments

Monday and Tuesday Events Feature NCRC Scientists

NCRC Monday, April 16 and Tuesday, April 17, the Live and Learn Film Series and State of the Studies at the NC Research Campus are free events that provide opportunities for people to talk with scientists and learn about the research and clinical studies that are underway on campus. (NC Research Campus, Kannapolis, NC- April […]

0 comments

NCRC Scientists Open A Window To Chinese Culture

Scientists at the North Carolina Research Campus in Kannapolis formed the Cabarrus Chinese American Association and are hosting a Chinese New Year celebration on January 14, 2012 to raise money for their Chinese Language and Art School. In American culture, January is usually a quiet month to recover from the revelry of Thanksgiving, Christmas and […]

0 comments

HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance

Huang X,Wang S,Lee CK,Yang X,Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Letters.2011 Aug 1;307(1):72-9. doi: 10.1016/j.canlet.2011.03.019. Epub 2011 Apr 16. Abstract Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with […]

0 comments

Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.

Shi Y,Yang S,Troup S,Lu X,Callaghan S,Park DS,Xing Y,Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.Oncology Reports.2011 Jun;25(6):1713-9. doi: 10.3892/or.2011.1248. Epub 2011 Apr 6. Abstract Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. […]

0 comments

Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation

Yang X,Yang S,McKimmey C,Liu B,Edgerton SM,Bales W,Archer LT,Thor AD. Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation.Carcinogenesis.2010 Apr;31(4):695-702. Epub 2010 Jan 12. Abstract Genistein is a major isoflavone with known hormonal and tyrosine kinase-modulating activities. Genistein has been shown to promote the growth of estrogen receptor positive […]

0 comments

Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin

Huang X,Gao L,Wang S,McManaman JL,Thor AD,Yang X,Esteva FJ,Liu B. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. CancerRes.2010Feb 1;70(3):1204-14. Epub 2010 Jan 26. Abstract Primary and acquired resistance to the breast cancer drug trastuzumab (Herceptin) is a significant clinical problem. Here, we report […]

0 comments

Comments are closed.