UNC Greensboro Search Results

New Approach To Treat Alcoholic Liver Disease Identified

Read the story on BioSpace. A new study found evidence of a pharmacological approach that reversed some of the effects of alcoholic liver disease. Kannapolis, NC- It’s sweet. It’s bitter. It’s tangy and even tart. The tastes and types of alcohol seem endless. Despite the variety, alcohol when metabolized becomes one thing: toxic. Through processes […]

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Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats, J Nutr. 2015 Oct 14, Zhong W1, Li Q1, Sun Q2, Zhang W1, Zhang J3, Sun X1, Yin X3, Zhang X3, Zhou Z4. 1Center for Translational Biomedical Research and. 2Center for Translational Biomedical Research and Department of Nutrition, University of […]

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Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice

Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice,2 Sep 2015 The Journal of Nutritional Biotechnology, Jessie Baldwin1, Brian Collins1, Patricia G. Wolf, Kristina Martinez, Wan Shen, Chia-Chi Chuang, Wei Zhong, Paula Cooney, Chase Cockrell, Eugene Chang, H. Rex Gaskins, Michael K. McIntosh. Author Afiliations Department of Nutrition, University of North Carolina at Greensboro (UNCG), Greensboro, NC Carl […]

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Serum Proteome Profiles in Stricturing Crohn’s Disease: A Pilot Study

Serum Proteome Profiles in Stricturing Crohn’s Disease: A Pilot Study, 19 May 2015, Crohn’s & Colitis Foundation of America, Inc, Townsend, Peter MD; Zhang, Qibin PhD; Shapiro, Jason MD; Webb-Robertson, Bobbie-Jo PhD; Bramer, Lisa PhD; Schepmoes, Athena A. BS; Weitz, Karl K. BS; Mallette, Meaghan BS, MS; Moniz, Heather BS; Bright, Renee MS; Kamphaus, Tania PhD; Shah, […]

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California Table Grape Consumption Reduces Adiposity, Hepatic Triglycerides, Lipogenic Gene Expression, and Abundance of Sulfidogenic Bacteria in Mice

California Table Grape Consumption Reduces Adiposity, Hepatic Triglycerides, Lipogenic Gene Expression, and Abundance of Sulfidogenic Bacteria in Mice, Apr 2015, The FASEB Journal, Jessie Baldwin1, Brian Collins1, Patricia Wolfe2, Wan Shen1, Chia-Chi Chuang3, Wei Zhong4, Paula Cooney1, H Rex Gaskins2 and Michael McIntosh1 1Nutrition UNC-Greensboro NC United States 2Animal Science University of Illinois IL United States 3Pathology Wake Forest School of Medicine Winston Salem NC […]

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Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats

Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats, 2015 Mar 26, Am J Physiol Gastrointest Liver Physiol., Song M1, Schuschke DA2, Zhou Z3, Zhong W3, Zhang J2, Zhang X2, Wang Y2, McClain CJ2. 1University of Louisville m0song03@louisville.edu. 2University of Louisville. 3University of North […]

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Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease, 2015 Mar 12, Am J Physiol Gastrointest Liver Physiol. Sun Q1, Zhong W2, Zhang W2, Li Q2, Sun X2, Tan X2, Sun X2, Dong D2, Zhou Z3. UNC greensboro. 2University of North Carolina at Greensboro. 3University of North Carolina at Greensboro z_zhou@uncg.edu. Abstract […]

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Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde

Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde, Alcohol Clin Exp Res. 2015 Feb 19, Zhang W1, Zhong W, Sun X, Sun Q, Tan X, Li Q, Sun X, Zhou Z. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina. Abstract BACKGROUND: Chronic alcohol exposure causes […]

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Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease

Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease, Food Research International, 16Jan2015,  Jianmei Yua, , ,Michelle Hernandezd,Hao Lib, e,Ipek Goktepec,Carole Robinetted,Amy Auerbachd,David Pedend,Mohamed Ahmednac a Department of Family and Consumer Sciences, North Carolina A&T State University, Greensboro, NC 27411 b Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, Kannapolis, NC 28081, USA c […]

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Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.  J Hepatol. 2014 Dec 24, Zhong W1, Zhang W1, Li Q1, Xie G2, Sun Q3, Sun X1, Tan X1, Sun X1, Jia W2, Zhou Z4. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA 28081. 2University of Hawaii Cancer Center, Honolulu, Hawaii, USA 96813. 3Center for Translational […]

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Former Department of Energy Scientist Joins UNCG as Co-director of Biomedical Research Center

Read the UNCG announcement. PRWeb Release The University of North Carolina at Greensboro (UNCG), a national research university located In the Piedmont Triad, announced today that Dr. Qibin Zhang has joined UNCG as co-director of the Center for Translational Biomedical Research (CTBR). Zhang, an expert in bioanalytical chemistry, comes to UNCG after nearly a decade […]

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RCCC partners up with UNC-Greensboro to offer bachelor’s degree in nursing

June 9 The nursing profession has seen a dramatic increase in demand for bachelor’s trained nurses due to changing standards in the Affordable Care Act and from the Institute of Medicine. Rowan-Cabarrus Community College, in partnership with the University of North Carolina at Greensboro, will now be able to help our local area keep up […]

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Effect of microfluidisation on antioxidant properties of corn bran

Effect of microfluidisation on antioxidant properties of corn bran. Food Chemistry. June 1, 2014 Wang T, Zhu Y, Sun X, Raddatz J, Zhou Z, Chen G. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, NC Research Campus; School of Food Science & Technology, Dalian Polytechnic University, Dalian, China; Center for Translational & Biomedical Research, The University of North […]

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Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats

Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats. Alcoholism Clinical and Experimental Research. May 21, 2014. Qiong Li1, Guoxiang Xie2, Wenliang Zhang1, Wei Zhong1, Xiuhua Sun1, Xiaobing Tan1, Xinguo Sun1, Wei Jia2,3and Zhanxiang Zhou1,4,* 1 Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina; 2 University of Hawaii Cancer Center, Honolulu, Hawaii; 3 Center for Translational […]

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A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential

A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential. Clinical Cancer Research: An Official Journal of the American Association of Cancer Research. March 25, 2014. Qiu Y, Cai G, Zhou B, Li D, Zhao A, Xie G, Li H, Cai S, Xie D, Huang C, Ge W, Zhou Z, Xu LX, Jia W, Zheng S, Yen Y, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth […]

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Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice.

Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice. American Journal of Physiology. Gatrointestinal and liver physiology. December 2013. [Epub Oct 10, 2013]. Sun X, Luo W, Tan X, Li Q, Zhao Y, Zhong W, Sun X, Brouwer C, Zhou Z. Center for Translational & Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis. Abstract […]

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Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors.

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PlosOne. Oct 14, 2013. Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract Clinical studies have demonstrated that alcoholics have a […]

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Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.

Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. Cell Death & Disease. October 2013. Li H, Zhou Y, Zhao A, Qiu Y, Xie G, Jiang Q, Zheng X, Zhong W, Sun X, Zhou Z, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University, Affiliated Sixth People’s Hospital, Shanghai, […]

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Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes

Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes. Electrophoresis. Jun 17, 2013. [Epub ahead of print]. Xie G, Zhang S, Zheng X, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North […]

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Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites

Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites. Journal of Proteome Research. June 14, 2013. [Epub ahead of print] Xie G, Zhong W, Zheng X, Li Q, Qiu Y, Li H, Chen H, Zhou Z, Jia W. Center for Translational Biomedical Research, University of North Carolina at Greensboro , North Carolina Research Campus, Kannapolis Abstract […]

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Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB: Official Publication of the Federation of American Societies for Experimental Biology.  Epub May 14, 2013. Xie G, Zhong W, Li H, Li Q, Qiu Y, Zheng X, Chen H, Zhao X, Zhang S, Zhou Z, Zeisel SH, Jia W. Center for […]

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High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways. PLoS One. April 2013.  Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract High […]

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Klebsiella Linked to Infant Melamine Deaths

The UNC Greensboro Center for Translational Biomedical Research and the David H. Murdock Research Institute in partnership with scientists from Shanghai Jiao Tong University in Shanghai, China and the Imperial College of London, United Kingdom have shed light on why so many babies who drank melamine-tainted milk in 2008 did not die. The bacteria Klebsiella terrigena […]

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Gut flora ‘had role’ in China’s milk scandal

HealthcareToday Chinese infants who drank infant formula milk contaminated with the industrial chemical melamine were probably more likely to develop severe kidney disease if a certain type of microbe was present in their gut, new research suggests. “Good” gut bacteria have evolved in a symbiotic relationship with humans over millions of years, and have a […]

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Gut microbes could determine the severity of melamine-induced kidney disease

  ScienceDaily Microbes present in the gut can affect the severity of kidney disease brought on by melamine poisoning, according to an international study led by Professor Wei Jia at the University of North Carolina in collaboration with the research group of Professor Jeremy Nicholson at Imperial College London. In 2008, nearly 300,000 Chinese children […]

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Melamine-induced renal toxicity is mediated by the gut microbiota

Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. February 13, 2013. Zheng X,Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Luther M, Su M, Nicholson JK, Jia W. Shanghai Key Laboratory of Diabestes Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated […]

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Gut Bacteria Conspired in Melamine Poisonings

Gut Bacteria Conspired in Melamine Poisonings Reuters/Landov Tainted milk. A gut microbe may have made contaminated infant formula deadly. In 2008, nearly 300,000 infants in China got sick from milk formula tainted with melamine, a plastics additive that was used illegally to bulk up the formula’s apparent protein content. Now, a study in rats implicates […]

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A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study

A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study. Evidence-based Complementary and Alternative Medicine. January 20, 2013. Li X, Chen H, Jia W, Xie G. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian China; Center for Translational Biomedical Research, University of North Carolina at […]

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NCRC Scientists Advance Nutritional Interventions for Fatty Liver Disease

NC Research Campus, Kannapolis, NC- January 3, 2013)- Alcohol-induced and non-alcoholic induced fatty liver disease are serious health conditions with few treatment options. Both conditions can lead to the inflammation, scarring and even cancer of the liver. Based on studies involving the essential nutrients zinc and choline, scientists at the North Carolina Research Campus are […]

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Zinc: A Potential Treatment for Alcohol-Induced Fatty Liver Disease

While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou is co-director of the UNC Greensboro Center forTranslational Biomedical Research and an expert on the disease. During his visit, Zhou counseled his friends on dietary changes that might help them. One day, […]

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Zinc A Potential Treatment for Alcohol-Induced Fatty Liver Disease

  While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou, who is co-director of the UNC Greensboro Center for Translational Biomedical Research at the North Carolina Research Campus (NCRC), is an expert on the disease. During his visit, Zhou counseled his […]

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Charlotte conference highlights region’s life-sciences research

By Jeremy Summers, NCBiotech Writer Charlotte is known for its strong financial roots, diverse business climate and   for being the unofficial home of NASCAR. Thanks to new commitments to education and research, the region is also gaining some recognition as a hotbed for cutting edge research and technologies in biotech and other life-sciences industries. […]

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NCRC Focus of UNC Charlotte Life Sciences Conference

Contact: Phyllis Beaver Marketing Director North Carolina Research Campus pbeaver@ncresearchcampus.net www.ncresearchcampus.net   (NC Research Campus, Kannapolis, NC- October 23, 2012)- The North Carolina Research Campus in Kannapolis, a 350-acre life science research center just north of Charlotte, is the focus of the eleventh annual UNC Charlotte Life Sciences Conference. The conference is being held on […]

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Cancer Treatments Emerge From Modern Metabolomics, Traditional Chinese Medicine

Over 1,800 years ago healers in China mixed together a formulation called Huangqin Decoctin to relieve their patients’ aches and pains. Today, colorectal cancer patients in a Phase II Clinical Trial are receiving a therapeutic treatment made from this ancient formulation. The potential new drug is being tested for its effectiveness in reducing the harsh […]

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Kannapolis Scholars Conference Focuses on the Role of Exercise in Obesity Prevention

  Link to original article The Kannapolis Scholars, a program of N.C. State University at the N.C. Research Campus, is hosting its second conference on how to address the challenges of obesity. “Lost in Translation: A Conversation on Exercise and Obesity” will be held on Friday, July 27, 2012, from 10:15 a.m. to 4 p.m. […]

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Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice.

Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice. The Journal of American Pathology, July 2012. Xiaobing Tan, Xiuhua Sun, Qiong Li, Yantao Zhao, Wei Zhong, Xinguo Sun, Wei Jia, Craig J. McClain, Zhanxiang Zhou. UNC Greensboro Center for Translational Biomedical Research. Abstract White adipose tissue (WAT) secretes adipokines, which critically regulate lipid […]

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UNC Greensboro Scientist Receives Elite Fellowship

UNC Greensboro scientist Wei Zhong, PhD, was awarded an elite Roger L. Jenkins, MD, Post doctoral Research Fellowship from the American Liver Foundation (ALF). The ALF Postdoctoral Research Fellowships provide professional development, additional training and experience in liver research for MDs, PhDs or MD/PhDs in their first or second year appointments as postdoctoral research fellows. Zhong is […]

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Therapeutic Modulation of Microbiota-Host Metabolic Interactions.

Therapeutic Modulation of Microbiota-Host Metabolic Interactions. Science Translational Medicine, June 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for R Abstract The complex metabolic relationships between the host and its microbiota change throughout life and vary extensively between  individuals, affecting disease risk factors […]

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Metabonomic Variations Associated with AOM-induced Precancerous Colorectal Lesions and Resveratrol Treatment.

Metabonomic Variations Associated with AOM-induced Precancerous Colorectal Lesions and Resveratrol Treatment. Journal of Proteome Research, April 2012. Liao W, Wei H, Wang X, Qiu Y, Gou X, Zhang X, Zhou M, Wu J, Wu T, Kou F, Zhang Y, Bian Z, Xie G, Jia W. UNC Greensboro Center for Research Excellence in Bioactive Food Components. […]

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Human gouty arthritis is associated with a distinct serum trace elemental profile

Human gouty arthritis is associated with a distinct serum trace elemental profile. Metallomics, March 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for Research Excellence in BioActive Food Components and David H. Murdock Research Institute. Abstract Homeostatic imbalance of essential trace elements […]

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Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors.

Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. Neurotoxicology Teratology, January-February 2012. Fordahl S, Cooney P, Qiu Y, Xie G, Jia W, Erikson KM. UNC Greensboro Department of Nutrition, Center for Research Excellence in Bioactive Food Components. Abstract Overexposure to waterborne manganese (Mn) is linked with cognitive impairment […]

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Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins.

ZhongW, Zhao Y, McClain CJ, Kang YJ, Zhou Z. Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins. Am J Physiol.2010; 299:G643-G651 Abstract Chronic alcohol exposure has been shown to increase the gut permeability in the distal intestine, in part, through induction of zinc deficiency. The present study evaluated the molecular […]

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The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction.

Zhong W, McClain CJ, Cave M, Kang YJ, Zhou Z. The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol.2010; G625-633. Abstract Disruption of the intestinal barrier is a causal factor in the development of alcoholic endotoxemia and hepatitis. This study was undertaken to determine whether zinc deficiency is related to the deleterious […]

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Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins.

Zhong W, Zhao Y, McClain CJ, Kang YJ, Zhou Z. Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins. Am J Physiol.2010; 299:G643-G651 Abstract Chronic alcohol exposure has been shown to increase the gut permeability in the distal intestine, in part, through induction of zinc deficiency. The present study evaluated […]

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Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4a and peroxisome proliferators activated receptor-a

Kang X, Zhong W, Liu J, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4a and peroxisome proliferators activated receptor-a. Hepatology2009; 50:1241-1250. Abstract Alcoholic steatosis is a fundamental metabolic disorder in the progression of alcoholic liver disease. Zinc deficiency is one of the most […]

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A rapid ultra-performance liquid chromatography–electrospray ionization mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng,

Dan, M., Xie, G., Gao, X., Long, X., Su, M., Zhao, A., Zhao, T., Zhou, M., Qiu, Y., Jia, W.*A rapid ultra-performance liquid chromatography–electrospray ionization mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng, Phytochemical Analysis, 20 (1), 68-76, 2009. Abstract INTRODUCTION: Saponins are bioactive compounds employed in the […]

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Paeonol attenuates high-fat-induced atherosclerosis in rabbits by anti-inflammatory activity

Li, H., Dai, M.,Jia, W. Paeonol attenuates high-fat-induced atherosclerosis in rabbits by anti-inflammatory activity, Planta Medica, 75(1), 7-11, 2009. Abstract Cortex Moutan (Paeonia suffruticosa Andrews, Ranunculaceae) has several uses in traditional medicine, such as analgesic, antipyretic, and anti-inflammatory applications and use in the prevention of thromboembolic diseases. Paeonol, a main active component in Cortex Moutan, […]

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Nephro-protective effect of Kangqianling decociton on chronic renal failure rats

He, L., Shen, P., Fu, Q.,Li, J., Dan, M., Wang, X.,Jia, W.*Nephro-protective effect of Kangqianling decociton on chronic renal failure rats, Journal of Ethnopharmacology, 122, 367-373, 2009. Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Kangqianling decoction (KQL), the modified formulation of a classical Chinese prescription named Taohongsiwu decoction, was clinically employed to treat renal fibrosis in chronic renal failure. […]

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Characterization of Pu-erh tea using chemical and metabolic profiling approaches

Xie, G., Ye, M., Wang, Y., Ni, Y., Su, M., Huang, H., Qiu, M., Zhao, A., Zheng, X., Chen, T., Jia, W.*Characterization of Pu-erh tea using chemical and metabolic profiling approaches, Journal of Agricultural and Food Chemistry, 57, 3046-3054, 2009. Abstract In this study, the chemical constituents of pu-erh tea, black tea, and green tea, […]

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Metabonomics approach to understanding acute and chronic stress in rat models

Wang, X., Zhao, T., Qiu, Y., Su, M., Jiang, T., Zhou, M., Zhao, A., Jia, W.*Metabonomics approach to understanding acute and chronic stress in rat models, Journal of Proteome Research,8(5), 2511-2518, 2009. Abstract The effects of acute and chronic stress on the production of systemic metabolites were investigated in male Sprague-Dawley (SD) rats. Metabolites excreted […]

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Trace element profiling using inductively coupled plasma mass spectrometry and its application in an osteoarthritis study

Zhao, T., Chen, T., Qiu, Y., Zou, X., Li, X., Su, M., Yan, C., Zhao, A., Jia, W.*Trace element profiling using inductively coupled plasma mass spectrometry and its application in an osteoarthritis study, Analytical Chemistry(IF = 5.287), 81(9), 3683-3692, 2009. Abstract In this study, a novel method of quantitatively measuring serum trace elements using inductively […]

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Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers

Bao, Y., Zhao, T., Wang, X., Qiu, Y., Su, M., Jia, W.*Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers, Journal of Proteome Research(IF = 5.675), 8(4), 1623-1630, 2009. Abstract The pathological development and the drug intervention of type 2 diabetes mellitus (T2DM) involve altered expression of downstream low molecular weight […]

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Metabonomic evaluation of Melamine-induced acute renal toxicity in rats.

Xie, G., Zheng, X., Qi, X., Cao, Y., Chi, Y., Su, M., Ni, Y., Qiu, Y., Liu, Y., Li, H., Zhao, A., Jia, W.*Metabonomic evaluation of Melamine-induced acute renal toxicity in rats. Journal of Proteome Research(IF = 5.675), Epubahead of print (DOI: 10.1021/pr900333h), 2009. Abstract The recent outbreak of renal failure in infants in China […]

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Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease.

Song Z, Zhou Z, Deaciuc I, Chen T, McClain CJ. Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease. Hepatology 2008; 47:867-879. Abstract Although recent evidence suggests that down-regulation of production of the adipocyte hormone adiponectin has pathophysiological consequences for the development of alcoholic liver disease (ALD), the underlying mechanisms are […]

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Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4ain mice subjected to a long-term ethanol administration

Kang X, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4ain mice subjected to a long-term ethanol administration. Am J Pathol.2008; 172:916- 925. Abstract Alcoholic liver disease is associated with sustained liver damage and impaired regeneration, as well as significant zinc deficiency. This study was undertaken […]

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The anti-diabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats

Xu, Z., Wang, X., Liu, J.,Jia, W.*The anti-diabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats, Phytotherapy Research, Vol 22, 97-101, 2008. Abstract The antidiabetic activity of the total lignan from the plant Fructus Arctii, used in China for the control of diabetes, was investigated in models of alloxan-induced […]

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Simultaneous analysisof nine saponins in flower buds of Panax notoginseng using high performance liquid chromatography

Gao, X., Dan, M., Zhao, A., Xie, G., Jia, W.*Simultaneous analysisof nine saponins in flower buds of Panax notoginseng using high performance liquid chromatography, Biomedical Chromatography, 22: 244-249, 2008. Abstract The flower buds of Panax notoginseng have been commonly used for the treatment of hypertension, vertigo, tinnitus and acute faucitis in China. The amount of […]

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Metabolite profiling ofPanax notoginsengusing UPLC-ESI-MS

Dan, M., Su, M., Gao, X., Zhao, T., Zhao, A., Xie, G., Qiu, Y., Zhou, M., Liu, Z., Jia, W.*Metabolite profiling of Panax notoginsengusing UPLC-ESI-MS, Phytochemistry, 69, 2237-2244, 2008. Abstract The metabolite profiling of different parts of Panax notoginseng was carried out using rapid ultra-performance liquid chromatography-electrospray ionization mass spectrometry (UPLC-ESI-MS) and multivariate statistical analysis. […]

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Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs

Xie, G., Ni, Y., Su, M., Zhang, Y., Zhao, A., Gao, X., Liu, Z., Long, X., Jia, W.*Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs, Metabolomics, 4: 248-260, 2008. Abstract The morphological appearance and some ingredients of Panax ginseng, Panax notoginseng and Panax                               japonicus of the Panax genus […]

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Mass Spectrometry-based Metabolic Profiling of Rat Urine Associated with General Toxicity Induced by Multiglycoside of Tripterygium Wilfordii Hook

Chen, M.,Ni, Y., Duan, H., Qiu, Y., Guo, C., Jiao, Y., Shi, H., Su, M., Jia, W.*Mass Spectrometry-based Metabolic Profiling of Rat Urine Associated with General Toxicity Induced by Multiglycoside of Tripterygium Wilfordii Hook. F.,Chemical Research in Toxicology, 21: 288-294, 2008. Abstract We propose here a combined gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry […]

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GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia

Tao, X., Liu, Y., Qiu, Y., Lin, J., Zhao, A., Su, M., Jia, W.*GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia, Analytical and Bioanalytical Chemistry, 391: 2881-288, 2008.  

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Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research

Xie, G., Plumb, R., Su, M., Xu, Z., Zhao, A., Qiu, Q., Long, X., Liu, Z. Jia, W.*Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research, Journal of Separation Science, 31, 1015-1026, 2008. Abstract In this study, metabolite profiling of five medicinal Panax herbs including Panax ginseng (Chinese ginseng), Panax notoginseng (Sanchi), Panax […]

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Symbiotic gut microbes modulate human metabolic phenotypes

Li, M., Wang, B., Zhang, M., Rantlainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., Wei , H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia,W., Xiao, C., Smith, L., Holmes, E., Tang, H., Zhao, G., Yang, S., Nicholson, J. K., Li, L., Zhao, L., Symbiotic gut […]

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Metabolic profiling reveals disorder of amino acid metabolism in various brain regions from a rat model of chronic unpredictable mild stress

Ni, N., Su, M., Lin, J., Wang, X., Qiu, Y., Zhao, A., Chen, T., Jia, W.*Metabolic profiling reveals disorder of amino acid metabolism in various brain regions from a rat model of chronic unpredictable mild stress, FEBS Letters, Vol. 582 (17), 2627-2636, 2008. Abstract Chronic stress is closely linked to clinical depression, which could be […]

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Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats

Shen, Q., Li, X., Qiu, Y., Su, M., Liu, Y., Li, H., Wang, X., Zou, X., Yan, C., Yu, L., Li, S., Wan, C., He, L., Jia, W.*Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats, Journal of Proteome Research, 7(5), 2151-2157, 2008. Abstract Epidemiology and studies in animal models have revealed […]

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Gut microbiota: a potential new territory for drug targeting

Jia, W.,*Li, H., Zhao, L., Nicholson, J., Gut microbiota: a potential new territory for drug targeting, Nature Reviews Drug Discovery(IF = 23.31),Vol 7, 123-131, 2008. Abstract The significant involvement of the gut microbiota in human health and disease suggests that manipulation of commensal microbial composition through combinations of antibiotics, probiotics and prebiotics could be a […]

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Transcriptomic and metabonomic profiling of obesity-Prone and obesity-resistant rats under high fat diet

Li, H., Xie, Z., Lin, J., Song, H., Wang, Q., Wang, K., Su, M., Qiu, Y., Zhao, T., Song, K., Wang, X., Zhou, M., Liu, P., Zhao, G., Zhang, Q.,Jia, W.* Transcriptomic and metabonomic profiling of obesity-Prone and obesity-resistant rats under high fat diet, Journal of Proteome Research, 7(11), 4775-4783, 2008. Abstract Rodents respond to […]

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Simultaneous determination of saponins in flower buds of Panax notoginseng using high performance liquid chromatography

Simultaneous determination of saponins in flower buds of Panax notoginseng using high performance liquid chromatography Xianfu Gao, Mo Dan, Aihua Zhao, Guoxiang Xie and Wei Jia* Abstract The flower buds of Panax notoginseng have been commonly used for the treatment of hypertension, vertigo, tinnitus and acute faucitis in China. The amount of total saponins in the flower buds is […]

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