UNC Chapel Hill Search Results

CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase

Qasim A. Khan, Peter Pediaditakis, Yuryi Malakhau, Amin Esmaeilniakooshkghazi, Zahra Ashkavand, Valentin Sereda, Natalia I. Krupenko, Sergey A. Krupenko. CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase. PLOS One Published: July 6, 2018. https://doi.org/10.1371/journal.pone.0199699 Author Affiliations Nutrition Research Institute, University of North Carolina […]

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Your doctor may not be the best source of nutrition advice

Read the original article by Rachel Cernansky, Washington Post When Americans hear about a health craze, they may turn to their physician for advice: Will that superfood really boost brain function? Is that supplement okay for me to take? Or they may be interested in food choices because of obesity, malnutrition or the role of […]

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Examination of muscle morphology and neuromuscular function in normal weight and overfat children aged 7 to 10 years

Trent J. Herda, Eric D. Ryan, Martin Kohlmeier, Michael A. Trevino, Gena R. Gerstner, Erica J. Roelofs.  Examination of muscle morphology and neuromuscular function in normal weight and overfat children aged 7 to 10 years. Scandinavian Journal of Medicine & Science in Sports. https://doi.org/10.1111/sms.13256 First published: 30 June 2018 Author Affiliations Neuromechanics Laboratory, University of KansasLawrence, […]

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You, Your Metabolism, and Science: How Research Studies Can Fight the Obesity Epidemic

The one-of-a-kind Human Whole-Room Calorimeter at the UNC Chapel Hill Nutrition Research Institute can be used for a wide variety of research studies – but they need YOU to participate. Read on to learn about how this technology works, how experts at the Appalachian State University Human Performance Laboratory are studying metabolism, how these studies […]

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Kannapolis and Concord Police Tackle an Overlooked Area of Public Safety- Good Health

Wednesday, June 27 from 8 am to 10 am, the Kannapolis and Concord Police Departments are taking part in a joint training mission to improve an often overlooked aspect of public safety – the health of police officers. As part of Cooking for a Healthy Life, the newest program under the city of Kannapolis’ Discover […]

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Heritability and genetic correlations of heart rate variability at rest and during stress in the Oman Family Study

Muñoz ML1, Jaju D2, Voruganti S3, Albarwani S2, Aslani A1, Bayoumi R4, Al-Yahyaee S2, Comuzzie AG5, Millar PJ6,7, Picton P7, Floras JS7, Nolte I1, Hassan MO2, Snieder H1. Heritability and genetic correlations of heart rate variability at rest and during stress in the Oman Family Study. J Hypertens. 2018 Jul;36(7):1477-1485. doi: 10.1097/HJH.0000000000001715. Author information 1 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 2 […]

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Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study

Balakrishnan P1, Navas-Acien A1, Haack K2, Vaidya D3, Umans JG4, Best LG5, Goessler W6, Francesconi KA6, Franceschini N7, North KE7, Cole SA2, Voruganti VS8, Gribble MO9. Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol. 2018 Jun 1;348:123-129. doi: 10.1016/j.taap.2018.03.034. Epub 2018 Apr 3. Author information 1 Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, United […]

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Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study

Vazquez-Vidal I1,2, Voruganti VS2, Hannon BA3, Andrade FCD4, Aradillas-García C5, Nakamura MT1,3, Terán-García M1,3,6. Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Lifestyle Genom. 2018 May 30:1-9. doi: 10.1159/000488085. [Epub ahead of print] Author information 1 Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. 2 Department of […]

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Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue

Sun X1, Stewart DA2, Sandhu R3, Kirk EL1, Pathmasiri WW2, McRitchie SL2, Clark RF4, Troester MA1,3,5, Sumner SJ2. Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue. PLoS One. 2018 Apr 18;13(4):e0193792. doi: 10.1371/journal.pone.0193792. eCollection 2018. Author information 1 Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. 2 National Institutes of Health […]

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Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme

Pietryk EW1, Clement K2, Elnagheeb M1, Kuster R2, Kilpatrick K3, Love MI4, Ideraabdullah FY5. Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme. Reprod Toxicol. 2018 Jun;78:9-19. doi: 10.1016/j.reprotox.2018.03.005. Epub 2018 Mar 10. Author information 1 Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, 120 Mason Farm Rd, CB#7264, Chapel Hill, […]

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Leptin Signaling Mediates Obesity-Associated CSC Enrichment and EMT in Preclinical TNBC Models

Bowers LW1,2, Rossi EL1,2, McDonell SB1, Doerstling SS1, Khatib SA1, Lineberger CG1, Albright JE3, Tang X4, deGraffenried LA5, Hursting SD6,2,3. Leptin Signaling Mediates Obesity-Associated CSC Enrichment and EMT in Preclinical TNBC Models. Mol Cancer Res. 2018 May;16(5):869-879. doi: 10.1158/1541-7786.MCR-17-0508. Epub 2018 Feb 16. Author information 1 Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina. 2 Lineberger Comprehensive Cancer Center, University of North […]

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Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Jacobson SW1,2,3, Carter RC4,5, Molteno CD3, Meintjes EM2,6, Senekal MS7, Lindinger NM2, Dodge NC1, Zeisel SH8, Duggan CP9, Jacobson JL1,2,3. Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcohol Clin Exp Res. 2018 May 11. doi: 10.1111/acer.13768. 1 Department of Psychiatry and Behavioral Neurosciences , Wayne State University School of Medicine, Detroit, Michigan. 2 Department of Human […]

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Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Jacobson SW1,2,3, Carter RC4,5, Molteno CD3, Stanton ME6, Herbert JS7, Lindinger NM2, Lewis CE2, Dodge NC1, Hoyme HE8,9, Zeisel SH10, Meintjes EM2,11, Duggan CP12, Jacobson JL1,2,3Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.  Alcohol Clin Exp Res. 2018 May 11. doi: 10.1111/acer.13769. 1 Department of Psychiatry and Behavioral Neurosciences, Wayne State […]

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Joint Life Science Caucus Visits the NC Research Campus

The original story was published by NCBIO. The Legislative Life Science Caucus members heard about nutrition and physiology research under way at the North Carolina Research Campus, which is celebrating its 10th anniversary. Presenters from Appalachian State University, told lawmakers the “Collaborative Approach to Human Performance Research” that it is undertaking with support from North […]

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Cooking for A Healthy Life Launched

On March 14, the City of Kannapolis hosted a community event to launch a new initiative called Cooking for a Healthy Life, the newest program under the Discover a Healthy Life brand. The new initiative follows the launch of Run Kannapolis and Loop the Loop that have encouraged hundreds of Kannapolis citizens to run or […]

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NRI & PHHI Grants

PHHI & NRI Grants Take Aim at Nutritional Challenges

Eighty seven percent of people in the US do not eat the USDA recommended four to five cups of fruits and vegetables per day. What if there was a way to help solve that problem by getting more of the natural goodness of produce into more of the foods people do eat? The NC State […]

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NCRC Hosts a “Taste of Science” for Cabarrus Big Brothers and Big Sisters

NCRC Hosts a “Taste of Science” for Cabarrus Big Brothers and Big Sisters Saturday, January 27 from 11 am to 1 pm, 40 children ages 8 to 12 will visit the NC Research Campus (NCRC) in Kannapolis for “A Taste of Science.” They will join several NCRC partners in the first floor of the David […]

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Free Bonsai Exhibition Coming to Kannapolis December 2 and 3

Bonsai artists and vendors from seven states display their trees at the fifth annual Bonsai Winter Silhouette Expo held in Kannapolis in the David H. Murdock Core Laboratory building on the NC Research Campus.    For the fifth year, bonsai artists from all over the USA will show their bonsai trees in the exceptionally beautiful […]

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Homegrown Scientists Working at the NCRC

The goal of many students when they graduate from high school is to get as far away from home as possible. Some students in Concord and Kannapolis, just outside of Charlotte, are finding that the best opportunity for careers in science is right in their own backyard at the NC Research Campus. Coming Home Grant […]

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NCRC Science Stop is a New Addition at Jiggy with a Piggy

Kannapolis, NC- The annual Jiggy with a Piggy Festival is this weekend in downtown Kannapolis. Scientists and staff from the research centers at the NC Research Campus are joining the fun on Saturday, May 6 from 10 am to 2 pm at the NCRC Science stop. Children and their families will find the Science Stop […]

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“Put Your Best Fork Forward” at Events Sponsored by NCRC Partners

  Programs offered by experts at the NC Research Campus help people “Put their Best Fork Forward” in March during National Nutrition Month. Kannapolis, NC – “Put Your Best Fork Forward” is the theme of this year’s National Nutrition Month celebration. Sponsored annually in March by The Academy of Nutrition and Dietetics, this year’s theme is […]

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Bonsai- Artistry for the Family to Enjoy this Holiday Season

The annual Winter Silhouette Bonsai Expo returns to the NC Research Campus Saturday, December 3 and Sunday, December 4.  The free event offers families an opportunity to relax and enjoy the artistry of bonsai before the holiday season kicks into high gear. Organized by bonsai artist Steven Zeisel, MD, PhD, director of the UNC Nutrition […]

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MURDOCK-NCRC Seed Funding Voucher Awardees

The MURDOCK Study has awarded six $10,000 vouchers as part of the MURDOCK-NCRC Seed Funding Voucher Program to investigators from North Carolina Research Campus partners. Duke University and the MURDOCK Study are pleased to announce the following voucher recipients: Saroja Voruganti, PhD, UNC Nutrition Research Institute (UNC NRI) “A pilot study to identify polymorphisms associated […]

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UNC Nutrition Research Institute Welcomes Renowned Scientist Susan Smith

Susan Smith, Ph.D., joined the UNC Nutrition Research Institute this month. She is an internally recognized expert in the field of nutritional affects on the risk for birth defects.  The UNC Nutrition Research Institute (NRI) welcomes Susan Smith, Ph.D., who joins the research facility’s roster of scientists this month. Dr. Smith is an internationally recognized […]

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UNC System President Margaret Spellings Tours the North Carolina Research Campus

See the original story and video on TimeWarner Cable News. KANNAPOLIS, N.C. — The University of North Carolina System president visited Kannapolis and Charlotte on Monday as part of her “100 Days” tour. As she toured the North Carolina Research Campus, she learned what researchers are doing across universities to further nutritional and agricultural research. […]

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UNC System President Margaret Spellings Visits the NC Research Campus

            On Monday, March 14, UNC system President Margaret Spellings visited the NC Research Campus as part of her “100 Days” tour. Along with the NC Research Campus, she is visiting all 16 public universities, the NC School of Science and Mathematics and UNC Health Care to “learn and experience […]

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NC Scientists Study Fetal Alcohol Syndrome

By Carly Stephenson See the original story on TimeWarner Cable. CABARRUS COUNTY — The Centers for Disease Control and Prevention recently released information on alcohol and pregnancy, and now scientists at the North Carolina Research Campus are building on that to recommend complete health solutions for women trying to have children. According to Dr. Philip May’s […]

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The NCRC Opens New Ready-to-Use Laboratory Suites and First Flexible Office

  Kannapolis, NC– Entrepreneurs take note. The NC Research Campus (NCRC) newest ready-to-use wet laboratory suites and its first flexible office space are both open for business. Located on the third floor of the NCRC’s David H. Murdock Core Laboratory Building both of the new 2,000-square-foot research laboratory suites can be sub-divided into smaller units. […]

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No amount of alcohol in pregnancy is safe: ‘There is too much that is unknown’, warns leading expert 

By Lisa Ryan Read the original article in DailyMail A fetal alcohol syndrome expert warns against pregnant alcohol use There is too much risk – and unknowns – to justify drinking, he says A recent study found fetal alcohol syndrome is more common than thought FAS said to affect 3 out of 1,000 kids – but […]

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Maternal Nutritional Status as a Contributing Factor for the Risk of Fetal Alcohol Spectrum Disorders

Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders, Reproductive Toxicology. December 3, 2015. Philip A. Maya, b, Kari J. Hamrickc, Karen D. Corbind, Julie M. Haskena, Anna-Susan Maraise, f, Jason Blankenshipb, H.Eugene Hoymeg, J.Phillip Gossageb a University of North Carolina at Chapel Hill, Nutrition Research Institute, Gillings School of Global Public Health, USA b The University of New Mexico Center on […]

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Bonsai show bares all for winter Dec 5 & 6

By Lisa Thornton Read the original article in the Charlotte Observer With bonsai – the art of growing dwarfed ornamental trees – old age, or at least the appearance of it, is the gold standard of beauty. Those interested in the hobby will get the chance to see how that’s achieved during the Winter Silhouette […]

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Annual Kannapolis Bonsai Expo Aims to Cultivate Beginners

 The third annual Winter Bonsai Silhouette Expo returns to the NC Research Campus in Kannapolis, NC December 5 and 6 with more opportunities for bonsai beginners to learn the art.   Kannapolis, NC- Holiday trees are thought of as tall, green and laden with decorations. On Saturday, December 5 from 10 am to 4 pm and […]

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Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study

Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study, Nutrients, November 3, 2015. Carol L. Cheatham and Kelly Will Sheppard. Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA and Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, […]

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Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus, Cell Rep. 2015 Oct 27, Mou Z1, Hyde TM2, Lipska BK3, Martinowich K4, Wei P5, Ong CJ5, Hunter LA5, Palaguachi GI5, Morgun E1, Teng R6, Lai C5, Condarco TA7, Demidowich AP7,Krause AJ7, Marshall LJ8, Haack K9, Voruganti VS10, Cole SA9, Butte NF11, Comuzzie AG9, […]

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Lessons learned from metabolomics in cystic fibrosis

Lessons learned from metabolomics in cystic fibrosis, Molecular and Cellular Pediatrics 2015, Marianne S. Muhlebach1* and Wei Sha2 1Department Pediatrics, Division Pulmonology, UNC Chapel Hill 430 MacNider, CB 7217, Chapel Hill 27599-7217, NC, USA 2Bioinformatics Services Division, University of North Carolina at Charlotte, Kannapolis 28081, NC, USA Abstract Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory […]

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An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation

An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation, JNB,  15 Oct 2015, Jing Xue, Folami Y. Ideraabdullah, UNC Chapel Hill Abstract In recent years, the etiology of human disease has greatly improved with the inclusion of epigenetic mechanisms, in particular as a common link between environment and disease. However, for […]

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Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial, Am J Clin Nutr. 2015 Oct 7, Wozniak JR1, Fuglestad AJ2, Eckerle JK3, Fink BA2, Hoecker HL4, Boys CJ3, Radke JP5, Kroupina MG3, Miller NC3, Brearley AM6, Zeisel SH7, Georgieff MK3. 1Department of Psychiatry, jwozniak@umn.edu. 2Department of Psychiatry. 3Department of Pediatrics, and. 4School […]

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Study: Fruits, vegetables help improve internal protection system

By Josh Bergeron Read the original article in the Salilsbury Post. KANNAPOLIS — Try eating the skin of an avocado. It’s good for you, according to a North Carolina Research Campus study. A recently published, joint study by the University of North Carolina and Dole Foods at the North Carolina Research Campus used various fruit and vegetable […]

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Researcher returns to familiar ground for groundbreaking work

  Growing up in Kannapolis, Summer Goodson knew that the mammoth Cannon Mills textile complex was the lifeblood of the community. Members of her family worked in the plant for 70 years before Pillowtex shuttered the facility in 2003. Little did Goodson know that she would carry on her family’s legacy by one day working […]

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The NCRC Is Changing the Landscape of Health Care

As written for Cabarrus Magazine. Learn more about how the NCRC is changing the landscape of health care in our latest edition of Bioactive Magazine and by watching our latest video on Individualizing Health Care. From the community to the clinic, the NC Research Campus (NCRC) is changing the landscape of healthcare from reactive and treatment-centered to […]

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Nutrition and the science of disease prevention: a systems approach to support metabolic health

Nutrition and the science of disease prevention: a systems approach to support metabolic health, Ann N Y Acad Sci. 2015 Sep, Bennett BJ1, Hall KD2, Hu FB3, McCartney AL4, Roberto C5. 1Departments of Genetics and Nutrition, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. 2Integrative Physiology Section, National Institute of Diabetes […]

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Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance

Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance, Nutrition Research, September 10, 2015, Carol L. Cheatham, Daniel S. Lupu, Mihai D. Niculescu UNC Chapel Hill Abstract Maternal transfer of fatty acids is important to fetal brain development. The prenatal environment may differentially affect the substrates supporting […]

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Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. FASEB J. 2015 Aug 27, Zwart SR1, Gregory JF1, Zeisel SH1, Gibson CR1, Mader TH2, Kinchen JM1, Ueland PM1, Ploutz-Snyder R1, Heer MA1, Smith SM2. Author Affiliations 1*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food […]

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Fatty acids linked to cardiovascular mortality are associated with risk factors

Fatty acids linked to cardiovascular mortality are associated with risk factors, International Journal of Circumpolar Health, Aug 2015, Sven O. E. Ebbesson1,2*, Venkata S. Voruganti3, Paul B. Higgins4, Richard R. Fabsitz5, Lars O. Ebbesson6, Sandra Laston7, William S. Harris8,9, John Kennish10, Benjamin D. Umans11, Hong Wang12, Richard B. Devereux13, Peter M. Okin13, Neil J. Weissman12, Jean W. MacCluer7, Jason G. Umans12 and Barbara V. Howard12,14 1Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA; 2Norton Sound Health Corporation, Nome, AK, USA; 3Department of Nutrition and UNC Nutrition Research Institute, […]

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Catawba scholar helps with research at UNC’s Nutrition Institute

Read the original story in the Salisbury Post. Noyce Scholar Brinsley Stewart of Boonville plans to be a math teacher after she graduates from Catawba College in May 2016, but her internship experience this summer at the University of North Carolina Chapel Hill Nutrition Research Institute in Kannapolis gave her some keen insights into just […]

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Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City

Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City. Drug and Alcohol Dependence, 14 Aug 2015, Philip A. May, Carol Keaster, Rosemary Bozeman, Joelene Goodover, Jason Blankenship, Wendy O. Kalberg, David Buckley, Marita Brooks, Julie Hasken, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, H. Eugene Hoyme Nutrition Research Institute, University of North Carolina at Chapel Hill, Gillings School […]

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Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells, J Nutr. 2015 Jul 29, Orena S1, Owen J1, Jin F2, Fabian M2, Gillitt ND2, Zeisel SH3. 1University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NC; 2Dole Nutrition Research Laboratory, Kannapolis, NC; and. 3University of North Carolina at Chapel Hill Nutrition […]

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Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study, Toxicol Sci. 2015 Jul 23, Gribble MO1, Voruganti VS2, Cole SA3, Haack K3, Balakrishnan P4, Laston SL5, Tellez-Plaza M6, Francesconi KA7, Goessler W7, Umans JG8, Thomas DC9,Gilliland F9, North KE10, Franceschini N10, Navas-Acien A11. 1* Department of Preventive Medicine; University of Southern California; […]

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H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1

H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1, 5Jul2015, Biomolecular NMR Assignments, Yang Li, Mirko Hennig UNC Chapel Hill Abstract Heterogeneous nuclear ribonucleoproteins (hnRNPs) can be divided into subgroups based on their RNA-binding characteristics. One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of […]

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NCRC Offers Start-Ups Advantages

While touring the NC Research Campus (NCRC), founders of a West Coast biotech start-up were impressed to find in one place the resources they need to launch their business: Collaborations exploring plant-based phytochemicals with scientists at the NC State Plants for Human Health Institute. Product testing with the Appalachian State University Human Performance Laboratory, Spectrum Discovery Center and the UNC Nutrition Research Institute’s Human Research Core. […]

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19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR

19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR, Methods in Enzymology, 19Jun2015, Lincoln G. Scott*, Mirko Hennig†, , * Cassia LLC, San Diego, California, USA † Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA Abstract Naturally occurring RNA lacks fluorine-19 (19F), thus, their specifically fluorinated counterparts are particularly well suited […]

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Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency, Mol Genet Metab. 2015 Jun 18, Strauss KA1, Ferreira C2, Bottiglieri T3, Zhao X4, Arning E3, Zhang S4, Zeisel SH4, Escolar ML5, Presnick N6, Puffenberger EG7, Vugrek O8, Kovacevic L8,Wagner C9, Mazariegos GV10, Mudd SH11, Soltys K10. Author information 1Clinic for Special Children, Strasburg, PA, USA; Franklin […]

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Global metabolomic profiling targeting childhood obesity in the Hispanic population

Global metabolomic profiling targeting childhood obesity in the Hispanic population, Am J Clin Nutr. 2015 Jun 17, Butte NF1, Liu Y2, Zakeri IF3, Mohney RP4, Mehta N2, Voruganti VS5, Göring H6, Cole SA6, Comuzzie AG6. 1USDA/Agricultural Research Service Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX; nbutte@bcm.edu. 2USDA/Agricultural Research Service Children’s Nutrition […]

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A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine, Electrophoresis. 2015 Jun 17, Zhao X1, Zeisel S1,2, Zhang S3. Author information 1Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, 28081, USA. 2Department of Nutrition, School of Public Health and School of Medicine, […]

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The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice, 2015 Jun 3, Stem Cell Reports. Zhou X1, Crow AL2, Hartiala J2, Spindler TJ1, Ghazalpour A3, Barsky LW1, Bennett BB4, Parks BW3, Eskin E5, Jain R6, Epstein JA6, Lusis AJ3, Adams GB7,Allayee H8. Author information 1Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at […]

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Internship opens up a world of possibilities for Noyce Scholar at Catawba

Katherine Quijada of Cooleemee, a graduating senior at Catawba and a Noyce Scholar, says her summer 2014 internship at the UNC Chapel Hill Nutrition Research Institute in Kannapolis made her want “to strive for so much more.” Quijada graduated from Catawba on May 16 with a mathematics major and a secondary education minor, but her education will […]

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Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. 2015 Apr 28, FASEB J., Silver MJ1, Corbin KD1, Hellenthal G1, da Costa KA1, Dominguez-Salas P1, Moore SE1, Owen J1, Prentice AM1, Hennig BJ1, Zeisel SH2. 1*Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United […]

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UNC-Chapel Hill explores “Food for All” with 2015-2017 campus theme

(Chapel Hill, N.C.—April 28, 2015) – The University of North Carolina at Chapel Hill will come together at a common table when it examines food and food studies as its 2015-2017 university-wide academic theme. “Food for All: Local and Global Perspectives,” which builds on Carolina’s 2012-2015 “Water in Our World” focus on global water issues, will challenge […]

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Effects of Mthfd1 Gene on Mouse Behavior

Effects of Mthfd1 Gene on Mouse Behavior, Apr 2015,The FASEB Journal,  Eneda Pjetri1 and Steven Zeisel1 1Nutrition Research Institute UNC Chapel Hill Kannapolis NC United States Abstract Methylenetetrahydrofolate dehydrogenase 1 (Mthfd1) gene encodes the trifunctional C1 tetrahydrofolate (C1THF) enzyme that plays an important role in the folate-mediated one-carbon metabolism. A polymorphism of this gene (1958G>A; rs2236225) has […]

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Bill aims to increase number of courses faculty teach

By Jane Stancill jstancill@newsobserver.com Read original article A Senate bill would dictate the number of classes UNC faculty teach, forcing the near doubling of course loads for professors at the state’s research campuses – N.C. State University and UNC-Chapel Hill. Senate Bill 593 has generated a good deal of discussion at the UNC system’s campuses, […]

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Local Research Institute Boosts Economy through Critical Nutrition Discoveries

Read the original article on the UNC Nutrition Research Institute website. Eleven faculty research scientists at the UNC Nutrition Research Institute (NRI) in Kannapolis currently have externally funded grants to support their work exploring individualized nutrition. These awards are significant not only for providing the means by which the NRI can advance its scientific discoveries […]

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Analysis of Nutrition Education in Osteopathic Medical Schools

Analysis of Nutrition Education in Osteopathic Medical Schools, 4 Mar 2015, Journal of Biomedical Education, Kathaleen Briggs Early,1 Kelly M. Adams,2 and Martin Kohlmeier2,3 1College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, 200 University Pkwy, Yakima, WA 98901, USA 2Department of Nutrition, School of Medicine and Gillings School of Global Public Health, University of North Carolina at […]

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COBRA-LIKE2, a Member of the Glycosylphosphatidylinositol-Anchored COBRA-LIKE Family, Plays a Role in Cellulose Deposition in Arabidopsis Seed Coat Mucilage Secretory Cells.

COBRA-LIKE2, a Member of the Glycosylphosphatidylinositol-Anchored COBRA-LIKE Family, Plays a Role in Cellulose Deposition in Arabidopsis Seed Coat Mucilage Secretory Cells. Plant Physiol. 2015 Mar, Ben-Tov D1, Abraham Y1, Stav S1, Thompson K1, Loraine A1, Elbaum R1, de Souza A1, Pauly M1, Kieber JJ1, Harpaz-Saad S2. 1Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, […]

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Volume changes and brain‐behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure

Volume changes and brain‐behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure, Hum Brain Mapp. 2015 Feb 25, Gautam P1, Lebel C, Narr KL, Mattson SN, May PA, Adnams CM, Riley EP, Jones KL, Kan EC, Sowell ER. 1Department of Pediatrics, Developmental Cognitive Neuroimaging Laboratory, Keck School of Medicine, USC/Children‘s Hospital […]

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Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice, Gastroenterology. 2015 Feb 18, Tsuchiya H1, Costa KA2, Lee S3, Renga B4, Jaeschke H5, Yang Z6, Orena SJ2, Goedken MJ7, Zhang Y5, Bo K8, Lebofsky M5, Rudraiah S3, Smalling R1, Guo G8, Fiorucci S4, Zeisel SH2, Wang L9. Department of Medicine, University of Utah […]

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Identification of Aortic Arch-Specific Quantitative Trait Loci for Atherosclerosis by an Intercross of DBA/2J and 129S6 Apolipoprotein E-Deficient Mice.

Identification of Aortic Arch-Specific Quantitative Trait Loci for Atherosclerosis by an Intercross of DBA/2J and 129S6 Apolipoprotein E-Deficient Mice. PLoS One. 2015 Feb 17, Kayashima Y1, Makhanova NA1, Matsuki K1, Tomita H1, Bennett BJ2, Maeda N1. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. […]

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Due to Weather, UNC NRI Feb 17 Presentation Cancelled

Due to inclement weather, the  Appetite for Life lecture presentation by Dr. Natalia Surzenko of UNC Chapel Hill ‘s Nutrition Research Institute that was scheduled for February 17 at 7 pm has been cancelled. Please visit www.uncnri.org for a rescheduled date.

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Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study

Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study, The American Journal of Clinical Nutrition,  V Saroja Voruganti, Sandra Laston, Karin Haack, Nitesh R Mehta, Shelley A Cole, Nancy F Butte, and Anthony G Comuzzie From the Department of Nutrition (VSV) and UNC Nutrition Research Institute (VSV), University of North Carolina at Chapel Hill, Kannapolis, NC; […]

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Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin

Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin, American Heart Association, 28 Jan 2015,Jonathan C. Schisler, PhD; Trisha J. Grevengoed, BS; Florencia Pascual, PhD; Daniel E. Cooper, BS; Jessica M. Ellis, PhD; David S. Paul, PhD; Monte S. Willis, MD, PhD; Cam Patterson, MD; Wei Jia, PhD; Rosalind A. Coleman, MD 1Division […]

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Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease

Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease, Food Research International, 16Jan2015,  Jianmei Yua, , ,Michelle Hernandezd,Hao Lib, e,Ipek Goktepec,Carole Robinetted,Amy Auerbachd,David Pedend,Mohamed Ahmednac a Department of Family and Consumer Sciences, North Carolina A&T State University, Greensboro, NC 27411 b Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, Kannapolis, NC 28081, USA c […]

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Nutrition Competencies in Health Professionals’ Education and Training: A New Paradigm

Nutrition Competencies in Health Professionals’ Education and Training: A New Paradigm Adv Nutr. 2015 Jan 15, Kris-Etherton PM1, Akabas SR2, Douglas P3, Kohlmeier M4, Laur C5, Lenders CM6, Levy MD7, Nowson C8, Ray S5, Pratt CA9, Seidner DL10, Saltzman E11. Penn State University, University Park, PA; pmk3@psu.edu. 2Columbia University, New York, NY; 3University of Ulster, Londonderry, Northern […]

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NRI Faculty Elected as AHA Fellow

Read the original story on the UNC Chapel Hill Nutrition Research Institute’s website. The NRI is proud to announce that Saroja Voruganti, Ph.D., assistant professor in the Department of Nutrition at UNC Chapel Hill, has been elected a Fellow with the American Heart Association. Dr. Voruganti is one of 17 American Heart Association Fellows from […]

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Aldehyde dehydrogenase homologous folate enzymes: evolutionary switch between cytoplasmic and mitochondrial localization.

Aldehyde dehydrogenase homologous folate enzymes: evolutionary switch between cytoplasmic andmitochondrial localization. Chem Biol Interact. 2014 Dec 27, Krupenko NI1, Holmes RS2, Tsybovsky Y3, Krupenko SA4. Department of Nutrition, UNC-Chapel Hill, UNC Nutrition Research Institute, Kannapolis, NC 28081, United States. 2The Eskitis Institute for Drug Discovery and School of Natural Sciences, Griffith University, Nathan 4111 Brisbane, Queensland, Australia. 3Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, […]

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Mechanisms and correlates of a healthy brain: a commentary.

Mechanisms and correlates of a healthy brain: a commentary. Monogr Soc Res Child Dev. 2014 Dec, Cheatham CL. Abstract In this monograph, the message is that early inactivity and obesity lead to later chronic disease, and, as such, physical inactivity should be recognized as a public health crisis. Sedentary behavior, to some extent, serves a purpose in […]

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Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians

Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians. J Clin Endocrinol Metab. 2014 Nov 20, Tsai CW1, North KE, Tin A, Haack K, Franceschini N, Saroja Voruganti V (UNC Nutrition Research Institute), Laston S, Zhang Y, Best LG, MacCluer JW, Beaty TH, Navas-Acien A, Linda Kao WH,Howard BV. Department […]

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Research Campus leaders take stock of ‘great experiment’

By: Michael Knox, Independent Tribune Read Original Article KANNAPOLIS, N.C. — To mark the North Carolina Research Campus’ sixth anniversary, academic and scientific leaders touted advances made at the Kannapolis complex and offered a glimpse of some of the world-class research projects currently underway there. Clyde Higgs, vice president of business development for campus developer […]

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Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism, FASEB J. 2014 Nov 10, Martínez-Vega R1, Garrido F2, Partearroyo T3, Cediel R4, Zeisel SH5, Martínez-Álvarez C6, Varela-Moreiras G3, Varela-Nieto I7, Pajares MA8. 1Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Unidad 761, Centro de Investigación Biomédica en […]

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Prevalence and characteristics of fetal alcohol spectrum disorders

Prevalence and characteristics of fetal alcohol spectrum disorders Pediatrics. 2014 Oct 27, May PA1, Baete A2, Russo J2, Elliott AJ3, Blankenship J4, Kalberg WO4, Buckley D4, Brooks M4, Hasken J5, Abdul-Rahman O6, Adam MP7, Robinson LK8,Manning M9, Hoyme HE3. 1Department of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel […]

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High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis

High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis G3 (Bethesda). 2014 Oct 23, Smallwood TL1, Gatti DM2, Quizon P3, Weinstock GM4, Jung KC1, Zhao L1, Hua K1, Pomp D1, Bennett BJ5. University of North Carolina at Chapel Hill; 2The Jackson Laboratory; 3University of North Carolina Nutrition Research Institute; […]

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Men Needed for Research Studies

The MURDOCK Study and UNC Nutrition Research Institute at the N.C. Research Campus in Kannapolis need men to sign up for research studies.   (Kannapolis, N.C., October 15, 2014)—Officials with Duke University’s MURDOCK Study and the UNC Nutrition Research Institute (NRI), both at the N.C. Research Campus in Kannapolis, N.C., are having a hard time […]

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NC Research Campus seeks faster growth after slow start

By Ely Portillo, Charlotte Observer Read the original article KANNAPOLIS A billionaire pineapple company owner’s vision for the future of nutrition science rises next to Main Street in this former mill town, massive red brick buildings with soaring columns that contrast with surrounding one-story houses, shops and churches. Dole Foods owner David Murdock, whose diet […]

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Community Seminar: For Better or Worse – Consequences of Living with Chemicals

The Center for the Environment at Catawba College in partnership with the UNC Nutrition Research Institute, invites you to a community lecture: For Better or Worse- Consequences of Living with Chemicals presented by Folami Ideraabdullah, PhD Tuesday, October 7, 6:30 pm Our lives are surrounded by chemicals. They are in products we use on our […]

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Carol L. Cheatham, Ph.D. presented with National TRIO Achiever’s Award

Carol L. Cheatham, Ph.D., an Associate Professor in the Department of Psychology is one of 13 faculty members at the Nutrition Research Institute. Her research focuses on how nutrition can improve brain function. Specifically, her team studies the importance of nutrients for the development of memory and attention abilities. Dr. Cheatham got her start at […]

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5 Ways to Make Cancer Research Work for You

Read the article as posted on UNC Nutrition Research Institute’s website. By Harriet Sugar Miller, for Zester Daily July 24, 2014 Garlic, broccoli, green tea and turmeric: Health experts keep telling us to consume these foods to fight cancer. But articles from a New York Times science journalist are challenging the view that diet can prevent cancer. The evidence […]

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Bipartisan Policy Center Selects NRI-developed Online Curriculum

Read the original article on the UNC Nutrition Research Institute website. Nutrition in Medicine (NIM), an online curriculum for medical students developed by NRI faculty member Martin Kohlmeier, M.D., Ph.D., and NRI Director Steven Zeisel, M.D., Ph.D., has been recommended by the nonprofit Bipartisan Policy Center (BPC), the Alliance for a Healthier Generation, and the […]

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Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway.

Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway. PLoS One. 2014 Sep 1, Zha L1, Chen J2, Sun S2, Mao L2, Chu X2, Deng H2, Cai J3, Li X4, Liu Z5, Cao W6. 1Department of Nutrition and Food Hygiene, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China; Nutrition Research Institute at Kannapolis, Department of Nutrition, Gillings School […]

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Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics.

Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics. Mamm Genome. 2014 Aug 27, O’Connor A1, Quizon PM, Albright JE, Lin FT, Bennett BJ. UNC Chapel Hill Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081, USA. Abstract Intestinal microbial community structure is driven by host genetics in addition to environmental factors such as diet. In comparison with environmental influences, the effect of host genetics on intestinal microbiota, […]

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Nutrithon returns to Kannapolis Sept. 6, expected to reach fundraising goal

by: Susan Shinn, Salisbury Post Greg Thompson takes the turn back to the transition area as he finishes the 5K leg of the 2013 Kannapolis Rotary Nutrithon. Thompson was the first-place male finisher. KANNAPOLIS — The fourth-annual Nutrithon road race and cycling race takes place Saturday, Sept. 6, on the North Carolina Research Campus. For […]

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Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery

Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery BMC Med Genomics. 2014 Aug 12, Albright J, Quizon PM, Lusis AJ, Bennett BJ. Department of Genetics, Nutrition Research Institute, University of North, Carolina, Chapel Hill, 500 Laureate Way, Suite 2303, Kannapolis, NC 28081, USA Abstract BACKGROUND: Atherosclerosis, the underlying cause of cardiovascular disease, results from both genetic and environmental factors. METHODS: […]

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he genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains

The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains. Eur J Pharmacol. 2014 Aug 5 de Mooij-van Malsen A1, Pjetri E2, Kas MJ3. 1Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Institute of Physiology, CAU Kiel, Germany. 2Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, the […]

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Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study

Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study Cereb Cortex. 2014 Aug  Gautam P1, Nuñez SC1, Narr KL2, Mattson SN3, May PA4, Adnams CM5, Riley EP3, Jones KL6, Kan EC1, Sowell ER1. Developmental Cognitive Neuroimaging Laboratory, Department of Pediatrics, Keck School of Medicine at USC/Children’s Hospital of Los Angeles, Los Angeles, CA, USA. 2Department of Neurology, University of California at […]

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A Small Amount of Dietary Carbohydrate Can Promote the HFD-Induced Insulin Resistance to a Maximal Level

A Small Amount of Dietary Carbohydrate Can Promote the HFD-Induced Insulin Resistance to a Maximal Level. PlosOne, July 23, 2014. Shuang Mei equal contributor; Xuefeng Yang equal contributor; Huailan Guo; Haihua Gu; Longying Zha; Junwei Cai; Xuefeng Li; Zhenqi Liu; Brian J. Bennett; Ling He; Wenhong Cao.  Author Affiliations: Nutrition Research Institute at Kannapolis, Department of Nutrition, Gillings School […]

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Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the ―Dop‖ System among Farm Workers in the Western Cape Province, South Africa: Hope Despite High Levels of Risky Drinking

Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the ―Dop‖ System among Farm Workers in the Western Cape Province, South Africa: Hope Despite High Levels of Risky Drinking International Journal of Environmental Research and Public Health Jul 21, 2014 J. Phillip Gossage 1, Cudore L. Snell 2, Charles D. H. Parry 3,4, Anna-Susan Marais 4, Ronel […]

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The Clinical Utility and Specificity of Parent Report of Executive Function among Children with Prenatal Alcohol Exposure.

The Clinical Utility and Specificity of Parent Report of Executive Function among Children with Prenatal Alcohol Exposure. Jul 17,2014 Journal of the International Neuropsychological Society. Nguyen TT1, Glass L1, Coles CD2, Kable JA2, May PA3, Kalberg WO4, Sowell ER5, Jones KL6, Riley EP1, Mattson SN1; the CIFASD. 11Center for Behavioral Teratology,Department of Psychology,San Diego State University,San […]

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Kannapolis research institute: Could nutrition affect male infertility?

By Karen Garloch, Charlotte Observer Link to original article Summer Goodson, researcher at UNC Nutrition Research Institute in Kannapolis Researcher Summer Goodson is used to getting snickers when she tells people she’s studying male infertility. “It’s expected,” said Goodson, a post-doctoral research associate at the UNC Nutrition Research Institute in Kannapolis. “It’s a sensitive subject. […]

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Tissue specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region

Tissue specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Jun 30, 2014 Human Molecular Genetics. July 2014. Folami Y. Ideraabdullah1,2,3; Joanne L. Thorvaldsen1; Jennifer A. Myers1; Marisa S. Bartolomei1 1Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, 9-123 SCTR, 3400 Civic Center Blvd, Philadelphia, PA 19104 USA Current address: […]

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Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus.

Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus. Jun 30,2014 Al-Sinani S1, Hassan MO2, Zadjali F2, Al-Yahyaee S2, Albarwani S2, Rizvi S2, Jaju D2, Comuzzie A3, Voruganti VS4, Bayoumi R2. 1College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: Sawsan.alsinani@gmail.com. 2College of Medicine & Health Sciences, […]

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Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Jun 26, 2014 The American Journal of Clinical Nutrition. August 2014. Carolyn A Miller, Karen D Corbin, Kerry-Ann da Costa, Shucha Zhang, Xueqing Zhao, Joseph A Galanko, Tondra Blevins, Brian J Bennett, Annalouise O’Connor, and Steven H Zeisel. The Nutrition Research Institute, University of North Carolina at Chapel Hill, […]

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Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis

Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis. Molecular Biosystem. June 11, 2014.  Warren C Byrd,  Sarah Schwartz Baxter,  James Carlson,  Silvana Barros,  Steven Offenbacher and Sompop Bencharit. 1Department of Prosthodontics, School of Dentistry, Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; 2David H. Murdock […]

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A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease RiskA Randomized Clinical Trial

A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease RiskA Randomized Clinical Trial. JAMA Internal Medicine. Published online May 26, 2014 Thomas C. Keyserling, MD, MPH1,2; Stacey L. Sheridan, MD, MPH1,2,3; Lindy B. Draeger, MPH2; Eric A. Finkelstein, PhD, MA, MHA4; Ziya Gizlice, PhD2; Eliza Kruger, MHE4; Larry F. Johnston, MA2; Philip D. Sloane, MD3,5; Carmen Samuel-Hodge, PhD, RD2,6; Kelly R. Evenson, PhD, MS7; Myron D. Gross, PhD8; Katrina E. Donahue, MD, […]

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Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring

Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring. International Journal of developmental neuroscience.  May 24, 2014.[Epub ahead of print] He F1, Lupu DS2, Niculescu MD3. 1Department of Nutrition and Nutrition Research Institute, University of North Carolina at […]

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Residency and specialties training in nutrition: a call for action

Residency and specialties training in nutrition: a call for action. American Journal of Clinical Nutrition. May 2014; Epub 2014 Mar 19. Lenders CM1, Deen DD, Bistrian B, Edwards MS, Seidner DL, McMahon MM, Kohlmeier M, Krebs NF. 1Division of Pediatric Nutrition, Boston Medical Center, and Department of Pediatrics, Boston University School of Medicine, Boston, MA (CML); the Department of Community Health and […]

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Nutrition education in medical school: a time of opportunity.

Nutrition education in medical school: a time of opportunity. American Journal of Clinical Nutrition. May 2014; Epub 2014 Mar 19. Kushner RF1, Van Horn L, Rock CL, Edwards MS, Bales CW, Kohlmeier M, Akabas SR. 1Feinberg School of Medicine, Northwestern University, Chicago, IL (RFK); the Department of Preventive Medicine, Northwestern University, Chicago, IL (LVH); the Department of Family and Preventive Medicine, University […]

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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications. April 29,2014; Dominguez-Salas P1, Moore SE1, Baker MS2, Bergen AW3, Cox SE1, Dyer RA4, Fulford AJ1, Guan Y5, Laritsky E2, Silver MJ1, Swan GE6, Zeisel SH7, Innis SM4, Waterland RA5, Prentice AM1, Hennig BJ1. 1MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street, London WC1E 7HT, UK.; […]

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Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat

Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat Am J Cardiovasc Dis 2014;4, Qiang Shi1,2, Vida Hodara1,3, Qinghe Meng4, V Saroja Voruganti5, Karen Rice1, Joel E Michalek6, Anthony G Comuzzie1,2, John L VandeBerg1,2 1Southwest National Primate Research Center, Texas Biomedical Research Institute, […]

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Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease.

Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease. The FASEB Journal, April 2014; Brian Bennett1,3; Karen Corbin2,; Tangi Smallwood3,; Annalouise o’Connor2; Steven Zeisel1,4. 1UNC Nutrition Research Institute Kannapolis NC United States; 2UNC Nutrition Research Institute Kannapolis NC United States; 3Department of Genetics University of North Carolina Chapel Hill NC United States; 4 Department of […]

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Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. The Journal of Endocrinology. Apr 16, 2014 [Epub ahead of print] Yang X1, Mei S, Gu H, Guo H, Zha L, Cai J, Li X, Liu Z, Cao W. 1X Yang, Nutrition, UNC at Chapel Hill, Kannapolis, United States. Abstract We have previously shown that insulin plays an essential role […]

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NCRC offers free science events throughout April

  The Salisbury Post KANNAPOLIS — Science lovers of all ages are invited to celebrate nutrition and science in April at the N.C. Research Campus in Kannapolis. The campus is offering several free events featuring everything from personalized nutrition to STEM (science, technology, engineering and math) As part of the N.C. Science Festival, Rowan-Cabarrus Community […]

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Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and L-Carnitine.

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and L-Carnitine. Arteriosclerosis, thrombosis, and vascular biology. Mar 27, 2014. [Epub ahead of print] Hartiala J1, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R; CARDIoGRAM Consortium, Lusis AJ, Hazen SL, Allayee H. From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., […]

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Celebrate Nutrition and Science at the NCRC in April

NC Research Campus, Kannapolis, NC. March 27, 2014)- Moms, Dads, kids and science lovers of all ages, April is the month to visit the North Carolina Research to enjoy free events headlining everything from personalized nutrition to STEM (science, technology, engineering and math). Tuesdays, April 1, 8 and 22, the UNC Chapel Hill Nutrition Research […]

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Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. March 26, 2014. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Department of Nutrition, School of Public Health, School of Medicine, […]

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Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1- phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut- Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity

Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1- phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut- Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity Bioorg. and Med. Chem. Let. 20:6797- 6801 Mar, 2014  Richard L. Elliott, Kimberly O. Cameron, Janice E. Chin, Jeremy A. Bartlett, Elena E. Beretta, Yue Chen, Paul Da Silva Jardine, Jeffrey S. Dubins, Melissa L. Gillaspy, Diane […]

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A Growing Campus

By Clyde Higgs, Vice President of Business Development Published in Opportunities, a quarterly real estate to research newsletter of the NC Research Campus March 14, 2014 I want to make sure everyone close to the campus is just as aware of how our momentum is building and the campus is growing: Jobs: Close to 1,000 jobs […]

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UNC’s lab at N.C. Research Campus to host free seminars in Kannapolis

Salisbury Post March 7, 2014 KANNAPOLIS ­— Join the University of North Carolina at Chapel Hill Nutrition Research Institute for the 2014 Appetite for Life Academy New Frontiers in Research series. Each seminar is free and will be held at 7 p.m. on Tuesdays in the events room of the David H. Murdock Core Laboratory […]

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Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa.

Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa. Reproductibe Toxicology. February 22. 2014. [Epub ahead of print] May PA, Hamrick KJ, Corbin KD, Hasken JM, Marais AS, Brooke LE, Blankenship J, Hoyme HE, Gossage JP. University of North Carolina at Chapel Hill, Nutrition Research Institute, NC Research […]

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Does RTP need a mega-donor to realize its grand vision?

February 20, 2014 Lauren K. Ohnesorge Staff Writer- Triangle Business Journal What Research Triangle Park needs is its own David Murdock. That’s one takeaway from a conversation I had with Lynne Scott Safrit, president and chief operating officer of Castle and Cooke, the organization that oversees the development of the Kannapolis-based North Carolina Research Campus. […]

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Quantitative Trait Loci Affecting Atherosclerosis at the Aortic Root Identified in an Intercross between DBA2J and 129S6 Apolipoprotein E-Null Mice.

Quantitative Trait Loci Affecting Atherosclerosis at the Aortic Root Identified in an Intercross between DBA2J and 129S6 Apolipoprotein E-Null Mice. PloS One, February 20, 2014. Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim HS, Bennett BJ, Maeda N. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill,  Department of Genetics, University of North Carolina at Chapel […]

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UNC NRI Appetite for Life Seminars This April

February 10, 2014 April 1, 8 and 22 join the University of North Carolina at Chapel Hill Nutrition Research Institute (NRI) for the 2014 Appetite for Life Academy. Each seminar is at 7 pm in the event room of the David H. Murdock Core Laboratory Building, 150 Research Campus Drive in Kannnapolis. April 1 – Uric […]

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Omega-3 intake linked to higher cognition in infants, toddlers and young children

YottaFire Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio of […]

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New Professor at NRI

  New professor at NRI: Saroja Voruganti, Ph.D., has joined the UNC Nutrition Research Institute in Kannapolis as an assistant professor in the Department of Nutrition at UNC Chapel Hill. Voruganti’s long-term research goal is to understand the genetic and environmental factors that affect complex human diseases using a combination of statistical, molecular and bioinformatics […]

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Omega-3 Intake Linked to Higher Cognition in Children

YottaFire Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio of […]

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Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.

Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Frontiers in Genetics. Dec 16, 2013. Voruganti VS, Kent JW Jr, Debnath S, Cole SA, Haack K, Göring HH, Carless MA, Curran JE, Johnson MP, Almasy L, Dyer TD, Maccluer JW,Moses EK, Abboud HE, Mahaney MC, Blangero J, Comuzzie AG. Department of Genetics, Texas Biomedical Research Institute San Antonio, TX; Department of Nutrition, […]

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Exhibition brings lovers of bonsai art to Kannapolis

By Lisa Thornton Slideshow – LISA THORNTON “Most people think bonsai is a certain type of tree. It’s not, though,” said Dr. Steven Zeisel, who sponsored the exhibition. “Any tree can be a bonsai.” To learn more The Bonsai Society of the Carolinas meets monthly at the UNC Charlotte Botanical Gardens. Its website is www.bonsaicarolina.org. […]

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Winter bonsai exhibition opening in Kannapolis on Saturday

Salisbury Post Submitted photo The artistry and beauty of bonsai will come to Kannapolis for the first Winter Silhouette Bonsai Exhibition. The exhibition will be held from 1 to 5 p.m. Saturday and Sunday in the event room and atrium of the first floor of the David H. Murdock Core Laboratory building, 150 N Research […]

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NRI Announces 2013 Art Contest Winners

UNC Chapel Hill Grand Prize Winners: Randall and Rhaisa Weber of the A-Beka Home School (left) and Moira Hunter, of Jackson Park Elementary (right). Steven H. Zeisel, M.D., Ph.D., director of the University of North Carolina at Chapel Hill Nutrition Research Institute (UNC NRI), has announced the winners of the 2013 Student Art Contest. As […]

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Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians.

Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. European Journal of Human Genetics. December 2013 [Epub ahead of print] Voruganti VS, Franceschini N, Haack K, Laston S, Maccluer JW, Umans JG, Comuzzie AG, North KE, Cole SA. Department of Nutrition and Nutrition Research Institute, University of North […]

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A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.

A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutrition Journal. November 25, 2013. David C Nieman, R Andrew Shanely, Beibei Luo, Dustin Dew, Mary Pat Meaney, and Wei Sha. Appalachian State University, Human Performance Lab, North Carolina Research Campus; Key Laboratory of Exercise and Health Sciences of Ministry […]

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Bonsai exhibition at N.C. Research Campus Dec. 7-8

Salisbury Post KANNAPOLIS — On Saturday, Dec. 7 and Sunday, Dec. 8, the artistry and beauty of bonsai will come to Kannapolis for the first Winter Silhouette Bonsai Exhibition. The exhibition will be held from 1 to 5 p.m. both days in the event room and atrium of the first floor of the David H. […]

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NCRC Start-Up Seeks to Stop Diabetes

Dr. Wenhong Cao, PhD, a researcher with the UNC Chapel Hill Nutrition Research Institute, launched a biotech start-up that is developing supplements and an at-home test for insulin resistance. The products are designed to stop diabetes long before it can develop. Cao is in the process of opening up his company’s lab in the NCRC’s ready-to-go […]

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Ready-to-Go Labs Expand N.C. Research Campus

NC Health News For scientific companies trying to get a start, but without a lot of money, having a lab at their disposal can make the difference between failing or flying. By Stephanie Soucheray Wenhong Cao has been studying diabetes and insulin resistance for 20 years, but last year the University of North Carolina-Chapel Hill […]

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