UNC Chapel Hill Search Results

“Put Your Best Fork Forward” at Events Sponsored by NCRC Partners

  Programs offered by experts at the NC Research Campus help people “Put their Best Fork Forward” in March during National Nutrition Month. Kannapolis, NC – “Put Your Best Fork Forward” is the theme of this year’s National Nutrition Month celebration. Sponsored annually in March by The Academy of Nutrition and Dietetics, this year’s theme is […]

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Bonsai- Artistry for the Family to Enjoy this Holiday Season

The annual Winter Silhouette Bonsai Expo returns to the NC Research Campus Saturday, December 3 and Sunday, December 4.  The free event offers families an opportunity to relax and enjoy the artistry of bonsai before the holiday season kicks into high gear. Organized by bonsai artist Steven Zeisel, MD, PhD, director of the UNC Nutrition […]

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MURDOCK-NCRC Seed Funding Voucher Awardees

The MURDOCK Study has awarded six $10,000 vouchers as part of the MURDOCK-NCRC Seed Funding Voucher Program to investigators from North Carolina Research Campus partners. Duke University and the MURDOCK Study are pleased to announce the following voucher recipients: Saroja Voruganti, PhD, UNC Nutrition Research Institute (UNC NRI) “A pilot study to identify polymorphisms associated […]

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UNC Nutrition Research Institute Welcomes Renowned Scientist Susan Smith

Susan Smith, Ph.D., joined the UNC Nutrition Research Institute this month. She is an internally recognized expert in the field of nutritional affects on the risk for birth defects.  The UNC Nutrition Research Institute (NRI) welcomes Susan Smith, Ph.D., who joins the research facility’s roster of scientists this month. Dr. Smith is an internationally recognized […]

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UNC System President Margaret Spellings Tours the North Carolina Research Campus

See the original story and video on TimeWarner Cable News. KANNAPOLIS, N.C. — The University of North Carolina System president visited Kannapolis and Charlotte on Monday as part of her “100 Days” tour. As she toured the North Carolina Research Campus, she learned what researchers are doing across universities to further nutritional and agricultural research. […]

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UNC System President Margaret Spellings Visits the NC Research Campus

            On Monday, March 14, UNC system President Margaret Spellings visited the NC Research Campus as part of her “100 Days” tour. Along with the NC Research Campus, she is visiting all 16 public universities, the NC School of Science and Mathematics and UNC Health Care to “learn and experience […]

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NC Scientists Study Fetal Alcohol Syndrome

By Carly Stephenson See the original story on TimeWarner Cable. CABARRUS COUNTY — The Centers for Disease Control and Prevention recently released information on alcohol and pregnancy, and now scientists at the North Carolina Research Campus are building on that to recommend complete health solutions for women trying to have children. According to Dr. Philip May’s […]

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The NCRC Opens New Ready-to-Use Laboratory Suites and First Flexible Office

  Kannapolis, NC– Entrepreneurs take note. The NC Research Campus (NCRC) newest ready-to-use wet laboratory suites and its first flexible office space are both open for business. Located on the third floor of the NCRC’s David H. Murdock Core Laboratory Building both of the new 2,000-square-foot research laboratory suites can be sub-divided into smaller units. […]

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No amount of alcohol in pregnancy is safe: ‘There is too much that is unknown’, warns leading expert 

By Lisa Ryan Read the original article in DailyMail A fetal alcohol syndrome expert warns against pregnant alcohol use There is too much risk – and unknowns – to justify drinking, he says A recent study found fetal alcohol syndrome is more common than thought FAS said to affect 3 out of 1,000 kids – but […]

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Maternal Nutritional Status as a Contributing Factor for the Risk of Fetal Alcohol Spectrum Disorders

Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders, Reproductive Toxicology. December 3, 2015. Philip A. Maya, b, Kari J. Hamrickc, Karen D. Corbind, Julie M. Haskena, Anna-Susan Maraise, f, Jason Blankenshipb, H.Eugene Hoymeg, J.Phillip Gossageb a University of North Carolina at Chapel Hill, Nutrition Research Institute, Gillings School of Global Public Health, USA b The University of New Mexico Center on […]

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Bonsai show bares all for winter Dec 5 & 6

By Lisa Thornton Read the original article in the Charlotte Observer With bonsai – the art of growing dwarfed ornamental trees – old age, or at least the appearance of it, is the gold standard of beauty. Those interested in the hobby will get the chance to see how that’s achieved during the Winter Silhouette […]

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Annual Kannapolis Bonsai Expo Aims to Cultivate Beginners

 The third annual Winter Bonsai Silhouette Expo returns to the NC Research Campus in Kannapolis, NC December 5 and 6 with more opportunities for bonsai beginners to learn the art.   Kannapolis, NC- Holiday trees are thought of as tall, green and laden with decorations. On Saturday, December 5 from 10 am to 4 pm and […]

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Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study

Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study, Nutrients, November 3, 2015. Carol L. Cheatham and Kelly Will Sheppard. Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA and Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, […]

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Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus, Cell Rep. 2015 Oct 27, Mou Z1, Hyde TM2, Lipska BK3, Martinowich K4, Wei P5, Ong CJ5, Hunter LA5, Palaguachi GI5, Morgun E1, Teng R6, Lai C5, Condarco TA7, Demidowich AP7,Krause AJ7, Marshall LJ8, Haack K9, Voruganti VS10, Cole SA9, Butte NF11, Comuzzie AG9, […]

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Lessons learned from metabolomics in cystic fibrosis

Lessons learned from metabolomics in cystic fibrosis, Molecular and Cellular Pediatrics 2015, Marianne S. Muhlebach1* and Wei Sha2 1Department Pediatrics, Division Pulmonology, UNC Chapel Hill 430 MacNider, CB 7217, Chapel Hill 27599-7217, NC, USA 2Bioinformatics Services Division, University of North Carolina at Charlotte, Kannapolis 28081, NC, USA Abstract Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory […]

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An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation

An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation, JNB,  15 Oct 2015, Jing Xue, Folami Y. Ideraabdullah, UNC Chapel Hill Abstract In recent years, the etiology of human disease has greatly improved with the inclusion of epigenetic mechanisms, in particular as a common link between environment and disease. However, for […]

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Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial, Am J Clin Nutr. 2015 Oct 7, Wozniak JR1, Fuglestad AJ2, Eckerle JK3, Fink BA2, Hoecker HL4, Boys CJ3, Radke JP5, Kroupina MG3, Miller NC3, Brearley AM6, Zeisel SH7, Georgieff MK3. 1Department of Psychiatry, jwozniak@umn.edu. 2Department of Psychiatry. 3Department of Pediatrics, and. 4School […]

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Study: Fruits, vegetables help improve internal protection system

By Josh Bergeron Read the original article in the Salilsbury Post. KANNAPOLIS — Try eating the skin of an avocado. It’s good for you, according to a North Carolina Research Campus study. A recently published, joint study by the University of North Carolina and Dole Foods at the North Carolina Research Campus used various fruit and vegetable […]

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Researcher returns to familiar ground for groundbreaking work

  Growing up in Kannapolis, Summer Goodson knew that the mammoth Cannon Mills textile complex was the lifeblood of the community. Members of her family worked in the plant for 70 years before Pillowtex shuttered the facility in 2003. Little did Goodson know that she would carry on her family’s legacy by one day working […]

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The NCRC Is Changing the Landscape of Health Care

As written for Cabarrus Magazine. Learn more about how the NCRC is changing the landscape of health care in our latest edition of Bioactive Magazine and by watching our latest video on Individualizing Health Care. From the community to the clinic, the NC Research Campus (NCRC) is changing the landscape of healthcare from reactive and treatment-centered to […]

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Nutrition and the science of disease prevention: a systems approach to support metabolic health

Nutrition and the science of disease prevention: a systems approach to support metabolic health, Ann N Y Acad Sci. 2015 Sep, Bennett BJ1, Hall KD2, Hu FB3, McCartney AL4, Roberto C5. 1Departments of Genetics and Nutrition, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. 2Integrative Physiology Section, National Institute of Diabetes […]

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Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance

Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance, Nutrition Research, September 10, 2015, Carol L. Cheatham, Daniel S. Lupu, Mihai D. Niculescu UNC Chapel Hill Abstract Maternal transfer of fatty acids is important to fetal brain development. The prenatal environment may differentially affect the substrates supporting […]

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Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. FASEB J. 2015 Aug 27, Zwart SR1, Gregory JF1, Zeisel SH1, Gibson CR1, Mader TH2, Kinchen JM1, Ueland PM1, Ploutz-Snyder R1, Heer MA1, Smith SM2. Author Affiliations 1*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food […]

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Fatty acids linked to cardiovascular mortality are associated with risk factors

Fatty acids linked to cardiovascular mortality are associated with risk factors, International Journal of Circumpolar Health, Aug 2015, Sven O. E. Ebbesson1,2*, Venkata S. Voruganti3, Paul B. Higgins4, Richard R. Fabsitz5, Lars O. Ebbesson6, Sandra Laston7, William S. Harris8,9, John Kennish10, Benjamin D. Umans11, Hong Wang12, Richard B. Devereux13, Peter M. Okin13, Neil J. Weissman12, Jean W. MacCluer7, Jason G. Umans12 and Barbara V. Howard12,14 1Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA; 2Norton Sound Health Corporation, Nome, AK, USA; 3Department of Nutrition and UNC Nutrition Research Institute, […]

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Catawba scholar helps with research at UNC’s Nutrition Institute

Read the original story in the Salisbury Post. Noyce Scholar Brinsley Stewart of Boonville plans to be a math teacher after she graduates from Catawba College in May 2016, but her internship experience this summer at the University of North Carolina Chapel Hill Nutrition Research Institute in Kannapolis gave her some keen insights into just […]

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Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City

Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City. Drug and Alcohol Dependence, 14 Aug 2015, Philip A. May, Carol Keaster, Rosemary Bozeman, Joelene Goodover, Jason Blankenship, Wendy O. Kalberg, David Buckley, Marita Brooks, Julie Hasken, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, H. Eugene Hoyme Nutrition Research Institute, University of North Carolina at Chapel Hill, Gillings School […]

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Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells, J Nutr. 2015 Jul 29, Orena S1, Owen J1, Jin F2, Fabian M2, Gillitt ND2, Zeisel SH3. 1University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NC; 2Dole Nutrition Research Laboratory, Kannapolis, NC; and. 3University of North Carolina at Chapel Hill Nutrition […]

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Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study, Toxicol Sci. 2015 Jul 23, Gribble MO1, Voruganti VS2, Cole SA3, Haack K3, Balakrishnan P4, Laston SL5, Tellez-Plaza M6, Francesconi KA7, Goessler W7, Umans JG8, Thomas DC9,Gilliland F9, North KE10, Franceschini N10, Navas-Acien A11. 1* Department of Preventive Medicine; University of Southern California; […]

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H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1

H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1, 5Jul2015, Biomolecular NMR Assignments, Yang Li, Mirko Hennig UNC Chapel Hill Abstract Heterogeneous nuclear ribonucleoproteins (hnRNPs) can be divided into subgroups based on their RNA-binding characteristics. One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of […]

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NCRC Offers Start-Ups Advantages

While touring the NC Research Campus (NCRC), founders of a West Coast biotech start-up were impressed to find in one place the resources they need to launch their business: Collaborations exploring plant-based phytochemicals with scientists at the NC State Plants for Human Health Institute. Product testing with the Appalachian State University Human Performance Laboratory, Spectrum Discovery Center and the UNC Nutrition Research Institute’s Human Research Core. […]

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19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR

19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR, Methods in Enzymology, 19Jun2015, Lincoln G. Scott*, Mirko Hennig†, , * Cassia LLC, San Diego, California, USA † Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA Abstract Naturally occurring RNA lacks fluorine-19 (19F), thus, their specifically fluorinated counterparts are particularly well suited […]

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Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency, Mol Genet Metab. 2015 Jun 18, Strauss KA1, Ferreira C2, Bottiglieri T3, Zhao X4, Arning E3, Zhang S4, Zeisel SH4, Escolar ML5, Presnick N6, Puffenberger EG7, Vugrek O8, Kovacevic L8,Wagner C9, Mazariegos GV10, Mudd SH11, Soltys K10. Author information 1Clinic for Special Children, Strasburg, PA, USA; Franklin […]

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Global metabolomic profiling targeting childhood obesity in the Hispanic population

Global metabolomic profiling targeting childhood obesity in the Hispanic population, Am J Clin Nutr. 2015 Jun 17, Butte NF1, Liu Y2, Zakeri IF3, Mohney RP4, Mehta N2, Voruganti VS5, Göring H6, Cole SA6, Comuzzie AG6. 1USDA/Agricultural Research Service Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX; nbutte@bcm.edu. 2USDA/Agricultural Research Service Children’s Nutrition […]

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A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine, Electrophoresis. 2015 Jun 17, Zhao X1, Zeisel S1,2, Zhang S3. Author information 1Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, 28081, USA. 2Department of Nutrition, School of Public Health and School of Medicine, […]

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The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice, 2015 Jun 3, Stem Cell Reports. Zhou X1, Crow AL2, Hartiala J2, Spindler TJ1, Ghazalpour A3, Barsky LW1, Bennett BB4, Parks BW3, Eskin E5, Jain R6, Epstein JA6, Lusis AJ3, Adams GB7,Allayee H8. Author information 1Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at […]

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Internship opens up a world of possibilities for Noyce Scholar at Catawba

Katherine Quijada of Cooleemee, a graduating senior at Catawba and a Noyce Scholar, says her summer 2014 internship at the UNC Chapel Hill Nutrition Research Institute in Kannapolis made her want “to strive for so much more.” Quijada graduated from Catawba on May 16 with a mathematics major and a secondary education minor, but her education will […]

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Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. 2015 Apr 28, FASEB J., Silver MJ1, Corbin KD1, Hellenthal G1, da Costa KA1, Dominguez-Salas P1, Moore SE1, Owen J1, Prentice AM1, Hennig BJ1, Zeisel SH2. 1*Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United […]

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UNC-Chapel Hill explores “Food for All” with 2015-2017 campus theme

(Chapel Hill, N.C.—April 28, 2015) – The University of North Carolina at Chapel Hill will come together at a common table when it examines food and food studies as its 2015-2017 university-wide academic theme. “Food for All: Local and Global Perspectives,” which builds on Carolina’s 2012-2015 “Water in Our World” focus on global water issues, will challenge […]

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Effects of Mthfd1 Gene on Mouse Behavior

Effects of Mthfd1 Gene on Mouse Behavior, Apr 2015,The FASEB Journal,  Eneda Pjetri1 and Steven Zeisel1 1Nutrition Research Institute UNC Chapel Hill Kannapolis NC United States Abstract Methylenetetrahydrofolate dehydrogenase 1 (Mthfd1) gene encodes the trifunctional C1 tetrahydrofolate (C1THF) enzyme that plays an important role in the folate-mediated one-carbon metabolism. A polymorphism of this gene (1958G>A; rs2236225) has […]

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Bill aims to increase number of courses faculty teach

By Jane Stancill jstancill@newsobserver.com Read original article A Senate bill would dictate the number of classes UNC faculty teach, forcing the near doubling of course loads for professors at the state’s research campuses – N.C. State University and UNC-Chapel Hill. Senate Bill 593 has generated a good deal of discussion at the UNC system’s campuses, […]

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Local Research Institute Boosts Economy through Critical Nutrition Discoveries

Read the original article on the UNC Nutrition Research Institute website. Eleven faculty research scientists at the UNC Nutrition Research Institute (NRI) in Kannapolis currently have externally funded grants to support their work exploring individualized nutrition. These awards are significant not only for providing the means by which the NRI can advance its scientific discoveries […]

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Analysis of Nutrition Education in Osteopathic Medical Schools

Analysis of Nutrition Education in Osteopathic Medical Schools, 4 Mar 2015, Journal of Biomedical Education, Kathaleen Briggs Early,1 Kelly M. Adams,2 and Martin Kohlmeier2,3 1College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, 200 University Pkwy, Yakima, WA 98901, USA 2Department of Nutrition, School of Medicine and Gillings School of Global Public Health, University of North Carolina at […]

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COBRA-LIKE2, a Member of the Glycosylphosphatidylinositol-Anchored COBRA-LIKE Family, Plays a Role in Cellulose Deposition in Arabidopsis Seed Coat Mucilage Secretory Cells.

COBRA-LIKE2, a Member of the Glycosylphosphatidylinositol-Anchored COBRA-LIKE Family, Plays a Role in Cellulose Deposition in Arabidopsis Seed Coat Mucilage Secretory Cells. Plant Physiol. 2015 Mar, Ben-Tov D1, Abraham Y1, Stav S1, Thompson K1, Loraine A1, Elbaum R1, de Souza A1, Pauly M1, Kieber JJ1, Harpaz-Saad S2. 1Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, […]

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Volume changes and brain‐behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure

Volume changes and brain‐behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure, Hum Brain Mapp. 2015 Feb 25, Gautam P1, Lebel C, Narr KL, Mattson SN, May PA, Adnams CM, Riley EP, Jones KL, Kan EC, Sowell ER. 1Department of Pediatrics, Developmental Cognitive Neuroimaging Laboratory, Keck School of Medicine, USC/Children‘s Hospital […]

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Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice, Gastroenterology. 2015 Feb 18, Tsuchiya H1, Costa KA2, Lee S3, Renga B4, Jaeschke H5, Yang Z6, Orena SJ2, Goedken MJ7, Zhang Y5, Bo K8, Lebofsky M5, Rudraiah S3, Smalling R1, Guo G8, Fiorucci S4, Zeisel SH2, Wang L9. Department of Medicine, University of Utah […]

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Identification of Aortic Arch-Specific Quantitative Trait Loci for Atherosclerosis by an Intercross of DBA/2J and 129S6 Apolipoprotein E-Deficient Mice.

Identification of Aortic Arch-Specific Quantitative Trait Loci for Atherosclerosis by an Intercross of DBA/2J and 129S6 Apolipoprotein E-Deficient Mice. PLoS One. 2015 Feb 17, Kayashima Y1, Makhanova NA1, Matsuki K1, Tomita H1, Bennett BJ2, Maeda N1. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. […]

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Due to Weather, UNC NRI Feb 17 Presentation Cancelled

Due to inclement weather, the  Appetite for Life lecture presentation by Dr. Natalia Surzenko of UNC Chapel Hill ‘s Nutrition Research Institute that was scheduled for February 17 at 7 pm has been cancelled. Please visit www.uncnri.org for a rescheduled date.

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Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study

Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study, The American Journal of Clinical Nutrition,  V Saroja Voruganti, Sandra Laston, Karin Haack, Nitesh R Mehta, Shelley A Cole, Nancy F Butte, and Anthony G Comuzzie From the Department of Nutrition (VSV) and UNC Nutrition Research Institute (VSV), University of North Carolina at Chapel Hill, Kannapolis, NC; […]

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Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin

Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin, American Heart Association, 28 Jan 2015,Jonathan C. Schisler, PhD; Trisha J. Grevengoed, BS; Florencia Pascual, PhD; Daniel E. Cooper, BS; Jessica M. Ellis, PhD; David S. Paul, PhD; Monte S. Willis, MD, PhD; Cam Patterson, MD; Wei Jia, PhD; Rosalind A. Coleman, MD 1Division […]

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Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease

Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease, Food Research International, 16Jan2015,  Jianmei Yua, , ,Michelle Hernandezd,Hao Lib, e,Ipek Goktepec,Carole Robinetted,Amy Auerbachd,David Pedend,Mohamed Ahmednac a Department of Family and Consumer Sciences, North Carolina A&T State University, Greensboro, NC 27411 b Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, Kannapolis, NC 28081, USA c […]

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Nutrition Competencies in Health Professionals’ Education and Training: A New Paradigm

Nutrition Competencies in Health Professionals’ Education and Training: A New Paradigm Adv Nutr. 2015 Jan 15, Kris-Etherton PM1, Akabas SR2, Douglas P3, Kohlmeier M4, Laur C5, Lenders CM6, Levy MD7, Nowson C8, Ray S5, Pratt CA9, Seidner DL10, Saltzman E11. Penn State University, University Park, PA; pmk3@psu.edu. 2Columbia University, New York, NY; 3University of Ulster, Londonderry, Northern […]

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NRI Faculty Elected as AHA Fellow

Read the original story on the UNC Chapel Hill Nutrition Research Institute’s website. The NRI is proud to announce that Saroja Voruganti, Ph.D., assistant professor in the Department of Nutrition at UNC Chapel Hill, has been elected a Fellow with the American Heart Association. Dr. Voruganti is one of 17 American Heart Association Fellows from […]

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Aldehyde dehydrogenase homologous folate enzymes: evolutionary switch between cytoplasmic and mitochondrial localization.

Aldehyde dehydrogenase homologous folate enzymes: evolutionary switch between cytoplasmic andmitochondrial localization. Chem Biol Interact. 2014 Dec 27, Krupenko NI1, Holmes RS2, Tsybovsky Y3, Krupenko SA4. Department of Nutrition, UNC-Chapel Hill, UNC Nutrition Research Institute, Kannapolis, NC 28081, United States. 2The Eskitis Institute for Drug Discovery and School of Natural Sciences, Griffith University, Nathan 4111 Brisbane, Queensland, Australia. 3Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, […]

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Mechanisms and correlates of a healthy brain: a commentary.

Mechanisms and correlates of a healthy brain: a commentary. Monogr Soc Res Child Dev. 2014 Dec, Cheatham CL. Abstract In this monograph, the message is that early inactivity and obesity lead to later chronic disease, and, as such, physical inactivity should be recognized as a public health crisis. Sedentary behavior, to some extent, serves a purpose in […]

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Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians

Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians. J Clin Endocrinol Metab. 2014 Nov 20, Tsai CW1, North KE, Tin A, Haack K, Franceschini N, Saroja Voruganti V (UNC Nutrition Research Institute), Laston S, Zhang Y, Best LG, MacCluer JW, Beaty TH, Navas-Acien A, Linda Kao WH,Howard BV. Department […]

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Research Campus leaders take stock of ‘great experiment’

By: Michael Knox, Independent Tribune Read Original Article KANNAPOLIS, N.C. — To mark the North Carolina Research Campus’ sixth anniversary, academic and scientific leaders touted advances made at the Kannapolis complex and offered a glimpse of some of the world-class research projects currently underway there. Clyde Higgs, vice president of business development for campus developer […]

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Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism, FASEB J. 2014 Nov 10, Martínez-Vega R1, Garrido F2, Partearroyo T3, Cediel R4, Zeisel SH5, Martínez-Álvarez C6, Varela-Moreiras G3, Varela-Nieto I7, Pajares MA8. 1Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Unidad 761, Centro de Investigación Biomédica en […]

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Prevalence and characteristics of fetal alcohol spectrum disorders

Prevalence and characteristics of fetal alcohol spectrum disorders Pediatrics. 2014 Oct 27, May PA1, Baete A2, Russo J2, Elliott AJ3, Blankenship J4, Kalberg WO4, Buckley D4, Brooks M4, Hasken J5, Abdul-Rahman O6, Adam MP7, Robinson LK8,Manning M9, Hoyme HE3. 1Department of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel […]

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High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis

High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis G3 (Bethesda). 2014 Oct 23, Smallwood TL1, Gatti DM2, Quizon P3, Weinstock GM4, Jung KC1, Zhao L1, Hua K1, Pomp D1, Bennett BJ5. University of North Carolina at Chapel Hill; 2The Jackson Laboratory; 3University of North Carolina Nutrition Research Institute; […]

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Men Needed for Research Studies

The MURDOCK Study and UNC Nutrition Research Institute at the N.C. Research Campus in Kannapolis need men to sign up for research studies.   (Kannapolis, N.C., October 15, 2014)—Officials with Duke University’s MURDOCK Study and the UNC Nutrition Research Institute (NRI), both at the N.C. Research Campus in Kannapolis, N.C., are having a hard time […]

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NC Research Campus seeks faster growth after slow start

By Ely Portillo, Charlotte Observer Read the original article KANNAPOLIS A billionaire pineapple company owner’s vision for the future of nutrition science rises next to Main Street in this former mill town, massive red brick buildings with soaring columns that contrast with surrounding one-story houses, shops and churches. Dole Foods owner David Murdock, whose diet […]

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Community Seminar: For Better or Worse – Consequences of Living with Chemicals

The Center for the Environment at Catawba College in partnership with the UNC Nutrition Research Institute, invites you to a community lecture: For Better or Worse- Consequences of Living with Chemicals presented by Folami Ideraabdullah, PhD Tuesday, October 7, 6:30 pm Our lives are surrounded by chemicals. They are in products we use on our […]

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Carol L. Cheatham, Ph.D. presented with National TRIO Achiever’s Award

Carol L. Cheatham, Ph.D., an Associate Professor in the Department of Psychology is one of 13 faculty members at the Nutrition Research Institute. Her research focuses on how nutrition can improve brain function. Specifically, her team studies the importance of nutrients for the development of memory and attention abilities. Dr. Cheatham got her start at […]

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5 Ways to Make Cancer Research Work for You

Read the article as posted on UNC Nutrition Research Institute’s website. By Harriet Sugar Miller, for Zester Daily July 24, 2014 Garlic, broccoli, green tea and turmeric: Health experts keep telling us to consume these foods to fight cancer. But articles from a New York Times science journalist are challenging the view that diet can prevent cancer. The evidence […]

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Bipartisan Policy Center Selects NRI-developed Online Curriculum

Read the original article on the UNC Nutrition Research Institute website. Nutrition in Medicine (NIM), an online curriculum for medical students developed by NRI faculty member Martin Kohlmeier, M.D., Ph.D., and NRI Director Steven Zeisel, M.D., Ph.D., has been recommended by the nonprofit Bipartisan Policy Center (BPC), the Alliance for a Healthier Generation, and the […]

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Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway.

Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway. PLoS One. 2014 Sep 1, Zha L1, Chen J2, Sun S2, Mao L2, Chu X2, Deng H2, Cai J3, Li X4, Liu Z5, Cao W6. 1Department of Nutrition and Food Hygiene, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China; Nutrition Research Institute at Kannapolis, Department of Nutrition, Gillings School […]

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Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics.

Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics. Mamm Genome. 2014 Aug 27, O’Connor A1, Quizon PM, Albright JE, Lin FT, Bennett BJ. UNC Chapel Hill Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081, USA. Abstract Intestinal microbial community structure is driven by host genetics in addition to environmental factors such as diet. In comparison with environmental influences, the effect of host genetics on intestinal microbiota, […]

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Nutrithon returns to Kannapolis Sept. 6, expected to reach fundraising goal

by: Susan Shinn, Salisbury Post Greg Thompson takes the turn back to the transition area as he finishes the 5K leg of the 2013 Kannapolis Rotary Nutrithon. Thompson was the first-place male finisher. KANNAPOLIS — The fourth-annual Nutrithon road race and cycling race takes place Saturday, Sept. 6, on the North Carolina Research Campus. For […]

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Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery

Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery BMC Med Genomics. 2014 Aug 12, Albright J, Quizon PM, Lusis AJ, Bennett BJ. Department of Genetics, Nutrition Research Institute, University of North, Carolina, Chapel Hill, 500 Laureate Way, Suite 2303, Kannapolis, NC 28081, USA Abstract BACKGROUND: Atherosclerosis, the underlying cause of cardiovascular disease, results from both genetic and environmental factors. METHODS: […]

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he genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains

The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains. Eur J Pharmacol. 2014 Aug 5 de Mooij-van Malsen A1, Pjetri E2, Kas MJ3. 1Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Institute of Physiology, CAU Kiel, Germany. 2Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, the […]

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Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study

Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study Cereb Cortex. 2014 Aug  Gautam P1, Nuñez SC1, Narr KL2, Mattson SN3, May PA4, Adnams CM5, Riley EP3, Jones KL6, Kan EC1, Sowell ER1. Developmental Cognitive Neuroimaging Laboratory, Department of Pediatrics, Keck School of Medicine at USC/Children’s Hospital of Los Angeles, Los Angeles, CA, USA. 2Department of Neurology, University of California at […]

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A Small Amount of Dietary Carbohydrate Can Promote the HFD-Induced Insulin Resistance to a Maximal Level

A Small Amount of Dietary Carbohydrate Can Promote the HFD-Induced Insulin Resistance to a Maximal Level. PlosOne, July 23, 2014. Shuang Mei equal contributor; Xuefeng Yang equal contributor; Huailan Guo; Haihua Gu; Longying Zha; Junwei Cai; Xuefeng Li; Zhenqi Liu; Brian J. Bennett; Ling He; Wenhong Cao.  Author Affiliations: Nutrition Research Institute at Kannapolis, Department of Nutrition, Gillings School […]

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Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the ―Dop‖ System among Farm Workers in the Western Cape Province, South Africa: Hope Despite High Levels of Risky Drinking

Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the ―Dop‖ System among Farm Workers in the Western Cape Province, South Africa: Hope Despite High Levels of Risky Drinking International Journal of Environmental Research and Public Health Jul 21, 2014 J. Phillip Gossage 1, Cudore L. Snell 2, Charles D. H. Parry 3,4, Anna-Susan Marais 4, Ronel […]

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The Clinical Utility and Specificity of Parent Report of Executive Function among Children with Prenatal Alcohol Exposure.

The Clinical Utility and Specificity of Parent Report of Executive Function among Children with Prenatal Alcohol Exposure. Jul 17,2014 Journal of the International Neuropsychological Society. Nguyen TT1, Glass L1, Coles CD2, Kable JA2, May PA3, Kalberg WO4, Sowell ER5, Jones KL6, Riley EP1, Mattson SN1; the CIFASD. 11Center for Behavioral Teratology,Department of Psychology,San Diego State University,San […]

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Kannapolis research institute: Could nutrition affect male infertility?

By Karen Garloch, Charlotte Observer Link to original article Summer Goodson, researcher at UNC Nutrition Research Institute in Kannapolis Researcher Summer Goodson is used to getting snickers when she tells people she’s studying male infertility. “It’s expected,” said Goodson, a post-doctoral research associate at the UNC Nutrition Research Institute in Kannapolis. “It’s a sensitive subject. […]

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Tissue specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region

Tissue specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Jun 30, 2014 Human Molecular Genetics. July 2014. Folami Y. Ideraabdullah1,2,3; Joanne L. Thorvaldsen1; Jennifer A. Myers1; Marisa S. Bartolomei1 1Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, 9-123 SCTR, 3400 Civic Center Blvd, Philadelphia, PA 19104 USA Current address: […]

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Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus.

Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus. Jun 30,2014 Al-Sinani S1, Hassan MO2, Zadjali F2, Al-Yahyaee S2, Albarwani S2, Rizvi S2, Jaju D2, Comuzzie A3, Voruganti VS4, Bayoumi R2. 1College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: Sawsan.alsinani@gmail.com. 2College of Medicine & Health Sciences, […]

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Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Jun 26, 2014 The American Journal of Clinical Nutrition. August 2014. Carolyn A Miller, Karen D Corbin, Kerry-Ann da Costa, Shucha Zhang, Xueqing Zhao, Joseph A Galanko, Tondra Blevins, Brian J Bennett, Annalouise O’Connor, and Steven H Zeisel. The Nutrition Research Institute, University of North Carolina at Chapel Hill, […]

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Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis

Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis. Molecular Biosystem. June 11, 2014.  Warren C Byrd,  Sarah Schwartz Baxter,  James Carlson,  Silvana Barros,  Steven Offenbacher and Sompop Bencharit. 1Department of Prosthodontics, School of Dentistry, Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; 2David H. Murdock […]

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A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease RiskA Randomized Clinical Trial

A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease RiskA Randomized Clinical Trial. JAMA Internal Medicine. Published online May 26, 2014 Thomas C. Keyserling, MD, MPH1,2; Stacey L. Sheridan, MD, MPH1,2,3; Lindy B. Draeger, MPH2; Eric A. Finkelstein, PhD, MA, MHA4; Ziya Gizlice, PhD2; Eliza Kruger, MHE4; Larry F. Johnston, MA2; Philip D. Sloane, MD3,5; Carmen Samuel-Hodge, PhD, RD2,6; Kelly R. Evenson, PhD, MS7; Myron D. Gross, PhD8; Katrina E. Donahue, MD, […]

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Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring

Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring. International Journal of developmental neuroscience.  May 24, 2014.[Epub ahead of print] He F1, Lupu DS2, Niculescu MD3. 1Department of Nutrition and Nutrition Research Institute, University of North Carolina at […]

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Residency and specialties training in nutrition: a call for action

Residency and specialties training in nutrition: a call for action. American Journal of Clinical Nutrition. May 2014; Epub 2014 Mar 19. Lenders CM1, Deen DD, Bistrian B, Edwards MS, Seidner DL, McMahon MM, Kohlmeier M, Krebs NF. 1Division of Pediatric Nutrition, Boston Medical Center, and Department of Pediatrics, Boston University School of Medicine, Boston, MA (CML); the Department of Community Health and […]

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Nutrition education in medical school: a time of opportunity.

Nutrition education in medical school: a time of opportunity. American Journal of Clinical Nutrition. May 2014; Epub 2014 Mar 19. Kushner RF1, Van Horn L, Rock CL, Edwards MS, Bales CW, Kohlmeier M, Akabas SR. 1Feinberg School of Medicine, Northwestern University, Chicago, IL (RFK); the Department of Preventive Medicine, Northwestern University, Chicago, IL (LVH); the Department of Family and Preventive Medicine, University […]

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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications. April 29,2014; Dominguez-Salas P1, Moore SE1, Baker MS2, Bergen AW3, Cox SE1, Dyer RA4, Fulford AJ1, Guan Y5, Laritsky E2, Silver MJ1, Swan GE6, Zeisel SH7, Innis SM4, Waterland RA5, Prentice AM1, Hennig BJ1. 1MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street, London WC1E 7HT, UK.; […]

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Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat

Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat Am J Cardiovasc Dis 2014;4, Qiang Shi1,2, Vida Hodara1,3, Qinghe Meng4, V Saroja Voruganti5, Karen Rice1, Joel E Michalek6, Anthony G Comuzzie1,2, John L VandeBerg1,2 1Southwest National Primate Research Center, Texas Biomedical Research Institute, […]

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Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease.

Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease. The FASEB Journal, April 2014; Brian Bennett1,3; Karen Corbin2,; Tangi Smallwood3,; Annalouise o’Connor2; Steven Zeisel1,4. 1UNC Nutrition Research Institute Kannapolis NC United States; 2UNC Nutrition Research Institute Kannapolis NC United States; 3Department of Genetics University of North Carolina Chapel Hill NC United States; 4 Department of […]

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Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. The Journal of Endocrinology. Apr 16, 2014 [Epub ahead of print] Yang X1, Mei S, Gu H, Guo H, Zha L, Cai J, Li X, Liu Z, Cao W. 1X Yang, Nutrition, UNC at Chapel Hill, Kannapolis, United States. Abstract We have previously shown that insulin plays an essential role […]

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NCRC offers free science events throughout April

  The Salisbury Post KANNAPOLIS — Science lovers of all ages are invited to celebrate nutrition and science in April at the N.C. Research Campus in Kannapolis. The campus is offering several free events featuring everything from personalized nutrition to STEM (science, technology, engineering and math) As part of the N.C. Science Festival, Rowan-Cabarrus Community […]

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Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and L-Carnitine.

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and L-Carnitine. Arteriosclerosis, thrombosis, and vascular biology. Mar 27, 2014. [Epub ahead of print] Hartiala J1, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R; CARDIoGRAM Consortium, Lusis AJ, Hazen SL, Allayee H. From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., […]

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Celebrate Nutrition and Science at the NCRC in April

NC Research Campus, Kannapolis, NC. March 27, 2014)- Moms, Dads, kids and science lovers of all ages, April is the month to visit the North Carolina Research to enjoy free events headlining everything from personalized nutrition to STEM (science, technology, engineering and math). Tuesdays, April 1, 8 and 22, the UNC Chapel Hill Nutrition Research […]

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Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. March 26, 2014. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Department of Nutrition, School of Public Health, School of Medicine, […]

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Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1- phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut- Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity

Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1- phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut- Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity Bioorg. and Med. Chem. Let. 20:6797- 6801 Mar, 2014  Richard L. Elliott, Kimberly O. Cameron, Janice E. Chin, Jeremy A. Bartlett, Elena E. Beretta, Yue Chen, Paul Da Silva Jardine, Jeffrey S. Dubins, Melissa L. Gillaspy, Diane […]

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A Growing Campus

By Clyde Higgs, Vice President of Business Development Published in Opportunities, a quarterly real estate to research newsletter of the NC Research Campus March 14, 2014 I want to make sure everyone close to the campus is just as aware of how our momentum is building and the campus is growing: Jobs: Close to 1,000 jobs […]

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Annual Catalyst Research Symposium April 15

NCRC News The Catalyst group fosters personal and professional relationships between researchers at the NCRC, specifically helping postdoctoral researchers with professional development. As part of their mission, they host an annual research symposium. The 2014 Catalyst Research Sumposium is Tuesday, April 15 from 11:30 am to 5 pm at the NC Research Campus in the […]

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UNC’s lab at N.C. Research Campus to host free seminars in Kannapolis

Salisbury Post March 7, 2014 KANNAPOLIS ­— Join the University of North Carolina at Chapel Hill Nutrition Research Institute for the 2014 Appetite for Life Academy New Frontiers in Research series. Each seminar is free and will be held at 7 p.m. on Tuesdays in the events room of the David H. Murdock Core Laboratory […]

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Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa.

Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa. Reproductibe Toxicology. February 22. 2014. [Epub ahead of print] May PA, Hamrick KJ, Corbin KD, Hasken JM, Marais AS, Brooke LE, Blankenship J, Hoyme HE, Gossage JP. University of North Carolina at Chapel Hill, Nutrition Research Institute, NC Research […]

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Does RTP need a mega-donor to realize its grand vision?

February 20, 2014 Lauren K. Ohnesorge Staff Writer- Triangle Business Journal What Research Triangle Park needs is its own David Murdock. That’s one takeaway from a conversation I had with Lynne Scott Safrit, president and chief operating officer of Castle and Cooke, the organization that oversees the development of the Kannapolis-based North Carolina Research Campus. […]

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Quantitative Trait Loci Affecting Atherosclerosis at the Aortic Root Identified in an Intercross between DBA2J and 129S6 Apolipoprotein E-Null Mice.

Quantitative Trait Loci Affecting Atherosclerosis at the Aortic Root Identified in an Intercross between DBA2J and 129S6 Apolipoprotein E-Null Mice. PloS One, February 20, 2014. Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim HS, Bennett BJ, Maeda N. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill,  Department of Genetics, University of North Carolina at Chapel […]

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UNC NRI Appetite for Life Seminars This April

February 10, 2014 April 1, 8 and 22 join the University of North Carolina at Chapel Hill Nutrition Research Institute (NRI) for the 2014 Appetite for Life Academy. Each seminar is at 7 pm in the event room of the David H. Murdock Core Laboratory Building, 150 Research Campus Drive in Kannnapolis. April 1 – Uric […]

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Omega-3 intake linked to higher cognition in infants, toddlers and young children

YottaFire Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio of […]

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New Professor at NRI

  New professor at NRI: Saroja Voruganti, Ph.D., has joined the UNC Nutrition Research Institute in Kannapolis as an assistant professor in the Department of Nutrition at UNC Chapel Hill. Voruganti’s long-term research goal is to understand the genetic and environmental factors that affect complex human diseases using a combination of statistical, molecular and bioinformatics […]

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Omega-3 Intake Linked to Higher Cognition in Children

YottaFire Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio of […]

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Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.

Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Frontiers in Genetics. Dec 16, 2013. Voruganti VS, Kent JW Jr, Debnath S, Cole SA, Haack K, Göring HH, Carless MA, Curran JE, Johnson MP, Almasy L, Dyer TD, Maccluer JW,Moses EK, Abboud HE, Mahaney MC, Blangero J, Comuzzie AG. Department of Genetics, Texas Biomedical Research Institute San Antonio, TX; Department of Nutrition, […]

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Exhibition brings lovers of bonsai art to Kannapolis

By Lisa Thornton Slideshow – LISA THORNTON “Most people think bonsai is a certain type of tree. It’s not, though,” said Dr. Steven Zeisel, who sponsored the exhibition. “Any tree can be a bonsai.” To learn more The Bonsai Society of the Carolinas meets monthly at the UNC Charlotte Botanical Gardens. Its website is www.bonsaicarolina.org. […]

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Winter bonsai exhibition opening in Kannapolis on Saturday

Salisbury Post Submitted photo The artistry and beauty of bonsai will come to Kannapolis for the first Winter Silhouette Bonsai Exhibition. The exhibition will be held from 1 to 5 p.m. Saturday and Sunday in the event room and atrium of the first floor of the David H. Murdock Core Laboratory building, 150 N Research […]

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NRI Announces 2013 Art Contest Winners

UNC Chapel Hill Grand Prize Winners: Randall and Rhaisa Weber of the A-Beka Home School (left) and Moira Hunter, of Jackson Park Elementary (right). Steven H. Zeisel, M.D., Ph.D., director of the University of North Carolina at Chapel Hill Nutrition Research Institute (UNC NRI), has announced the winners of the 2013 Student Art Contest. As […]

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Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians.

Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. European Journal of Human Genetics. December 2013 [Epub ahead of print] Voruganti VS, Franceschini N, Haack K, Laston S, Maccluer JW, Umans JG, Comuzzie AG, North KE, Cole SA. Department of Nutrition and Nutrition Research Institute, University of North […]

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A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.

A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutrition Journal. November 25, 2013. David C Nieman, R Andrew Shanely, Beibei Luo, Dustin Dew, Mary Pat Meaney, and Wei Sha. Appalachian State University, Human Performance Lab, North Carolina Research Campus; Key Laboratory of Exercise and Health Sciences of Ministry […]

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Bonsai exhibition at N.C. Research Campus Dec. 7-8

Salisbury Post KANNAPOLIS — On Saturday, Dec. 7 and Sunday, Dec. 8, the artistry and beauty of bonsai will come to Kannapolis for the first Winter Silhouette Bonsai Exhibition. The exhibition will be held from 1 to 5 p.m. both days in the event room and atrium of the first floor of the David H. […]

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NCRC Start-Up Seeks to Stop Diabetes

Dr. Wenhong Cao, PhD, a researcher with the UNC Chapel Hill Nutrition Research Institute, launched a biotech start-up that is developing supplements and an at-home test for insulin resistance. The products are designed to stop diabetes long before it can develop. Cao is in the process of opening up his company’s lab in the NCRC’s ready-to-go […]

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Ready-to-Go Labs Expand N.C. Research Campus

NC Health News For scientific companies trying to get a start, but without a lot of money, having a lab at their disposal can make the difference between failing or flying. By Stephanie Soucheray Wenhong Cao has been studying diabetes and insulin resistance for 20 years, but last year the University of North Carolina-Chapel Hill […]

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Internships at Nutrition Research Institute transform Catawba students

Salisbury Post Thomas Benton, a chemistry major at Catawba College, has learned a lot during his internship with the Nutrition Research Institute at the N.C. Research Campus. On the surface, Aliyah Khan and Thomas Benton’s internships at the University of North Carolina at Chapel Hill’s Nutrition Research Institute may appear to be all about the […]

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Omega-3 intake linked to higher cognition in infants, toddlers and young children

Medical Press Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio […]

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Infants to Teens Impacted by Genetics, Nutrition and Exercise

NCRC News Scientists at the NC Research Campus are exploring areas of genetics, nutrition and human performance that impact brain development, risk factors for disease and the overall health of infants, toddlers, young children and teenagers.   Omega-3 Intake Linked to Higher Cognition in Infants, Toddlers and Young Children Carol L. Cheatham, PhD, developmental cognitive […]

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Preventing Disease and Improving Health Starts Early In Life

Disease prevention and good health is not a goal just for adults. NC Research Campus scientists are contributing scientific findings that show a a lifetime of good health starts as early as infancy with a mother’s diet and her genotype playing a critical role. As a child grows, their eating habits and activity level determine their risk for […]

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Conceptual shifts needed to understand the dynamic interactions of genes, environment, epigenetics, social processes, and behavioral choices

Conceptual shifts needed to understand the dynamic interactions of genes, environment, epigenetics, social processes, and behavioral choices. American Journal of Public Health. October 2013. Jackson FL, Niculescu MD, University of North Carolina at Chapel Hill;  Jackson RT, University of Maryland at College Park. Abstract Social and behavioral research in public health is often intimately tied […]

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Interface between Pharmacotherapy and Genes in Human Obesity

Interface between Pharmacotherapy and Genes in Human Obesity. Human Heredity. September 27, 2013. O’Connor A, Swick AG. UNC Chapel Hill Nutrition Research Institute, Kannapolis, NC. Abstract Obesity is a polygenic chronic condition, and dysregulation in multiple underlying energy balance processes drives the obese phenotype. Lifestyle changes can be difficult to sustain long term, and anti-obesity drugs can […]

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Local study seeks to find out if eating blueberries slows memory loss

Salisbury Post KANNAPOLIS — Researchers at the Cheatham Nutrition and Cognition Lab are currently recruiting participants for the B. E. R. R. Y. study. Fact Box What: B.E.R.R.Y. study, stands for Blueberries: Exciting Research Relevant to You. Who: Individuals who are age 65 to 79, beginning to experience mild memory decline and have not been […]

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N.C. Scientists Work To Develop Fat-Burning Product

Thu, 09/12/2013 – 10:30am Richard Craver, Winston-Salem Journal Get today’s manufacturing headlines and news – Sign up now! WINSTON-SALEM, N.C. (AP) — It sounds on the surface like a too-good-to-be-true infomercial offer – boost your metabolism and burn fat during your sleep. However, a group of scientists at the N.C. Research Campus, led by researcher […]

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Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): Quantity, frequency, and timing of drinking

Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): Quantity, frequency, and timing of drinking. Drug Alcohol Dependence. Aug 8, 2013 [Epub ahead of print]. May PA, Blankenship J, Marais AS, Gossage JP, Kalberg WO, Joubert B, Cloete M, Barnard R, De Vries M, Hasken J, Robinson LK, Adnams CM, Buckley D, Manning M, Parry […]

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Omega-6 to omega-3 fatty acid ratio and higher-order cognitive functions in 7- to 9-y-olds: a cross-sectional study

Omega-6 to omega-3 fatty acid ratio and higher-order cognitive functions in 7- to 9-y-olds: a cross-sectional study. American Journal of Clinical Nutrition. July 3, 2013. Sheppard KW, Cheatham CL. Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC, and the Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, […]

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Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives

Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives. Computational and Structural Biotechnol Journal. 2013 Jun 28;4:e201301013. eCollection 2013. Du X, Zeisel SH. Department of Bioinformatics, University of North Carolina at Charlotte, Charlotte, NC; Nutrition Research Institute, University of North Carolina at Chapel Hill, NC Research Campus, Kannapolis, NC. Abstract Mass spectrometry coupled to […]

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UNC Research Institute gets creative with arts contest

Michael Knox Previous winners of the UNC Chapel Hill Nutrition Research Institute’s art contest are displayed at the group’s facility at the North Carolina Research Campus in Kannapolis. Independent Tribune Posted: Sunday, June 23, 2013 8:37 am By Michael Knox mknox@independenttribune.com KANNAPOLIS, N.C. — Celebrating five years of the North Carolina Research Campus in Kannapolis, […]

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Heart and Liver Disease: Deciphering Metabolic and Genetic Connections

The human genetic code is 99.9 percent identical. What makes people individuals, genetically speaking, equates to .1 percent of their individual genetic make-up and accounts for thousands of differentiations at the molecular level.  Deciphering those differentiations or polymorphisms and their involvement in the development of disease is the work of scientists like Karen Corbin, PhD, RD, and […]

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Nutrition Research Institute: Helping the world get healthier, one person at the time

The Nutrition Research Institute is located on the developing North Carolina Research Campus in Kannapolis. Scientific studies under way at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI), located on the North Carolina Research Campus (NCRC) in Kannapolis, show promise of a healthier future for children and adults based on new […]

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NRI Director recognized for excellence in teaching, research and service

UNC NRI Newsletter Dr. Steven Zeisel, M.D. Ph.D., Director of the UNC Nutrition Research Institute The University of North Carolina Nutrition Research Institute (UNC NRI) announces today that Stephen H. Zeisel, M.D., Ph.D., Kenan Distinguished University Professor in Nutrition and Pediatrics and UNC NRI Director, has been selected as the 2012 recipient of the Bernard […]

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NC Research Campus study shows blueberries may slow effects of mild memory loss

By: Jenna Barnes, TWC News NC Research Campus study shows blueberries may slow effects of mild memory loss KANNAPOLIS — Blueberries might be a key ingredient to keeping the mind sharp. Psychologists at the North Carolina Research Campus think the fruit can slow the effects of mild memory loss. “Blueberries have an active ingredient in […]

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NC Research Campus study shows blueberries may slow effects of mild memory loss

By: Jenna Barnes, News 14 Carolina TWC News: NC Research Campus study shows blueberries may slow effects of mild memory loss KANNAPOLIS — Blueberries might be a key ingredient to keeping the mind sharp. Psychologists at the North Carolina Research Campus think the fruit can slow the effects of mild memory loss. “Blueberries have an […]

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Blueberries and Your Mind

Carol L. Cheatham, PhD, a developmental cognitive neuroscientist and an assistant professor of psychology at UNC Chapel Hill and the UNC Chapel Hill Nutrition Research Institute, is leading the B.E.R.R.Y Study, which stands for Blueberries: Exciting Research Relevant to You. The study is enrolling 65 to 79 year olds who are just beginning to experience memory issues but […]

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Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass

Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Metabolism.  Aug 2013, Swick AG1, Orena S, O’Connor A. UNC Nutrition Research Institute, University of North Carolina Chapel Hill, North Carolina Research Campus, Kannapolis, North Carolina, USA. andrew_swick@unc.edu Abstract Objective Obesity is a result of chronic overconsumption of […]

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Nutrition in pregnancy: the argument for including a source of choline

Nutrition in pregnancy: the argument for including a source of choline April 2013. International Journal of Women’s Health. April 2013. Zeisel, SH. Nutrition Research Institute at Kannapolis, Department of Nutrition, University of North Carolina at Chapel Hill. Abstract Women, during pregnancy and lactation, should eat foods that contain adequate amounts of choline. A mother delivers […]

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Frontiers in Nutrition series comes to Kannapolis in April

  The Salisbury Post KANNAPOLIS — The UNC-Chapel Hill Nutrition Research Institute will present several nutrition-science seminars in April. The Frontiers in Nutrition series brings in leading experts to present their research in sessions “designed to help people eat better and live healthier lives,” according to information provided by the Research Institute. The seminars will […]

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UNC Nutrition scientist awarded $5.3 million grant to study fetal alcohol disorders

  The Salsibury Post The UNC Nutrition Research Institute in Kannapolis has received a $5.3 million grant to study fetal alcohol disorders in South Africa.  The funds are from the National Institute of Health’s National Institute on Alcohol Abuse and Alcoholism. The study will be conducted by Dr. Philip May, a faculty member at the […]

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UNC Nutrition scientist awarded $5.3 million grant to study fetal alcohol disorders

The Salisbury Post The UNC Nutrition Research Institute in Kannapolis has received a $5.3 million grant to study fetal alcohol disorders in South Africa.  The funds are from the National Institute of Health’s National Institute on Alcohol Abuse and Alcoholism. The study will be conducted by Dr. Philip May, a faculty member at the University […]

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Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis.

Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis. Plant Physiology. May 2013. Epub Mar 22, 2013. Bhargava A, Clabaugh I, To JP, Maxwell BB, Chiang YH, Schaller GE, Loraine A (UNC Charlotte at the NC Research Campus), Kieber JJ. Department of Biology, University of North Carolina, Chapel Hill, North Carolina. Abstract Cytokinins […]

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Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms. Current Opinion in Clinical Nutrition and Metabolomic Care. March 13, 2013. Mehedint, MG, Zeisel SH. Nutrition Research Institute at the NC Research Campus, Kannapolis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Abstract PURPOSE OF REVIEW: Humans eating diets low in […]

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Weight Loss Strategies That Really Work!

Deborah Tate, PhD, with the UNC Chapel Hill Gillings School of Global Public Health, spoke at one of the UNC Chapel Hill Nutrition Research Institute’s Appetite for Life Academy seminars and offered researched-backed, practical weight loss strategies: Tracking your food intake and weighing frequently are behaviors that along with diet and exercise support weight loss. Weight […]

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UNC professor outlines simple strategies for managing weight

By Sarah Campbell, Salisbury Post   KANNAPOLIS — An associate professor for nutrition at the University of North Carolina at Chapel Hill mapped out ways to manage weight during the sixth annual Appetite for Life Academy lecture series held at the North Carolina Research Campus. “In order to manage your weight today it takes active […]

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Nutrition researcher: Family plays vital role in reducing childhood obesity

By: Sarah Campbell, Salisbury Post KANNAPOLIS — An associate professor with the University of North Carolina at Chapel Hill recently kicked off the sixth annual Appetite for Life Academy lecture series with information about the role family plays in childhood obesity. “It’s hard to find a topic that’s more in the public mind than childhood […]

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Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB Journal. February 1, 2013. Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. University of North Carolina at Chapel Hill Nutrition Research Institute, Abstract […]

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Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.

Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.  Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka D, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract SCOPE: There are limited data on the metabolism of [6]-shogaol (6S), […]

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NC scientists work toward treatment and prevention of liver cancer

By: Sarah Pisciuneri, Time Warner Cable News TWC News: NC scientists work toward treatment and prevention of liver cancer Play now KANNAPOLIS, N.C. — Scientists at the North Carolina Research Campus are looking for ways to treat and prevent certain types of liver disease. Researchers in Kannapolis say both alcoholic and non-alcoholic forms of liver […]

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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.  Cell Metabolism. January 8, 2013. Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Department of Medicine, University of California, Los […]

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Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metabolism. January 8, 2013. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, […]

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Elicited Imitation Performance at 20 Months Predicts Memory Abilities in School-Age Children

Elicited Imitation Performance at 20 Months Predicts Memory Abilities in School-Age Children. Journal of Cognition and Developmental: official journal of the Cognitive Development Society. January 1, 2013 Riggins T, Cheatham CL, Stark E, Bauer PJ. University of Maryland, College Park; University of North Carolina, Chapel Hill Nutrition Research Institute, NC Research Campus; Minnesota State University, Mankato; Emory […]

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Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study.

Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study. Alcoholism, Clinical and Experimental Research. December 2012. May PA, Blankenship J, Marais AS, Gossage JP, Kalberg WO, Barnard R, De Vries M, Robinson LK, Adnams CM, Buckley D, Manning M, Jones KL, Parry C, Hoyme HE, Seedat […]

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Perinatal epigenetic determinants of cognitive and metabolic disorders

Perinatal epigenetic determinants of cognitive and metabolic disorders Aging and Disease.Aging and Disease. December 2012. Lupo, DS, Tint D, Niculescu MD. UNC Chaple Hill Nutrition Research Institute. Abstract Multiple cues from the environment of our indirect and immediate ancestors, which often persist throughout the prenatal period and adulthood, are shaping our phenotypes through either direct, […]

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Extra prenatal choline doesn’t help kids’ brains

Kerry Grens, The Chicago Tribune  NEW YORK (Reuters Health) – Taking extra choline during pregnancy does not improve babies’ language and memory skills, according to a new study. “I think eating the recommended amount of choline, which is just about a half of a gram a day for pregnant women, would probably do you well,” […]

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A Brief History of Choline

A Brief History of Choline. Annals of Nutrition and Metabolism. Epub November 2012. Zeisel SH. UNC Nutrition Research Institute. Abstract In 1850, Theodore Gobley, working in Paris, described a substance, ‘lecithine’, which he named after the Greek ‘lekithos’ for egg yolk. Adolph Strecker noted in 1862 that when lecithin from bile was heated, it generated […]

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Untitled

    Contact: Phyllis Beaver Marketing Director NC Research Campus pbeaver@ncresearchcampus.net www.ncresearchcampus.net or Pamela Krasen, MS Research Manager Appalachian State University lambethpg@email.appstate.edu www.ncrc.appstate.edu   (NC Research Campus, Kannapolis, NC- November 8, 2012)- Women 18 to 75 years of age are invited to kick-off 2013 with the Appalachian State Human Performance Laboratory at the North Carolina […]

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Charlotte conference highlights region’s life-sciences research

By Jeremy Summers, NCBiotech Writer Charlotte is known for its strong financial roots, diverse business climate and   for being the unofficial home of NASCAR. Thanks to new commitments to education and research, the region is also gaining some recognition as a hotbed for cutting edge research and technologies in biotech and other life-sciences industries. […]

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Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages

Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell. October 2012. Orozco LD, Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Farber CR, Ghazalpour A, Pan C, Che N, Wen P, Qi HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, Lusis AJ. Department of Human […]

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What mum eats before pregnancy may affect child’s health

Now, new research in mice has suggested that what she ate before pregnancy might be important too. What a group of female mice ate-before pregnancy-chemically altered their DNA and these changes were passed to her offspring. These DNA alterations, called “epigenetic” changes, drastically affected the pups’ metabolism of many essential fatty acids, the research found. […]

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60,000 Square-Foot Medical Office Building Breaks Ground

Published in Opportunities, a quarterly real estate to research newsletter of the NC Research Campus August  30, 2012   Heavy equipment rolled onto the NCRC breaking the ground for the construction of a new medical office building. The 60,000-square-foot building along with the Cabarrus Health Alliance headquarters, which opened earlier this year, anchors the campus’ medical […]

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High-resolution association mapping of atherosclerosis loci in mice.

High-resolution association mapping of atherosclerosis loci in mice. Artiosclerosis, Thrombosis, and Vascular Biology, August 2012. Bennett BJ, Orozco L, Kostem E, Erbilgin A, Dallinga M, Neuhaus I, Guan B, Wang X, Eskin E, Lusis AJ. UNC Chapel Hill Nutrition Research Institute. Abstract OBJECTIVE: The purpose of this study was to fine map previously identified quantitative […]

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Kannapolis Scholars Conference Focuses on the Role of Exercise in Obesity Prevention

  Link to original article The Kannapolis Scholars, a program of N.C. State University at the N.C. Research Campus, is hosting its second conference on how to address the challenges of obesity. “Lost in Translation: A Conversation on Exercise and Obesity” will be held on Friday, July 27, 2012, from 10:15 a.m. to 4 p.m. […]

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Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.

Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.  Annals of Nutrition Metabolism, May 2012. Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract One of the underlying mechanisms for metabolic individuality is genetic variation. Single nucleotide polymorphisms (SNPs) in genes of metabolic pathways can create […]

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NRI Director Wins Gates Grand Challenges Grant

The UNC Chapel Hill Nutrition Research Institute Director Steven H. Zeisel, MD, PhD, who is also a Kenan Distinguished University Professor in Nutrition and Pediatrics, was recently awarded a Grand Challenges Explorations Grant from the Bill & Melinda Gates Foundation for research on “Choline and Optimal Development” that will benefit mothers and their babies in […]

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UNC Nutrition Research Institute Hosts Events for Local Children

  UNCNRI.ORG Children to learn about nutrition through fun activities The University of North Carolina Nutrition Research Institute (NRI) will host two community events in conjunction with the upcoming statewide North Carolina Science Festival. Kindergarten Science Expo, “The Great Food Experiment” From April 17 – 24, the NRI welcomes all five Kannapolis City elementary schools […]

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Diet Soda Getting a bad rap?

DailyRX   The debate rages on… are diet drinks okay when trying to cut calories when you’re losing weight? Or do they put you at higher risk for heart disease, as some recent studies have claimed? Researchers can’t be sure that diet drinks have no risks at all, but they are beginning to understand that […]

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Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function.

Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function. PLoS One, April 2012. Corbin KD, Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract Approximately 15% of couples are affected by infertility and up to half of these cases arise from male factor infertility. Unidentified genetic […]

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Monday and Tuesday Events Feature NCRC Scientists

NCRC Monday, April 16 and Tuesday, April 17, the Live and Learn Film Series and State of the Studies at the NC Research Campus are free events that provide opportunities for people to talk with scientists and learn about the research and clinical studies that are underway on campus. (NC Research Campus, Kannapolis, NC- April […]

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Spring Into Science through Events at NCRC and in Kannapolis April 2012 Events

NCRC Spring into Science at NCRC (NC Research Campus, Kannapolis, NC- April 4, 2012)- April marks a record setting number of science-oriented events at the NC Research Campus (NCRC) and in Kannapolis that are free and for families. Live and Learn Film Series A free showing of the movie Living Proof will be held on April […]

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Monday and Tuesday Events Feature NCRC Scientists

Monday, April 16 and Tuesday, April 17, the Live and Learn Film Series and State of the Studies at the NC Research Campus are free events that provide opportunities for people to talk with scientists and learn about the research and clinical studies that are underway on campus. (NC Research Campus, Kannapolis, NC- April 12, […]

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Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.Current Opinion Gastroenterology, March 2012. Corbin KD, Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract PURPOSE OF REVIEW: Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans […]

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Cheatham Lab Enrolling for the B.E.R.R.Y Study

If you are 65 to 79 years old and beginning to experience mild memory decline but have not been diagnosed with dementia or Alzheimer’s disease, the Cheatham Nutrition and Cognition Lab of the UNC Chapel Hill Nutrition Research Institute is enrolling for a studying examining blueberries and cognitive ability. For information or to enroll, visit […]

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Fight cancer with your fork

Salisbury Post By Katie Scarvey kscarvey@salisburypost.com It might be tempting to think of cancer as something we have little control over, but in fact, what we eat — and how much we eat — can be important factors in whether we get cancer or not. The American Institute of Cancer Research estimates that one out […]

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Switch to water, diet beverages to cut extra kilos

The Indian Express Replacing calorie-laden beverages with water or diet soft drinks can help people lose 4 to 5 pounds, health experts say. In a new study, University of North Carolina at Chapel Hill researchers compared weight loss for 318 overweight or obese people, who were divided into three groups: those who switched from calorie-laden […]

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STUDY: Switching to water, diet beverages can tip the scales

Wway CHAPEL HILL, NC (NEWS RELEASE) — Making a simple substitution of water or diet soft drinks for drinks with calories can help people lose 4 to 5 pounds, a new University of North Carolina at Chapel Hill study shows. The study, published online and scheduled to appear in the March 2012 print issue of […]

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Nutrition Institute gets $1 million endowment

Salisbury Post UNC Nutrition Research Institute KANNAPOLIS — Alan T. Dickson, a member of the Board of Advisers of the UNC Nutrition Research Institute at the N.C. Research Campus, has made a pledge that will create a $1 million endowment fund at the Research Institute. Dickson made a joint gift of $666,000 from the Dickson […]

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GenoVive Announces Formation of Scientific Advisory Board

PrWeb Key Appointments Include Doctors and Experts in the Health and Weight Management Fields from Yale University and the University of North Carolina Who Will Provide Critical Scientific Input and Strategic Insight GenoVive, a pioneer in DNA-based, all-natural weight management solutions, today announced the formation of a scientific advisory board (SAB) comprised of prominent, multi-disciplinary experts […]

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What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders

Zeisel, S.H.(2011)What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. Molecular Neurobiology. doi 10.1007/s12035-011-8165-5. Abstract The consequences of fetal exposure to alcohol are very diverse and the likely molecular mechanisms involved must be able to explain how so many developmental processes could go awry. If pregnant rat dams are […]

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Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment

Tint, D.,Anghel, M., Lupu, D. S., Fischer, L. M., and Niculescu, M. D. (2011)Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment .J Nutrition Disorder TherS7, 1 Abstract Many studies indicated that increased intakes of ω-3 fatty acids could positively impact the progression […]

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Discovery of microsomal triglyceride transfer protein (MTP) inhibitorswith potential for decreased active metabolite load compared to dirlotapide

Ralph P. Robinson , Jeremy A. Bartlett, Peter Bertinato, Andrew J. Bessire, Judith Cosgrove, Patrick M. Foley, Tara B. Manion, Martha L. Minich, Brenda Ramos, Matthew R. Reese, Theodore J. Schmahai, Andrew G. Swick , David A. Tess, Alfin Vaz, Angela Wolford(2011)Discovery of microsomal triglyceride transfer protein (MTP) inhibitorswith potential for decreased active metabolite load […]

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Prevalence of Children with Fetal Alcohol Spectrum Disorders in Communities Near Rome, Italy: Rates Are Substantially Higher Than Previous Estimates

Philip A. May, Daniela Fiorentino, Giovana Coraile, Wendy O. Kalberg, H. Eugene Hoyme, Alfredo S. Aragon, David Buckley, Chandra Stellavato, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, and Mauro Ceccanti.(2011)Prevalence of Children with Fetal Alcohol Spectrum Disorders in Communities Near Rome, Italy: Rates Are Substantially Higher Than Previous Estimates. International Journal of Environmental Research […]

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Maternal Risk Factors Predicting Child Physical Characteristics and Dysmorphology in Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome

Philip A. May, Barbara G. Tabachnick, Luther K. Robinson, H. Eugene Hoyme, and J. Phillip Gossage (2011)Maternal Risk Factors Predicting Child Physical Characteristics and Dysmorphology in Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome. Drug and Alcohol Dependencedoi:10,1016/j.drugaldep.2011.05.009 Abstract BACKGROUND: Previous research in South Africa revealed very high rates of fetal alcohol syndrome (FAS), of 46-89 […]

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Maternal Risk Factors for Fetal Alcohol Spectrum Disorders: Not as Simple as it Might Seem

Philip A. May and J. Phillip Gossage(2011)Maternal Risk Factors for Fetal Alcohol Spectrum Disorders: Not as Simple as it Might Seem.Alcohol Research and Health34(1):15-26 Abstract Gathering information about drinking during pregnancy is one of the most difficult aspects of studying fetal alcohol spectrum disorders (FASD). This information is critical to linking specific risk factors to […]

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Nutritional influence on epigenetics and effects on longevity

Niculescu, M.D. & Lupu, D.S.(2011)Nutritional influence on epigenetics and effects on longevity. Curr Opin Clin Nutr Metab CareJan;14(1):35-40 Abstract PURPOSE OF REVIEW: This review synthesizes recently published information regarding nutrition and its impact upon epigenetically mediated mechanisms involved in longevity and aging. RECENT FINDINGS: Recent studies enriched considerably our understanding of the relationship between aging […]

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Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring.

Niculescu, M. D., Lupu, D. S., and Craciunescu, C. N. (2011)Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. Int J Dev Neurosci29, 795-802 Abstract The availability of ω-3 polyunsaturated fatty acids is essential for perinatal brain development. While the roles of docosahexaenoic acid (the most abundant […]

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Alteration of PTGS2 promoter methylation in chronic periodontitis

Zhang, S., Barros, S. P., Niculescu, M. D., Moretti, A. J., Preisser, J. S., and Offenbacher, S. (2010)Alteration of PTGS2 promoter methylation in chronic periodontitis.J Dent Res89, 133-137 Abstract   Levels of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in actively progressing periodontal lesions, but decrease in chronic disease. We hypothesized that […]

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A Grand Challenge for Nutrigenomics

Zeisel, S.H.(2010)A Grand Challenge for Nutrigenomics. Frontiers in Nutrigenomics.1(2): 1-3.

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Nutritional Genomics Defining the dietary requirement and effects of choline

Zeisel, S.H.(2010)Nutritional Genomics Defining the dietary requirement and effects of choline. The Journal of Nutrition. 531-534. Abstract As it becomes evident that single nucleotide polymorphisms (SNPs) in humans can create metabolic inefficiencies, it is reasonable to ask if such SNPs influence dietary requirements. Epidemiologic studies that examine SNPs relative to risks for diseases are common, […]

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Choline: An essential nutrient for public health

Zeisel, S.H.(2010)Choline: An essential nutrient for public health. SCAN’S PULSE29(3): 4–7. Abstract Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998. There is significant variation in the dietary requirement for choline that can be explained by common genetic polymorphisms. Because of its wide-ranging roles in human metabolism, from […]

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Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.

Spencer, M.D., Hamp, T.J., Reid, R.W., Fischer, L.M., Zeisel, S.H., Fodor, A.A. (2010)Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology. doi:10.1053/j.gastro.2010.11.049. Abstract BACKGROUND & AIMS: Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood. […]

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Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

Resseguie, M.,da Costa, K-A, Galanko, J., Davis, I.J., Zeisel, S.H. (2010)Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. Journal of Biological Chemistry.286(2): 1649-58. PMCID: PMC3020773. Abstract When dietary choline is restricted, most men and postmenopausal women develop multiorgan dysfunction marked by hepatic steatosis (choline deficiency syndrome (CDS)). However, a significant subset of […]

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Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.

Mehedint, M.G., Craciunescu, C.N., Zeisel, S.H. (2010)Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proceedings of the National Academy of Sciences USA. 107(29): 12834-39. PMCID: PMC2919920. Abstract We examined whether maternal dietary choline modulates angiogenesis in fetal brain. Pregnant C57BL/6 mice were fed either a choline-deficient (CD), control (CT), or choline-supplemented diet (CS) from […]

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Choline intake and genetic polymorphisms influence cholinemetabolite concentrations in human breast milk and plasma.

Fischer, L.M., daCosta, K-A, Galanko, J., Sha, W., Stephenson, B., Vick, J., Zeisel, S.H. (2010)Choline intake and genetic polymorphisms influence cholinemetabolite concentrations in human breast milk and plasma. American Journal of Clinical Nutrition.92(2): 336-346. PMCID: PMC2904035. Abstract BACKGROUND: Choline is essential for infant nutrition, and breast milk is a rich source of this nutrient. Common […]

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Dietary choline requirements of women: effects of estrogen and genetic variation

Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010)Dietary choline requirements of women: effects of estrogen and genetic variation. American Journal of Clinical Nutrition.92(5):1113-19. PMCID: PMC2954445. Abstract BACKGROUND: Choline is obtained from the diet and from the biosynthesis of phosphatidylcholine. Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by […]

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Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain

Craciunescu, C.N., Johnson, A.R., Zeisel, S.H. (2010)Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain.The Journal of Nutrition. 140:1162-6. PMCID: PMC2869500. Abstract In mice, maternal dietary folate, a cofactor in 1-carbon metabolism, modulates neurogenesis and apoptosis in the fetal brain. Similarly, maternal dietary choline, […]

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Declarative memory in abused and neglected infants

Cheatham, C.L., Larkina, M., Bauer, P.J., Toth, S., Cicchetti, D. (2010)Declarative memory in abused and neglected infants.Advances in Child Development and Behavior, Volume 38 -Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy (pp. 161-182). London, U.K.: Elsevier. Abstract To summarize, all children interacted with the experimenter and actively participated in […]

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The development of declarative memory in infants born preterm

Cheatham, C. L., Sesma, H. W., & Georgieff, M. K. (2010)The development of declarative memory in infants born preterm.In P.J. Bauer (Ed.), Advances in Child Development and Behavior, Volume 38 -Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy(pp. 111-135). London, U.K.: Elsevier.

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Adiponectin lowers glucose production by increasing SOGA

Bryan, R.P., Asmar, M.M., Alderman, J.M., Alderman, E.A., Garland, A.L., Busby, W.H., Bodnar, W.M., Rusyn, I., Medoff, B., Tisch, R., Swenberg, J.A., Zeisel, S.H., Combs, T.P. (2010)Adiponectin lowers glucose production by increasing SOGA. American Journal of Pathology. 177(40): 1936-1945. PMCID: PMC2947288. Abstract Adiponectin is a hormone that lowers glucose production by increasing liver insulin sensitivity. […]

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Nutrition in Medicine: Nutrition education for medical students and residents

Adams, K.M., Kohlmeier, M., Powell, M., Zeisel, S.H. (2010)Nutrition in Medicine: Nutrition education for medical students and residents. Nutrition in Clinical Practice.25(5):471-80. Abstract Proper nutrition plays a key role in disease prevention and treatment. Many patients understand this link and look to physicians for guidance diet and physical activity. Actual physician practice, however, is often […]

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Cardiac involvement in trichinellosis: a case of left ventricular thrombosis

Tint, D., Cocuz, M. E., Ortan, O. F., Niculescu, M. D., and Radoi, M. (2009)Cardiac involvement in trichinellosis: a case of left ventricular thrombosis. Am J Trop Med Hyg81, 313-316. Abstract We report the case of a 42-year-old woman who was admitted to the hospital for fever, chills, nausea, vomiting, fatigue, myalgia, and general muscle […]

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High fat diet-induced maternal obesity alters fetal hippocampal development

Niculescu, M. D., and Lupu, D. S.(2009)High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci27, 627-633 Abstract The importance of maternal nutrition for fetal brain development is increasingly recognized. Previous studies have suggested that maternal obesity or maternal exposure to obesogenic diets may permanently alter brain structure and function in the […]

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Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans

Craciunescu, C. N., Niculescu, M. D., Guo, Z., Johnson, A. R., Fischer, L., and Zeisel, S. H. (2009)Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans.Toxicol Sci107, 220-226 Abstract Diethanolamine (DEA) is a common ingredient of personal care products. Dermal administration of DEA diminishes hepatic stores […]

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