N.C. A&T received 11 grants totaling $1.80 million in January.
One highlight of January’s s funding was a grant worth $489,884 from the USDA Agricultural and Food Initiative to Dr. Shengmin Sang of the Center for Excellence in Post Harvest Technologies, located ta the N.C. Research Campus in Kannapolis.
The project: Dietary flavonoids inhibit the formation of advanced glycation end products by trapping reactive dicarbonyl compounds: An in vivo study
The issue: Increasing evidence has identified the formation of advanced glycation end products (AGEs) as a major pathogenic link between hyperglycemia and diabetes-related complications.
Abstract: As the precursor of AGEs, methylglyoxal (MGO) and glyoxal (GO) are observed at relative higher levels (2-6 fold) in diabetic patients’ plasma than in healthy people’s plasma and are also found in many food products, beverages and cigarette smoke. Chronic intake of exogenous MGO has been demonstrated as the cause factor for the development of diabetes. Therefore, decreasing the levels of MGO and GO will be an effective approach to reduce the formation of AGEs and the development of diabetic complications. Our recent studies show that dietary flavonoids can inhibit the formation of AGEs by trapping MGO. Based on our previous and preliminary data, the hypothesis of this project is that dietary flavonoids can trap reactive dicarbonyls and thus inhibit the formation of AGEs and prevent the development of diabetes and diabetic complications under in vivo conditions. The present study will provide important information on the in vivo effectiveness of flavonoids in decreasing the levels of AGEs by trapping exogenous and endogenous MGO and GO.