zinc

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats

October 14, 2015

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats, J Nutr. 2015 Oct 14, Zhong W1, Li Q1, Sun Q2, Zhang W1, Zhang J3, Sun X1, Yin X3, Zhang X3, Zhou Z4. 1Center for Translational Biomedical Research and. 2Center for Translational Biomedical Research and Department of Nutrition, University of […]

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease

March 12, 2015

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease, 2015 Mar 12, Am J Physiol Gastrointest Liver Physiol. Sun Q1, Zhong W2, Zhang W2, Li Q2, Sun X2, Tan X2, Sun X2, Dong D2, Zhou Z3. UNC greensboro. 2University of North Carolina at Greensboro. 3University of North Carolina at Greensboro z_zhou@uncg.edu. Abstract […]

Niacin Supplementation Shown to Reverse Fatty Liver Disease

August 28, 2014

Zhanxiang Zhou, PhD, with the UNC Greensboro Center for Translational Biomedical Research at the NC Research Campus in Kannapolis, published new findings in the July 2014 edition of Alcoholism: Clinical and Experimental Research that established a connection between niacin supplementation and lowering lipid levels in the liver. Zhou researches the pathology of and potential treatments […]

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors.

October 14, 2013

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PlosOne. Oct 14, 2013. Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract Clinical studies have demonstrated that alcoholics have a […]

Zinc A Potential Treatment for Alcohol-Induced Fatty Liver Disease

December 12, 2012

While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou, who is co-director of the UNC Greensboro Center for Translational Biomedical Research at the North Carolina Research Campus (NCRC), is an expert on the disease. During his visit, Zhou counseled his friends […]

Zinc: A Potential Treatment for Alcohol-Induced Fatty Liver Disease

December 09, 2012

While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou is co-director of the UNC Greensboro Center forTranslational Biomedical Research and an expert on the disease. During his visit, Zhou counseled his friends on dietary changes that might help them. One day, […]

The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction.

March 19, 2010

Zhong W, McClain CJ, Cave M, Kang YJ, Zhou Z. The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol.2010; G625-633. Abstract Disruption of the intestinal barrier is a causal factor in the development of alcoholic endotoxemia and hepatitis. This study was undertaken to determine whether zinc deficiency is related to the deleterious […]

Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4a and peroxisome proliferators activated receptor-a

May 19, 2009

Kang X, Zhong W, Liu J, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4a and peroxisome proliferators activated receptor-a. Hepatology2009; 50:1241-1250. Abstract Alcoholic steatosis is a fundamental metabolic disorder in the progression of alcoholic liver disease. Zinc deficiency is one of the most […]

Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4ain mice subjected to a long-term ethanol administration

March 20, 2008

Kang X, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4ain mice subjected to a long-term ethanol administration. Am J Pathol.2008; 172:916- 925. Abstract Alcoholic liver disease is associated with sustained liver damage and impaired regeneration, as well as significant zinc deficiency. This study was undertaken […]