Zebrafish

Go Fish! Zebrafish Advance Cancer Research

March 08, 2015

In the fight against cancer, zebrafish may seem like an unlikely weapon. For TinChung Leung, PhD, with the North Carolina Central University Nutrition Research Program at the NC Research Campus (NCRC) in Kannapolis, zebrafish have the potential to deliver the answers to some of the most fundamental questions about cancer. Namely how tumors grow and […]

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts

April 05, 2014

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts AACR Annual Meeting 2014; April 5-9, 2014, K. Sean Kimbro, Karine Ferri-Lagneau, Jamil Haider, Susan Yeyeodu, Xiaohe Yang, and TinChung Leung North Carolina Central University, Durham, NC. Abstract Growing evidence indicates that incongruities in the inflammatory and immune response pathways contribute to tumorigenesis. We seek to explore the underlying biological mechanisms […]

A Model Fish

January 15, 2014

Scientists with North Carolina Central University Nutrition Research Program and NCA&T’s Center for Excellence in Post-Harvest Technologies teamed up to study the bioactive compounds in ginger. They did it using a rather model fish called zebrafish. NC Central scientist TinChung Leung, PhD, uses the model fish for research into natural compounds that can help prevent […]

NCCU and NCA&T Cancer Research on UNC-TV

December 18, 2013

UNC TV Researchers can’t test experimental cures for diseases and possible drug therapies on humans so they use the zebrafish for initial testing. That’s because the journey from egg to embryo is the same in zebrafish and humans. The image on the computer screen in the North Carolina Central University lab at the North Carolina […]

A Model Fish

December 06, 2013

As featured on UNC-TV’s Science Now. Written and produced by Frank Graff. The image on the computer screen in the North Carolina Central University lab at the North Carolina Research Campus is both creepy and fascinating. It is a creature that is green, with a giant eye, a rapidly opening and closing mouth, and what […]

A Microbial Answer to Malnutrition

September 09, 2013

The West African Sahel region is a corner of the world that Steven Maranz, PhD, knows well. He spent part of his childhood there and worked with the Consultative Group on International Agricultural Research (CGIAR) in the region. Maranz is currently a visiting scientist with the David H. Murdock Research Institute, a provider of collaborative […]

Ginger Shogaols: Promising Preventation for Lung and Colon Cancer

June 15, 2013

North Carolina Research Campus Shengmin Sang, PhD, associate professor and lead scientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies (CEPHT) at the North Carolina Research Campus in Kannapolis, has published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most […]

[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos.

May 23, 2013

[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos. Journal of Agricultural and Food Chemistry.  Epub May 23, 2013. Chen H, Soroka DN, Haider J, Ferri-Lagneau KF, Leung T (NC Central University Nutrition Research Program), Sang S. Center for Excellence in Post-Harvest Technologies, North […]

Collaborations Driving Ginger Research For Cancer, Anemia Treatments

December 05, 2012

Ginger is more commonly appreciated for its aromatic and tangy taste enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

Collaborations Driving Ginger Research For Cancer, Anemia Treatments

December 05, 2012

Ginger is more commonly appreciated for its aromatic and tangy taste enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

Ginger Stimulates Hematopoiesis via Bmp Pathway in Zebrafish.

July 10, 2012

Ginger Stimulates Hematopoiesis via Bmp Pathway in Zebrafish. PLoS One. July 2012. Epub June 2012. Ferri-Lagneau KF, Moshal KS, Grimes M, Zahora B, Lv L, Sang S, Leung T. North Carolina Central University Nutrition Research Program. Abstract BACKGROUND: Anemia is a hematologic disorder with decreased number of erythrocytes. Erythropoiesis, the process by which red blood […]

Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide.

May 19, 2011

Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide. Bansode RR1, Ahmedna M, Svoboda KR, Losso JN. Abstract The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined. The […]

Zebrafish model:worth considering indefining tumor angiogenesis

May 20, 2010

MoshalKS,Ferri-LagneauKF,LeungT. Zebrafish model:worth considering indefining tumor angiogenesis. Trends in Cardiovascular Medicine. 2010 May;20(4):114-9. Abstract The process of angiogenesis is essential for tumor progression and metastasis; however, antiangiogenesis therapy-induced hypoxia and inflammation are perhaps the driving force for tumor escape and metastasis formation, thereby compromising its efficacy. This warrants the complete understanding of the molecular and […]