Xiaohe Yang

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

July 28, 2015

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer

July 22, 2015

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer, July 22, 2015, In Press Accepted Manuscript, Yujie Fu, Onat Kadioglu, Benjamin Wiench, Zuofu Wei, Wei Wang, Meng Luo, Xiaohe Yang, Chengbo Gu, Yuangang Zu, Thomas Efferth NC Central University <style>.requiresJS{display:none}.dartAd{display:block !important}</style> Abstract Anti-estrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established anti-hormones such as tamoxifen, novel […]

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib

April 22, 2015

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib, Journal of Cancer Research, April 22, 2015, Ming Zhao, Amanda Blackwelder, Harry Lee, and Xiaohe Yang Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC. Abstract 3557: Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib Abstract […]

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

April 07, 2015

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice, 2015 Apr 7, Int J Mol Sci, Ma Z1, Blackwelder AJ2, Lee H3, Zhao M4, Yang X5. 1Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA. mzhao@nccu.edu. 2Julius L. Chambers Biomedical/Biotechnology […]

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells

March 11, 2015

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells, Phytomedicine, 11 March 2015,  Yujie Fua, b, 1, Onat Kadiogluc, 1, Benjamin Wienchc, Zuofu Weia, b, Chang Gaod, Meng Luoa, b, Xiaohe Yange, Chengbo Gua, b, Yuangang Zua, b, Thomas Efferth Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer […]

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk

November 18, 2014

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk.  Molecular Cancer Research. Nov 2014, Zhikun Ma, Amanda Blackwelder, and Xiaohe Yang North Carolina Central Unversity, Kannapolis, NC. Abstract A09: In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk Abstract The mammary […]

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet

April 16, 2014

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. The Journal of Endocrinology. Apr 16, 2014 [Epub ahead of print] Yang X1, Mei S, Gu H, Guo H, Zha L, Cai J, Li X, Liu Z, Cao W. 1X Yang, Nutrition, UNC at Chapel Hill, Kannapolis, United States. Abstract We have previously shown that insulin plays an essential role […]

BRITE Futures for Kannapolis Students

March 06, 2014

Salisbury Post Dr. TinChung Leung, of the NC Central University Nutrition Research Program at the NC Research Campus, is usually focused on cancer, cardiovascular and blood research. This year, he is expanding his focus to make an investment in the future of middle and high school students in Kannapolis City Schools. He worked together with […]

Investing in Bright Futures for Kannapolis Students

February 13, 2014

NCRC News February 13, 2014 TinChung Leung, PhD, of the NC Central University Nutrition Research Program at the NC Research Campus, is usually focused on cancer, cardiovascular and blood research. This year, he is expanding his focus to make an investment in the future of middle and high school students in Kannapolis City Schools (KCS). […]

Finding Natural Solutions to Prevent and Treat Cancer

March 19, 2013

When you sit down to a salad full of pumpkins seeds, tofu, almonds and healthy greens followed by a main course of seafood flavored with ginger and a glass of wine, cancer prevention is probably not on your mind. Unless, that is, you are a scientist at the North Carolina Research Campus (NCRC) in Kannapolis, […]

Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

February 09, 2013

One of the most controversial and confusing questions surrounding breast cancer is the effect of eating soy. Some studies say soy and the isoflavone genistein that it contains prevents breast cancer. Other studies say genistein is a risk factor for developing breast cancer. Breast cancer researcher Xiaohe Yang, PhD, associate professor with the North Carolina Central […]

Monday and Tuesday Events Feature NCRC Scientists

April 05, 2012

NCRC Monday, April 16 and Tuesday, April 17, the Live and Learn Film Series and State of the Studies at the NC Research Campus are free events that provide opportunities for people to talk with scientists and learn about the research and clinical studies that are underway on campus. (NC Research Campus, Kannapolis, NC- April […]

NCRC Scientists Open A Window To Chinese Culture

January 03, 2012

Scientists at the North Carolina Research Campus in Kannapolis formed the Cabarrus Chinese American Association and are hosting a Chinese New Year celebration on January 14, 2012 to raise money for their Chinese Language and Art School. In American culture, January is usually a quiet month to recover from the revelry of Thanksgiving, Christmas and […]

HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance

August 12, 2011

Huang X,Wang S,Lee CK,Yang X,Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Letters.2011 Aug 1;307(1):72-9. doi: 10.1016/j.canlet.2011.03.019. Epub 2011 Apr 16. Abstract Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with […]

Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.

April 06, 2011

Shi Y,Yang S,Troup S,Lu X,Callaghan S,Park DS,Xing Y,Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.Oncology Reports.2011 Jun;25(6):1713-9. doi: 10.3892/or.2011.1248. Epub 2011 Apr 6. Abstract Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. […]

Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation

April 12, 2010

Yang X,Yang S,McKimmey C,Liu B,Edgerton SM,Bales W,Archer LT,Thor AD. Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation.Carcinogenesis.2010 Apr;31(4):695-702. Epub 2010 Jan 12. Abstract Genistein is a major isoflavone with known hormonal and tyrosine kinase-modulating activities. Genistein has been shown to promote the growth of estrogen receptor positive […]

Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin

February 01, 2010

Huang X,Gao L,Wang S,McManaman JL,Thor AD,Yang X,Esteva FJ,Liu B. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. CancerRes.2010Feb 1;70(3):1204-14. Epub 2010 Jan 26. Abstract Primary and acquired resistance to the breast cancer drug trastuzumab (Herceptin) is a significant clinical problem. Here, we report […]