UNC Greensboro

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

May 14, 2013

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB: Official Publication of the Federation of American Societies for Experimental Biology.  Epub May 14, 2013. Xie G, Zhong W, Li H, Li Q, Qiu Y, Zheng X, Chen H, Zhao X, Zhang S, Zhou Z, Zeisel SH, Jia W. Center for […]

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways

April 07, 2013

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways. PLoS One. April 2013.  Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract High […]

Finding Natural Solutions to Prevent and Treat Cancer

March 19, 2013

When you sit down to a salad full of pumpkins seeds, tofu, almonds and healthy greens followed by a main course of seafood flavored with ginger and a glass of wine, cancer prevention is probably not on your mind. Unless, that is, you are a scientist at the North Carolina Research Campus (NCRC) in Kannapolis, […]

Klebsiella Linked to Infant Melamine Deaths

March 09, 2013

The UNC Greensboro Center for Translational Biomedical Research and the David H. Murdock Research Institute in partnership with scientists from Shanghai Jiao Tong University in Shanghai, China and the Imperial College of London, United Kingdom have shed light on why so many babies who drank melamine-tainted milk in 2008 did not die. The bacteria Klebsiella terrigena […]

NCRC Scientists Lead Study Linking Klebsiella Bacteria to Infant Deaths in Melamine Scandal

February 27, 2013

Scientists with UNC Greensboro Center for Translational Biomedical Research and the David H. Murdock Research Institute (DHMRI), both located at the NC Research Campus in Kannapolis, in partnership with scientists from Shanghai Jiao Tong University in Shanghai, China and the Imperial College of London, United Kingdom have shed light on why so many babies who […]

Melamine-induced renal toxicity is mediated by the gut microbiota

February 13, 2013

Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. February 13, 2013. Zheng X,Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Luther M, Su M, Nicholson JK, Jia W. Shanghai Key Laboratory of Diabestes Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated […]

A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study

January 20, 2013

A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study. Evidence-based Complementary and Alternative Medicine. January 20, 2013. Li X, Chen H, Jia W, Xie G. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian China; Center for Translational Biomedical Research, University of North Carolina at […]

Zinc A Potential Treatment for Alcohol-Induced Fatty Liver Disease

December 12, 2012

While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou, who is co-director of the UNC Greensboro Center for Translational Biomedical Research at the North Carolina Research Campus (NCRC), is an expert on the disease. During his visit, Zhou counseled his friends […]

Zinc: A Potential Treatment for Alcohol-Induced Fatty Liver Disease

December 09, 2012

While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou is co-director of the UNC Greensboro Center forTranslational Biomedical Research and an expert on the disease. During his visit, Zhou counseled his friends on dietary changes that might help them. One day, […]

Where Innovation Begins

November 19, 2012

The North Carolina Research Campus in Kannapolis, a 350-acre life science research center just north of Charlotte, was the focus of the eleventh annual UNC Charlotte Life Sciences Conference held on Thursday, October 25, 2012 on the University of North Carolina Charlotte (UNCC) campus. The conference featured the research, technology and commercialization strategies at play […]

Cancer Treatments Emerge From Modern Metabolomics, Traditional Chinese Medicine

October 09, 2012

Over 1,800 years ago healers in China mixed together a formulation called Huangqin Decoctin to relieve their patients’ aches and pains. Today, colorectal cancer patients in a Phase II Clinical Trial are receiving a therapeutic treatment made from this ancient formulation. The potential new drug is being tested for its effectiveness in reducing the harsh […]

Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice.

July 10, 2012

Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice. The Journal of American Pathology, July 2012. Xiaobing Tan, Xiuhua Sun, Qiong Li, Yantao Zhao, Wei Zhong, Xinguo Sun, Wei Jia, Craig J. McClain, Zhanxiang Zhou. UNC Greensboro Center for Translational Biomedical Research. Abstract White adipose tissue (WAT) secretes adipokines, which critically regulate lipid […]

UNC Greensboro Scientist Receives Elite Fellowship

July 09, 2012

UNC Greensboro scientist Wei Zhong, PhD, was awarded an elite Roger L. Jenkins, MD, Post doctoral Research Fellowship from the American Liver Foundation (ALF). The ALF Postdoctoral Research Fellowships provide professional development, additional training and experience in liver research for MDs, PhDs or MD/PhDs in their first or second year appointments as postdoctoral research fellows. Zhong is […]

Therapeutic Modulation of Microbiota-Host Metabolic Interactions.

June 10, 2012

Therapeutic Modulation of Microbiota-Host Metabolic Interactions. Science Translational Medicine, June 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for R Abstract The complex metabolic relationships between the host and its microbiota change throughout life and vary extensively between  individuals, affecting disease risk factors […]

Human gouty arthritis is associated with a distinct serum trace elemental profile

March 11, 2012

Human gouty arthritis is associated with a distinct serum trace elemental profile. Metallomics, March 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for Research Excellence in BioActive Food Components and David H. Murdock Research Institute. Abstract Homeostatic imbalance of essential trace elements […]

Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors.

February 11, 2012

Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. Neurotoxicology Teratology, January-February 2012. Fordahl S, Cooney P, Qiu Y, Xie G, Jia W, Erikson KM. UNC Greensboro Department of Nutrition, Center for Research Excellence in Bioactive Food Components. Abstract Overexposure to waterborne manganese (Mn) is linked with cognitive impairment […]

Kannapolis Scholar Adam Baxter: From Mapping Anthocyanins to Mapping a Career

July 03, 2011

Kannapolis Scholar Adam Baxter: From Mapping Anthocyanins to Mapping a Career After five years of traveling North Carolina repairing and maintaining computers, 2011 Kannapolis Scholar Adam Baxter decided to apply his undergraduate degree in computer systems and computer programming to a new field. He chose bioinformatics and enrolled in the Professional Science master’s program in […]

An automated data analysis pipeline for GC-TOF-MS metabonomics studies

September 11, 2010

Jiang W,Qiu Y,Ni Y,Su M,Jia W,Du X.An automated data analysis pipeline for GC-TOF-MS metabonomics studies. Also in partnership with UNC Greensboro. Department ofBioinformatics & Genomics, University of North Carolina at Charlotte, Kannapolis, NC 28081, USA. JournalofProteomeResearch.2010 Nov 5;9(11):5974-81. Epub 2010 Sep 29. Abstract Recent technological advances have made it possible to carry out high-throughput metabonomics […]

Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins.

March 19, 2010

ZhongW, Zhao Y, McClain CJ, Kang YJ, Zhou Z. Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins. Am J Physiol.2010; 299:G643-G651 Abstract Chronic alcohol exposure has been shown to increase the gut permeability in the distal intestine, in part, through induction of zinc deficiency. The present study evaluated the molecular […]