UNC Greensboro

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats

October 14, 2015

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats, J Nutr. 2015 Oct 14, Zhong W1, Li Q1, Sun Q2, Zhang W1, Zhang J3, Sun X1, Yin X3, Zhang X3, Zhou Z4. 1Center for Translational Biomedical Research and. 2Center for Translational Biomedical Research and Department of Nutrition, University of […]

New Approach to Treat Alcoholic Liver Disease Identified

September 14, 2015

A study by Zhanxiang Zhou, PhD, co-director of the UNC Greensboro Center for Translational Biomedical Research,  found evidence of a pharmacological approach that in animal models reversed some of the effects of alcoholic liver disease. It’s sweet. It’s bitter. It’s tangy and even tart. The tastes and types of alcohol seem endless. Despite the variety, alcohol […]

Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice

September 02, 2015

Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice,2 Sep 2015 The Journal of Nutritional Biotechnology, Jessie Baldwin1, Brian Collins1, Patricia G. Wolf, Kristina Martinez, Wan Shen, Chia-Chi Chuang, Wei Zhong, Paula Cooney, Chase Cockrell, Eugene Chang, H. Rex Gaskins, Michael K. McIntosh. Author Afiliations Department of Nutrition, University of North Carolina at Greensboro (UNCG), Greensboro, NC Carl […]

Potential Biomarkers for Crohn’s Disease Advance Diabetes Research

August 31, 2015

A scientist based at the NC Research Campus helped identify potential protein biomarkers for sub-types of Crohn’s disease. The discovery is also advancing research into biomarkers for type 1 diabetes and other autoimmune disorders.   Many people may not link type 1 diabetes (T1D) and Crohn’s Disease. Qibin Zhang, PhD, co-director of the UNC Greensboro […]

Serum Proteome Profiles in Stricturing Crohn’s Disease: A Pilot Study

May 19, 2015

Serum Proteome Profiles in Stricturing Crohn’s Disease: A Pilot Study, 19 May 2015, Crohn’s & Colitis Foundation of America, Inc, Townsend, Peter MD; Zhang, Qibin PhD; Shapiro, Jason MD; Webb-Robertson, Bobbie-Jo PhD; Bramer, Lisa PhD; Schepmoes, Athena A. BS; Weitz, Karl K. BS; Mallette, Meaghan BS, MS; Moniz, Heather BS; Bright, Renee MS; Kamphaus, Tania PhD; Shah, […]

California Table Grape Consumption Reduces Adiposity, Hepatic Triglycerides, Lipogenic Gene Expression, and Abundance of Sulfidogenic Bacteria in Mice

April 07, 2015

California Table Grape Consumption Reduces Adiposity, Hepatic Triglycerides, Lipogenic Gene Expression, and Abundance of Sulfidogenic Bacteria in Mice, Apr 2015, The FASEB Journal, Jessie Baldwin1, Brian Collins1, Patricia Wolfe2, Wan Shen1, Chia-Chi Chuang3, Wei Zhong4, Paula Cooney1, H Rex Gaskins2 and Michael McIntosh1 1Nutrition UNC-Greensboro NC United States 2Animal Science University of Illinois IL United States 3Pathology Wake Forest School of Medicine Winston Salem NC […]

Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats

March 26, 2015

Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats, 2015 Mar 26, Am J Physiol Gastrointest Liver Physiol., Song M1, Schuschke DA2, Zhou Z3, Zhong W3, Zhang J2, Zhang X2, Wang Y2, McClain CJ2. 1University of Louisville m0song03@louisville.edu. 2University of Louisville. 3University of North […]

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease

March 12, 2015

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease, 2015 Mar 12, Am J Physiol Gastrointest Liver Physiol. Sun Q1, Zhong W2, Zhang W2, Li Q2, Sun X2, Tan X2, Sun X2, Dong D2, Zhou Z3. UNC greensboro. 2University of North Carolina at Greensboro. 3University of North Carolina at Greensboro z_zhou@uncg.edu. Abstract […]

Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde

February 19, 2015

Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde, Alcohol Clin Exp Res. 2015 Feb 19, Zhang W1, Zhong W, Sun X, Sun Q, Tan X, Li Q, Sun X, Zhou Z. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina. Abstract BACKGROUND: Chronic alcohol exposure causes […]

Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease

January 16, 2015

Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease, Food Research International, 16Jan2015,  Jianmei Yua, , ,Michelle Hernandezd,Hao Lib, e,Ipek Goktepec,Carole Robinetted,Amy Auerbachd,David Pedend,Mohamed Ahmednac a Department of Family and Consumer Sciences, North Carolina A&T State University, Greensboro, NC 27411 b Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, Kannapolis, NC 28081, USA c […]

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.

December 24, 2014

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.  J Hepatol. 2014 Dec 24, Zhong W1, Zhang W1, Li Q1, Xie G2, Sun Q3, Sun X1, Tan X1, Sun X1, Jia W2, Zhou Z4. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA 28081. 2University of Hawaii Cancer Center, Honolulu, Hawaii, USA 96813. 3Center for Translational […]

Effect of microfluidisation on antioxidant properties of corn bran

June 01, 2014

Effect of microfluidisation on antioxidant properties of corn bran. Food Chemistry. June 1, 2014 Wang T, Zhu Y, Sun X, Raddatz J, Zhou Z, Chen G. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, NC Research Campus; School of Food Science & Technology, Dalian Polytechnic University, Dalian, China; Center for Translational & Biomedical Research, The University of North […]

Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats

May 21, 2014

Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats. Alcoholism Clinical and Experimental Research. May 21, 2014. Qiong Li1, Guoxiang Xie2, Wenliang Zhang1, Wei Zhong1, Xiuhua Sun1, Xiaobing Tan1, Xinguo Sun1, Wei Jia2,3and Zhanxiang Zhou1,4,* 1 Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina; 2 University of Hawaii Cancer Center, Honolulu, Hawaii; 3 Center for Translational […]

A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential

March 25, 2014

A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential. Clinical Cancer Research: An Official Journal of the American Association of Cancer Research. March 25, 2014. Qiu Y, Cai G, Zhou B, Li D, Zhao A, Xie G, Li H, Cai S, Xie D, Huang C, Ge W, Zhou Z, Xu LX, Jia W, Zheng S, Yen Y, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth […]

Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice.

December 06, 2013

Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice. American Journal of Physiology. Gatrointestinal and liver physiology. December 2013. [Epub Oct 10, 2013]. Sun X, Luo W, Tan X, Li Q, Zhao Y, Zhong W, Sun X, Brouwer C, Zhou Z. Center for Translational & Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis. Abstract […]

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors.

October 14, 2013

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PlosOne. Oct 14, 2013. Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract Clinical studies have demonstrated that alcoholics have a […]

Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.

October 06, 2013

Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. Cell Death & Disease. October 2013. Li H, Zhou Y, Zhao A, Qiu Y, Xie G, Jiang Q, Zheng X, Zhong W, Sun X, Zhou Z, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University, Affiliated Sixth People’s Hospital, Shanghai, […]

Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes

June 17, 2013

Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes. Electrophoresis. Jun 17, 2013. [Epub ahead of print]. Xie G, Zhang S, Zheng X, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North […]

Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites

June 14, 2013

Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites. Journal of Proteome Research. June 14, 2013. [Epub ahead of print] Xie G, Zhong W, Zheng X, Li Q, Qiu Y, Li H, Chen H, Zhou Z, Jia W. Center for Translational Biomedical Research, University of North Carolina at Greensboro , North Carolina Research Campus, Kannapolis Abstract […]