UNC Chapel Hill

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

October 27, 2015

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus, Cell Rep. 2015 Oct 27, Mou Z1, Hyde TM2, Lipska BK3, Martinowich K4, Wei P5, Ong CJ5, Hunter LA5, Palaguachi GI5, Morgun E1, Teng R6, Lai C5, Condarco TA7, Demidowich AP7,Krause AJ7, Marshall LJ8, Haack K9, Voruganti VS10, Cole SA9, Butte NF11, Comuzzie AG9, […]

Lessons learned from metabolomics in cystic fibrosis

October 26, 2015

Lessons learned from metabolomics in cystic fibrosis, Molecular and Cellular Pediatrics 2015, Marianne S. Muhlebach1* and Wei Sha2 1Department Pediatrics, Division Pulmonology, UNC Chapel Hill 430 MacNider, CB 7217, Chapel Hill 27599-7217, NC, USA 2Bioinformatics Services Division, University of North Carolina at Charlotte, Kannapolis 28081, NC, USA Abstract Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory […]

An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation

October 15, 2015

An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation, JNB,  15 Oct 2015, Jing Xue, Folami Y. Ideraabdullah, UNC Chapel Hill Abstract In recent years, the etiology of human disease has greatly improved with the inclusion of epigenetic mechanisms, in particular as a common link between environment and disease. However, for […]

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial

October 07, 2015

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial, Am J Clin Nutr. 2015 Oct 7, Wozniak JR1, Fuglestad AJ2, Eckerle JK3, Fink BA2, Hoecker HL4, Boys CJ3, Radke JP5, Kroupina MG3, Miller NC3, Brearley AM6, Zeisel SH7, Georgieff MK3. 1Department of Psychiatry, jwozniak@umn.edu. 2Department of Psychiatry. 3Department of Pediatrics, and. 4School […]

Nutrition and the science of disease prevention: a systems approach to support metabolic health

September 13, 2015

Nutrition and the science of disease prevention: a systems approach to support metabolic health, Ann N Y Acad Sci. 2015 Sep, Bennett BJ1, Hall KD2, Hu FB3, McCartney AL4, Roberto C5. 1Departments of Genetics and Nutrition, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. 2Integrative Physiology Section, National Institute of Diabetes […]

Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance

September 10, 2015

Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance, Nutrition Research, September 10, 2015, Carol L. Cheatham, Daniel S. Lupu, Mihai D. Niculescu UNC Chapel Hill Abstract Maternal transfer of fatty acids is important to fetal brain development. The prenatal environment may differentially affect the substrates supporting […]

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes

August 27, 2015

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. FASEB J. 2015 Aug 27, Zwart SR1, Gregory JF1, Zeisel SH1, Gibson CR1, Mader TH2, Kinchen JM1, Ueland PM1, Ploutz-Snyder R1, Heer MA1, Smith SM2. Author Affiliations 1*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food […]

Fatty acids linked to cardiovascular mortality are associated with risk factors

August 25, 2015

Fatty acids linked to cardiovascular mortality are associated with risk factors, International Journal of Circumpolar Health, Aug 2015, Sven O. E. Ebbesson1,2*, Venkata S. Voruganti3, Paul B. Higgins4, Richard R. Fabsitz5, Lars O. Ebbesson6, Sandra Laston7, William S. Harris8,9, John Kennish10, Benjamin D. Umans11, Hong Wang12, Richard B. Devereux13, Peter M. Okin13, Neil J. Weissman12, Jean W. MacCluer7, Jason G. Umans12 and Barbara V. Howard12,14 1Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA; 2Norton Sound Health Corporation, Nome, AK, USA; 3Department of Nutrition and UNC Nutrition Research Institute, […]

Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City

August 14, 2015

Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City. Drug and Alcohol Dependence, 14 Aug 2015, Philip A. May, Carol Keaster, Rosemary Bozeman, Joelene Goodover, Jason Blankenship, Wendy O. Kalberg, David Buckley, Marita Brooks, Julie Hasken, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, H. Eugene Hoyme Nutrition Research Institute, University of North Carolina at Chapel Hill, Gillings School […]

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells

July 29, 2015

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells, J Nutr. 2015 Jul 29, Orena S1, Owen J1, Jin F2, Fabian M2, Gillitt ND2, Zeisel SH3. 1University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NC; 2Dole Nutrition Research Laboratory, Kannapolis, NC; and. 3University of North Carolina at Chapel Hill Nutrition […]

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

July 23, 2015

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study, Toxicol Sci. 2015 Jul 23, Gribble MO1, Voruganti VS2, Cole SA3, Haack K3, Balakrishnan P4, Laston SL5, Tellez-Plaza M6, Francesconi KA7, Goessler W7, Umans JG8, Thomas DC9,Gilliland F9, North KE10, Franceschini N10, Navas-Acien A11. 1* Department of Preventive Medicine; University of Southern California; […]

H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1

July 05, 2015

H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1, 5Jul2015, Biomolecular NMR Assignments, Yang Li, Mirko Hennig UNC Chapel Hill Abstract Heterogeneous nuclear ribonucleoproteins (hnRNPs) can be divided into subgroups based on their RNA-binding characteristics. One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of […]

19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR

June 19, 2015

19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR, Methods in Enzymology, 19Jun2015, Lincoln G. Scott*, Mirko Hennig†, , * Cassia LLC, San Diego, California, USA † Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA Abstract Naturally occurring RNA lacks fluorine-19 (19F), thus, their specifically fluorinated counterparts are particularly well suited […]

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency

June 18, 2015

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency, Mol Genet Metab. 2015 Jun 18, Strauss KA1, Ferreira C2, Bottiglieri T3, Zhao X4, Arning E3, Zhang S4, Zeisel SH4, Escolar ML5, Presnick N6, Puffenberger EG7, Vugrek O8, Kovacevic L8,Wagner C9, Mazariegos GV10, Mudd SH11, Soltys K10. Author information 1Clinic for Special Children, Strasburg, PA, USA; Franklin […]

Global metabolomic profiling targeting childhood obesity in the Hispanic population

June 17, 2015

Global metabolomic profiling targeting childhood obesity in the Hispanic population, Am J Clin Nutr. 2015 Jun 17, Butte NF1, Liu Y2, Zakeri IF3, Mohney RP4, Mehta N2, Voruganti VS5, Göring H6, Cole SA6, Comuzzie AG6. 1USDA/Agricultural Research Service Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX; nbutte@bcm.edu. 2USDA/Agricultural Research Service Children’s Nutrition […]

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine

June 17, 2015

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine, Electrophoresis. 2015 Jun 17, Zhao X1, Zeisel S1,2, Zhang S3. Author information 1Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, 28081, USA. 2Department of Nutrition, School of Public Health and School of Medicine, […]

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice

June 03, 2015

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice, 2015 Jun 3, Stem Cell Reports. Zhou X1, Crow AL2, Hartiala J2, Spindler TJ1, Ghazalpour A3, Barsky LW1, Bennett BB4, Parks BW3, Eskin E5, Jain R6, Epstein JA6, Lusis AJ3, Adams GB7,Allayee H8. Author information 1Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at […]

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

April 28, 2015

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. 2015 Apr 28, FASEB J., Silver MJ1, Corbin KD1, Hellenthal G1, da Costa KA1, Dominguez-Salas P1, Moore SE1, Owen J1, Prentice AM1, Hennig BJ1, Zeisel SH2. 1*Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United […]

Effects of Mthfd1 Gene on Mouse Behavior

April 07, 2015

Effects of Mthfd1 Gene on Mouse Behavior, Apr 2015,The FASEB Journal,  Eneda Pjetri1 and Steven Zeisel1 1Nutrition Research Institute UNC Chapel Hill Kannapolis NC United States Abstract Methylenetetrahydrofolate dehydrogenase 1 (Mthfd1) gene encodes the trifunctional C1 tetrahydrofolate (C1THF) enzyme that plays an important role in the folate-mediated one-carbon metabolism. A polymorphism of this gene (1958G>A; rs2236225) has […]

Analysis of Nutrition Education in Osteopathic Medical Schools

March 04, 2015

Analysis of Nutrition Education in Osteopathic Medical Schools, 4 Mar 2015, Journal of Biomedical Education, Kathaleen Briggs Early,1 Kelly M. Adams,2 and Martin Kohlmeier2,3 1College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, 200 University Pkwy, Yakima, WA 98901, USA 2Department of Nutrition, School of Medicine and Gillings School of Global Public Health, University of North Carolina at […]