Steven H. Zeisel

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial

October 07, 2015

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial, Am J Clin Nutr. 2015 Oct 7, Wozniak JR1, Fuglestad AJ2, Eckerle JK3, Fink BA2, Hoecker HL4, Boys CJ3, Radke JP5, Kroupina MG3, Miller NC3, Brearley AM6, Zeisel SH7, Georgieff MK3. 1Department of Psychiatry, jwozniak@umn.edu. 2Department of Psychiatry. 3Department of Pediatrics, and. 4School […]

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes

August 27, 2015

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. FASEB J. 2015 Aug 27, Zwart SR1, Gregory JF1, Zeisel SH1, Gibson CR1, Mader TH2, Kinchen JM1, Ueland PM1, Ploutz-Snyder R1, Heer MA1, Smith SM2. Author Affiliations 1*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food […]

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells

July 29, 2015

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells, J Nutr. 2015 Jul 29, Orena S1, Owen J1, Jin F2, Fabian M2, Gillitt ND2, Zeisel SH3. 1University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NC; 2Dole Nutrition Research Laboratory, Kannapolis, NC; and. 3University of North Carolina at Chapel Hill Nutrition […]

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency

June 18, 2015

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency, Mol Genet Metab. 2015 Jun 18, Strauss KA1, Ferreira C2, Bottiglieri T3, Zhao X4, Arning E3, Zhang S4, Zeisel SH4, Escolar ML5, Presnick N6, Puffenberger EG7, Vugrek O8, Kovacevic L8,Wagner C9, Mazariegos GV10, Mudd SH11, Soltys K10. Author information 1Clinic for Special Children, Strasburg, PA, USA; Franklin […]

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine

June 17, 2015

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine, Electrophoresis. 2015 Jun 17, Zhao X1, Zeisel S1,2, Zhang S3. Author information 1Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, 28081, USA. 2Department of Nutrition, School of Public Health and School of Medicine, […]

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

April 28, 2015

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. 2015 Apr 28, FASEB J., Silver MJ1, Corbin KD1, Hellenthal G1, da Costa KA1, Dominguez-Salas P1, Moore SE1, Owen J1, Prentice AM1, Hennig BJ1, Zeisel SH2. 1*Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United […]

Effects of Mthfd1 Gene on Mouse Behavior

April 07, 2015

Effects of Mthfd1 Gene on Mouse Behavior, Apr 2015,The FASEB Journal,  Eneda Pjetri1 and Steven Zeisel1 1Nutrition Research Institute UNC Chapel Hill Kannapolis NC United States Abstract Methylenetetrahydrofolate dehydrogenase 1 (Mthfd1) gene encodes the trifunctional C1 tetrahydrofolate (C1THF) enzyme that plays an important role in the folate-mediated one-carbon metabolism. A polymorphism of this gene (1958G>A; rs2236225) has […]

Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

February 18, 2015

Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice, Gastroenterology. 2015 Feb 18, Tsuchiya H1, Costa KA2, Lee S3, Renga B4, Jaeschke H5, Yang Z6, Orena SJ2, Goedken MJ7, Zhang Y5, Bo K8, Lebofsky M5, Rudraiah S3, Smalling R1, Guo G8, Fiorucci S4, Zeisel SH2, Wang L9. Department of Medicine, University of Utah […]

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

November 10, 2014

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism, FASEB J. 2014 Nov 10, Martínez-Vega R1, Garrido F2, Partearroyo T3, Cediel R4, Zeisel SH5, Martínez-Álvarez C6, Varela-Moreiras G3, Varela-Nieto I7, Pajares MA8. 1Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Unidad 761, Centro de Investigación Biomédica en […]

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

March 26, 2014

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. March 26, 2014. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Department of Nutrition, School of Public Health, School of Medicine, […]

What is Personalized Nutrition?

March 01, 2014

Steven Zeisel, MD, PhD, director of the UNC Chapel Hill Nutrition Research Institute, explains what personalized nutrition is and how it is the mission of his institute to advance the field so that nutritional decisions are based on genetic information. The result: healthier people and new avenues to prevent and treat disease. Physicians know that […]

Parental Nutrition Impacts Future Generations

February 10, 2014

Mihai Niculescu, MD, PhD, with the UNC Chapel Hill Nutrition Research Institute, is an expert in the field of epigenetics. He is researching how nutrition influences the genetic interplay between parents and children, specifically looking at omega-3 fatty acid supplementation.   When you make a habit of snacking on fruits and vegetables versus grabbing a […]

Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives

June 28, 2013

Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives. Computational and Structural Biotechnol Journal. 2013 Jun 28;4:e201301013. eCollection 2013. Du X, Zeisel SH. Department of Bioinformatics, University of North Carolina at Charlotte, Charlotte, NC; Nutrition Research Institute, University of North Carolina at Chapel Hill, NC Research Campus, Kannapolis, NC. Abstract Mass spectrometry coupled to […]

Nutrition in pregnancy: the argument for including a source of choline

April 07, 2013

Nutrition in pregnancy: the argument for including a source of choline April 2013. International Journal of Women’s Health. April 2013. Zeisel, SH. Nutrition Research Institute at Kannapolis, Department of Nutrition, University of North Carolina at Chapel Hill. Abstract Women, during pregnancy and lactation, should eat foods that contain adequate amounts of choline. A mother delivers […]

Finding Natural Solutions to Prevent and Treat Cancer

March 19, 2013

When you sit down to a salad full of pumpkins seeds, tofu, almonds and healthy greens followed by a main course of seafood flavored with ginger and a glass of wine, cancer prevention is probably not on your mind. Unless, that is, you are a scientist at the North Carolina Research Campus (NCRC) in Kannapolis, […]

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

March 13, 2013

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms. Current Opinion in Clinical Nutrition and Metabolomic Care. March 13, 2013. Mehedint, MG, Zeisel SH. Nutrition Research Institute at the NC Research Campus, Kannapolis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Abstract PURPOSE OF REVIEW: Humans eating diets low in […]

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

February 01, 2013

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB Journal. February 1, 2013. Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. University of North Carolina at Chapel Hill Nutrition Research Institute, Abstract […]

New Genetic Approaches to Predict and Prevent Fatty Liver

December 20, 2012

When Karen Corbin, PhD, RD, first read the UNC Chapel Hill Nutrition Research Institute’s (NRI) mission- exploring nutritional individuality- she knew she’d found the place she could build her career. As a clinical dietitian, certified diabetes educator and co-director of preventive services at the Heart and Vascular Institute of Florida from 1998 to 2003, Corbin […]

A Brief History of Choline

November 08, 2012

A Brief History of Choline. Annals of Nutrition and Metabolism. Epub November 2012. Zeisel SH. UNC Nutrition Research Institute. Abstract In 1850, Theodore Gobley, working in Paris, described a substance, ‘lecithine’, which he named after the Greek ‘lekithos’ for egg yolk. Adolph Strecker noted in 1862 that when lecithin from bile was heated, it generated […]

Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.

May 10, 2012

Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.  Annals of Nutrition Metabolism, May 2012. Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract One of the underlying mechanisms for metabolic individuality is genetic variation. Single nucleotide polymorphisms (SNPs) in genes of metabolic pathways can create […]