Shengmin Sang

Plant Compounds Delay Diabetic Complications, Offer New Treatment Options

September 22, 2015

Research from Shengmin Sang, PhD, at the NC Research Campus in Kannapolis, NC, is proving that ginger compounds and some flavonoids are effective at stopping physiological processes that lead to diabetic complications.   Scientific evidence is building that plant compounds may be a safe and effective alternative to approved pharmaceutical treatments for type 2 diabetes […]

Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal

August 13, 2015

Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal, Chem Res Toxicol. 2015 Aug 13, Zhu Y1, Zhao Y1, Wang P1, Ahmedna M, Sang S1. 1†Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina 28081, United States. Abstract Considerable evidence suggests […]

Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity

July 23, 2015

Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity, J Med Chem. 2015 J Zhu Y, Fu J, Shurlknight K, Soroka D, Hu Y, Chen XL, Sang S. Abstract Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized […]

Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer

April 07, 2015

Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer, Apr 2015, The FASEB Journal, Jennifer McBride1, Yingdong Zhu1, Pei Wang1 and Shengmin Sang1 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Colorectal cancer (CRC) is a leading cause of cancer related deaths in the United States. Epidemiological […]

Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice

April 07, 2015

Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice, Apr 2015, The FASEB Journal, Yantao Zhao1, Rashin Sedighi1, Pei Wang1, Huadong Chen1, Yingdong Zhu1 and Shengmin Sang1 –1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Rosemary has been used as a natural […]

Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells

April 07, 2015

Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells, Apr 2015, The FASEB Journal, Shengmin Sang1, Junsheng Fu1, Yingdong Zhu1, Aaron Yerke1, Mitchell Wise2, Jodee Johnson3 and YiFang Chu3 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States 2Cereal Crops Research Unit USDA Madison WI United States 3Quaker Oats Center of Excellence […]

Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review

February 10, 2015

Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review, Current Opinion in Food Science, 10 February 2015,  Rashin Sedighi, Yantao Zhao, Aaron Yerke, Shengmin Sang Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina […]

Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation

February 06, 2015

Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation, J Agric Food Chem. 2015 Feb 6, Zhu Y, Soroka D, Sang S. NC A&T University Abstract Consumption of whole grains has been reported to be associated with a lower risk of several lifestyle-related diseases such as colorectal […]

Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites

December 27, 2014

Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites,2015 American Society for Nutrition Dec 2014, Pei Wang4, Huadong Chen4, Yingdong Zhu, Jennifer McBride, Junsheng Fu, and Shengmin Sang* Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human […]

Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid.

December 01, 2014

Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid. Chem Res Toxicol. 2014 Dec 1, Zhu Y, Zhao Y, Wang P, Ahmedna M, Ho CT, Sang S. NC A&T University Abstract Growing evidence has shown that ascorbic acid (ASA) can contribute to protein glycation and the formation of advanced glycation end products (AGEs), especially in the lens. The mechanism by which ascorbic acid can cause […]

Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal

November 20, 2014

Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal. J Agric Food Chem. 2014 Nov 20, Li X, Zheng T, Sang S, Lv L. NC A&T University Abstract Methylglyoxal (MGO) and glyoxal (GO) are not only endogenous metabolites, but also exist in exogenous resources, such as food, beverages, urban atmosphere, and cigarette smoke. They […]

Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo.

August 22, 2014

Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo. Chem Res Toxicol. 2014 Aug 22, Chen H, Fu J, Chen H, Hu Y, Soroka DN, Prigge J, Schmidt EE, Yan F, Major MB, Chen XL, Sang S. Abstract In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in […]

Biotransformation of tea polyphenols by gut microbiota

February 06, 2014

Biotransformation of tea polyphenols by gut microbiota. Journal of Functional Foods. February 2014. Huadong Chen, Shengmin Sang. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract Tea is one of the most widely consumed beverages worldwide and has received increasing attention from researchers and food industries […]

Whole Grains: Eating to Prescribing Grains for Better Health, Cancer Prevention

June 28, 2013

Understanding the biology of grains is only one challenge. Understanding how they interact with human biology to prevent disease is another. Shengmin Sang, PhD, associate professor and lead scientist in functional food for NC A&T State University’s Center for Excellence in Post-Harvest Technologies (CEPHT) at the NCRC, envisions his research contributing to the day when […]

Ginger Shogaols: Promising Preventation for Lung and Colon Cancer

June 20, 2013

Shengmin Sang, PhD, associate professor and lead scientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies (CEPHT) at the North Carolina Research Campus in Kannapolis, has published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most recent findings concentrate on […]

Finding Natural Solutions to Prevent and Treat Cancer

March 19, 2013

When you sit down to a salad full of pumpkins seeds, tofu, almonds and healthy greens followed by a main course of seafood flavored with ginger and a glass of wine, cancer prevention is probably not on your mind. Unless, that is, you are a scientist at the North Carolina Research Campus (NCRC) in Kannapolis, […]

Collaborations Driving Ginger Research For Cancer, Anemia Treatments

December 09, 2012

Ginger is more appreciated for its aromatic and tangy taste that is  enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. […]

Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.

September 10, 2012

Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. Journal of Chromatography, September 2012. Chen H, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract Ginger is frequently consumed as a spice and has numerous medicinal properties. Extensive research […]

Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols

September 10, 2012

Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols. Journal of Agricultural and Food Chemistry. September 2012. Zhu Y, Soroka DN, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract We have identified alkylresorcinols (ARs) as the major active components […]