oxidative stress

Scientist finds a way to help families cope with a rare neurological disorder

July 13, 2017

Giuseppe Valacchi, PhD, a scientist with the N.C. State Plants for Human Health Institute, has found that dietary interventions alleviate many symptoms of a rare genetic disorder called Rett Syndrome. Giuseppe Valacchi, PhD, arrived in Kannapolis, North Carolina from Ferrara, Italy in the summer of 2016. As the newest Associate Professor with the N.C. State […]

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells

April 27, 2017

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells, PLOS One, Ming Zhao, Erin W. Howard, Zhiying Guo, Amanda B. Parris, Xiaohe Yang.  Department of Biological and Biomedical Sciences, Julius L. Chambers Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Kannapolis, North Carolina Abstract Alcohol consumption is associated with increased breast cancer risk; however, […]

4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation

January 12, 2017

Giuseppe Valacchi, Alessandra Pecorelli, Carlo Cervellati, Joussef Hayek. 4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation. Free Radical Biology and Medicine (2017). Author Affiliations a. Plants for Human Health Institute, Department of Animal Sciences, NC State University, NC Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA b. Department of Life Sciences and Biotechnology, […]

Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress

December 08, 2016

Rita Canella, Marta Martini, Roberta Borriello, Carlotta Cavicchio, Ximena M Muresan, Mascia Benedusi, Franco Cervellati, Giuseppe Valacchi (2016). Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress. Journal of Cellular Physiology doi: [10.1002/jcp.25705] Author Affiliations Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy Department of Animal Science, […]

Bioactive Brief: Ginger-Derived Compounds Activate Cytoprotective Molecules

May 26, 2016

In an innovative study from NC Research Campus partners at the NC A&T Center for Excellence in Post-Harvest Technologies (the Sang lab) and the NC Central Nutrition Research Program (the Leung lab), scientists discovered four novel, cytoprotective compounds derived from dry ginger that act as the “most potent Nrf2 activators” in a zebrafish embryo model. The […]

Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells

January 05, 2016

Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells. Phytomedicine, January 5, 2016. Chethan Sampath a, Yingdong Zhu b, Shengmin Sang b, Mohamed Ahmedna a. Author Affiliations a Department of Health Sciences, College of Arts & Sciences, Qatar University, Doha 2713, Qatar b Center for […]

RNA-seq analysis reveals genetic response and tolerance mechanisms to ozone exposure in soybean

June 04, 2015

RNA-seq analysis reveals genetic response and tolerance mechanisms to Ozone exposure in soybean, BMC Genomics. 2015 Jun 4, Whaley A1, Sheridan J2, Safari S3, Burton A4, Burkey K5, Schlueter J6. Author information 1Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC, 28223, USA. awhaley9@uncc.edu. 2Department of Bioinformatics and Genomics, University of […]

Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin

January 28, 2015

Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin, American Heart Association, 28 Jan 2015,Jonathan C. Schisler, PhD; Trisha J. Grevengoed, BS; Florencia Pascual, PhD; Daniel E. Cooper, BS; Jessica M. Ellis, PhD; David S. Paul, PhD; Monte S. Willis, MD, PhD; Cam Patterson, MD; Wei Jia, PhD; Rosalind A. Coleman, MD 1Division […]

NC Research Campus Scientists Create Gold Standard for Measuring Oxidative Stress

August 08, 2014

By Lukas Johnson Charlotte Observer View the original article. – COURTESY OF DAVID NIEMAN A team of scientists at the North Carolina Research Campus in Kannapolis have developed what they believe could become the new global standard for measuring free radicals in athletes. Test subjects included several high-performing athletes who rode bicycles on a computerized, […]

Turbocharge Your Food- Excercising Ups Nutrient Absorption from Berries, Tea

July 15, 2014

As published in the Dole Nutrition Institute’s July 2014 newsletter. “Gut permeability,” “leaky colon,” “hot gut”– none of these terms conjure up conditions you’d think to put on your wish list.  The colon carries digested food away from the stomach and towards the exit, so “leaking” would be the very last thing you’d want your […]

New Biomarker for Oxidative Stress When Exercising Discovered

May 14, 2014

View the abstract published in the American Journal of Physiology. New research led by David Nieman, DrPH, FACSM, director of the Appalachian State University Human Performance Laboratory at the NC Research Campus, identified a new biomarker for oxidative stress generated during exercise. In the field of exercise science, measuring oxidative stress can be difficult, time […]

NCRC team discovers new biomarker for oxidative stress

May 14, 2014

Posted: Wednesday, May 14, 2014 5:23 pm Read the original article as posted by the Independent Tribune staff KANNAPOLIS, N.C. — Scientists at the North Carolina Research Campus (NCRC) have discovered a new way to detect oxidative stress generated during exercise. A team led by Dr. David Nieman, director of the Appalachian State University Human Performance Laboratory […]

Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid

April 23, 2014

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 23. [Epub ahead of print] Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. Nieman DC, Shanely RA, Luo B, Meaney MP, Dew DA, Pappan KL. Appalachian State University Human Performance Laboratory, NC Research Campus. Abstract Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- […]

Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists

March 06, 2014

Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists.  Applied Physiology, Nutrition and Metabolism. March 2014. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson D, Sha W, Meaney MP. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus; Dole Nutrition Research Laboratory, NC Research Campus; UNC Charlotte Bioinformatics Services Division, […]

The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide

September 20, 2013

The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide. PLoS One.  September 20, 2013. Sha W, Martins AM, Laubenbacher R, Mendes P, Shulaev V. Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia; Bioinformatics Research Division, University of North Carolina at Charlotte, Kannapolis, NC. Abstract Oxidative stress is a well-known biological process that occurs in all […]

Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach.

November 10, 2012

Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach. Plants for Human Nutrition. November 2012. Nieman DC, Cialdella-Kam L, Knab AM, Shanely RA. Appalachian State University Human Performance Lab. Abstract Red pepper spice (RP) and turmeric (TM) are used as flavorings in foods and for […]

Effects of a Flavonoid-rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics Based Approach.

October 10, 2012

Effects of a Flavonoid-rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics Based Approach. International Journal of  Sport Nutrition and Exercise Metabolism. October 2012. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson DA, Sha W. Appalachian State University Human Performance Laboratory, Dole Nutrition Research Laboratory and UNC Charlotte […]

Effect of n-3 fatty acids and antioxidants on oxidative stress after exercise.

September 11, 2010

McAnulty SR, Nieman DC, Fox-Rabinovich M, Duran V, McAnulty LS, Henson DA, Jin F, Landram MJ. Effect of n-3 fatty acids and antioxidants on oxidative stress after exercise. Department of Health, Leisure, and Exercise Science, AppalachianStateUniversity, Boone, NC 28608, USA. Med Sci Sports Exerc. 2010 Sep;42(9):1704-11. Abstract PURPOSE: n-3 fatty acids are known to exert […]