NC Central University

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

July 28, 2015

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer

July 22, 2015

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer, July 22, 2015, In Press Accepted Manuscript, Yujie Fu, Onat Kadioglu, Benjamin Wiench, Zuofu Wei, Wei Wang, Meng Luo, Xiaohe Yang, Chengbo Gu, Yuangang Zu, Thomas Efferth NC Central University <style>.requiresJS{display:none}.dartAd{display:block !important}</style> Abstract Anti-estrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established anti-hormones such as tamoxifen, novel […]

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib

April 22, 2015

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib, Journal of Cancer Research, April 22, 2015, Ming Zhao, Amanda Blackwelder, Harry Lee, and Xiaohe Yang Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC. Abstract 3557: Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib Abstract […]

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

April 07, 2015

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice, 2015 Apr 7, Int J Mol Sci, Ma Z1, Blackwelder AJ2, Lee H3, Zhao M4, Yang X5. 1Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA. mzhao@nccu.edu. 2Julius L. Chambers Biomedical/Biotechnology […]

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells

March 11, 2015

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells, Phytomedicine, 11 March 2015,  Yujie Fua, b, 1, Onat Kadiogluc, 1, Benjamin Wienchc, Zuofu Weia, b, Chang Gaod, Meng Luoa, b, Xiaohe Yange, Chengbo Gua, b, Yuangang Zua, b, Thomas Efferth Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer […]

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk

November 18, 2014

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk.  Molecular Cancer Research. Nov 2014, Zhikun Ma, Amanda Blackwelder, and Xiaohe Yang North Carolina Central Unversity, Kannapolis, NC. Abstract A09: In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk Abstract The mammary […]

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet

April 16, 2014

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. The Journal of Endocrinology. Apr 16, 2014 [Epub ahead of print] Yang X1, Mei S, Gu H, Guo H, Zha L, Cai J, Li X, Liu Z, Cao W. 1X Yang, Nutrition, UNC at Chapel Hill, Kannapolis, United States. Abstract We have previously shown that insulin plays an essential role […]

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts

April 05, 2014

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts AACR Annual Meeting 2014; April 5-9, 2014, K. Sean Kimbro, Karine Ferri-Lagneau, Jamil Haider, Susan Yeyeodu, Xiaohe Yang, and TinChung Leung North Carolina Central University, Durham, NC. Abstract Growing evidence indicates that incongruities in the inflammatory and immune response pathways contribute to tumorigenesis. We seek to explore the underlying biological mechanisms […]

BRITE Futures for Kannapolis Students

March 06, 2014

Salisbury Post Dr. TinChung Leung, of the NC Central University Nutrition Research Program at the NC Research Campus, is usually focused on cancer, cardiovascular and blood research. This year, he is expanding his focus to make an investment in the future of middle and high school students in Kannapolis City Schools. He worked together with […]

Investing in Bright Futures for Kannapolis Students

February 25, 2014

TinChung Leung, PhD, of the NC Central University Nutrition Research Program at the NC Research Campus, is usually focused on cancer, cardiovascular and blood research. This year, he is expanding his focus to make an investment in the future of middle and high school students in Kannapolis City Schools (KCS).   BRITE Futures He worked […]

A Model Fish

January 15, 2014

Scientists with North Carolina Central University Nutrition Research Program and NCA&T’s Center for Excellence in Post-Harvest Technologies teamed up to study the bioactive compounds in ginger. They did it using a rather model fish called zebrafish. NC Central scientist TinChung Leung, PhD, uses the model fish for research into natural compounds that can help prevent […]

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models

December 09, 2013

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models. Cancer Prevention Research (Philadephia, PA). December 9, 2013. [Epub ahead of print] Zhu P, Davis M, Blackwelder A, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Julius L. Chambers Biomedical Biotechnology Research Institute, Julius L. Chambers Biomedical Biotechnology Research Institute/NC Central University Nutrition Research Program, NC Research […]

A Model Fish

December 06, 2013

As featured on UNC-TV’s Science Now. Written and produced by Frank Graff. The image on the computer screen in the North Carolina Central University lab at the North Carolina Research Campus is both creepy and fascinating. It is a creature that is green, with a giant eye, a rapidly opening and closing mouth, and what […]

A Microbial Answer to Malnutrition

September 09, 2013

The West African Sahel region is a corner of the world that Steven Maranz, PhD, knows well. He spent part of his childhood there and worked with the Consultative Group on International Agricultural Research (CGIAR) in the region. Maranz is currently a visiting scientist with the David H. Murdock Research Institute, a provider of collaborative […]

[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos.

May 23, 2013

[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos. Journal of Agricultural and Food Chemistry.  Epub May 23, 2013. Chen H, Soroka DN, Haider J, Ferri-Lagneau KF, Leung T (NC Central University Nutrition Research Program), Sang S. Center for Excellence in Post-Harvest Technologies, North […]

Collaborations Driving Ginger Research for Cancer, Anemia

April 09, 2013

Ginger is appreciated for its aromatic and tangy taste and is enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

Finding Natural Solutions to Prevent and Treat Cancer

March 19, 2013

When you sit down to a salad full of pumpkins seeds, tofu, almonds and healthy greens followed by a main course of seafood flavored with ginger and a glass of wine, cancer prevention is probably not on your mind. Unless, that is, you are a scientist at the North Carolina Research Campus (NCRC) in Kannapolis, […]

Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

February 09, 2013

One of the most controversial and confusing questions surrounding breast cancer is the effect of eating soy. Some studies say soy and the isoflavone genistein that it contains prevents breast cancer. Other studies say genistein is a risk factor for developing breast cancer. Breast cancer researcher Xiaohe Yang, PhD, associate professor with the North Carolina Central […]

ADAP-GC 2.0: Deconvolution of Coeluting Metabolites from GC/TOF-MS Data for Metabolomics Studies.

July 10, 2012

ADAP-GC 2.0: Deconvolution of Coeluting Metabolites from GC/TOF-MS Data for Metabolomics Studies. Analytical Chemistry, July 2012. Ni Y, Qiu Y, Jiang W, Suttlemyre K, Su M, Zhang W, Jia W, Du X. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, North Carolina Research Campus. Abstract ADAP-GC 2.0 has been developed to deconvolute […]