Mihai Niculescu

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

March 26, 2014

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. March 26, 2014. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Department of Nutrition, School of Public Health, School of Medicine, […]

Parental Nutrition Impacts Future Generations

February 10, 2014

Mihai Niculescu, MD, PhD, with the UNC Chapel Hill Nutrition Research Institute, is an expert in the field of epigenetics. He is researching how nutrition influences the genetic interplay between parents and children, specifically looking at omega-3 fatty acid supplementation.   When you make a habit of snacking on fruits and vegetables versus grabbing a […]

Omega-3 intake linked to higher cognition in infants, toddlers and young children

January 19, 2014

YottaFire Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio of […]

Omega-3 Intake Linked to Higher Cognition in Children

December 19, 2013

YottaFire Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio of […]

Omega-3 intake linked to higher cognition in infants, toddlers and young children

October 16, 2013

Medical Press Carol L. Cheatham, PhD, developmental cognitive neuroscientist with the UNC Chapel Hill Nutrition Research Institute (NRI) at the NC Research Campus, has research findings that prove just how critical fatty acids are to the cognitive development and cognitive functioning of infants, toddlers and young children. A study on the effect of the ratio […]

What mum eats before pregnancy may affect child’s health

September 21, 2012

Now, new research in mice has suggested that what she ate before pregnancy might be important too. What a group of female mice ate-before pregnancy-chemically altered their DNA and these changes were passed to her offspring. These DNA alterations, called “epigenetic” changes, drastically affected the pups’ metabolism of many essential fatty acids, the research found. […]

Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment

March 18, 2011

Tint, D.,Anghel, M., Lupu, D. S., Fischer, L. M., and Niculescu, M. D. (2011)Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment .J Nutrition Disorder TherS7, 1 Abstract Many studies indicated that increased intakes of ω-3 fatty acids could positively impact the progression […]

Nutritional influence on epigenetics and effects on longevity

March 18, 2011

Niculescu, M.D. & Lupu, D.S.(2011)Nutritional influence on epigenetics and effects on longevity. Curr Opin Clin Nutr Metab CareJan;14(1):35-40 Abstract PURPOSE OF REVIEW: This review synthesizes recently published information regarding nutrition and its impact upon epigenetically mediated mechanisms involved in longevity and aging. RECENT FINDINGS: Recent studies enriched considerably our understanding of the relationship between aging […]

Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring.

March 18, 2011

Niculescu, M. D., Lupu, D. S., and Craciunescu, C. N. (2011)Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. Int J Dev Neurosci29, 795-802 Abstract The availability of ω-3 polyunsaturated fatty acids is essential for perinatal brain development. While the roles of docosahexaenoic acid (the most abundant […]

Epigenetic transgenerational inheritance: Should obesity-prevention policies be reconsidered

March 18, 2011

Niculescu M.D.(2011)Epigenetic transgenerational inheritance: Should obesity-prevention policies be reconsidered?SynesisJ, 2, G18-26. Studies have shown that the nutrition of one generation can alter the epigenetics of DNA in subsequent generations. The increase in the obesity epidemic, especially in the US requires significant health care-related expenditures and negatively impacts the quality of life for many Americans. Obesity […]

Alteration of PTGS2 promoter methylation in chronic periodontitis

March 19, 2010

Zhang, S., Barros, S. P., Niculescu, M. D., Moretti, A. J., Preisser, J. S., and Offenbacher, S. (2010)Alteration of PTGS2 promoter methylation in chronic periodontitis.J Dent Res89, 133-137 Abstract   Levels of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in actively progressing periodontal lesions, but decrease in chronic disease. We hypothesized that […]

High fat diet-induced maternal obesity alters fetal hippocampal development

March 19, 2009

Niculescu, M. D., and Lupu, D. S.(2009)High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci27, 627-633 Abstract The importance of maternal nutrition for fetal brain development is increasingly recognized. Previous studies have suggested that maternal obesity or maternal exposure to obesogenic diets may permanently alter brain structure and function in the […]

Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans

March 19, 2009

Craciunescu, C. N., Niculescu, M. D., Guo, Z., Johnson, A. R., Fischer, L., and Zeisel, S. H. (2009)Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans.Toxicol Sci107, 220-226 Abstract Diethanolamine (DEA) is a common ingredient of personal care products. Dermal administration of DEA diminishes hepatic stores […]