mass spectrometry

GCxGC-MS Validated for Metabolomics Profiling, Biomarker Discovery

November 19, 2015

Read the story on Advanced Health Network. Scientists at the David H. Murdock Research Institute (DHMRI), located at the NC Research Campus in Kannapolis, NC, validated the use of comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) for metabolite biomarker discovery. “GC x GC-MS is an approach to biomarker research that tends to be under-used,” commented […]

Metabolism of dictamnine in liver microsomes from mouse, rat, dog, monkey, and human

November 18, 2015

Metabolism of dictamnine in liver microsomes from mouse, rat, dog, monkey, and human, Journal of Pharmaceutical and Biomedical Analysis. November 18, 2015. Pei Wang (A,B), Yunli Zhao (A), Yingdong Zhu (B), Jianbo Sun (C), Aaron Yerke (B), Shengmin Sang (B), Zhiguo Yu (A). Author Affiliations A School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China […]

Lessons learned from metabolomics in cystic fibrosis

October 26, 2015

Lessons learned from metabolomics in cystic fibrosis, Molecular and Cellular Pediatrics 2015, Marianne S. Muhlebach1* and Wei Sha2 1Department Pediatrics, Division Pulmonology, UNC Chapel Hill 430 MacNider, CB 7217, Chapel Hill 27599-7217, NC, USA 2Bioinformatics Services Division, University of North Carolina at Charlotte, Kannapolis 28081, NC, USA Abstract Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory […]

Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis.

April 25, 2014

Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Molecular Biosystems. Apr 25,2014. [Epub ahead of print] Baxter SS1, Dibble CF, Byrd WC, Carlson J, Mack CR, Saldarriaga I, Bencharit S. 1David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA. Abstract Three genetic mutations were found to cause cerebral cavernous malformation (CCM), a vascular anomaly […]

Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives

June 28, 2013

Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives. Computational and Structural Biotechnol Journal. 2013 Jun 28;4:e201301013. eCollection 2013. Du X, Zeisel SH. Department of Bioinformatics, University of North Carolina at Charlotte, Charlotte, NC; Nutrition Research Institute, University of North Carolina at Chapel Hill, NC Research Campus, Kannapolis, NC. Abstract Mass spectrometry coupled to […]