liver

Heart and Liver Disease: Deciphering Metabolic and Genetic Connections

June 09, 2013

The human genetic code is 99.9 percent identical. What makes people individuals, genetically speaking, equates to .1 percent of their individual genetic make-up and accounts for thousands of differentiations at the molecular level. Deciphering those differentiations or polymorphisms and their involvement in the development of disease is the work of scientists like Karen  Corbin, PhD, RD, […]

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

May 14, 2013

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB: Official Publication of the Federation of American Societies for Experimental Biology.  Epub May 14, 2013. Xie G, Zhong W, Li H, Li Q, Qiu Y, Zheng X, Chen H, Zhao X, Zhang S, Zhou Z, Zeisel SH, Jia W. Center for […]

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways

April 07, 2013

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways. PLoS One. April 2013.  Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract High […]

Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.

January 16, 2013

Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.  Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka D, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract SCOPE: There are limited data on the metabolism of [6]-shogaol (6S), […]

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

March 11, 2012

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.Current Opinion Gastroenterology, March 2012. Corbin KD, Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract PURPOSE OF REVIEW: Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans […]

Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors.

February 11, 2012

Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. Neurotoxicology Teratology, January-February 2012. Fordahl S, Cooney P, Qiu Y, Xie G, Jia W, Erikson KM. UNC Greensboro Department of Nutrition, Center for Research Excellence in Bioactive Food Components. Abstract Overexposure to waterborne manganese (Mn) is linked with cognitive impairment […]

An optimized procedure for metabonomic analysis of rat liver tissue using gas chromatography/time-of-flight mass spectrometry

March 11, 2010

Pan, Li, Qiu, Yunping, Chen, Tianlu, Lin, Jinchao, Chi, Yi, Su, Mingming, Zhao, Aihua, Jia, Wei (2010). An optimized procedure for metabonomic analysis of rat liver tissue using gas chromatography/time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 52(4) 589-596. Abstract In this paper, we present a tissue metabonomic method with an optimized extraction procedure […]