hepatitis C

Charlotte Doctor Involved In Groundbreaking Hepatitis C Study

January 08, 2013

By Michael Tomsic, WFAE Charlotte A doctor at Carolinas Medical Center in Charlotte was involved in a groundbreaking study on treating African-Americans who have Hepatitis C. Hepatitis C is a liver infection that people usually get through contaminated blood transfusions or intravenous drug use. Dr. Herbert Bonkovsky said doctors have known for years that African-Americans […]

Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C

July 05, 2011

Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C Derek D. Cyr,  Joseph E. Lucas, J. Will Thompson, Keyur Patel, Paul J. Clark, Alexander Thompson, Hans L. Tillmann, John G. McHutchison, Jeanette J. McCarthy Abstract Introduction Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous clearance and treatment response to pegIFN/RBV in chronic hepatitis […]

Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.

June 12, 2010

Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin. McCarthy JJ1, Li JH, Thompson A, Suchindran S, Lao XQ, Patel K, Tillmann HL, Muir AJ, McHutchison JG. Abstract BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infections are treated with pegylated interferon and ribavirin (PEG-IFN/RBV), which is effective in less than 50% of those infected with HCV genotype 1. Genome-wide association […]

Interferon-lambda Genotype and Low Serum Low- Density Lipoprotein Cholesterol Levels in Patients with Chronic Hepatitis C Infection

June 12, 2010

Interferon-lambda Genotype and Low Serum Low-Density Lipoprotein Cholesterol Levels in Patients with Chronic Hepatitis C Infection Li JH1, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG, McCarthy JJ. Abstract Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment ofhepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with […]

Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection.

March 12, 2010

Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG and  McCarthy JJ.  Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection. Hepatology 2010;51(6): 1904-11.  PMID: 20235331. Abstract Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda […]