Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats. Alcoholism Clinical and Experimental Research. May 21, 2014. Qiong Li1, Guoxiang Xie2, Wenliang Zhang1, Wei Zhong1, Xiuhua Sun1, Xiaobing Tan1, Xinguo Sun1, Wei Jia2,3and Zhanxiang Zhou1,4,* 1 Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina; 2 University of Hawaii Cancer Center, Honolulu, Hawaii; 3 Center for Translational […]
Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.
Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. March 26, 2014. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Department of Nutrition, School of Public Health, School of Medicine, […]
The human genetic code is 99.9 percent identical. What makes people individuals, genetically speaking, equates to .1 percent of their individual genetic make-up and accounts for thousands of differentiations at the molecular level. Deciphering those differentiations or polymorphisms and their involvement in the development of disease is the work of scientists like Karen Corbin, PhD, RD, and […]
Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms. Current Opinion in Clinical Nutrition and Metabolomic Care. March 13, 2013. Mehedint, MG, Zeisel SH. Nutrition Research Institute at the NC Research Campus, Kannapolis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Abstract PURPOSE OF REVIEW: Humans eating diets low in […]
When Karen Corbin, PhD, RD, first read the UNC Chapel Hill Nutrition Research Institute’s (NRI) mission- exploring nutritional individuality- she knew she’d found the place she could build her career. As a clinical dietitian, certified diabetes educator and co-director of preventive services at the Heart and Vascular Institute of Florida from 1998 to 2003, Corbin […]
While visiting former college classmates in China, Zhanxiang Zhou, PhD, learned that several of them suffered from alcohol-induced fatty liver disease (FLD). Zhou is co-director of the UNC Greensboro Center forTranslational Biomedical Research and an expert on the disease. During his visit, Zhou counseled his friends on dietary changes that might help them. One day, […]
Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice. The Journal of American Pathology, July 2012. Xiaobing Tan, Xiuhua Sun, Qiong Li, Yantao Zhao, Wei Zhong, Xinguo Sun, Wei Jia, Craig J. McClain, Zhanxiang Zhou. UNC Greensboro Center for Translational Biomedical Research. Abstract White adipose tissue (WAT) secretes adipokines, which critically regulate lipid […]
Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.
Spencer, M.D., Hamp, T.J., Reid, R.W., Fischer, L.M., Zeisel, S.H., Fodor, A.A. (2010)Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology. doi:10.1053/j.gastro.2010.11.049. Abstract BACKGROUND & AIMS: Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood. […]