estrogen

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk

November 18, 2014

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk.  Molecular Cancer Research. Nov 2014, Zhikun Ma, Amanda Blackwelder, and Xiaohe Yang North Carolina Central Unversity, Kannapolis, NC. Abstract A09: In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk Abstract The mammary […]

Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

March 18, 2010

Resseguie, M.,da Costa, K-A, Galanko, J., Davis, I.J., Zeisel, S.H. (2010)Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. Journal of Biological Chemistry.286(2): 1649-58. PMCID: PMC3020773. Abstract When dietary choline is restricted, most men and postmenopausal women develop multiorgan dysfunction marked by hepatic steatosis (choline deficiency syndrome (CDS)). However, a significant subset of […]

Dietary choline requirements of women: effects of estrogen and genetic variation

March 18, 2010

Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010)Dietary choline requirements of women: effects of estrogen and genetic variation. American Journal of Clinical Nutrition.92(5):1113-19. PMCID: PMC2954445. Abstract BACKGROUND: Choline is obtained from the diet and from the biosynthesis of phosphatidylcholine. Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by […]