David Nieman

How Does Ibuprofen (Advil, Motrin) Before a Race Affect Your Body?

October 04, 2016

Read the original article by Healthline’s Kristen Buettner, medically reviewed by Peggy Pletcher, MS, RD, LD, CDE Part 1 of 5: Overview Highlights Almost 60 percent of runners use non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. Taking ibuprofen before a race has not been found to reduce muscle damage and pain. Even in runners, long-term use […]

Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA expression

August 26, 2015

Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA expression, Frontiers in Nutrition, 26 Aug 2015, David C. Nieman1* 1Appalachian State University, USA Abstract Objectives: The purpose of this study was to correlate post-exercise muscle glycogen levels with changes in plasma cytokine, and muscle mRNA cytokine […]

Rhodiola Rosea Study Provides More Evidence Polyphenols Protect Against Viral Infection  

August 20, 2015

  A new study published by the Appalachian State University Human Performance Laboratory at the NC Research Campus strengthens the case for the anti-viral effects of plant-based polyphenols. Human trials with marathon runners found that the herb Rhodiola rosea protects against viral infection. These findings build on previous human trials that demonstrate the anti-viral activity […]

Rhodiola rosea Exerts Antiviral Activity in Athletes Following a Competitive Marathon Race

July 31, 2015

Rhodiola rosea Exerts Antiviral Activity in Athletes Following a Competitive Marathon Race, Front. Nutr., 31 July 2015, Maryam Ahmed1*, Dru A. Henson1, Matthew C. Sanderson1, David C. Nieman2, Jose M. Zubeldia3 and R. Andrew Shanely4 1Department of Biology, Appalachian State University, Boone, NC, USA 2Human Performance Laboratory, Appalachian State University, Kannapolis, NC, USA 3PoliNat SL, Las Palmas, […]

No Positive Influence of Ingesting Chia Seed Oil on Human Running Performance

May 15, 2015

No Positive Influence of Ingesting Chia Seed Oil on Human Running Performance, 15 May 2015,  Nutrients , David C. Nieman 1,*, Nicholas D. Gillitt 2, Mary Pat Meaney 1 and Dustin A. Dew Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA; E-Mails: meaneymp@appstate.edu (M.P.M.); dustindew@gmail.com (D.A.D.) Dole Nutrition Research Laboratory, […]

Human Performance Lab Validates Non-invasive Method to Measure Muscle Glycogen

May 05, 2015

Summary:  Muscle glycogen levels directly impact an athlete’s performance. The standard method to measure muscle glycogen requires an invasive muscle biopsy. The Appalachian State University Human Performance Laboratory at the NC Research Campus has validated a non-invasive ultrasound technology created by MuscleSound® of Denver, Colorado that measures muscle glycogen just as effectively.    Researchers in exercise […]

Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content

April 18, 2015

Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content, 2015 Apr 18, BMC Sports Sci Med Rehabil. Nieman DC1, Shanely RA2, Zwetsloot KA2, Meaney MP1, Farris GE3. 1Appalachian State University, Human Performance Lab, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081 USA. 2Department of Health and Exercise Science, Appalachian State University, Boone, NC USA. 3Department […]

Adiposity, Aerobic and Anaerobic Fitness in Middle School Aged Children

April 07, 2015

Adiposity, Aerobic and Anaerobic Fitness in Middle School Aged Children,  Apr 2015 ,The FASEB Journal, David Nieman1, Dustin Dew1 and Pamela Krasen1 1North Carolina Research Campus Appalachian State University Kannapolis NC United States Abstract National data suggest that aerobic fitness and adiposity are negatively correlated in children, but this relationship was established using submaximal exercise tests and skinfold […]

Chia Seed Oil Supplementation Has No Influence on Running Performance

April 02, 2015

Chia Seed Oil Supplementation Has No Influence on Running Performance, The FASEB Journal, April 2015, David Nieman1, Nicholas Gillitt2, Mary Pat Meaney1, Dustin Dew1 and Fuxia Jin2 1NCRC Appalachian State University United States 2Dole Nutrition Research Laboratory Dole Foods United States Chia Seed Oil Supplementation Has No Influence on Running Performance Abstract Plasma ALA levels peak about 2 h after ingestion, […]

Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects

February 24, 2015

Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects, Queensland University, Feb 2015, Jonathan M. Peake1, Paul Della Gatta2, Katsuhiko Suzuki3, David C. Nieman4 Affiliations: 1 School of Biomedical Sciences and Institute of Health and Biomedical Sciences, Queensland University of Technology, Brisbane, Australia 2 Centre for Physical Activity and Nutrition, School of Exercise and […]

Influence of Pistachios on Performance and Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, and Metabolite Shifts in Cyclists: A Randomized, Crossover Trial.

November 19, 2014

Influence of Pistachios on Performance and Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, and Metabolite Shifts in Cyclists: A Randomized, Crossover Trial. PLoS One. 2014 Nov 19, Nieman DC1, Scherr J2, Luo B3, Meaney MP1, Dréau D4, Sha W5, Dew DA1, Henson DA6, Pappan KL7. Appalachian State University, Human Performance Lab, North Carolina Research Campus, Kannapolis, NC, United States of America. 2Department of Prevention and […]

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

September 10, 2014

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique JoVE Clinical and Translational Medicine, Sept 10, 2014, R. Andrew Shanely1,2, Kevin A. Zwetsloot2, N. Travis Triplett2, Mary Pat Meaney1,2, Gerard E. Farris3, David C. Nieman Human Performance Laboratory, North Carolina Research Campus, Appalacian State University, 2College of Health Sciences, Appalachian State University, 3Department of Emergency Medicine, […]

The Metabolite Profiles of the Obese Population Are Gender-Dependent

August 17, 2014

The Metabolite Profiles of the Obese Population Are Gender-Dependent J Proteome Res. 2014 Aug 17, Xie G, Ma X, Zhao A, Wang C, Zhang Y, Nieman D, Nicholson JK, Jia W, Bao Y, Jia W. Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China. Appalachian State University Human Performance Laboratory Abstract Recent studies have […]

The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection

August 02, 2014

The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection Phytother Res. 2014 Aug 2, Ahmed M1, Henson DA, Sanderson MC, Nieman DC, Gillitt ND, Lila MA. Department of Biology, Appalachian State University, Boone, NC, 28608, USA. Abstract Prolonged and intensive exercise induces transient immunosuppression and is associated with an increased risk and severity of infections. The goal of […]

New Biomarker for Oxidative Stress When Exercising Discovered

May 14, 2014

View the abstract published in the American Journal of Physiology. New research led by David Nieman, DrPH, FACSM, director of the Appalachian State University Human Performance Laboratory at the NC Research Campus, identified a new biomarker for oxidative stress generated during exercise. In the field of exercise science, measuring oxidative stress can be difficult, time […]

Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid

April 23, 2014

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 23. [Epub ahead of print] Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. Nieman DC, Shanely RA, Luo B, Meaney MP, Dew DA, Pappan KL. Appalachian State University Human Performance Laboratory, NC Research Campus. Abstract Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- […]

Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists

March 06, 2014

Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists.  Applied Physiology, Nutrition and Metabolism. March 2014. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson D, Sha W, Meaney MP. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus; Dole Nutrition Research Laboratory, NC Research Campus; UNC Charlotte Bioinformatics Services Division, […]

Vitamin D2 vs D3

February 15, 2014

 Known for decades as the sunshine vitamin, vitamin D today is clouded by controversy. Physicians and scientists are in heated debates over the actuality of a global rise in vitamin D deficiency as well as the effectiveness of and need for more vitamin D testing. Vitamin D deficiency is linked to rickets and other bone deforming […]