Chen H

Induction of Lung Cancer Cell Apoptosis through a p53 Pathway by [6]-Shogaol and Its Cysteine-Conjugated Metabolite M2

February 12, 2014

Induction of Lung Cancer Cell Apoptosis through a p53 Pathway by [6]-Shogaol and Its Cysteine-Conjugated Metabolite M2. Journal of Agricultural Food Chemistry. January 30, 2014. Epub ahead of print. Warin RF, Chen H, Soroka DN, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus Abstract Dietary chemoprevention of […]

Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice

May 15, 2013

Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice. Chemical Research in Toxicology.  Epub May 15, 2013.  Chen H, Soroka DN, Zhu Y, Hu Y, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University , North Carolina Research […]

Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation

January 30, 2013

Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation. PloS One, January 30, 2013. Zhu Y, Warin RF, Soroka DN, Chen H, Sang S.  Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. – Abstract Our previous study found that […]

A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study

January 20, 2013

A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study. Evidence-based Complementary and Alternative Medicine. January 20, 2013. Li X, Chen H, Jia W, Xie G. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian China; Center for Translational Biomedical Research, University of North Carolina at […]

Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.

January 16, 2013

Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.  Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka D, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract SCOPE: There are limited data on the metabolism of [6]-shogaol (6S), […]

Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol

January 16, 2013

Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.  Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka DN, Hu Y, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract […]

The microbiota is essential for the generation of black tea theaflavins-derived metabolites

December 08, 2012

The microbiota is essential for the generation of black tea theaflavins-derived metabolites. PLoS One. December 2012. Chen H, Hayek S, Rivera Guzman J, Gillitt ND, Ibrahim SA, Jobin C, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University and Dole Foods Nutrition Research Institute Abstract BACKGROUND: Theaflavins including theaflavin […]

6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cell.

November 08, 2012

6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cell. Jounral of Agricultural and Food Chemistry. November 2012. Lv L, Chen H, Soroka D, Chen X, Leung T, Sang S. (NC A&T Center for Excellence in Post Harvest Technologies). Department of Food Science and […]