Breast Cancer

New Strategies for Breast Cancer Prevention Tied to Diabetes Drugs, Diet

June 08, 2017

Research by breast cancer expert Xiaohe Yang, M.D., Ph.D., shows that well-known drugs for type 2 diabetes and dietary factors may be the key to breast cancer prevention.    Kannapolis, N.C.– Research published in the last year by Xiaohe Yang, M.D., Ph.D., an associate professor at North Carolina Central University’s (NCCU) Nutrition Research Program at the North […]

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells

April 27, 2017

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells, PLOS One, Ming Zhao, Erin W. Howard, Zhiying Guo, Amanda B. Parris, Xiaohe Yang.  Department of Biological and Biomedical Sciences, Julius L. Chambers Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Kannapolis, North Carolina Abstract Alcohol consumption is associated with increased breast cancer risk; however, […]

Finding Strategies to Prevent Breast Cancer

March 02, 2017

Breast cancer expert Xiaohe Yang, MD, PhD, tackles this complex disease and the many factors involved in its treatment, prevention, and progression. Xiaohe Yang, MD, PhD, knows there is not a “one-size-fits-all” cure for breast cancer. He and his research team are instead identifying the factors involved in different breast cancer subtypes, testing novel preventative […]

Breast Cancer Subtype Important in Deciding Impact of Folate

February 02, 2017

Read the original article from the UNC Nutrition Research Institute. It is generally known that folate (vitamin B9) is important in early pregnancy to prevent neural tube defects in babies, because folate is needed by rapidly dividing cells (e.g., those of a developing embryo) for DNA synthesis and cellular energy production. As a consequence, many […]

Cancer, Obesity and Diet- New Research from UNC NRI

March 30, 2016

Watch Dr. Hursting talk about his latest findings on WJZY/Fox News Charlotte. Stephen Hursting, PhD, MPH, with the UNC Lineberger Comprehensive Cancer Center, UNC Gillings School of Global Public Health and the UNC Nutrition Research Institute at the NC Research Campus in Kannapolis, leads a team of researchers who explore the link between cancer, obesity and […]

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

July 28, 2015

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer

July 22, 2015

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer, July 22, 2015, In Press Accepted Manuscript, Yujie Fu, Onat Kadioglu, Benjamin Wiench, Zuofu Wei, Wei Wang, Meng Luo, Xiaohe Yang, Chengbo Gu, Yuangang Zu, Thomas Efferth NC Central University <style>.requiresJS{display:none}.dartAd{display:block !important}</style> Abstract Anti-estrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established anti-hormones such as tamoxifen, novel […]

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib

April 22, 2015

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib, Journal of Cancer Research, April 22, 2015, Ming Zhao, Amanda Blackwelder, Harry Lee, and Xiaohe Yang Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC. Abstract 3557: Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib Abstract […]

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

April 07, 2015

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice, 2015 Apr 7, Int J Mol Sci, Ma Z1, Blackwelder AJ2, Lee H3, Zhao M4, Yang X5. 1Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA. mzhao@nccu.edu. 2Julius L. Chambers Biomedical/Biotechnology […]

Study Shows New Mechanism for the Prevention of HER2/neu Breast Cancer

March 11, 2015

According to the American Cancer Society, up to 30 percent of all breast cancer patients are HER2/neu positive. This means they have too much of the HER2/neu growth-promoting protein, which causes the development of an aggressive form of breast cancer. Although several drugs are available to treat HER2/neu producing breast cancer, such as Trastuzumab (Herceptin) […]

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells

March 11, 2015

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells, Phytomedicine, 11 March 2015,  Yujie Fua, b, 1, Onat Kadiogluc, 1, Benjamin Wienchc, Zuofu Weia, b, Chang Gaod, Meng Luoa, b, Xiaohe Yange, Chengbo Gua, b, Yuangang Zua, b, Thomas Efferth Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer […]

Go Fish! Zebrafish Advance Cancer Research

March 08, 2015

In the fight against cancer, zebrafish may seem like an unlikely weapon. For TinChung Leung, PhD, with the North Carolina Central University Nutrition Research Program at the NC Research Campus (NCRC) in Kannapolis, zebrafish have the potential to deliver the answers to some of the most fundamental questions about cancer. Namely how tumors grow and […]

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts

April 05, 2014

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts AACR Annual Meeting 2014; April 5-9, 2014, K. Sean Kimbro, Karine Ferri-Lagneau, Jamil Haider, Susan Yeyeodu, Xiaohe Yang, and TinChung Leung North Carolina Central University, Durham, NC. Abstract Growing evidence indicates that incongruities in the inflammatory and immune response pathways contribute to tumorigenesis. We seek to explore the underlying biological mechanisms […]

Cabarrus Health Alliance Receives Grant Funds to Support Breast Health

February 28, 2014

Cabarrus Health Alliance Receives Grant Funds to Support Breast Health Kannapolis, N.C. – The Cabarrus Health Alliance was presented with a $15,000 check at the Board of Health meeting on February 11 to continue breast cancer prevention and treatment efforts. Focused on a Cure is the foundation of Karen Goforth, owner of Irresistible Portraits in […]

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models

December 09, 2013

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models. Cancer Prevention Research (Philadephia, PA). December 9, 2013. [Epub ahead of print] Zhu P, Davis M, Blackwelder A, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Julius L. Chambers Biomedical Biotechnology Research Institute, Julius L. Chambers Biomedical Biotechnology Research Institute/NC Central University Nutrition Research Program, NC Research […]

Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

February 09, 2013

One of the most controversial and confusing questions surrounding breast cancer is the effect of eating soy. Some studies say soy and the isoflavone genistein that it contains prevents breast cancer. Other studies say genistein is a risk factor for developing breast cancer. Breast cancer researcher Xiaohe Yang, PhD, associate professor with the North Carolina Central […]

HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance

August 12, 2011

Huang X,Wang S,Lee CK,Yang X,Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Letters.2011 Aug 1;307(1):72-9. doi: 10.1016/j.canlet.2011.03.019. Epub 2011 Apr 16. Abstract Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with […]

Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.

April 06, 2011

Shi Y,Yang S,Troup S,Lu X,Callaghan S,Park DS,Xing Y,Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.Oncology Reports.2011 Jun;25(6):1713-9. doi: 10.3892/or.2011.1248. Epub 2011 Apr 6. Abstract Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. […]