alcoholic liver disease

UNC-G Scientists Discover Link Between Zinc Deficiency and ROS Buildup in ALD

August 26, 2016

Scientists from the UNC Greensboro Center for Translational Biomedical Research made unprecedented connections between alcohol-induced hepatic zinc deficiency and a defect in the mitochondria in their American Journal of Physiological: Gastrointestinal and Liver Physiology paper: “Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role […]

Bioactive Brief: Targeting Hepatic PPAR Gamma Signaling To Treat Alcoholic Liver Disease

May 05, 2016

A certain signaling pathway in the liver has been identified as a factor in the progression of alcoholic liver disease, report scientists from the University of North Carolina at Greensboro’s Center for Translational Biomedical Research at the NC Research Campus. Peroxisome proliferator-activated receptor gamma (PPARγ) signaling governs several processes in the body tissues such as […]

New Approach To Treat Alcoholic Liver Disease Identified

October 15, 2015

Read the story on BioSpace. A new study found evidence of a pharmacological approach that reversed some of the effects of alcoholic liver disease. Kannapolis, NC- It’s sweet. It’s bitter. It’s tangy and even tart. The tastes and types of alcohol seem endless. Despite the variety, alcohol when metabolized becomes one thing: toxic. Through processes […]

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats

October 14, 2015

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats, J Nutr. 2015 Oct 14, Zhong W1, Li Q1, Sun Q2, Zhang W1, Zhang J3, Sun X1, Yin X3, Zhang X3, Zhou Z4. 1Center for Translational Biomedical Research and. 2Center for Translational Biomedical Research and Department of Nutrition, University of […]

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease

March 12, 2015

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease, 2015 Mar 12, Am J Physiol Gastrointest Liver Physiol. Sun Q1, Zhong W2, Zhang W2, Li Q2, Sun X2, Tan X2, Sun X2, Dong D2, Zhou Z3. UNC greensboro. 2University of North Carolina at Greensboro. 3University of North Carolina at Greensboro z_zhou@uncg.edu. Abstract […]

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors.

October 14, 2013

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PlosOne. Oct 14, 2013. Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract Clinical studies have demonstrated that alcoholics have a […]

Elite ALF fellowship awarded to Zhong

June 22, 2012

The University of North Carolina at Greensboro Link to original article UNCG Research congratulates Dr. Wei Zhong on winning an elite Roger L. Jenkins, M.D., Postdoctoral Research Fellowship from the American Liver Foundation (ALF). The ALF Postdoctoral Research Fellowships support M.D.s,  Ph.D.s, and M.D./Ph.D.s in their first or second year appointments as postdoctoral research fellows […]