Alcohol

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells

April 27, 2017

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells, PLOS One, Ming Zhao, Erin W. Howard, Zhiying Guo, Amanda B. Parris, Xiaohe Yang.  Department of Biological and Biomedical Sciences, Julius L. Chambers Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Kannapolis, North Carolina Abstract Alcohol consumption is associated with increased breast cancer risk; however, […]

What We’re Learning about Mom’s Nutrition and Alcohol

January 05, 2017

Read the original article from the UNC Nutrition Research Institute. Dr. Phil May’s research group at the NRI studies the prevalence of Fetal Alcohol Spectrum Disorders (FASD) in humans. The recent addition to the NRI faculty of Dr. Susan Smith now provides an avenue toward understanding how maternal nutrition might affect the relationship between alcohol […]

Maternal Nutritional Status as a Contributing Factor for the Risk of Fetal Alcohol Spectrum Disorders

December 10, 2015

Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders, Reproductive Toxicology. December 3, 2015. Philip A. Maya, b, Kari J. Hamrickc, Karen D. Corbind, Julie M. Haskena, Anna-Susan Maraise, f, Jason Blankenshipb, H.Eugene Hoymeg, J.Phillip Gossageb a University of North Carolina at Chapel Hill, Nutrition Research Institute, Gillings School of Global Public Health, USA b The University of New Mexico Center on […]

New study: More Birth Defects Caused By Drinking During Pregnancy Than Previously Reported

October 22, 2015

Fetal Alcohol Syndrome (FAS) in the United States has long been estimated at no more than three children per 1,000. A new study published in the journal of Drug and Alcohol Dependence reports that the prevalence of fetal alcohol syndrome (FAS) is between 3 and 8 per 1,000 and when combined with partial FAS (PFAS) […]

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats

October 14, 2015

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats, J Nutr. 2015 Oct 14, Zhong W1, Li Q1, Sun Q2, Zhang W1, Zhang J3, Sun X1, Yin X3, Zhang X3, Zhou Z4. 1Center for Translational Biomedical Research and. 2Center for Translational Biomedical Research and Department of Nutrition, University of […]

New Approach to Treat Alcoholic Liver Disease Identified

September 14, 2015

A study by Zhanxiang Zhou, PhD, co-director of the UNC Greensboro Center for Translational Biomedical Research,  found evidence of a pharmacological approach that in animal models reversed some of the effects of alcoholic liver disease. It’s sweet. It’s bitter. It’s tangy and even tart. The tastes and types of alcohol seem endless. Despite the variety, alcohol […]

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

April 07, 2015

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice, 2015 Apr 7, Int J Mol Sci, Ma Z1, Blackwelder AJ2, Lee H3, Zhao M4, Yang X5. 1Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA. mzhao@nccu.edu. 2Julius L. Chambers Biomedical/Biotechnology […]

Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde

February 19, 2015

Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde, Alcohol Clin Exp Res. 2015 Feb 19, Zhang W1, Zhong W, Sun X, Sun Q, Tan X, Li Q, Sun X, Zhou Z. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina. Abstract BACKGROUND: Chronic alcohol exposure causes […]

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.

December 24, 2014

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.  J Hepatol. 2014 Dec 24, Zhong W1, Zhang W1, Li Q1, Xie G2, Sun Q3, Sun X1, Tan X1, Sun X1, Jia W2, Zhou Z4. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA 28081. 2University of Hawaii Cancer Center, Honolulu, Hawaii, USA 96813. 3Center for Translational […]

A Field Trial of Alcohol Server Training for Prevention of Fetal Alcohol Spectrum Disorders

March 18, 2011

Jack Dresser, Randall Starling, W. Gill Woodall, Paula Stanghetta, and Philip A. May (2011)A Field Trial of Alcohol Server Training for Prevention of Fetal Alcohol Spectrum Disorders Journal of Studies on Alcohol and Drugs 72(3): 490-496 Abstract OBJECTIVE: An alcohol-server training program to prevent fetal alcohol syndrome was developed, implemented, and evaluated in a comparison […]

Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease.

March 20, 2008

Song Z, Zhou Z, Deaciuc I, Chen T, McClain CJ. Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease. Hepatology 2008; 47:867-879. Abstract Although recent evidence suggests that down-regulation of production of the adipocyte hormone adiponectin has pathophysiological consequences for the development of alcoholic liver disease (ALD), the underlying mechanisms are […]