Steven H. Zeisel Search Results

Free Bonsai Exhibition Coming to Kannapolis December 2 and 3

Bonsai artists and vendors from seven states display their trees at the fifth annual Bonsai Winter Silhouette Expo held in Kannapolis in the David H. Murdock Core Laboratory building on the NC Research Campus.    For the fifth year, bonsai artists from all over the USA will show their bonsai trees in the exceptionally beautiful […]

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NCRC Science Stop is a New Addition at Jiggy with a Piggy

Kannapolis, NC- The annual Jiggy with a Piggy Festival is this weekend in downtown Kannapolis. Scientists and staff from the research centers at the NC Research Campus are joining the fun on Saturday, May 6 from 10 am to 2 pm at the NCRC Science stop. Children and their families will find the Science Stop […]

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“Put Your Best Fork Forward” at Events Sponsored by NCRC Partners

  Programs offered by experts at the NC Research Campus help people “Put their Best Fork Forward” in March during National Nutrition Month. Kannapolis, NC – “Put Your Best Fork Forward” is the theme of this year’s National Nutrition Month celebration. Sponsored annually in March by The Academy of Nutrition and Dietetics, this year’s theme is […]

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Bonsai- Artistry for the Family to Enjoy this Holiday Season

The annual Winter Silhouette Bonsai Expo returns to the NC Research Campus Saturday, December 3 and Sunday, December 4.  The free event offers families an opportunity to relax and enjoy the artistry of bonsai before the holiday season kicks into high gear. Organized by bonsai artist Steven Zeisel, MD, PhD, director of the UNC Nutrition […]

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UNC Nutrition Research Institute Welcomes Renowned Scientist Susan Smith

Susan Smith, Ph.D., joined the UNC Nutrition Research Institute this month. She is an internally recognized expert in the field of nutritional affects on the risk for birth defects.  The UNC Nutrition Research Institute (NRI) welcomes Susan Smith, Ph.D., who joins the research facility’s roster of scientists this month. Dr. Smith is an internationally recognized […]

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Bonsai show bares all for winter Dec 5 & 6

By Lisa Thornton Read the original article in the Charlotte Observer With bonsai – the art of growing dwarfed ornamental trees – old age, or at least the appearance of it, is the gold standard of beauty. Those interested in the hobby will get the chance to see how that’s achieved during the Winter Silhouette […]

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Annual Kannapolis Bonsai Expo Aims to Cultivate Beginners

 The third annual Winter Bonsai Silhouette Expo returns to the NC Research Campus in Kannapolis, NC December 5 and 6 with more opportunities for bonsai beginners to learn the art.   Kannapolis, NC- Holiday trees are thought of as tall, green and laden with decorations. On Saturday, December 5 from 10 am to 4 pm and […]

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Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial, Am J Clin Nutr. 2015 Oct 7, Wozniak JR1, Fuglestad AJ2, Eckerle JK3, Fink BA2, Hoecker HL4, Boys CJ3, Radke JP5, Kroupina MG3, Miller NC3, Brearley AM6, Zeisel SH7, Georgieff MK3. 1Department of Psychiatry, jwozniak@umn.edu. 2Department of Psychiatry. 3Department of Pediatrics, and. 4School […]

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Study: Fruits, vegetables help improve internal protection system

By Josh Bergeron Read the original article in the Salilsbury Post. KANNAPOLIS — Try eating the skin of an avocado. It’s good for you, according to a North Carolina Research Campus study. A recently published, joint study by the University of North Carolina and Dole Foods at the North Carolina Research Campus used various fruit and vegetable […]

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The NCRC Is Changing the Landscape of Health Care

As written for Cabarrus Magazine. Learn more about how the NCRC is changing the landscape of health care in our latest edition of Bioactive Magazine and by watching our latest video on Individualizing Health Care. From the community to the clinic, the NC Research Campus (NCRC) is changing the landscape of healthcare from reactive and treatment-centered to […]

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Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. FASEB J. 2015 Aug 27, Zwart SR1, Gregory JF1, Zeisel SH1, Gibson CR1, Mader TH2, Kinchen JM1, Ueland PM1, Ploutz-Snyder R1, Heer MA1, Smith SM2. Author Affiliations 1*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food […]

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UNC wants to buy downtown Kannapolis apartments for $500K

By Michael Knox | mknox@independenttribune.com KANNAPOLIS, N.C. — The UNC Nutrition Institute has approached the City of Kannapolis about purchasing apartments that sit over the downtown Kannapolis stores to have a place for students to stay when they are in town working at the North Carolina Research Campus. The Kannapolis City Council will discuss the […]

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Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells, J Nutr. 2015 Jul 29, Orena S1, Owen J1, Jin F2, Fabian M2, Gillitt ND2, Zeisel SH3. 1University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NC; 2Dole Nutrition Research Laboratory, Kannapolis, NC; and. 3University of North Carolina at Chapel Hill Nutrition […]

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Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency, Mol Genet Metab. 2015 Jun 18, Strauss KA1, Ferreira C2, Bottiglieri T3, Zhao X4, Arning E3, Zhang S4, Zeisel SH4, Escolar ML5, Presnick N6, Puffenberger EG7, Vugrek O8, Kovacevic L8,Wagner C9, Mazariegos GV10, Mudd SH11, Soltys K10. Author information 1Clinic for Special Children, Strasburg, PA, USA; Franklin […]

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A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine, Electrophoresis. 2015 Jun 17, Zhao X1, Zeisel S1,2, Zhang S3. Author information 1Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, 28081, USA. 2Department of Nutrition, School of Public Health and School of Medicine, […]

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Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. 2015 Apr 28, FASEB J., Silver MJ1, Corbin KD1, Hellenthal G1, da Costa KA1, Dominguez-Salas P1, Moore SE1, Owen J1, Prentice AM1, Hennig BJ1, Zeisel SH2. 1*Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United […]

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Effects of Mthfd1 Gene on Mouse Behavior

Effects of Mthfd1 Gene on Mouse Behavior, Apr 2015,The FASEB Journal,  Eneda Pjetri1 and Steven Zeisel1 1Nutrition Research Institute UNC Chapel Hill Kannapolis NC United States Abstract Methylenetetrahydrofolate dehydrogenase 1 (Mthfd1) gene encodes the trifunctional C1 tetrahydrofolate (C1THF) enzyme that plays an important role in the folate-mediated one-carbon metabolism. A polymorphism of this gene (1958G>A; rs2236225) has […]

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Local Research Institute Boosts Economy through Critical Nutrition Discoveries

Read the original article on the UNC Nutrition Research Institute website. Eleven faculty research scientists at the UNC Nutrition Research Institute (NRI) in Kannapolis currently have externally funded grants to support their work exploring individualized nutrition. These awards are significant not only for providing the means by which the NRI can advance its scientific discoveries […]

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Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice, Gastroenterology. 2015 Feb 18, Tsuchiya H1, Costa KA2, Lee S3, Renga B4, Jaeschke H5, Yang Z6, Orena SJ2, Goedken MJ7, Zhang Y5, Bo K8, Lebofsky M5, Rudraiah S3, Smalling R1, Guo G8, Fiorucci S4, Zeisel SH2, Wang L9. Department of Medicine, University of Utah […]

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Bonsai Winter Silhouette Exhibition Returns to NCRC December 6 and 7

Steven Zeisel, MD, PhD, director of the UNC Chapel Hill Nutrition Research Institute, hosts the second Bonsai Winter Silhouette Exhibition December 6 and 7. The event is open and free to the public and will be held in the atrium of the David H. Murdock Core Laboratory Building, 150 Research Campus Drive on the NC […]

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Kannapolis’ North Carolina Research Campus foresees growth

Monday, Nov. 24, 2014 By: Lisa Thornton, Charlotte Observer Read Original Article By the time they celebrate the North Carolina Research Campus’ seventh anniversary next year, leaders say, 10 buildings will have been erected on campus, and another two nearby. The North Carolina Research Campus in Kannapolis celebrated its sixth anniversary earlier this month with […]

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Research Campus leaders take stock of ‘great experiment’

By: Michael Knox, Independent Tribune Read Original Article KANNAPOLIS, N.C. — To mark the North Carolina Research Campus’ sixth anniversary, academic and scientific leaders touted advances made at the Kannapolis complex and offered a glimpse of some of the world-class research projects currently underway there. Clyde Higgs, vice president of business development for campus developer […]

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Kannapolis Rotary presents donation to UNC research institute

By Susan Shinn Read Original Article KANNAPOLIS — The Kannapolis Rotary Club on Tuesday presented the UNC Nutrition Research Institute with a $63,500 donation, culminating four years of fundraising efforts by local Rotarians. The money will be used to create student housing at the North Carolina Research Campus in downtown Kannapolis. Dr. Steven H. Zeisel, […]

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Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism, FASEB J. 2014 Nov 10, Martínez-Vega R1, Garrido F2, Partearroyo T3, Cediel R4, Zeisel SH5, Martínez-Álvarez C6, Varela-Moreiras G3, Varela-Nieto I7, Pajares MA8. 1Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Unidad 761, Centro de Investigación Biomédica en […]

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NC Research Campus seeks faster growth after slow start

By Ely Portillo, Charlotte Observer Read the original article KANNAPOLIS A billionaire pineapple company owner’s vision for the future of nutrition science rises next to Main Street in this former mill town, massive red brick buildings with soaring columns that contrast with surrounding one-story houses, shops and churches. Dole Foods owner David Murdock, whose diet […]

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5 Ways to Make Cancer Research Work for You

Read the article as posted on UNC Nutrition Research Institute’s website. By Harriet Sugar Miller, for Zester Daily July 24, 2014 Garlic, broccoli, green tea and turmeric: Health experts keep telling us to consume these foods to fight cancer. But articles from a New York Times science journalist are challenging the view that diet can prevent cancer. The evidence […]

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Bipartisan Policy Center Selects NRI-developed Online Curriculum

Read the original article on the UNC Nutrition Research Institute website. Nutrition in Medicine (NIM), an online curriculum for medical students developed by NRI faculty member Martin Kohlmeier, M.D., Ph.D., and NRI Director Steven Zeisel, M.D., Ph.D., has been recommended by the nonprofit Bipartisan Policy Center (BPC), the Alliance for a Healthier Generation, and the […]

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NCRC & CHS on Charlotte Talks July 15

Don’t miss the July 15 WFAE Charlotte Talks show on personalized medicine featuring panelists from the NC Research Campus and Carolinas Healthcare System: Steven Zeisel, MD, PhD – Professor and Director of the UNC Nutrition Research Institute, NC Research Campus Kristin Newby, MD, MHS – Professor of Medicine Duke University; Principal Investigator, MURDOCK Study, NC Research Campus […]

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Kannapolis research institute: Could nutrition affect male infertility?

By Karen Garloch, Charlotte Observer Link to original article Summer Goodson, researcher at UNC Nutrition Research Institute in Kannapolis Researcher Summer Goodson is used to getting snickers when she tells people she’s studying male infertility. “It’s expected,” said Goodson, a post-doctoral research associate at the UNC Nutrition Research Institute in Kannapolis. “It’s a sensitive subject. […]

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Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Jun 26, 2014 The American Journal of Clinical Nutrition. August 2014. Carolyn A Miller, Karen D Corbin, Kerry-Ann da Costa, Shucha Zhang, Xueqing Zhao, Joseph A Galanko, Tondra Blevins, Brian J Bennett, Annalouise O’Connor, and Steven H Zeisel. The Nutrition Research Institute, University of North Carolina at Chapel Hill, […]

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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications. April 29,2014; Dominguez-Salas P1, Moore SE1, Baker MS2, Bergen AW3, Cox SE1, Dyer RA4, Fulford AJ1, Guan Y5, Laritsky E2, Silver MJ1, Swan GE6, Zeisel SH7, Innis SM4, Waterland RA5, Prentice AM1, Hennig BJ1. 1MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street, London WC1E 7HT, UK.; […]

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Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease.

Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease. The FASEB Journal, April 2014; Brian Bennett1,3; Karen Corbin2,; Tangi Smallwood3,; Annalouise o’Connor2; Steven Zeisel1,4. 1UNC Nutrition Research Institute Kannapolis NC United States; 2UNC Nutrition Research Institute Kannapolis NC United States; 3Department of Genetics University of North Carolina Chapel Hill NC United States; 4 Department of […]

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Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. March 26, 2014. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Department of Nutrition, School of Public Health, School of Medicine, […]

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Exhibition brings lovers of bonsai art to Kannapolis

By Lisa Thornton Slideshow – LISA THORNTON “Most people think bonsai is a certain type of tree. It’s not, though,” said Dr. Steven Zeisel, who sponsored the exhibition. “Any tree can be a bonsai.” To learn more The Bonsai Society of the Carolinas meets monthly at the UNC Charlotte Botanical Gardens. Its website is www.bonsaicarolina.org. […]

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Winter bonsai exhibition opening in Kannapolis on Saturday

Salisbury Post Submitted photo The artistry and beauty of bonsai will come to Kannapolis for the first Winter Silhouette Bonsai Exhibition. The exhibition will be held from 1 to 5 p.m. Saturday and Sunday in the event room and atrium of the first floor of the David H. Murdock Core Laboratory building, 150 N Research […]

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NRI Announces 2013 Art Contest Winners

UNC Chapel Hill Grand Prize Winners: Randall and Rhaisa Weber of the A-Beka Home School (left) and Moira Hunter, of Jackson Park Elementary (right). Steven H. Zeisel, M.D., Ph.D., director of the University of North Carolina at Chapel Hill Nutrition Research Institute (UNC NRI), has announced the winners of the 2013 Student Art Contest. As […]

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Bonsai exhibition at N.C. Research Campus Dec. 7-8

Salisbury Post KANNAPOLIS — On Saturday, Dec. 7 and Sunday, Dec. 8, the artistry and beauty of bonsai will come to Kannapolis for the first Winter Silhouette Bonsai Exhibition. The exhibition will be held from 1 to 5 p.m. both days in the event room and atrium of the first floor of the David H. […]

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Internships at Nutrition Research Institute transform Catawba students

Salisbury Post Thomas Benton, a chemistry major at Catawba College, has learned a lot during his internship with the Nutrition Research Institute at the N.C. Research Campus. On the surface, Aliyah Khan and Thomas Benton’s internships at the University of North Carolina at Chapel Hill’s Nutrition Research Institute may appear to be all about the […]

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Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives

Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives. Computational and Structural Biotechnol Journal. 2013 Jun 28;4:e201301013. eCollection 2013. Du X, Zeisel SH. Department of Bioinformatics, University of North Carolina at Charlotte, Charlotte, NC; Nutrition Research Institute, University of North Carolina at Chapel Hill, NC Research Campus, Kannapolis, NC. Abstract Mass spectrometry coupled to […]

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UNC Research Institute gets creative with arts contest

Michael Knox Previous winners of the UNC Chapel Hill Nutrition Research Institute’s art contest are displayed at the group’s facility at the North Carolina Research Campus in Kannapolis. Independent Tribune Posted: Sunday, June 23, 2013 8:37 am By Michael Knox mknox@independenttribune.com KANNAPOLIS, N.C. — Celebrating five years of the North Carolina Research Campus in Kannapolis, […]

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Nutrition Research Institute: Helping the world get healthier, one person at the time

The Nutrition Research Institute is located on the developing North Carolina Research Campus in Kannapolis. Scientific studies under way at the University of North Carolina at Chapel Hill’s Nutrition Research Institute (NRI), located on the North Carolina Research Campus (NCRC) in Kannapolis, show promise of a healthier future for children and adults based on new […]

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Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB: Official Publication of the Federation of American Societies for Experimental Biology.  Epub May 14, 2013. Xie G, Zhong W, Li H, Li Q, Qiu Y, Zheng X, Chen H, Zhao X, Zhang S, Zhou Z, Zeisel SH, Jia W. Center for […]

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NRI Director recognized for excellence in teaching, research and service

UNC NRI Newsletter Dr. Steven Zeisel, M.D. Ph.D., Director of the UNC Nutrition Research Institute The University of North Carolina Nutrition Research Institute (UNC NRI) announces today that Stephen H. Zeisel, M.D., Ph.D., Kenan Distinguished University Professor in Nutrition and Pediatrics and UNC NRI Director, has been selected as the 2012 recipient of the Bernard […]

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2013 NRI Faculty Awards

See link Below: NRI Faculty Awards  

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Nutrition in pregnancy: the argument for including a source of choline

Nutrition in pregnancy: the argument for including a source of choline April 2013. International Journal of Women’s Health. April 2013. Zeisel, SH. Nutrition Research Institute at Kannapolis, Department of Nutrition, University of North Carolina at Chapel Hill. Abstract Women, during pregnancy and lactation, should eat foods that contain adequate amounts of choline. A mother delivers […]

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Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms. Current Opinion in Clinical Nutrition and Metabolomic Care. March 13, 2013. Mehedint, MG, Zeisel SH. Nutrition Research Institute at the NC Research Campus, Kannapolis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Abstract PURPOSE OF REVIEW: Humans eating diets low in […]

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Rowan-Cabarrus Biotech Graduates Advancing Scientific Discovery

              (NC Research Campus, Kannapolis, NC- February 18, 2013)- Behind every great scientist is a great research assistant. At the North Carolina Research Campus (NCRC) in Kannapolis those great research assistants and research technicians are most often graduates of Rowan-Cabarrus Community College’s two-year applied science associate degree program in biotechnology. Graduates are working […]

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Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB Journal. February 1, 2013. Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. University of North Carolina at Chapel Hill Nutrition Research Institute, Abstract […]

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Extra prenatal choline doesn’t help kids’ brains

Kerry Grens, The Chicago Tribune  NEW YORK (Reuters Health) – Taking extra choline during pregnancy does not improve babies’ language and memory skills, according to a new study. “I think eating the recommended amount of choline, which is just about a half of a gram a day for pregnant women, would probably do you well,” […]

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Treatment for brain injury disappoints in study

CHICAGO (AP) — The hunt for brain injury treatments has suffered a big disappointment in a major study that found zero benefits from a supplement that the U.S. military had hoped would help wounded troops. The supplement is marketed as a memory booster online and in over-the-counter powders and drinks. It is also widely used […]

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A Brief History of Choline

A Brief History of Choline. Annals of Nutrition and Metabolism. Epub November 2012. Zeisel SH. UNC Nutrition Research Institute. Abstract In 1850, Theodore Gobley, working in Paris, described a substance, ‘lecithine’, which he named after the Greek ‘lekithos’ for egg yolk. Adolph Strecker noted in 1862 that when lecithin from bile was heated, it generated […]

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A Visit to an “Emerald City” of Science

Across the country, academic scientists are struggling with tight budgets for equipment and staff. In the North Carolina Piedmont town of Kannapolis, however, researchers affiliated with half a dozen universities and several corporations work in bright, modern laboratory buildings whose decor, equipment, and scientific resources verge on the lavish. Once the home of Cannon Towels, […]

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Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.

Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.  Annals of Nutrition Metabolism, May 2012. Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract One of the underlying mechanisms for metabolic individuality is genetic variation. Single nucleotide polymorphisms (SNPs) in genes of metabolic pathways can create […]

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NRI Director Wins Gates Grand Challenges Grant

The UNC Chapel Hill Nutrition Research Institute Director Steven H. Zeisel, MD, PhD, who is also a Kenan Distinguished University Professor in Nutrition and Pediatrics, was recently awarded a Grand Challenges Explorations Grant from the Bill & Melinda Gates Foundation for research on “Choline and Optimal Development” that will benefit mothers and their babies in […]

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Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function.

Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function. PLoS One, April 2012. Corbin KD, Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract Approximately 15% of couples are affected by infertility and up to half of these cases arise from male factor infertility. Unidentified genetic […]

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Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.Current Opinion Gastroenterology, March 2012. Corbin KD, Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract PURPOSE OF REVIEW: Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans […]

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Fight cancer with your fork

Salisbury Post By Katie Scarvey kscarvey@salisburypost.com It might be tempting to think of cancer as something we have little control over, but in fact, what we eat — and how much we eat — can be important factors in whether we get cancer or not. The American Institute of Cancer Research estimates that one out […]

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Nutrition Institute gets $1 million endowment

Salisbury Post UNC Nutrition Research Institute KANNAPOLIS — Alan T. Dickson, a member of the Board of Advisers of the UNC Nutrition Research Institute at the N.C. Research Campus, has made a pledge that will create a $1 million endowment fund at the Research Institute. Dickson made a joint gift of $666,000 from the Dickson […]

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GenoVive Announces Formation of Scientific Advisory Board

PrWeb Key Appointments Include Doctors and Experts in the Health and Weight Management Fields from Yale University and the University of North Carolina Who Will Provide Critical Scientific Input and Strategic Insight GenoVive, a pioneer in DNA-based, all-natural weight management solutions, today announced the formation of a scientific advisory board (SAB) comprised of prominent, multi-disciplinary experts […]

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What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders

Zeisel, S.H.(2011)What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. Molecular Neurobiology. doi 10.1007/s12035-011-8165-5. Abstract The consequences of fetal exposure to alcohol are very diverse and the likely molecular mechanisms involved must be able to explain how so many developmental processes could go awry. If pregnant rat dams are […]

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A Grand Challenge for Nutrigenomics

Zeisel, S.H.(2010)A Grand Challenge for Nutrigenomics. Frontiers in Nutrigenomics.1(2): 1-3.

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Nutritional Genomics Defining the dietary requirement and effects of choline

Zeisel, S.H.(2010)Nutritional Genomics Defining the dietary requirement and effects of choline. The Journal of Nutrition. 531-534. Abstract As it becomes evident that single nucleotide polymorphisms (SNPs) in humans can create metabolic inefficiencies, it is reasonable to ask if such SNPs influence dietary requirements. Epidemiologic studies that examine SNPs relative to risks for diseases are common, […]

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Choline: An essential nutrient for public health

Zeisel, S.H.(2010)Choline: An essential nutrient for public health. SCAN’S PULSE29(3): 4–7. Abstract Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998. There is significant variation in the dietary requirement for choline that can be explained by common genetic polymorphisms. Because of its wide-ranging roles in human metabolism, from […]

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Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.

Spencer, M.D., Hamp, T.J., Reid, R.W., Fischer, L.M., Zeisel, S.H., Fodor, A.A. (2010)Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology. doi:10.1053/j.gastro.2010.11.049. Abstract BACKGROUND & AIMS: Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood. […]

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Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

Resseguie, M.,da Costa, K-A, Galanko, J., Davis, I.J., Zeisel, S.H. (2010)Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. Journal of Biological Chemistry.286(2): 1649-58. PMCID: PMC3020773. Abstract When dietary choline is restricted, most men and postmenopausal women develop multiorgan dysfunction marked by hepatic steatosis (choline deficiency syndrome (CDS)). However, a significant subset of […]

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Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.

Mehedint, M.G., Craciunescu, C.N., Zeisel, S.H. (2010)Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proceedings of the National Academy of Sciences USA. 107(29): 12834-39. PMCID: PMC2919920. Abstract We examined whether maternal dietary choline modulates angiogenesis in fetal brain. Pregnant C57BL/6 mice were fed either a choline-deficient (CD), control (CT), or choline-supplemented diet (CS) from […]

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Choline intake and genetic polymorphisms influence cholinemetabolite concentrations in human breast milk and plasma.

Fischer, L.M., daCosta, K-A, Galanko, J., Sha, W., Stephenson, B., Vick, J., Zeisel, S.H. (2010)Choline intake and genetic polymorphisms influence cholinemetabolite concentrations in human breast milk and plasma. American Journal of Clinical Nutrition.92(2): 336-346. PMCID: PMC2904035. Abstract BACKGROUND: Choline is essential for infant nutrition, and breast milk is a rich source of this nutrient. Common […]

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Dietary choline requirements of women: effects of estrogen and genetic variation

Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010)Dietary choline requirements of women: effects of estrogen and genetic variation. American Journal of Clinical Nutrition.92(5):1113-19. PMCID: PMC2954445. Abstract BACKGROUND: Choline is obtained from the diet and from the biosynthesis of phosphatidylcholine. Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by […]

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Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain

Craciunescu, C.N., Johnson, A.R., Zeisel, S.H. (2010)Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain.The Journal of Nutrition. 140:1162-6. PMCID: PMC2869500. Abstract In mice, maternal dietary folate, a cofactor in 1-carbon metabolism, modulates neurogenesis and apoptosis in the fetal brain. Similarly, maternal dietary choline, […]

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Adiponectin lowers glucose production by increasing SOGA

Bryan, R.P., Asmar, M.M., Alderman, J.M., Alderman, E.A., Garland, A.L., Busby, W.H., Bodnar, W.M., Rusyn, I., Medoff, B., Tisch, R., Swenberg, J.A., Zeisel, S.H., Combs, T.P. (2010)Adiponectin lowers glucose production by increasing SOGA. American Journal of Pathology. 177(40): 1936-1945. PMCID: PMC2947288. Abstract Adiponectin is a hormone that lowers glucose production by increasing liver insulin sensitivity. […]

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Nutrition in Medicine: Nutrition education for medical students and residents

Adams, K.M., Kohlmeier, M., Powell, M., Zeisel, S.H. (2010)Nutrition in Medicine: Nutrition education for medical students and residents. Nutrition in Clinical Practice.25(5):471-80. Abstract Proper nutrition plays a key role in disease prevention and treatment. Many patients understand this link and look to physicians for guidance diet and physical activity. Actual physician practice, however, is often […]

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Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans

Craciunescu, C. N., Niculescu, M. D., Guo, Z., Johnson, A. R., Fischer, L., and Zeisel, S. H. (2009)Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans.Toxicol Sci107, 220-226 Abstract Diethanolamine (DEA) is a common ingredient of personal care products. Dermal administration of DEA diminishes hepatic stores […]

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