Shengmin Sang Search Results

Six More Dietary Ingredients Picked for Analytical Evaluation

By Richard A. Lovett, JD, PhD, Contributing Writer Read the original article in Nutraceuticals World An advisory panel has selected aloe vera, vitamin B12, protein, ginger, vitamins K1 and K2 and free amino acids as priority ingredients for review. In a continuing endeavor to help the dietary supplements industry agree on and evaluate analytical methods […]

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Ginger, Other Plant Compounds Found to Delay Diabetic Complications

Read the story in Nutraceuticals World. Ginger compounds and some flavonoids are effective at stopping physiological processes that lead to diabetic complications. Scientific evidence is building that plant compounds may be a safe and effective alternative to approved pharmaceutical treatments for type 2 diabetes because they provide a natural means to prevent diabetic complications without side […]

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Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal

Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal, Chem Res Toxicol. 2015 Aug 13, Zhu Y1, Zhao Y1, Wang P1, Ahmedna M, Sang S1. 1†Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina 28081, United States. Abstract Considerable evidence suggests […]

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Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity

Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity, J Med Chem. 2015 J Zhu Y, Fu J, Shurlknight K, Soroka D, Hu Y, Chen XL, Sang S. Abstract Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized […]

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Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer

Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer, Apr 2015, The FASEB Journal, Jennifer McBride1, Yingdong Zhu1, Pei Wang1 and Shengmin Sang1 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Colorectal cancer (CRC) is a leading cause of cancer related deaths in the United States. Epidemiological […]

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Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice

Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice, Apr 2015, The FASEB Journal, Yantao Zhao1, Rashin Sedighi1, Pei Wang1, Huadong Chen1, Yingdong Zhu1 and Shengmin Sang1 –1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Rosemary has been used as a natural […]

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Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells

Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells, Apr 2015, The FASEB Journal, Shengmin Sang1, Junsheng Fu1, Yingdong Zhu1, Aaron Yerke1, Mitchell Wise2, Jodee Johnson3 and YiFang Chu3 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States 2Cereal Crops Research Unit USDA Madison WI United States 3Quaker Oats Center of Excellence […]

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Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review

Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review, Current Opinion in Food Science, 10 February 2015,  Rashin Sedighi, Yantao Zhao, Aaron Yerke, Shengmin Sang Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina […]

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Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation

Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation, J Agric Food Chem. 2015 Feb 6, Zhu Y, Soroka D, Sang S. NC A&T University Abstract Consumption of whole grains has been reported to be associated with a lower risk of several lifestyle-related diseases such as colorectal […]

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NCA&T Research Technician Honored for Work on Wheat and Cancer Prevention

NCA&T Research Technician Nicholas Stone is a finalist in the Undergraduate Student Research Symposium sponsored by the Agricultural and Food Chemistry Division (AGFD) of the American Chemical Society (ACS). The AGFD symposium is open to all undergraduates conducting research in agricultural food chemistry. Stone, a senior biology major at Davidson College, is one of six […]

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Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites

Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites,2015 American Society for Nutrition Dec 2014, Pei Wang4, Huadong Chen4, Yingdong Zhu, Jennifer McBride, Junsheng Fu, and Shengmin Sang* Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human […]

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Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid.

Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid. Chem Res Toxicol. 2014 Dec 1, Zhu Y, Zhao Y, Wang P, Ahmedna M, Ho CT, Sang S. NC A&T University Abstract Growing evidence has shown that ascorbic acid (ASA) can contribute to protein glycation and the formation of advanced glycation end products (AGEs), especially in the lens. The mechanism by which ascorbic acid can cause […]

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Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal

Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal. J Agric Food Chem. 2014 Nov 20, Li X, Zheng T, Sang S, Lv L. NC A&T University Abstract Methylglyoxal (MGO) and glyoxal (GO) are not only endogenous metabolites, but also exist in exogenous resources, such as food, beverages, urban atmosphere, and cigarette smoke. They […]

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Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion

Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion. Journal of Agricultural and Food Chemistry. October 7, 2014. Lin Lei †, Yuwei Liu †, Xiaobo Wang †, Rui Jiao ‡,Ka Ying Ma †, Yuk Man Li †, Lijun Wang †, Sun Wa Man †, Shengmin Sang §, Yu Huang #, and Zhen-Yu Chen *† Author Affiliations † Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, […]

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Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo.

Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo. Chem Res Toxicol. 2014 Aug 22, Chen H, Fu J, Chen H, Hu Y, Soroka DN, Prigge J, Schmidt EE, Yan F, Major MB, Chen XL, Sang S. Abstract In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in […]

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Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells

Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells. Journal of Agricultural Food Chemistry. May 21, 2014; Epub 2014 May 12. Fu J1, Chen H, Soroka DN, Warin RF, Sang S. 1Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus , 500 Laureate […]

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Scientists: Heart benefits of oats goes beyond fiber

UPI Health News, March. 17, 2014 at 4:31 PM   Bioactive compounds in oats — AVEs — might protect heart. UPI /Monika Graff UPI /Monika Graff | License Photo DALLAS, March 17 (UPI) — Eating whole grains is associated with a reduced risk of heart disease and U.S. researchers suggest a compound in oats may […]

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NCCU and NCA&T Cancer Research on UNC-TV

UNC TV Researchers can’t test experimental cures for diseases and possible drug therapies on humans so they use the zebrafish for initial testing. That’s because the journey from egg to embryo is the same in zebrafish and humans. The image on the computer screen in the North Carolina Central University lab at the North Carolina […]

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Ginger Shogaols: Promising Prevention for Lung and Colon Cancer

Shengmin Sang, PhD, associate professor and leadscientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies, published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most recent findings concentrate on shogaol metabolites and lung and colon cancer prevention. Shogaols are the dehydrated […]

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NC Research Campus scientists seek to make foods healthier

By: Jenna Barnes, News 14 Carolina KANNAPOLIS—Doctors say whole grains are part of a healthy diet, but scientists at the North Carolina Research Campus are working on a way to make them even better. “It can prevent a lot of chronic diseases, like diabetes, obesity, and some heart diseases,” said Dr. Guibing Chen of NC […]

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Ginger Shogaols: Promising Preventation for Lung and Colon Cancer

North Carolina Research Campus Shengmin Sang, PhD, associate professor and lead scientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies (CEPHT) at the North Carolina Research Campus in Kannapolis, has published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most […]

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Grains for Better Health and Disease Prevention

  Shengmin Sang, PhD, with the NC A&T Center for Excellence in Post-Harvest Technologies, is researching metabolites and dietary markers of grains like wheat and rye that can help increase their use as a preventative for diabetes and lung and colon cancer. Sang and  NC A&T’s Guibing Chen, PhD, are experimenting with a process called microfluidization […]

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Collaborations Driving Ginger Research for Cancer, Anemia

Ginger is appreciated for its aromatic and tangy taste and is enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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Collaborations Driving Ginger Research For Cancer, Anemia Treatments

Ginger is more commonly appreciated for its aromatic and tangy taste enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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Collaborations Driving Ginger Research For Cancer, Anemia Treatments

Ginger is more commonly appreciated for its aromatic and tangy taste enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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3 diverse new research projects at N.C. A&T explore blood-brain barrier, risk management, wheat bran

Three new research projects at N.C. A&T aim to explore the weakening of the blood-brain barrier in  Alzheimer’s disease patients, to apply risk management to supply chain logistics, and to find a way to make dietary fiber taste better. The projects are the first ones funded at A&T for each of the three principal investigators. […]

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Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.

Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. Journal of Chromatography, September 2012. Chen H, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract Ginger is frequently consumed as a spice and has numerous medicinal properties. Extensive research […]

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Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols

Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols. Journal of Agricultural and Food Chemistry. September 2012. Zhu Y, Soroka DN, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract We have identified alkylresorcinols (ARs) as the major active components […]

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Ginger: A Potential Treatment for Anemia

Ginger is a spice recognized for its tangy flavor and its many health benefits. TinChung Leung, PhD, of NC Central University and Shengmin Sang, PhD, of NC A&T State University, both scientists at the NC Research Campus, have collaborated on a series of studies using a zebrafish model that found ginger may be a treatment […]

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An Old-Time Remedy With Modern Proof

by Ruth Kinzey, Refresh             Heading down the produce aisle, it’s common to see fresh ginger root. And while it is a spice frequently used in Indian, Korean, Japanese and Chinese cooking, recently released findings indicate modern science is continuing to learn about the medicinal benefits it offers. At the […]

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Ginger Could Treat Anemia

Tangy and aromatic, ginger is a spice used to flavor meats, vegetables and even baked goods. More than a culinary delight, ginger has been valued for thousands of years for its numerous health benefits. Ginger, which is the rhizome or underground stem of the plant Zingiber officinale, is recognized as a natural solution for digestive […]

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Metabolism of [6]-shogaol in mice and in cancer cells.

Metabolism of [6]-shogaol in mice and in cancer cells. Drug Metablism and Disposition: The Biological Fate of Chemicals, April 2012. Chen H, Lv L, Soroka D, Warin RF, Parks TA, Hu Y, Zhu Y, Chen X, Sang S. North Carolina Agricultural and Technical State University Center for Excellence in Post-Harvest Technologies. Abstract Ginger has received […]

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Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. Journal of Agricultural and Food Chemistry. April 2012. Chiou YS, Ma NJ, Sang S (NC A&T Center for Excellence in Post Harvest Technology), Ho CT, Wang YJ, Pan MH. Department of Seafood Science, National Kaohsiung Marine University, Nanzih District, Kaohsiung, Taiwan. […]

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Researchers from NCCU, N.C. A&T Develop Anemia Treatment

NCCU News Scientists at North Carolina Central University and North Carolina A&T State University have discovered a promising use of ginger that may lead to the development of a treatment for anemia. Dr. TinChung Leung of NCCU and Dr. Shengemin Sang of N.C. A&T will present their findings April 3 at the annual meeting of […]

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The N.C. A&T grant of the month for January: Dietary flavonoids vs. pathogenic link to diabetes

Aggie Research   N.C. A&T received 11 grants totaling $1.80 million in January. One highlight of January’s s funding was a grant worth $489,884 from the USDA Agricultural and Food Initiative to Dr. Shengmin Sang of the Center for Excellence in Post Harvest Technologies, located ta the N.C. Research Campus in Kannapolis. The project:  Dietary flavonoids […]

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New grant for dietary research approaches half a million

By ag e-dispatch Dr. Shengmin Sang, lead scientist for functional foods at the Center for Excellence in Post-Harvest Technologies, has received a $490,000 grant from the USDA to research the connection between diabetes and flavonoids, which are a group of compounds found in fruits, vegetables, herbs and teas. Sang’s project was deemed “outstanding” by the USDA’s […]

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NCRC Scientists Open A Window To Chinese Culture

Scientists at the North Carolina Research Campus in Kannapolis formed the Cabarrus Chinese American Association and are hosting a Chinese New Year celebration on January 14, 2012 to raise money for their Chinese Language and Art School. In American culture, January is usually a quiet month to recover from the revelry of Thanksgiving, Christmas and […]

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5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth

5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth Yingdong Zhu, Dawn R. Conklin, Huadong Chen, Liyan Wang, Shengmin Sang Abstract We and others have found that wheat bran oil is the active constituent in wheat bran for colon cancer prevention. However, the active components in wheat bran oil are still unknown. Using […]

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Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects

Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects Lv L1, Chen H, Ho CT, Sang S. Abstract Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were […]

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Genistein inhibits advanced glycation end product formation by trapping methylglyoxal.

Genistein inhibits advanced glycation end product formation by trapping methylglyoxal. Lv L1, Shao X, Chen H, Ho CT, Sang S. Abstract Methylglyoxal (MGO) is a highly reactive endogenous metabolite derived from several nonenzymatic and enzymatic reactions, and identified as a well-known precursor of advanced glycation end products (AGEs). In the present study, genistein, a naturally occurring isoflavone derived from […]

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The chemistry and biotransformation of tea constituents

Sang S, Lambert JD, Ho CT, Yang CS. The chemistry and biotransformation of tea constituents. Pharmacological Research2011 Aug;64(2):87-99. Epub 2011 Mar 1. Abstract Tea (Camellia sinensis, Theaceae) is one of the most widely consumed beverages in the world. The three major types of tea, green tea, oolong tea, and black tea, differ in terms of […]

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Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection

ShaoX,LvL,ParksT,WuH,HoCT,SangS.Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. Journal of Agricultural and Food Chemistry. 2010 Dec 22;58(24):12608-14. Epub 2010 Nov 23. Abstract For the first time, a sensitive reversed-phase HPLC electrochemical array method has been developed for the quantitative analysis of 8 major ginger components ([6]-, [8]-, and […]

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Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandemmassspectrometry.

Shao X,Chen X,Badmaev V,Ho CT,Sang S. Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandemmassspectrometry. Rapid Communications in Mass Spectrometry.2010 Jun 30;24(12):1770-8. Abstract Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the […]

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