Appalachian State

NCRC team discovers new biomarker for oxidative stress

May 14, 2014

Posted: Wednesday, May 14, 2014 5:23 pm

Read the original article as posted by the Independent Tribune staff

KANNAPOLIS, N.C. — Scientists at the North Carolina Research Campus (NCRC) have discovered a new way to detect oxidative stress generated during exercise.

A team led by Dr. David Nieman, director of the Appalachian State University Human Performance Laboratory at NCRC, identified 13-HODE + 9-HODE as an oxidative stress biomarker for studies involving intense exercise, according to information provided by campus officials.

Oxidative stress is important to measure because it is linked to aging and is thought to be an underlying cause of some cancers, Parkinson’s Disease, Alzheimer’s disease, heart disease and other illnesses, NCRC officials say.

In the field of exercise science, measuring oxidative stress can be difficult, time consuming and expensive because previously used standards like the compound F2-isoprostanes are found in small amounts in the body.

The NCRC discovery provides, for the first time, an abundant and stable biomarker to measure.

“We are the first group to show that 13-HODE + 9-HODE reflects exercise-induced, oxidative stress in parallel to F2-isoprostanes, a well-established biomarker,” Nieman said in a statement. “The good news is that HODE is 20 times more abundant than the gold standard F2, is stable and can be altered in response to lifestyle related interventions like exercise. I think the future is going to be that others will use it as a marker for oxidative stress in exercise studies.”

The findings were published in the April 2014 edition of the American Journal of Physiology in the article entitled “Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling.”

The study was conducted in partnership with the David H. Murdock Research Institute (DHMRI), a contract research organization located on the NC Research Campus, and Metabolon, a company specializing in metabolomics and biochemical profiling located in Durham. Metabolon also provides metabolomic services for DHRMI.

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