NC A&T University

NCA&T Research Technician Honored for Work on Wheat and Cancer Prevention

February 02, 2015

NCA&T Research Technician Nicholas Stone is a finalist in the Undergraduate Student Research Symposium sponsored by the Agricultural and Food Chemistry Division (AGFD) of the American Chemical Society (ACS).


Nicholas Stone, NCA&T Research Technician and Davidson College Senior

The AGFD symposium is open to all undergraduates conducting research in agricultural food chemistry. Stone, a senior biology major at Davidson College, is one of six finalists chosen from an international pool of applicants. He will present his research on “Alkylresorcinols: purification from wheat bran and quantification in whole grain wheat breads” at the 249th ACS National Meeting in Denver, Colorado from March 22 to 26.

Stone, who is originally from Winston-Salem, NC, works part-time in the lab of Shengmin Sang, PhD, associate professor in the NCA&T State University Center of Excellence for Post-Harvest Technologies on the NC Research Campus. He started working as a summer intern in Sang’s lab in June of 2013 before spending the rest of the summer interning on Capitol Hill in Washington DC. In the fall, Sang invited him back to work part-time in his laboratory.

Stone quickly progressed from helping with small tasks like washing dishes to becoming a full-fledged member of the research team focusing on the study of alkylresorcinols (AR), a bioactive compound in whole grain wheat and rye.

ARs are recognized for their anti-carcinogenic effects against the growth of human colon cancer cells, but they aren’t commercially available for research. Stone helped develop a purification method to isolate five AR compounds from wheat bran using column chromatography techniques and high throughput liquid chromatography (HPLC). They also developed an HPLC method to measure ARs in different varieties of wholegrain wheat breads, which will be used to study how they are metabolized in the human body.

Sang’s research goal is to prevent chronic diseases like cancer and diabetes through the study of grain metabolites. Each type of whole grain leaves a unique set of metabolites in the blood, a signature that can be correlated to the level of consumption and the effect on human disease.

“My goal is to develop unique exposure markers,” Sang explained. “I want to use compounds and their metabolites to reflect wheat intake, and the long-term goal is to study dietary exposure. Eventually, I want to cover all of the major cereals. So far, we are working on wheat and oat.”

“The end goal from talking to Dr. Sang, and the research I’ve done,” Stone added, “is to try and find a quantitative answer to a qualitative association between high fiber diets and slowing metastasis of colon cancer.”

Stone receives a $1,000 travel stipend for his trip to Denver where he will present his research in hopes of winning a cash prize, $750 for first and $250 for second place. More than the prize, he relishes the opportunity to meet other scientists. Before he leaves for Denver, Stone is analyzing additional samples and finalizing his presentation.

“This is a tremendous experience, and Dr. Sang is an amazing mentor,” Stone commented. “I’ve been able to build a base of techniques and lab experiences that I wouldn’t have gotten at school.”

Learn more about NCA&T’s research at the NC Research Campus.

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