NC Central University Search Results

UNC System President Margaret Spellings Visits the NC Research Campus

            On Monday, March 14, UNC system President Margaret Spellings visited the NC Research Campus as part of her “100 Days” tour. Along with the NC Research Campus, she is visiting all 16 public universities, the NC School of Science and Mathematics and UNC Health Care to “learn and experience […]

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p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

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Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer, July 22, 2015, In Press Accepted Manuscript, Yujie Fu, Onat Kadioglu, Benjamin Wiench, Zuofu Wei, Wei Wang, Meng Luo, Xiaohe Yang, Chengbo Gu, Yuangang Zu, Thomas Efferth NC Central University <style>.requiresJS{display:none}.dartAd{display:block !important}</style> Abstract Anti-estrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established anti-hormones such as tamoxifen, novel […]

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Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib, Journal of Cancer Research, April 22, 2015, Ming Zhao, Amanda Blackwelder, Harry Lee, and Xiaohe Yang Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC. Abstract 3557: Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib Abstract […]

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In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice, 2015 Apr 7, Int J Mol Sci, Ma Z1, Blackwelder AJ2, Lee H3, Zhao M4, Yang X5. 1Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA. mzhao@nccu.edu. 2Julius L. Chambers Biomedical/Biotechnology […]

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Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells, Phytomedicine, 11 March 2015,  Yujie Fua, b, 1, Onat Kadiogluc, 1, Benjamin Wienchc, Zuofu Weia, b, Chang Gaod, Meng Luoa, b, Xiaohe Yange, Chengbo Gua, b, Yuangang Zua, b, Thomas Efferth Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer […]

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In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk.  Molecular Cancer Research. Nov 2014, Zhikun Ma, Amanda Blackwelder, and Xiaohe Yang North Carolina Central Unversity, Kannapolis, NC. Abstract A09: In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk Abstract The mammary […]

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NCRC Scientist Helps Cabarrus High School Students Visit STEM Program

For Immediate Release        (Kannapolis, NC- Monday, October 20)- Tuesday, October 21, students from Northwest Cabarrus High School’s biotechnology academy will travel to the main campus of North Carolina Central University (NCCU) in Durham, NC to take part in BRITE Futures, a STEM (science, technology, engineering and math) program that gives students hands-on […]

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Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. The Journal of Endocrinology. Apr 16, 2014 [Epub ahead of print] Yang X1, Mei S, Gu H, Guo H, Zha L, Cai J, Li X, Liu Z, Cao W. 1X Yang, Nutrition, UNC at Chapel Hill, Kannapolis, United States. Abstract We have previously shown that insulin plays an essential role […]

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IRAK4 and breast cancer cell migration in culture and zebrafish xenografts

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts AACR Annual Meeting 2014; April 5-9, 2014, K. Sean Kimbro, Karine Ferri-Lagneau, Jamil Haider, Susan Yeyeodu, Xiaohe Yang, and TinChung Leung North Carolina Central University, Durham, NC. Abstract Growing evidence indicates that incongruities in the inflammatory and immune response pathways contribute to tumorigenesis. We seek to explore the underlying biological mechanisms […]

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BRITE future for Kannapolis students

By Jennifer Woodford Link to original article in Business Today As a child, TinChung Leung, PhD, enjoyed raising fish. Today, he is a scientist with the NC Central University Nutrition Research Program at the NC Research Campus and an expert in the use of zebra fish as a model system for cancer and cardiovascular disease […]

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BRITE Futures for Kannapolis Students

Salisbury Post Dr. TinChung Leung, of the NC Central University Nutrition Research Program at the NC Research Campus, is usually focused on cancer, cardiovascular and blood research. This year, he is expanding his focus to make an investment in the future of middle and high school students in Kannapolis City Schools. He worked together with […]

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Investing in Bright Futures for Kannapolis Students

NCRC News February 13, 2014 TinChung Leung, PhD, of the NC Central University Nutrition Research Program at the NC Research Campus, is usually focused on cancer, cardiovascular and blood research. This year, he is expanding his focus to make an investment in the future of middle and high school students in Kannapolis City Schools (KCS). […]

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A Model Fish

Scientists with North Carolina Central University Nutrition Research Program and NCA&T’s Center for Excellence in Post-Harvest Technologies teamed up to study the bioactive compounds in ginger. They did it using a rather model fish called zebrafish. NC Central scientist TinChung Leung, PhD, uses the model fish for research into natural compounds that can help prevent […]

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NCCU and NCA&T Cancer Research on UNC-TV

UNC TV Researchers can’t test experimental cures for diseases and possible drug therapies on humans so they use the zebrafish for initial testing. That’s because the journey from egg to embryo is the same in zebrafish and humans. The image on the computer screen in the North Carolina Central University lab at the North Carolina […]

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Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models. Cancer Prevention Research (Philadephia, PA). December 9, 2013. [Epub ahead of print] Zhu P, Davis M, Blackwelder A, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Julius L. Chambers Biomedical Biotechnology Research Institute, Julius L. Chambers Biomedical Biotechnology Research Institute/NC Central University Nutrition Research Program, NC Research […]

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Ginger Shogaols: Promising Preventation for Lung and Colon Cancer

North Carolina Research Campus Shengmin Sang, PhD, associate professor and lead scientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies (CEPHT) at the North Carolina Research Campus in Kannapolis, has published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most […]

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[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos.

[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos. Journal of Agricultural and Food Chemistry.  Epub May 23, 2013. Chen H, Soroka DN, Haider J, Ferri-Lagneau KF, Leung T (NC Central University Nutrition Research Program), Sang S. Center for Excellence in Post-Harvest Technologies, North […]

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Catalyst Group’s 2013 Symposium Celebrates NCRC Research

 NCRC The NC Research Campus Catalyst Group hosted their second annual research symposium, Celebrating Research and Collaborations at the NCRC, on Monday, April 15, 2013 in the core lab event room. The Catalyst Group, which fosters personal and professional relationships between researchers on campus, hosted 100 attendees who benefited from a poster competition, faculty presentations, […]

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Collaborations Driving Ginger Research for Cancer, Anemia

Ginger is appreciated for its aromatic and tangy taste and is enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

NRCR News The impact of soy on breast cancer is puzzling to many consumers including women at risk for breast cancer. Numerous studies label the isoflavone genistein in soy as a natural compound that can prevent breast cancer. At the same time, increasing numbers of reports suggest that genistein may be a risk factor for […]

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Making Sense of the Soy-Genistein-Her2 Breast Cancer Connection

One of the most controversial and confusing questions surrounding breast cancer is the effect of eating soy. Some studies say soy and the isoflavone genistein that it contains prevents breast cancer. Other studies say genistein is a risk factor for developing breast cancer. Breast cancer researcher Xiaohe Yang, PhD, associate professor with the North Carolina Central […]

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Collaborations Driving Ginger Research For Cancer, Anemia Treatments

Ginger is more commonly appreciated for its aromatic and tangy taste enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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Charlotte conference highlights region’s life-sciences research

By Jeremy Summers, NCBiotech Writer Charlotte is known for its strong financial roots, diverse business climate and   for being the unofficial home of NASCAR. Thanks to new commitments to education and research, the region is also gaining some recognition as a hotbed for cutting edge research and technologies in biotech and other life-sciences industries. […]

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Kannapolis Scholars Conference Focuses on the Role of Exercise in Obesity Prevention

  Link to original article The Kannapolis Scholars, a program of N.C. State University at the N.C. Research Campus, is hosting its second conference on how to address the challenges of obesity. “Lost in Translation: A Conversation on Exercise and Obesity” will be held on Friday, July 27, 2012, from 10:15 a.m. to 4 p.m. […]

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ADAP-GC 2.0: Deconvolution of Coeluting Metabolites from GC/TOF-MS Data for Metabolomics Studies.

ADAP-GC 2.0: Deconvolution of Coeluting Metabolites from GC/TOF-MS Data for Metabolomics Studies. Analytical Chemistry, July 2012. Ni Y, Qiu Y, Jiang W, Suttlemyre K, Su M, Zhang W, Jia W, Du X. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, North Carolina Research Campus. Abstract ADAP-GC 2.0 has been developed to deconvolute […]

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Ginger Stimulates Hematopoiesis via Bmp Pathway in Zebrafish.

Ginger Stimulates Hematopoiesis via Bmp Pathway in Zebrafish. PLoS One. July 2012. Epub June 2012. Ferri-Lagneau KF, Moshal KS, Grimes M, Zahora B, Lv L, Sang S, Leung T. North Carolina Central University Nutrition Research Program. Abstract BACKGROUND: Anemia is a hematologic disorder with decreased number of erythrocytes. Erythropoiesis, the process by which red blood […]

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An Old-Time Remedy With Modern Proof

by Ruth Kinzey, Refresh             Heading down the produce aisle, it’s common to see fresh ginger root. And while it is a spice frequently used in Indian, Korean, Japanese and Chinese cooking, recently released findings indicate modern science is continuing to learn about the medicinal benefits it offers. At the […]

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Ginger Could Treat Anemia

Tangy and aromatic, ginger is a spice used to flavor meats, vegetables and even baked goods. More than a culinary delight, ginger has been valued for thousands of years for its numerous health benefits. Ginger, which is the rhizome or underground stem of the plant Zingiber officinale, is recognized as a natural solution for digestive […]

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Monday and Tuesday Events Feature NCRC Scientists

NCRC Monday, April 16 and Tuesday, April 17, the Live and Learn Film Series and State of the Studies at the NC Research Campus are free events that provide opportunities for people to talk with scientists and learn about the research and clinical studies that are underway on campus. (NC Research Campus, Kannapolis, NC- April […]

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Researchers from NCCU, N.C. A&T Develop Anemia Treatment

NCCU News Scientists at North Carolina Central University and North Carolina A&T State University have discovered a promising use of ginger that may lead to the development of a treatment for anemia. Dr. TinChung Leung of NCCU and Dr. Shengemin Sang of N.C. A&T will present their findings April 3 at the annual meeting of […]

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NCRC Scientists Open A Window To Chinese Culture

Scientists at the North Carolina Research Campus in Kannapolis formed the Cabarrus Chinese American Association and are hosting a Chinese New Year celebration on January 14, 2012 to raise money for their Chinese Language and Art School. In American culture, January is usually a quiet month to recover from the revelry of Thanksgiving, Christmas and […]

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HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance

Huang X,Wang S,Lee CK,Yang X,Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Letters.2011 Aug 1;307(1):72-9. doi: 10.1016/j.canlet.2011.03.019. Epub 2011 Apr 16. Abstract Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with […]

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Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.

Shi Y,Yang S,Troup S,Lu X,Callaghan S,Park DS,Xing Y,Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.Oncology Reports.2011 Jun;25(6):1713-9. doi: 10.3892/or.2011.1248. Epub 2011 Apr 6. Abstract Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. […]

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Zebrafish model:worth considering indefining tumor angiogenesis

MoshalKS,Ferri-LagneauKF,LeungT. Zebrafish model:worth considering indefining tumor angiogenesis. Trends in Cardiovascular Medicine. 2010 May;20(4):114-9. Abstract The process of angiogenesis is essential for tumor progression and metastasis; however, antiangiogenesis therapy-induced hypoxia and inflammation are perhaps the driving force for tumor escape and metastasis formation, thereby compromising its efficacy. This warrants the complete understanding of the molecular and […]

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Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation

Yang X,Yang S,McKimmey C,Liu B,Edgerton SM,Bales W,Archer LT,Thor AD. Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation.Carcinogenesis.2010 Apr;31(4):695-702. Epub 2010 Jan 12. Abstract Genistein is a major isoflavone with known hormonal and tyrosine kinase-modulating activities. Genistein has been shown to promote the growth of estrogen receptor positive […]

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Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin

Huang X,Gao L,Wang S,McManaman JL,Thor AD,Yang X,Esteva FJ,Liu B. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. CancerRes.2010Feb 1;70(3):1204-14. Epub 2010 Jan 26. Abstract Primary and acquired resistance to the breast cancer drug trastuzumab (Herceptin) is a significant clinical problem. Here, we report […]

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