NC A&T University Search Results

Shengmin Sang of NCA&T Wins Innovation for Impact Grand Prize

By Barry Teater, NCBiotech Writer. Research to prevent colon cancer by pairing the classic wonder drug aspirin with an active ingredient in ginger has earned a Greensboro scientist a statewide honor that carries an $11,000 reward. Shengmin Sang, Ph.D., associate professor with the North Carolina Agricultural and Technical State University in Greensboro,was awarded the inaugural Innovation […]

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NCA&T’s Shengmin Sang Reaping Research Rewards

By Mindy Hamlin, NCBiotech Writer. Read the original article on the NC Biotech Center website. It has been a good run lately for Shengmin Sang, Ph.D. Sang, associate professor and lead scientist in the Center for Excellence in Post-Harvest Technologies ​at North Carolina Agricultural and Technical State University labs in Kannapolis, was awarded the inaugural […]

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UNC System President Margaret Spellings Visits the NC Research Campus

            On Monday, March 14, UNC system President Margaret Spellings visited the NC Research Campus as part of her “100 Days” tour. Along with the NC Research Campus, she is visiting all 16 public universities, the NC School of Science and Mathematics and UNC Health Care to “learn and experience […]

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Six More Dietary Ingredients Picked for Analytical Evaluation

By Richard A. Lovett, JD, PhD, Contributing Writer Read the original article in Nutraceuticals World An advisory panel has selected aloe vera, vitamin B12, protein, ginger, vitamins K1 and K2 and free amino acids as priority ingredients for review. In a continuing endeavor to help the dietary supplements industry agree on and evaluate analytical methods […]

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Grocery shopping habits could affect food safety, quality

Featured on America Now, the TV magazine program with news you can use. View the original story with video. By reporter Jeff Rivenbark. Grocery shopping is a routine chore. You fill up a cart, pay the cashier, and walk out of the store with bags of fresh food. But just how fresh is the food […]

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Chemopreventative Effect of Phytochemimcals against Colon Cancer

Chemopreventative Effect of Phytochemimcals against Colon Cancer, Medicinal and Aromatic Plants, December 2015. Williams LL, Khatiwada J and Davis S. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, North Carolina Research Campus, Kannapolis, NC. Editorial Currently, the incidence of colorectal cancer (CRC) has been declining, even though it remains a major public […]

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N.C. A&T to research new approach to peanut allergies

Read the original article on the NC A&T website. North Carolina Agricultural and Technical State University continues to lead the charge against peanut allergies, as evidenced by its recent $500,000 grant from the United State Department of Agriculture (USDA) for researching new immunotherapies. In the U.S., approximately 3 million people report mild to severe allergies […]

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Ginger, Other Plant Compounds Found to Delay Diabetic Complications

Read the story in Nutraceuticals World. Ginger compounds and some flavonoids are effective at stopping physiological processes that lead to diabetic complications. Scientific evidence is building that plant compounds may be a safe and effective alternative to approved pharmaceutical treatments for type 2 diabetes because they provide a natural means to prevent diabetic complications without side […]

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Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal

Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal, Chem Res Toxicol. 2015 Aug 13, Zhu Y1, Zhao Y1, Wang P1, Ahmedna M, Sang S1. 1†Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina 28081, United States. Abstract Considerable evidence suggests […]

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Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity

Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity, J Med Chem. 2015 J Zhu Y, Fu J, Shurlknight K, Soroka D, Hu Y, Chen XL, Sang S. Abstract Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized […]

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Numerical solution of a microbial growth model applied to dynamic environments.

Numerical solution of a microbial growth model applied to dynamic environments, 2015 May, J Microbiol Methods,  Zhu S1, Chen G2. 1Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA. 2Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research […]

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Species authentication and geographical origin discrimination of herbal medicines by near infrared spectroscopy: A review

Species authentication and geographical origin discrimination of herbal medicines by near infrared spectroscopy: A review, 23 April 2015,  Journal of Pharmaceutical Analysis, Pei Wanga, b, Zhiguo Yua School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China b Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, […]

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Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer

Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer, Apr 2015, The FASEB Journal, Jennifer McBride1, Yingdong Zhu1, Pei Wang1 and Shengmin Sang1 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Colorectal cancer (CRC) is a leading cause of cancer related deaths in the United States. Epidemiological […]

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Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice

Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice, Apr 2015, The FASEB Journal, Yantao Zhao1, Rashin Sedighi1, Pei Wang1, Huadong Chen1, Yingdong Zhu1 and Shengmin Sang1 –1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Rosemary has been used as a natural […]

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Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells

Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells, Apr 2015, The FASEB Journal, Shengmin Sang1, Junsheng Fu1, Yingdong Zhu1, Aaron Yerke1, Mitchell Wise2, Jodee Johnson3 and YiFang Chu3 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States 2Cereal Crops Research Unit USDA Madison WI United States 3Quaker Oats Center of Excellence […]

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Explicit modeling of microbial growth under nonisothermal conditions.

Explicit modeling of microbial growth under nonisothermal conditions. J Microbiol Methods. 2015 Mar 10, Zhu S1, Chen G2. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA. 2Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA. […]

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Research campus moving past slow start, looking to define future

By Josh Bergeron, Salisbury Post Contact reporter Josh Bergeron at 704-797-4246. Read Original Article The N.C. Research Campus still lags behind initial employment projections, but, as the nation and state recover from an economic recession, growth is beginning to pick up. Following billionaire businessman David Murdock’s $15 million annual endowment last year, the research campus […]

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NCA&T Opens Second Research Lab at NCRC

When the NCA&T Center for Excellence in Post-Harvest Technologies on the NC Research Campus (NCRC) in Kannapolis reached 40 employees, Director Leonard Williams, PhD, knew it was time to expand. The Ready-to-Go Laboratory suites in the David H. Murdock Core Laboratory Building were the obvious choice. The 1,500-square-foot laboratories come with administrative areas, bench tops, […]

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NC Research Campus Ready To Go on New Lab and Office Space

          Contact: Clyde Higgs, Vice President of Business Development NC Research Campus partner@ncresearchcampus.net 704-273-1206 NC Research Campus, Kannapolis, NC– Officials at the NC Research Campus (NCRC) in Kannapolis are investing up to $1.5 million in the construction of a third speculative laboratory suite and new, flexible office space on the third […]

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Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review

Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review, Current Opinion in Food Science, 10 February 2015,  Rashin Sedighi, Yantao Zhao, Aaron Yerke, Shengmin Sang Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina […]

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Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation

Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation, J Agric Food Chem. 2015 Feb 6, Zhu Y, Soroka D, Sang S. NC A&T University Abstract Consumption of whole grains has been reported to be associated with a lower risk of several lifestyle-related diseases such as colorectal […]

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NCA&T Research Technician Honored for Work on Wheat and Cancer Prevention

NCA&T Research Technician Nicholas Stone is a finalist in the Undergraduate Student Research Symposium sponsored by the Agricultural and Food Chemistry Division (AGFD) of the American Chemical Society (ACS). The AGFD symposium is open to all undergraduates conducting research in agricultural food chemistry. Stone, a senior biology major at Davidson College, is one of six […]

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Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites

Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites,2015 American Society for Nutrition Dec 2014, Pei Wang4, Huadong Chen4, Yingdong Zhu, Jennifer McBride, Junsheng Fu, and Shengmin Sang* Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human […]

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Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid.

Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid. Chem Res Toxicol. 2014 Dec 1, Zhu Y, Zhao Y, Wang P, Ahmedna M, Ho CT, Sang S. NC A&T University Abstract Growing evidence has shown that ascorbic acid (ASA) can contribute to protein glycation and the formation of advanced glycation end products (AGEs), especially in the lens. The mechanism by which ascorbic acid can cause […]

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Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal

Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal. J Agric Food Chem. 2014 Nov 20, Li X, Zheng T, Sang S, Lv L. NC A&T University Abstract Methylglyoxal (MGO) and glyoxal (GO) are not only endogenous metabolites, but also exist in exogenous resources, such as food, beverages, urban atmosphere, and cigarette smoke. They […]

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Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion

Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion. Journal of Agricultural and Food Chemistry. October 7, 2014. Lin Lei †, Yuwei Liu †, Xiaobo Wang †, Rui Jiao ‡,Ka Ying Ma †, Yuk Man Li †, Lijun Wang †, Sun Wa Man †, Shengmin Sang §, Yu Huang #, and Zhen-Yu Chen *† Author Affiliations † Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, […]

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NC Research Campus seeks faster growth after slow start

By Ely Portillo, Charlotte Observer Read the original article KANNAPOLIS A billionaire pineapple company owner’s vision for the future of nutrition science rises next to Main Street in this former mill town, massive red brick buildings with soaring columns that contrast with surrounding one-story houses, shops and churches. Dole Foods owner David Murdock, whose diet […]

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Bioavailability and Hypolipidemic Effects of Peanut Skin Polyphenols

Bioavailability and Hypolipidemic Effects of Peanut Skin Polyphenols J Med Food. 2014 Sep 3, Bansode RR1, Randolph P, Ahmedna M, Williams LL, Yu J.  Center for Excellence in Post Harvest Technologies, North Carolina Agricultural and Technical State University , North Carolina Research Campus, Kannapolis, North Carolina, USA . Abstract Abstract Peanut skin is a rich source of polyphenols, such as proanthocyanidins. Peanut skin proanthocyanidins mainly consist of a subgroup […]

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Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo.

Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo. Chem Res Toxicol. 2014 Aug 22, Chen H, Fu J, Chen H, Hu Y, Soroka DN, Prigge J, Schmidt EE, Yan F, Major MB, Chen XL, Sang S. Abstract In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in […]

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A&T SIGNS AGREEMENT TO COMMERCIALIZE HYPOALLERGENIC PEANUT

North Carolina A&T Hypoallergenic peanuts, peanut butter, and other peanut products are a step closer to grocery stores with the signing of an exclusive licensing agreement for the patented process that reduces allergens in peanuts by 98 percent. North Carolina Agricultural and Technical State University signed the agreement with Xemerge, a Toronto-based firm that commercializes […]

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Effect of microfluidisation on antioxidant properties of corn bran

Effect of microfluidisation on antioxidant properties of corn bran. Food Chemistry. June 1, 2014 Wang T, Zhu Y, Sun X, Raddatz J, Zhou Z, Chen G. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, NC Research Campus; School of Food Science & Technology, Dalian Polytechnic University, Dalian, China; Center for Translational & Biomedical Research, The University of North […]

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Keep Summer Produce Healthy and Safe

Published in Cabarrus Magazine June 2014. Read the PDF: Williams Cab Mag June 2014 A recent study published in the journal Brain Research, found that the phytochemicals anthocyanins and proanthocyanidins are effective in protecting against the loss of nerve cell function in the brain brought on by Parkinson’s Disease. One of the lead scientists on the study […]

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Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells

Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells. Journal of Agricultural Food Chemistry. May 21, 2014; Epub 2014 May 12. Fu J1, Chen H, Soroka DN, Warin RF, Sang S. 1Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus , 500 Laureate […]

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Production and characterization of biochars from agricultural by-products for use in soil quality enhancement

Production and characterization of biochars from agricultural by-products for use in soil quality enhancement Apr 24, 2014 D. Rehraha, M.R. Reddyb, J.M. Novakc, R.R. Bansodeb, K.A. Schimmelb, J. Yub, D.W. Wattsc, M. Ahmednaa,    Department of Health Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar b Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and […]

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Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal

Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal. Journal of Agricultural and Food Chemistry. April 1, 2014. [Epub ahead of print] Shao X, Chen H, Zhu Y, Sedighi R, Ho CT, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University , North Carolina Research Campus. Abstract Reactive dicarbonyl species, such as […]

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Scientists: Heart benefits of oats goes beyond fiber

UPI Health News, March. 17, 2014 at 4:31 PM   Bioactive compounds in oats — AVEs — might protect heart. UPI /Monika Graff UPI /Monika Graff | License Photo DALLAS, March 17 (UPI) — Eating whole grains is associated with a reduced risk of heart disease and U.S. researchers suggest a compound in oats may […]

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Microfluidization of Brans and Uses Thereof

Microfluidization of Brans and Uses Thereof FPO 28 Feb 2014, Chen, Guibing (Concord, NC, US) ,Raddatz, Julia (Cornelius, NC, US), Wang, Tao (Kannapolis, NC, US) Abstract The present application generally relates to the development of palatable fiber-enriched foodstuffs, including but not limited to soups, salad dressings, dips, sauces, baked goods and beverages, through modifying various dietary fiber ingredients using […]

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Induction of Lung Cancer Cell Apoptosis through a p53 Pathway by [6]-Shogaol and Its Cysteine-Conjugated Metabolite M2

Induction of Lung Cancer Cell Apoptosis through a p53 Pathway by [6]-Shogaol and Its Cysteine-Conjugated Metabolite M2. Journal of Agricultural Food Chemistry. January 30, 2014. Epub ahead of print. Warin RF, Chen H, Soroka DN, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus Abstract Dietary chemoprevention of […]

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Identification and Pharmacokinetics of Novel Alkylresorcinol Metabolites in Human Urine, New Candidate Biomarkers for Whole-Grain Wheat and Rye Intake.

Identification and Pharmacokinetics of Novel Alkylresorcinol Metabolites in Human Urine, New Candidate Biomarkers for Whole-Grain Wheat and Rye Intake. The Journal of Nutrition. November 20, 2013. [Epub ahead of print] Zhu Y, Shurlknight KL, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, Kannapolis, NC. Abstract Biomarkers of dietary intake […]

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Biotransformation of tea polyphenols by gut microbiota

Biotransformation of tea polyphenols by gut microbiota. Journal of Functional Foods. February 2014. Huadong Chen, Shengmin Sang. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract Tea is one of the most widely consumed beverages worldwide and has received increasing attention from researchers and food industries […]

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A Model Fish

Scientists with North Carolina Central University Nutrition Research Program and NCA&T’s Center for Excellence in Post-Harvest Technologies teamed up to study the bioactive compounds in ginger. They did it using a rather model fish called zebrafish. NC Central scientist TinChung Leung, PhD, uses the model fish for research into natural compounds that can help prevent […]

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NCCU and NCA&T Cancer Research on UNC-TV

UNC TV Researchers can’t test experimental cures for diseases and possible drug therapies on humans so they use the zebrafish for initial testing. That’s because the journey from egg to embryo is the same in zebrafish and humans. The image on the computer screen in the North Carolina Central University lab at the North Carolina […]

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What are Lipids?

By Rishipal Bansode, PhD, NC A&T Center for Excellence in Post-Harvest Technologies Lipids are a variety of compounds that are non-soluble in water and include fats, oil, waxes, phospholipids and steroids that are easily stored in the body. Because some lipids are fats, they often get a bad rap. Actually, lipids are involved in very important […]

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NC A&T Finds Health Benefits in Peanut Skin Extract

Rishipal Bansode, PhD, with the North Carolina Agricultural and Technical State University’s Center for Excellence in Post-Harvest Technologies, recently found that in an animal model an extract of peanut skin polyphenols reduced lipid levels in the blood stream. The study also showed up to a 30 percent loss of belly fat in the study animals. The findings were published in […]

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Peanut Skin Polyphenols Lower Lipid Levels, Reduce Fat

For Immediate Release Phyllis Beaver Marketing Director NC Research Campus pbeaver@ncresearchcampus.net   Laurie Gengenbach NCA&T Communications lagengen@ncat.edu View the full story.   (NC Research Campus, Kannapolis, NC- December 3, 2013) Scientists with North Carolina Agricultural and Technical State University’s Center for Excellence in Post-Harvest Technologies at the NC Research Campus in Kannapolis have discovered in […]

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Researchers find peanut skins could help reduce fat

TWC News: Researchers find peanut skins could help reduce fat Play now By: Jenna Barnes KANNAPOLIS, N.C. — Every year, United States farmers produce an estimated five billion pounds of peanuts, but most of the shells and skins end up in the trash. Researchers at North Carolina A&T have found the parts thrown away might […]

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Bioavailability of polyphenols from peanut skin extract associated with plasma lipid lowering function

Bioavailability of polyphenols from peanut skin extract associated with plasma lipid lowering function. Food Chemistry. October 2013. R.R. Bansode, P. Randolph, M. Ahmedna, S. Hurley, T. Hanner, S. Baxter, T. Johnston, M. Su, B. Holmes, J. Yu, L.L. Williams. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus; Department of Health Sciences, Qatar University, P.O. Box […]

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Effects of microfluidization on antioxidant properties of wheat bran.

Effects of microfluidization on antioxidant properties of wheat bran. Journal of Cereal Science. August 22, 2013. Tao Wang, Julia Raddatz, Guibing Chen. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, NC Research Campus; College of Food Science and Engineering, Dalian Ocean University. Abstract Phenolic compounds present in native wheat bran are majorly […]

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Ginger Shogaols: Promising Prevention for Lung and Colon Cancer

Shengmin Sang, PhD, associate professor and leadscientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies, published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most recent findings concentrate on shogaol metabolites and lung and colon cancer prevention. Shogaols are the dehydrated […]

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Effects of microfluidization on microstructure and physicochemical properties of corn bran

Effects of microfluidization on microstructure and physicochemical properties of corn bran. Journal of Cereal Science, July 29, 2013. Tao Wang, Xiuhua Sun, Julia Raddatz, Guibing Chen. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus;  School of Food Science & Technology, Dalian Polytechnic University; Department of Nutrition, University of North Carolina […]

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NC Research Campus scientists seek to make foods healthier

By: Jenna Barnes, News 14 Carolina KANNAPOLIS—Doctors say whole grains are part of a healthy diet, but scientists at the North Carolina Research Campus are working on a way to make them even better. “It can prevent a lot of chronic diseases, like diabetes, obesity, and some heart diseases,” said Dr. Guibing Chen of NC […]

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Ginger Shogaols: Promising Preventation for Lung and Colon Cancer

North Carolina Research Campus Shengmin Sang, PhD, associate professor and lead scientist in functional food for NC A&T State University’s Center for Excellence in Post Harvest Technologies (CEPHT) at the North Carolina Research Campus in Kannapolis, has published four peer-reviewed articles this year that further the understanding of the chemopreventive potential of ginger. Sang’s most […]

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Grains for Better Health and Disease Prevention

  Shengmin Sang, PhD, with the NC A&T Center for Excellence in Post-Harvest Technologies, is researching metabolites and dietary markers of grains like wheat and rye that can help increase their use as a preventative for diabetes and lung and colon cancer. Sang and  NC A&T’s Guibing Chen, PhD, are experimenting with a process called microfluidization […]

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[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos.

[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos. Journal of Agricultural and Food Chemistry.  Epub May 23, 2013. Chen H, Soroka DN, Haider J, Ferri-Lagneau KF, Leung T (NC Central University Nutrition Research Program), Sang S. Center for Excellence in Post-Harvest Technologies, North […]

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Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice

Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice. Chemical Research in Toxicology.  Epub May 15, 2013.  Chen H, Soroka DN, Zhu Y, Hu Y, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University , North Carolina Research […]

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Collaborations Driving Ginger Research for Cancer, Anemia

Ginger is appreciated for its aromatic and tangy taste and is enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment

Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment. Food Chemistry. March 2013. Hao Lia, Jianmei Yub, Mohamed Ahmednaa, Ipek Goktepeb. Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus; Department of Family and Consumer Sciences, North Carolina A&T State University; College of […]

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Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Carcinogenesis. March 4 2013. Chiou YS, Sang S (NC A&T Center for Excellence in Post Harvest Technologies at the NC Research Campus), Cheng KH, Ho CT, Wang YJ, Pan MH. Department of Seafood Science, […]

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Structure Elucidation and Chemical Profile of Sphingolipids in Wheat Bran and Their Cytotoxic Effects against Human Colon Cancer Cells.

Structure Elucidation and Chemical Profile of Sphingolipids in Wheat Bran and Their Cytotoxic Effects against Human Colon Cancer Cells. Journal of Agricultural and Food Chemistry. January 30, 2013. Zhu Y, Soroka DN, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract Sphingolipids are known to have […]

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Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation

Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation. PloS One, January 30, 2013. Zhu Y, Warin RF, Soroka DN, Chen H, Sang S.  Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. – Abstract Our previous study found that […]

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NCRC Scientist Offers Tips on Recognizing and Preventing Norovirus

    Contact: Phyllis Beaver Marketing Director North Carolina Research Campus pbeaver@ncresearchcampus.net or Leonard Williams, PhD NC A&T Center for Excellence in Post Harvest Technologies llw@ag.ncat.edu 704-250-5705 (NC Research Campus, Kannapolis, NC- January 29, 2013)- Last week the Centers for Disease Control (CDC) reported that a new strain of norovirus, the GII4Sydney, is sweeping the […]

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Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol

Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.  Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka DN, Hu Y, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract […]

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How to Recognize and Prevent Norovirus

The Centers for Disease Control (CDC) recently announced that a new strain of norovirus, the GII4Sydney, is sweeping the United States. First reported in Australia in March 2012, the CDC reported that the strain caused 58 percent of norovirus infections in December 2012. Norovirus is a common foodborne pathogen with as many as 21 million […]

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Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet

Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet. Food Chemistry. December 2012. Bansode RR, Randolph P, Hurley S, Ahmedna M. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract The effect of water soluble polyphenolic extract of peanut skin (PE) was investigated for its hypolipidemic properties […]

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The microbiota is essential for the generation of black tea theaflavins-derived metabolites

The microbiota is essential for the generation of black tea theaflavins-derived metabolites. PLoS One. December 2012. Chen H, Hayek S, Rivera Guzman J, Gillitt ND, Ibrahim SA, Jobin C, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University and Dole Foods Nutrition Research Institute Abstract BACKGROUND: Theaflavins including theaflavin […]

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Collaborations Driving Ginger Research For Cancer, Anemia Treatments

Ginger is more commonly appreciated for its aromatic and tangy taste enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

0 comments

Collaborations Driving Ginger Research For Cancer, Anemia Treatments

Ginger is more commonly appreciated for its aromatic and tangy taste enjoyed the world over in everything from entrées to baked goods. Beyond the kitchen, the spice has been used for centuries to calm digestive upsets.  More recent studies have found that bioactive components in ginger have strong anti-oxidative, anti-inflammatory, anti-cancer and anti-diabetic activities. At […]

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N.C. State Studying Cancer-fighting Compounds in Ginger

  N.C. State University’s Plants for Human Health Institute (PHHI), located at the N.C. Research Campus in Kannapolis, has partnered with the University of Surrey in England to conduct research involving plants and potential cancer treatments. At the root of the research is ginger, which scientists are studying for its potential cancer-fighting properties. Dr. Mary […]

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3 diverse new research projects at N.C. A&T explore blood-brain barrier, risk management, wheat bran

Three new research projects at N.C. A&T aim to explore the weakening of the blood-brain barrier in  Alzheimer’s disease patients, to apply risk management to supply chain logistics, and to find a way to make dietary fiber taste better. The projects are the first ones funded at A&T for each of the three principal investigators. […]

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6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cell.

6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cell. Jounral of Agricultural and Food Chemistry. November 2012. Lv L, Chen H, Soroka D, Chen X, Leung T, Sang S. (NC A&T Center for Excellence in Post Harvest Technologies). Department of Food Science and […]

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Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol

Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol.  Nutrition and Cancer. November 2012. Chen X, Zhang X, Lu Y, Shim JY, Sang S (NC A&T Center for Excellence in Post Harvest Technologies), Sun Z, Chen X. School of Pharmaceutical & Life Sciences, Changzhou University, Jiangsu, China. Abstract Our previous studies […]

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Charlotte conference highlights region’s life-sciences research

By Jeremy Summers, NCBiotech Writer Charlotte is known for its strong financial roots, diverse business climate and   for being the unofficial home of NASCAR. Thanks to new commitments to education and research, the region is also gaining some recognition as a hotbed for cutting edge research and technologies in biotech and other life-sciences industries. […]

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Agromedicine Institute hosting symposium on N.C. Research Campus in mid-October

The North Carolina Agromedicine Institute and the SAES’s Center of Excellence for Post-Harvest Technologies are hosting the 2012 North Carolina Agricultural Health and Safety Symposium. The Symposium will be Friday, Oct. 12, from 8:30 a.m. to 4:30 p.m. at the David H. Murdock Core Laboratory Building on the N.C. Research Campus. Featured speakers will be […]

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NC Research Campus scientists work to engineer high fiber foods

By: Sarah Pisciuneri, Time Warner Cable News KANNAPOLIS — At the North Carolina Research Campus, scientists are working to solve an everyday diet dilemma; how to get more fiber into the foods most of us eat everyday. Dr. Guibing Chen is one of the scientists at the NC A&T Center for Excellence in Postharvest Technologies […]

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Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.

Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. Journal of Chromatography, September 2012. Chen H, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract Ginger is frequently consumed as a spice and has numerous medicinal properties. Extensive research […]

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Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols

Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols. Journal of Agricultural and Food Chemistry. September 2012. Zhu Y, Soroka DN, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract We have identified alkylresorcinols (ARs) as the major active components […]

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Antioxidants to Fiber: Solving Dietary Dilemmas

Common advice given to those pursuing a healthy diet is to eat more fiber, and it is good advice to follow.    Dietary fiber delivers numerous health benefits beginning with a fuller feeling after eating, which contributes to weight loss. Insoluble fiber doesn’t dissolve in water and is found in foods like wheat bran, nuts […]

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Kannapolis Scholars Conference Focuses on the Role of Exercise in Obesity Prevention

  Link to original article The Kannapolis Scholars, a program of N.C. State University at the N.C. Research Campus, is hosting its second conference on how to address the challenges of obesity. “Lost in Translation: A Conversation on Exercise and Obesity” will be held on Friday, July 27, 2012, from 10:15 a.m. to 4 p.m. […]

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An Old-Time Remedy With Modern Proof

by Ruth Kinzey, Refresh             Heading down the produce aisle, it’s common to see fresh ginger root. And while it is a spice frequently used in Indian, Korean, Japanese and Chinese cooking, recently released findings indicate modern science is continuing to learn about the medicinal benefits it offers. At the […]

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Ginger Could Treat Anemia

Tangy and aromatic, ginger is a spice used to flavor meats, vegetables and even baked goods. More than a culinary delight, ginger has been valued for thousands of years for its numerous health benefits. Ginger, which is the rhizome or underground stem of the plant Zingiber officinale, is recognized as a natural solution for digestive […]

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Metabolism of [6]-shogaol in mice and in cancer cells.

Metabolism of [6]-shogaol in mice and in cancer cells. Drug Metablism and Disposition: The Biological Fate of Chemicals, April 2012. Chen H, Lv L, Soroka D, Warin RF, Parks TA, Hu Y, Zhu Y, Chen X, Sang S. North Carolina Agricultural and Technical State University Center for Excellence in Post-Harvest Technologies. Abstract Ginger has received […]

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Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. Journal of Agricultural and Food Chemistry. April 2012. Chiou YS, Ma NJ, Sang S (NC A&T Center for Excellence in Post Harvest Technology), Ho CT, Wang YJ, Pan MH. Department of Seafood Science, National Kaohsiung Marine University, Nanzih District, Kaohsiung, Taiwan. […]

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Researchers from NCCU, N.C. A&T Develop Anemia Treatment

NCCU News Scientists at North Carolina Central University and North Carolina A&T State University have discovered a promising use of ginger that may lead to the development of a treatment for anemia. Dr. TinChung Leung of NCCU and Dr. Shengemin Sang of N.C. A&T will present their findings April 3 at the annual meeting of […]

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The N.C. A&T grant of the month for January: Dietary flavonoids vs. pathogenic link to diabetes

Aggie Research   N.C. A&T received 11 grants totaling $1.80 million in January. One highlight of January’s s funding was a grant worth $489,884 from the USDA Agricultural and Food Initiative to Dr. Shengmin Sang of the Center for Excellence in Post Harvest Technologies, located ta the N.C. Research Campus in Kannapolis. The project:  Dietary flavonoids […]

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Norovirus spreading rapidly in Mecklenburg Co. nursing homes

By Tina Terry MECKLENBURG CO., N.C. WSOC TV The Mecklenburg County Health Department released numbers Friday showing how rapidly the norovirus is spreading through nursing homes. So far this year, between 150 and 200 cases have been reported. About 30 of those are staff members at nursing homes. “This virus spreads pretty quickly from person to person,” said […]

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Norovirus experts at research campus prepare to tackle future outbreaks

By: Sarah Pisciuneri Time Warner Cable News KANNAPOLIS, N.C. – The norovirus is still at outbreak status in eight North Carolina counties. Scientists at the North Carolina Research Campus say though the symptoms are very similar, the virus is not to be confused with the flu. Dr. Leonard Williams, a lead scientist with N.C. A&T who […]

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New grant for dietary research approaches half a million

By ag e-dispatch Dr. Shengmin Sang, lead scientist for functional foods at the Center for Excellence in Post-Harvest Technologies, has received a $490,000 grant from the USDA to research the connection between diabetes and flavonoids, which are a group of compounds found in fruits, vegetables, herbs and teas. Sang’s project was deemed “outstanding” by the USDA’s […]

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Antimicrobial susceptibility testing of Shiga toxin-producing Escherichia coli from various samples by using a spiral gradient endpoint technique.

Antimicrobial susceptibility testing of Shiga toxin-producing Escherichia coli from various samples by using a spiral gradient endpoint technique. Foodborne Pathogens and Disease, January 2012. Khatiwada J, Fullerton M, Davis S, Williams LL. North Carolina A&T State University Center for Excellence in Post-Harvest Technologies. Abstract Shiga toxin-producing Escherichia coli (STEC) remains a major public health concern. […]

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Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats.

Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. Khatiwada J1, Verghese M, Davis S, Williams LL. Abstract Experimental as well as epidemiologic studies in human populations provide evidence that consumption of phytochemicals reduces the incidence of degenerative diseases. Green tea (GT) catechins are known for their […]

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5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth

5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth Yingdong Zhu, Dawn R. Conklin, Huadong Chen, Liyan Wang, Shengmin Sang Abstract We and others have found that wheat bran oil is the active constituent in wheat bran for colon cancer prevention. However, the active components in wheat bran oil are still unknown. Using […]

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Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects

Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects Lv L1, Chen H, Ho CT, Sang S. Abstract Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were […]

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Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide.

Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide. Bansode RR1, Ahmedna M, Svoboda KR, Losso JN. Abstract The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined. The […]

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Genistein inhibits advanced glycation end product formation by trapping methylglyoxal.

Genistein inhibits advanced glycation end product formation by trapping methylglyoxal. Lv L1, Shao X, Chen H, Ho CT, Sang S. Abstract Methylglyoxal (MGO) is a highly reactive endogenous metabolite derived from several nonenzymatic and enzymatic reactions, and identified as a well-known precursor of advanced glycation end products (AGEs). In the present study, genistein, a naturally occurring isoflavone derived from […]

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The chemistry and biotransformation of tea constituents

Sang S, Lambert JD, Ho CT, Yang CS. The chemistry and biotransformation of tea constituents. Pharmacological Research2011 Aug;64(2):87-99. Epub 2011 Mar 1. Abstract Tea (Camellia sinensis, Theaceae) is one of the most widely consumed beverages in the world. The three major types of tea, green tea, oolong tea, and black tea, differ in terms of […]

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Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection

ShaoX,LvL,ParksT,WuH,HoCT,SangS.Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. Journal of Agricultural and Food Chemistry. 2010 Dec 22;58(24):12608-14. Epub 2010 Nov 23. Abstract For the first time, a sensitive reversed-phase HPLC electrochemical array method has been developed for the quantitative analysis of 8 major ginger components ([6]-, [8]-, and […]

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Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandemmassspectrometry.

Shao X,Chen X,Badmaev V,Ho CT,Sang S. Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandemmassspectrometry. Rapid Communications in Mass Spectrometry.2010 Jun 30;24(12):1770-8. Abstract Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the […]

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