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Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood

Jessica L. Bolton, Melanie G. Wiley, Bailey Ryan, Samantha Truong, Melva Strait, Dana Creighton Baker, Nancy Y. Yang, Olga Ilkayeva, Thomas M. O’Connell, Shelley W. Wroth, Cristina L. Sánchez, Geeta Swamy, Christopher Newgard, Cynthia Kuhn, Staci D. Bilbo, Leigh Ann Simmons (2017). Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood. Brain […]

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Recent urbanization in China is correlated with a Westernized microbiome encoding increased virulence and antibiotic resistance genes

Kathryn Winglee, Annie Green Howard, Wei Sha, Raad Z. Gharaibeh, Jiawu Liu, Donghui Jin, Anthony A. Fodor and Penny Gordon-Larsen (2017). Recent urbanization in China is correlated with a Westernized microbiome encoding increased virulence and antibiotic resistance genes. Microbiome 5:121. Author Affiliations Department of Bioinformatics and Genomics, University of North Carolina at Charlotte Department of […]

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LinkageMapView – Rendering High Resolution Linkage and QTL Maps

Lisa A. Ouellette, Robert W. Reid, Steven G. Blanchard Jr., and Cory R. Brouwer (2017) LinkageMapView – Rendering High Resolution Linkage and QTL Maps. Bioinformatics. Author Affiliations Department of Bioinformatics and Genomics, University of North Carolina Charlotte, 150 Research Campus Drive, Suite 3333, Kannapolis, NC, USA. Abstract Linkage and quantitative trait loci (QTL) maps are […]

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Failure to Launch: Targeting Inflammation in Acute Coronary Syndromes

Jennifer A. Rymer, Kristin Newby (2017). Failure to Launch: Targeting Inflammation in Acute Coronary Syndromes. JACC: Basic to Translational Science 2(4) 484-497. Author Affiliations Division of Cardiology, Department of Medicine, and Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina Abstract The importance of inflammation and inflammatory pathways in atherosclerotic disease and […]

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Circadian clock as possible protective mechanism to pollution induced keratinocytes damage

Mascia Benedusi, Elena Frigato, Mattia Beltramello, Cristiano Bertolucci, Giuseppe Valacchi (2017). Circadian clock as possible protective mechanism to pollution induced keratinocytes damage. Mechanisms of Ageing and Development. Author Affiliations Department of Life Sciences and Biotechnology, Section of Medicinal and Health Products, University of Ferrara, I-44121 Ferrara, Italy NC State University, Plants for Human Health Institute, […]

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Structural Analysis of Unsaturated Glycosphingolipids Using Shotgun Ozone-Induced Dissociation Mass Spectrometry

Rodell C. Barrientos, Ngoc Vu, Qibin Zhang (2017) Structural Analysis of Unsaturated Glycosphingolipids Using Shotgun Ozone-Induced Dissociation Mass Spectrometry. Journal of The American Society for Mass Spectrometry 1-4. Author Affiliations 1.Department of Chemistry and Biochemistry The University of North Carolina at Greensboro Greensboro USA 2.UNCG Center for Translational Biomedical Research Kannapolis USA Abstract Glycosphingolipids are […]

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Short-term greenhouse emission lowering effect of biochars from solid organic municipal wastes

Djaafar Rehrah, Rishipal R. Bansode, Osman Hassan, Mohamed Ahmedna (2017) Short-term greenhouse emission lowering effect of biochars from solid organic municipal wastes. International Journal of Environmental Science and Technology 1-10. Author Affiliations 1.Department of Human Nutrition, College of Health Sciences Qatar University Doha Qatar 2.Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus North […]

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Effect of UV irradiation on aflatoxin reduction: a cytotoxicity evaluation study using human hepatoma cell line

Ankit Patras, Sharath Julakanti, Sudheer Yannam, Rishipal R. Bansode, Mallory Burns, Matthew J. Vergne (2017) Effect of UV irradiation on aflatoxin reduction: a cytotoxicity evaluation study using human hepatoma cell line. Mycotoxin Research 1-8. Author Affiliations 1.Food Biosciences and Technology Program, Department of Agricultural and Environmental Sciences Tennessee State University Nashville USA 2. Center for […]

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Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice.

Zhang W, Zhong W, Sun Q, Sun X, Zhou Z (2017) Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice. Scientific Reports 7(1):8976. Author Affiliations 1. Center for Translational Biomedical Research, University of North Carolina Greensboro, North Carolina Research Campus, Kannapolis, NC, 28081, USA. 2. Center for Translational Biomedical […]

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Metabolomics reveal physiological changes in mayfly larvae ( Neocloeon triangulifer ) at ecological upper thermal limits.

Hsuan Chou, Wimal Pathmasiri, Jocelin Deese-Spruill, Susan Sumner, David B Buchwalter (2017). Metabolomics reveal physiological changes in mayfly larvae ( Neocloeon triangulifer ) at ecological upper thermal limits. Journal of Insect Physiology 101 (107-112). Note: The David H. Murdock Research Institute provided NMR services and analysis for this paper. Author Affiliations Graduate Toxicology Program, Department […]

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Impact of Frequency of Multi-Vitamin/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults

Jeffrey B. Blumberg, Balz B. Frei, Victor L. Fulgoni III, Connie M. Weaver and Steven H. Zeisel (2017). Impact of Frequency of Multi-Vitamin/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults. Nutrients 9(8) 849. Author Affiliations 1 Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School […]

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Heritability and Genetic Variance Components Associated with Citrulline, Arginine, and Lycopene Content in Diverse Watermelon Cultigens

Todd C. Wehner, Rachel P. Naegele, Penelope Perkins-Veazie (2017). Heritability and Genetic Variance Components Associated with Citrulline, Arginine, and Lycopene Content in Diverse Watermelon Cultigens. HortScience 52(7) 936-940. Author Affiliations Department of Horticultural Science, North Carolina State University, Raleigh, NC 27695-7609 USDA, Agricultural Research Service, San Joaquin Valley Agricultural Sciences Center, 9611 S. Riverbend Avenue, […]

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Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway.

Guo Z, Zhao M, Howard EW, Zhao Q, Parris AB, Ma Z, Yang X (2017). Phenformin inhibits growth and epithelial-mesenchymal transition of ErbB2-overexpressing breast cancer cells through targeting the IGF1R pathway. Oncotarget. Author Affiliations Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, Kannapolis, North Carolina, USA. Abstract […]

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A proposed approach to accelerate evidence generation for genomic-based technologies in the context of a learning health system.

Lu CY 1, Williams MS 2, Ginsburg GS 3, Toh S 1, Brown JS 1, Khoury MJ 4 (2017). A proposed approach to accelerate evidence generation for genomic-based technologies in the context of a learning health system. Genetics in Medicine. Author Affiliations 1. Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care […]

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production.

Miller, C.; Pachanski, M.J.; Kirkland, M.E.; Kosinski, D.T.; Mane, J.; Bunzel, M.; Cao, J.; Souza, S.; Thomas-Fowlkes, B.; Di Salvo, J.; Weinglass, A.G.; Li, X.; Myers, R.W.; Knagge, K.; Carrington, P.E.; Hagmann, W.K.; Trujillo, M.E.  2017.  GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production.  PLos […]

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In-Hospital Cardiac Arrest: Complex Clinical Challenges in Need of Unique Solutions

Angela Lowenstern, MD, Anant Mandawat, MD, L. Kristin Newby, MD, MHS (2017). In-Hospital Cardiac Arrest: Complex Clinical Challenges in Need of Unique Solutions. American Heart Journal. Author Affiliations: Division of Cardiology, Department of Medicine (AL, AM, LKN) and the Duke Clinical Research Institute (AL, LKN), Duke University Medical Center, Durham, NC Abstract: It is estimated […]

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Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans

Brittany L. Grafa, Shaunak Kamat, Kuan Yu Cheong, Slavko Komarnytsky, Monica Driscoll, Rong Di (2017). Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans. Journal of Functional Foods 37(1-7). Author Affiliations a. Department of Plant Biology and Pathology, Rutgers University, 59 Dudley Rd, New Brunswick, NJ 08901, USA b. Department of Molecular […]

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Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice

Emily A.K. Prieur , Eneda Pjetri, Steven H. Zeisel, Nafisa M Jadavji (2017). Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Applied Physiology, Nutrition, and Metabolism. Abstract Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a […]

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Muskmelon Fruit Quality in Response to Postharvest Essential Oil and Whey Protein Sprays

Chen Jiang, Penelope Perkins-Veazie, Guoying Ma, and Christopher Gunter (2017). Muskmelon Fruit Quality in Response to Postharvest Essential Oil and Whey Protein Sprays. HortScience 52(6) 887-891. Author Affiliations Department of Horticultural Science, North Carolina State University, P.O. Box 7609, 2721 Founders Drive, Raleigh, NC 27695 Department of Horticultural Science, North Carolina State University, P.O. Box […]

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Quercetin and Green Tea Extract Supplementation Downregulates Genes Related to Tissue Inflammatory Responses to a 12-Week High Fat-Diet in Mice

Lynn Cialdella-Kam, Sujoy Ghosh, Mary Pat Meaney, Amy M. Knab, R. Andrew Shanely and David C. Nieman (2017). Quercetin and Green Tea Extract Supplementation Downregulates Genes Related to Tissue Inflammatory Responses to a 12-Week High Fat-Diet in Mice. Nutrients 9(7) 773. Author Affiliations 1 Department of Nutrition, School of Medicine—WG 48, Case Western Reserve University, […]

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Cross-Community Collaboration in Cabarrus County

Mardovich, Sarah (2017). Cross-Community Collaboration in Cabarrus County. North Carolina Medical Journal 78(4) 251-254. Author Affiliation: Cabarrus Health Alliance Abstract: Collaborative action is a part of Cabarrus Health Alliance’s mission statement. This commentary highlights several community-based initiatives that the Alliance has used to contribute to the Healthiest Cities & Counties Challenge, and demonstrates the importance […]

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Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Ramos-Lopez, O.; Milagro F.I.; Allayee H.; Chmurzynska A.; Choi M.S.; Curi R.; De Caterina R.; Ferguson L.R.; Goni L.; Kang J.X.; Kohlmeier M.; Marti A.; Moreno L.A.; Pérusse L.; Prasad C.; Qi L.; Reifen R.; Riezu-Boj J.I.; San-Cristobal R.; Santos J.L.; Martínez J.A (2017). Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition […]

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Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation

Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Lizziane Maria Belloto de Francisco, Elisabetta Esposito, Yunsook Lim, Giuseppe Valacchi, Rita Cortesi, Marcos Luciano Bruschi (2017). Nanostructured lipid systems modified with waste material of propolis for wound healing: Design, in vitro and in vivo evaluation. Colloids and Surfaces B: Biointerfaces, 158(441-452). Author Affiliations: a. Postgraduate […]

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Potassium ascorbate with ribose – promising therapeutic approach for melanoma treatment

Carlotta Cavicchio, Mascia Benedusi, Erika Pambianchi, Alessandra Pecorelli, Franco Cervellati, Vinno Savelli, Duccio Calamandrei, Emilia Maellaro, Giorgio Rispoli, Emanuela Maioli, Giuseppe Valacchi (2017). Potassium ascorbate with ribose – promising therapeutic approach for melanoma treatment. Oxidative Medicine and Cellular Longevity. Author Affiliations 1. Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy; 2. Plants […]

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Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling

Harry Lee, Nipun Saini, Amanda B. Parris, Ming Zhao, Xiaohe Yang (2017). Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. International Journal of Oncology. Author Affiliations Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical Sciences, North Carolina Central University, Kannapolis, NC […]

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Cytokinin induces genome-wide binding of the type-B response regulator ARR10 to regulate growth and development in Arabidopsis

Yan O. Zubo, Ivory Clabaugh Blakley, Maria V. Yamburenko, Jennifer M. Worthen, Ian H. Street, José M. Franco-Zorrilla, Wenjing Zhang, Kristine Hill, Tracy Raines, Roberto Solano, Joseph J. Kieber, Ann E. Loraine, and G. Eric Schaller (2017). Cytokinin induces genome-wide binding of the type-B response regulator ARR10 to regulate growth and development in Arabidopsis. Proceedings […]

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Multiple roles of RARRES1 in prostate cancer: Autophagy induction and angiogenesis inhibition

Arpita Roy, Malathi Ramalinga, Okjin J. Kim, Juliet Chijioke, Solomon Lynch, Stephen Byers, Deepak Kumar (2017). Multiple roles of RARRES1 in prostate cancer: Autophagy induction and angiogenesis inhibition. PLOS One. Author Affiliations Cancer Research Laboratory, University of the District of Columbia, Washington, DC, United States of America Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, […]

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Patulin degradation and cytotoxicity evaluation of UV irradiated apple juice using human peripheral blood mononuclear cells

Sharath Chandra, Ankit Patras, Bharat Pokharel, Rishipal R. Bansode, Afroza Begum, Michael Sasges (2017). Patulin degradation and cytotoxicity evaluation of UV irradiated apple juice using human peripheral blood mononuclear cells. Journal of Food Process Engineering. Author Affiliations Department of Agricultural and Environmental Sciences, Tennessee State University, Nashville, Tennessee Center for Excellence in Post-Harvest Technologies, North […]

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Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women

David C. Nieman, Sivapriya Ramamoorthy, Colin D. Kay, Courtney L. Goodman, Christopher R. Capps, Zack L. Shue, Nicole Heyl, Mary H. Grace, and Mary A. Lila (2017). Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women. Journal of Proteome Research. Author Affiliations Human Performance Lab, Appalachian State […]

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Tissue based metabolite profiling and qualitative comparison of two species of Achyranthes roots by use of UHPLC-QTOF MS and laser micro dissection

Yogini Jaiswal, Zhitao Liang, Alan Ho, Hubiao Chen, Leonard Williams, Zhongzhen Zhao (2017). Tissue based metabolite profiling and qualitative comparison of two species of Achyranthes roots by use of UHPLC-QTOF MS and laser micro dissection. Journal of Pharmaceutical Analysis. Author Affiliations a Center for Excellence in Post-Harvest Technologies, The North Carolina Research Campus, 500 Laureate […]

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Quantitative Trait Loci Mapping of Agronomic and Yield Traits in Two Grain Sorghum Biparental Families

Richard E. Boyles, Brian K. Pfieffer, Elizabeth A. Cooper, Kelsey J. Zielinski, Matthew T. Myers, William L. Rooney and Stephen Kresovich (2017). Quantitative Trait Loci Mapping of Agronomic and Yield Traits in Two Grain Sorghum Biparental Families. Crop Science. Author Affiliations a Advanced Plant Technology Program, Clemson Univ., Clemson, South Carolina 29634 b Pee Dee […]

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Virucidal Activity of Fogged Chlorine Dioxide- and Hydrogen Peroxide-Based Disinfectants against Human Norovirus and Its Surrogate, Feline Calicivirus, on Hard-to-Reach Surfaces

Naim Montazeri, Clyde Manuel, Eric Moorman, Janak R. Khatiwada, Leonard L. Williams and Lee-Ann Jaykus (2017). Virucidal Activity of Fogged Chlorine Dioxide- and Hydrogen Peroxide-Based Disinfectants against Human Norovirus and Its Surrogate, Feline Calicivirus, on Hard-to-Reach Surfaces. Frontiers in Microbiology. Author Affiliations 1 Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, […]

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First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Simone Brogi, Anna Ramunno, 1, Lida Savi, Giulia Chemi, Gloria Alfano, Alessandra Pecorelli, Erika Pambianchi, Paola Galatello, Giulia Compagnoni, Federico Focher, Giuseppe Biamonti, Giuseppe Valacchi, Stefania Butini, Sandra Gemmaa, Giuseppe Campiania, Margherita Brindisi (2017). First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents. European Journal of Medicinal Chemistry. Author Affiliatons a […]

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Who is most affected by prenatal alcohol exposure: Boys or girls?

Philip A. May, Barbara Tabachnick, Julie M. Hasken, Anna-Susan Marais, Marlene M. de Vries, Ronel Barnard, Belinda Joubert, Marise Cloete, Isobel Botha, Wendy O. Kalberg, David Buckley, Zachary R. Burroughs, Heidre Bezuidenhout, Luther K. Robinson, Melanie A. Manning, Colleen M. Adnams, Soraya Seedat, Charles D.H. Parry, H. Eugene Hoyme (2017). Who is most affected by […]

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Satisfying America’s Fruit Gap: Summary of an Expert Roundtable on the Role of 100% Fruit Juice

Carol Byrd-Bredbenner, Mario G. Ferruzzi, Victor L. Fulgoni III, Robert Murray, Elizabeth Pivonka, Taylor C. Wallace (2017). Satisfying America’s Fruit Gap: Summary of an Expert Roundtable on the Role of 100% Fruit Juice. Journal of Food Science. Author Affiliations Dept. of Nutritional Sciences, Rutgers Univ., New Brunswick, N.J., U.S.A Dept. Food, Bioprocessing and Nutrition, North […]

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Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice

Eneda Pjetria, Steven H. Zeisel (2017). Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice. Behavioural Brain Research 332(71-74). Author Affiliations a Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, United States b Department of Nutrition, Gillings Global School of Public Health, University of North Carolina […]

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Pathview Web: user friendly pathway visualization and data integration

Luo W, Pant G, Bhavnasi YK, Blanchard SG Jr, Brouwer C. Pathview Web: user friendly pathway visualization and data integration. Nucleic Acids Res. Abstract Pathway analysis is widely used in omics studies. Pathway-based data integration and visualization is a critical component of the analysis. To address this need, we recently developed a novel R package called Pathview. Pathview maps, […]

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

Corin Miller , Michele J. Pachanski , Melissa E. Kirkland, Daniel T. Kosinski, Joel Mane, Michelle Bunzel, Jin Cao, Sarah Souza, Brande Thomas-Fowlkes, Jerry Di Salvo, Adam B. Weinglass, Xiaoyan Li, Robert W. Myers, Kevin Knagge, Paul E. Carrington, William K. Hagmann, Maria E. Trujillo (2017). GPR40 partial agonist MK-2305 lower fasting glucose in the […]

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Astronaut ophthalmic syndrome

Sara R. Zwart*, Charles R. Gibson†, Jesse F. Gregory‡, Thomas H. Mader§,1, Patrick J. Stover¶, Steven H. Zeisel‖ and Scott M. Smith (2017). Astronaut ophthalmic syndrome. The FASEB Journal. Author Affiliations *Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas, USA; †Coastal Eye Associates, Webster, Texas, USA; ‡Food Science and […]

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Different phenolic compounds selectively slow down the hydrolysis rates of sucrose and isomaltose by mammalian mucosal α-glucosidases

Jongbin Lim 1, Mario G. Ferruzzi 2 and Bruce R. Hamaker 1 (2017). Different phenolic compounds selectively slow down the hydrolysis rates of sucrose and isomaltose by mammalian mucosal α-glucosidases. The FASEB Journal 31(1). Author Affiliations 1Purdue University, West Lafayette, IN 2North Carolina State University, Kannapolis, NC Abstract The mucosal α-glucosidases are major enzymes which […]

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Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network

Nina R. Sperber, Janet S. Carpenter, Larisa H. Cavallari, Laura J. Damschroder, Rhonda M. Cooper-DeHoff, Joshua C. Denny, Geoffrey S. Ginsburg, Yue Guan, Carol R. Horowitz, Kenneth D. Levy, Mia A. Levy, Ebony B. Madden, Michael E. Matheny, Toni I. Pollin, Victoria M. Pratt, Marc Rosenman, Corrine I. Voils, Kristen W. Weitzel, Russell A. Wilke, […]

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Identification and Characterization of a Class of MALAT1-like Genomic Loci

Bin Zhang, Yuntao S. Mao, Sarah D. Diermeier, Irina V. Novikova, Eric P. Nawrocki, Tom A. Jones, Zsolt Lazar, Chang-Shung Tung, Weijun Luo, Sean R. Eddy (2017). Identification and Characterization of a Class of MALAT1-like Genomic Loci. Cell Reports 19(8). Author Affiliations 1 Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, […]

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Protein-polyphenol particles for delivering structural and health functionality

E. Allen Foegeding, Nathalie Plundrich, Margaret Schneider, Caroline Campbell, Mary Ann Lila (2017). Protein-polyphenol particles for delivering structural and health functionality. Food Hydrocolloids. Author Affiliations 1 Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, USA 2 Plants for Human Health Institute, North Carolina State University at the North Carolina […]

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Bridging Research, Education and Practice across disciplines: Need for Nutrition Education/Innovation Programme (NNEdPro)

Shivani Bhat 1, Martin Kohlmeier 1,2 and Sumantra Ray 1 (2017). Bridging Research, Education and Practice across disciplines: Need for Nutrition Education/Innovation Programme (NNEdPro). The FASEB Journal 31(1). Author Affiliations 1. NNEdPro Global Centre for Nutrition and Health, Cambridge, United Kingdom 2. Nutrition in Medicine, UNC Chapel Hill, University of North Carolina, Chapel Hill, NC […]

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Linking Nutrition and Molecular Biology Using Data Mining and Graph Theory

Richard Linchangco, Jeremy J Jay and Cory Brouwer (2017). Linking Nutrition and Molecular Biology Using Data Mining and Graph Theory. The FASEB Journal 31(1). Author Affiliations Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC Abstract Cardiovascular disease, cancer, and diabetes are among the leading causes of death in the United States. Factors […]

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Replication of High Fetal Alcohol Spectrum Disorders Prevalence Rates, Child Characteristics, and Maternal Risk Factors in a Second Sample of Rural Communities in South Africa

Philip A. May 1,2,3,* , Marlene M. De Vries 2, Anna-Susan Marais 2, Wendy O. Kalberg 3, David Buckley 3, Colleen M. Adnams 4, Julie M. Hasken 1 et al (2017). Replication of High Fetal Alcohol Spectrum Disorders Prevalence Rates, Child Characteristics, and Maternal Risk Factors in a Second Sample of Rural Communities in South […]

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Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection

Nathalie Plundrich, Mary Ann Lila, Edward Foegeding, Scot Laster (2017). Protein-bound polyphenols create “ghost” band artifacts during chemiluminescence-based antigen detection. F1000 Research 6(254). Author Affiliations Plants for Human Health Institute , North Carolina Research Campus, North Carolina State University Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, North Carolina, USA Department of Biological Sciences, North Carolina State University, North Carolina, USA Abstract Antigen detection during Western blotting commonly utilizes a horseradish peroxidase-coupled secondary antibody and enhanced chemiluminescent substrate. We utilized this technique to examine the impact of green tea-derived polyphenols on the binding of egg white protein-specific IgE antibodies from allergic human plasma to their cognate antigens. Our experiments unexpectedly showed that green tea-derived polyphenols, when stably complexed with egg white proteins, caused hyperactivation of horseradish peroxidase resulting in the appearance of white “ghost” bands. This study suggests that caution should be taken when evaluating polyphenol-bound proteins by enhanced chemiluminescence Western blotting using horseradish peroxidase and demonstrates that protein-bound polyphenols can be a source of “ghost” band artifacts on Western blots.

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Choline, Other Methyl-Donors and Epigenetics

Steven H. Zeisel (2017). Choline, Other Methyl-Donors and Epigenetics. Nutrients 9(445). Author Affiliations UNC Nutrition Research Institute, Departments of Nutrition and Pediatrics, University of North Carolina at Chapel Hill, 500 Laureate Drive, Kannapolis, NC 28081, USA; steven_zeisel@unc.edu; Tel.: +1-704-250-5006 Abstract Choline dietary intake varies such that many people do not achieve adequate intakes. Diet intake […]

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The role of gut microbiota on the metabolism of black tea theaflavins

Shuwei Zhang 1, Christina L Ohland 2, Christian Jobin 2 and Shengmin Sang 1 (2017). The role of gut microbiota on the metabolism of black tea theaflavins. The FASEB Journal 31(1). Author Affiliations 1 Laboratory for Functional Foods and Human Health, North Carolina A&T State University, Kannapolis, NC 2 University of Florida, Gainesville, FL Abstract […]

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Avenacosides: Metabolism, and potential use as exposure biomarkers of oat intake

Pei Wang, Junli Yang, Aaron Yerke, Shengmin Sang (2017). Avenacosides: Metabolism, and potential use as exposure biomarkers of oat intake. Molecular Nutrition & Food Research. Author Affiliations Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, Kannapolis, NC, USA Abstract Scope Exposure biomarkers used […]

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Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells

Emily F. Warner, Michael J. Smith, Qingzhi Zhang, K. Saki Raheem, David O’Hagan, Maria A. O’Connell, Colin D. Kay (2017). Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells. Molecular Nutrition & Food Research. Author Affiliations Department of Nutrition, Norwich Medical School, Bob Champion Research and Education Building, […]

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Monoolein aqueous dispersions as a delivery system for quercetin

Rita Cortesi, Enrica Cappellozza, Markus Drechsler, Catia Contado, Anna Baldisserotto, Paolo Mariani, Federica Carducci, Alessandra Pecorelli, Elisabetta Esposito, Giuseppe Valacchi (2017). Monoolein aqueous dispersions as a delivery system for quercetin. Biomedical Microdevices 19(41). Author Affiliations 1. Department of Life Sciences and Biotechnology University of Ferrara Ferrara Italy 2. BIMF / Soft Matter Electron microscopy University […]

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Avenanthramides and their microbial metabolites as the urinary exposure markers for whole grain oat intake: a kinetic study in humans

Shengmin Sang, Pei Wang and Aaron Yerke (2017). Avenanthramides and their microbial metabolites as the urinary exposure markers for whole grain oat intake: a kinetic study in humans. The FASEB Journal 31(1). Author Affiliations Laboratory for Functional Foods and Human Health, North Carolina A&T State University, Kannapolis, NC Abstract Oats are commonly consumed as whole […]

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Nutritional Changes During Biofortified Maize Fermentation (Steeping) for Ogi Production

Darwin Ortiz 1, Smith Nkhata 1, Aimee Buechler 1, Torbert Rocheford 2 and Mario G. Ferruzzi 3 (2017). Nutritional Changes During Biofortified Maize Fermentation (Steeping) for Ogi Production. The FASEB Journal 31(1). Author Affiliations 1 Department of Food Science, Purdue University, West Lafayette, IN 2 Department of Agronomy, Purdue University, West Lafayette, IN 3 Plants […]

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Dietary genistein inhibits methylglyoxal-induced advanced glycation end products formation in high-fat diet-fed mice

Yantao Zhao, Pei Wang and Shengmin Sang (2017). Dietary genistein inhibits methylglyoxal-induced advanced glycation end products formation in high-fat diet-fed mice. The FASEB Journal 31(1). Author Affiliations Laboratory for Functional Foods and Human Health, North Carolina A&T State University, Kannapolis, NC Abstract The formation and accumulation of advanced glycation end products (AGEs) was considered as […]

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Seven Day Blackberry Feeding Lowers the Respiratory Quotient in Males And Improves Insulin Sensitivity

Patrick Solverson 1,2, William Rumpler 1, Jayme L Leger 1, Benjamin Redan 3, Mario G Ferruzzi 4, David J Baer 1 and Janet A Novotny 1 (2017). Seven Day Blackberry Feeding Lowers the Respiratory Quotient in Males And Improves Insulin Sensitivity. The FASEB Journal 31(1). Author Affiliations 1 Beltsville Human Nutrition Research Center, USDA, Beltsville, […]

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Dietary Long-chain PUFAs Enrich Porcine Alveolar Macrophages and Alter Prostaglandin E2 Production Following LPS Challenge

Kathleen R Walter 1, Lin Xi 1, Sheila K Jacobi 2, Debora Esposito 3 and Jack Odle 1 (2017). Dietary Long-chain PUFAs Enrich Porcine Alveolar Macrophages and Alter Prostaglandin E2 Production Following LPS Challenge. The FASEB Journal 31 (1). Author Affiliations 1 Animal Science, North Carolina State University, Raleigh, NC 2 Animal Science, Ohio State […]

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Health Modifying Regions in the Oat (Avena sativa) Genome Responsible for Beneficial Effects on Immune and Gastrointestinal Health

Weston Woodrow Bussler 1,2, Katelyn Dezego 1,4, Mikayla Bowen 1,5, Ashley Buige 1,5, Debora Esposito 1,3, Mary Ann Lila 1,2 and Slavko Komarnytsky 1,2 (2017). Health Modifying Regions in the Oat (Avena sativa) Genome Responsible for Beneficial Effects on Immune and Gastrointestinal Health. The FASEB Journal 31(1). Author Affiliations 1 Plants for Human Health Institute, […]

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In vitro Hypoallergenic Potential of Peanut Protein-Polyphenol Aggregate Particles

Nathalie J. Plundrich 1, Rishipal R. Bansode 2, Leonard L. Williams 2 and Mary Ann Lila 1 (2017). In vitro Hypoallergenic Potential of Peanut Protein-Polyphenol Aggregate Particles. The FASEB Journal 31(1). Author Affiliations 1 Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, North Carolina Research Campus, Kannapolis, […]

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Influence of Ingesting a Flavonoid-Rich Supplement On the Human Metabolome and Concentration of Urine Phenolics

David C. Nieman 1, Sivapriya Ramamoorthy 2, Colin D. Kay 3, Courtney L. Goodman 1, Christopher R. Capps 1, Zachary L Shue 1, Nicole Heyl 1, Mary H. Grace 3 and Mary Ann Lila 3 (2017). Influence of Ingesting a Flavonoid-Rich Supplement On the Human Metabolome and Concentration of Urine Phenolics. The FASEB Journal 31(1). […]

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Levels and formation of α-dicarbonyl compounds in beverages and the preventive effects of flavonoids

Chen Wang, Yongling Lu, Qiju Huang, Tiesong Zheng, Shengmin Sang, Lishuang Lv (2017). Levels and formation of α-dicarbonyl compounds in beverages and the preventive effects of flavonoids. Journal of Food Science and Technology (1-11). Author Affiliations: Department of Food Science and Technology Nanjing Normal University Nanjing People’s Republic of China 2.Center for Excellence in Post-Harvest Technologies North Carolina Agricultural […]

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Genetics of acute kidney injury markers in Hispanic children: the Viva La Familia Study.

Itzel Vazquez-Vidal 1, Geetha Chittoor 1, Baba Mass 1, Karin Haack 2, Sandra Laston 3, Nitesh Mehta 4, Anthony G Comuzzie 2, Shelley Cole 2, Nancy Butte 4 and V. Saroja Voruganti 1 (2017). Genetics of acute kidney injury markers in Hispanic children: the Viva La Familia Study. The FASEB Journal 31(1). Author Affiliations: 1. […]

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Influence of Carbohydrate Ingestion from Bananas or Sugar Beverage on 9- and 13-Hydroxy-octadecadienoic acids (9 + 13 HODE) During Recovery from 75-km Cycling

David C. Nieman 1, Nicholas D. Gillitt 2, Kevin J. Knagge 3, Huiyuan Chen 3, Courtney L. Goodman 1, Christopher R. Capps 1, Zachary L. Shue 1 and Nicole Heyl 1 (2017). Influence of Carbohydrate Ingestion from Bananas or Sugar Beverage on 9- and 13-Hydroxy-octadecadienoic acids (9 + 13 HODE) During Recovery from 75-km Cycling. […]

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Relationship in Broccoli Between Genetic Mapping and Small Molecule Profiling Using NMR Spectroscopy

Kevin Knagge 1, Gad Yousef 2, Jason Winnike 1, Kyle Blankenship 1, Aswathy Thomas 2 and Allan Brown 2 (2017). Relationship in Broccoli Between Genetic Mapping and Small Molecule Profiling Using NMR Spectroscopy. The FASEB Journal 31(1). Author Affiliations: 1. David H Murdock Research Institute, Kannapolis, NC 2. Plants for Human Health Institute, North Carolina […]

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Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research

Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research, Genetics in Medicine, Kathryn A. Phillips PhD, Patricia A. Deverka MD, MS,  Harold C. Sox MD, Muin J. Khoury MD, PhD, Lewis G. Sandy MD, FACP, Geoffrey S. Ginsburg MD, PhD, Sean R. Tunis MD, MSc, Lori A. Orlando MD, MHS, Michael P. Douglas MS Department […]

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Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory

Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory, Molecular Nutrition and Food Research, Kimberly M. Palatini Jackson, Thirumurugan Rathinasabapathy, Debora Esposito, Slavko Komarnytsky. Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA Abstract Scope Chicory (Cichorium intybus L.) is a perennial herb often consumed as […]

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p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells

p53 pathway determines the cellular response to alcohol-induced DNA damage in MCF-7 breast cancer cells, PLOS One, Ming Zhao, Erin W. Howard, Zhiying Guo, Amanda B. Parris, Xiaohe Yang.  Department of Biological and Biomedical Sciences, Julius L. Chambers Biomedical/Biotechnology Research Institute (BBRI), North Carolina Central University, Kannapolis, North Carolina Abstract Alcohol consumption is associated with increased breast cancer risk; however, […]

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Obesity, Diabetes, and Acute Coronary Syndrome: Differences between Asians and Whites

Obesity, Diabetes, and Acute Coronary Syndrome: Differences between Asians and Whites, The American Journal of Medicine, Masaya Koshizaka, MD, PhDa, b, , , Renato D. Lopes, MD, PhD, MHSa, L. Kristin Newby, MD, MHSa, Robert M. Clare, MSa, Phillip J. Schulte, PhDa, Pierluigi Tricoci, MD, MHSa, Kenneth W. Mahaffey,MDc, Hisao Ogawa, MD, PhDd, David J. Moliterno, MDe, Robert P. Giugliano, MD, SMf, Kurt Huber, MDg, Stefan James, MD, […]

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Relationship Between Peak Troponin Values and Long‐Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes

Relationship Between Peak Troponin Values and Long‐Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes, Journal of the American Heart Association, Sarah A. Goldstein, L. Kristin Newby, Derek D. Cyr, Megan Neely, Thomas F. Lüscher, Eileen B. Brown, Harvey D. White, E. Magnus Ohman, Matthew T. Roe, Christian W. Hamm Abstract Duke Clinical Research […]

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Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection

Thomas W. Burke, Ricardo Henao, Erik Soderblom, Ephraim L. Tsalik, J. Will Thompson, Micah T. McClaina, Marshall Nichols, Bradly P. Nicholson, Timothy Veldman, Joseph E. Lucas, M. Arthur Moseley, Ronald B. Turner, Robert Lambkin-Williams, Alfred O. Hero III, Christopher W. Woods, Geoffrey S. Ginsburg (2017). Nasopharyngeal Protein Biomarkers of Acute Respiratory Virus Infection. EBioMedicine. Author […]

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Phytochemicals in quinoa and amaranth grains and their antioxidant, anti-inflammatory and potential health beneficial effects: a review

Yao Tang, Rong Tsao (2017). Phytochemicals in quinoa and amaranth grains and their antioxidant, anti-inflammatory and potential health beneficial effects: a review. Molecular Nutrition & Food Research. Author Affiliations: Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, Kannapolis, NC, USA Guelph Research and […]

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Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes

Michael A. Timmers, Mary H. Grace, Gad G. Yousef, Mary Ann Lila (2017). Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes. Journal of Food Composition and Analysis 59:105-110. Author Affiliations: Plants for Human Health Institute, North Carolina State University, NCRC, 600 Laureate Way, Kannapolis, NC, 28081, USA Abstract: […]

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Entire plastid phylogeny of the carrot genus ( Daucus , Apiaceae): Concordance with nuclear data and mitochondrial and nuclear DNA insertions to the plastid 1

David M. Spooner, Holly Ruess, Massimo Iorizzo, Douglas Senalik, and Philipp Simon (2017). Entire plastid phylogeny of the carrot genus (Daucus, Apiaceae): Concordance with nuclear data and mitochondrial and nuclear DNA insertions to the plastid 1. American Journal of Botany 104 (2):1 –17. Author Affiliations U.S. Department of Agriculture, Agricultural Research Service, Vegetable Crops Research […]

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Protective Effects of Topical Vitamin C Compound Mixtures Against Ozone-Induced Damage In Human Skin

Giuseppe Valacchi, Alessandra Pecorelli, Giuseppe Belmonte, Erika Pambianchi, Franco Cervellati, Stephen Lynch, Yevgeniy Krol, Christian Oresajo, (2017). Protective Effects of Topical Vitamin C Compound Mixtures Against Ozone-Induced Damage In Human Skin. Journal of Investigative Dermatology. Author Affiliations 1 Plants for Human Health Institute, Department of Animal Sciences, NC State University, NC Research Campus, 600 Laureate […]

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Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms

Aurélie de Rus Jacquet, Michael Timmers, Sin Ying Ma, Andrew Thieme, George P. McCabe, Jay Hansford C. Vest, Mary Ann Lila, Jean-Christophe Rochet (2017). Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms. Journal of Ethnopharmacology. Author Affiliations a. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, […]

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Metabolic Effects of Berries with Structurally Diverse Anthocyanins

John Overall, Sierra A. Bonney, Mickey Wilson, Arnold Beermann III, Mary H. Grace, Debora Esposito, Mary Ann Lila, and Slavko Komarnytsky (2017). Metabolic Effects of Berries with Structurally Diverse Anthocyanins. International Journal of Molecular Sciences 18(2), 422. Author Affiliations 1. Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, 600 Laureate […]

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Effect of biochars produced from solid organic municipal waste on soil quality parameters

P. Randolph, R.R. Bansode, O.A. Hassan, Dj. Rehrah, R. Ravella, M.R. Reddy, D.W. Watts, J.M. Novak, M. Ahmedna (2017). Effect of biochars produced from solid organic municipal waste on soil quality parameters. Journal of Environmental Management 192(271-280). Author Affiliations Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research […]

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The effective rate of influenza reassortment is limited during human infection

Ashley Sobel Leonard, Micah T. McClain, Gavin J. D. Smith, David E. Wentworth, Rebecca A. Halpin, Xudong Lin, Amy Ransier, Timothy B. Stockwell, Suman R. Das, Anthony S. Gilbert, Rob Lambkin-Williams, Geoffrey S. Ginsburg, Christopher W. Woods, Katia Koelle, Christopher J. R. Illingworth (2017). The effective rate of influenza reassortment is limited during human infection. […]

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α-Amylase and α- Glucosidase Inhibitory Activities of Phenolic Extracts From Eucalyptus grandis x E. urophylla Bark

Ping Jiang, Jia Xiong, Fei Wang, Mary H. Grace, Mary Ann Lila, Rui Xu1 (2017). α-Amylase and α- Glucosidase Inhibitory Activities of Phenolic Extracts From Eucalyptus grandis x E. urophylla Bark. Author Affiliations 1. College of Chemical Engineering, Nanjing Forestry University, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Nanjing, Jiangsu 210037, China; 2.Plants […]

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Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci

Daniel S. Lupu, Luz D. Orozco, Ying Wang, John M. Cullen, Matteo Pellegrini and Steven H. Zeisel (2017). Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci. The FASEB Journal 31(2). Author Affiliations Department of Nutrition, Nutrition Research […]

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Phytochemicals in whole grain wheat and their health-promoting effects

Yingdong Zhu, Shengmin Sang (2017). Phytochemicals in whole grain wheat and their health-promoting effects. Molecular Nutrition & Food Research. Accepted Author Manuscript. Author Affiliations Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, Kannapolis, NC, United States Abstract Accumulated evidence in epidemiological studies has […]

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Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study

Chittoor G, Haack K, Mehta NR, Laston S, Cole SA, Comuzzie AG, Butte NF, Voruganti VS (2017). Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study. BMC Medical Genetics. 18(1):6. Author Affiliations Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate […]

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Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate (Papio hamadryas Sp.).

Peter Kochunov Hsiao-Ying Wey, Peter T. Fox, Jack L. Lancaster, Michael D. Davis, Danny J. Wang, Ai-Ling Lin, Raul A. Bastarrachea, Marcia C. Andrade, Patrice Frost, Paul B. Higgins, Vicki Mattern, Anthony G. Comuzzie and Venkata Saroja Voruganti (2017). Changes in cerebral blood flow during an alteration in glycemic state in a large non-human primate […]

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Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway

Chethan Sampath, Muhammed Raihan Rashid, Shengmin Sang, Mohamed Ahmedna. 2017. Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway. Food Chemistry. 226: 79-88. Author Affiliations a Department of Human Nutrition, College of Health Sciences, Qatar University, Qatar b Center for Excellence in Post-Harvest Technologies, […]

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Impact of polyphenols on physiological stress and cardiac burden in marathon runners – results from a substudy of the BeMAGIC study

Sebastian Clauss, Johannes Scherr, Alan Hanley, Jens Schneider, Ina Klier, Korbinian Lackermair, Eva Hoster, Michael Vogeser, David C. Nieman, Martin Halle, Thomas Nickel. Impact of polyphenols on physiological stress and cardiac burden in marathon runners – results from a substudy of the BeMAGIC study. Applied Physiology, Nutrition, and Metabolism 10.1139/apnm-2016-0457. Abstract Introduction Both physiologic stress […]

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Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer

Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer. Scientific Reports 7 (2017). Author Affiliations Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 […]

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Whole grain oats, more than just a fiber: role of unique phytochemicals

Shengmin Sang, YiFang Chu. Whole grain oats, more than just a fiber: role of unique phytochemicals. Molecular Nutrition & Food Research (2016). Author Affiliations Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC, USA Quaker Oats Center of […]

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Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice

Zhikun Ma, Amanda B. Parris, Zhengzheng Xiao, Erin W. Howard, Stanley D. Kosanke, Xiaoshan Feng and Xiaohe Yang. Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice. Journal of Experimental & Clinical Cancer Research (2017)36:6. Author Affiliations Julius L. Chambers Biomedical/Biotechnology Research Institute, Department of Biological and Biomedical […]

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Fasting Glucose, NT-proBNP, Treatment with Eptifibatide, and Outcomes in Non–ST-Segment Elevation Acute Coronary Syndromes: An Analysis from EARLY ACS

Serdar Farhan, Robert M. Clare, Rudolf Jarai, Robert P. Giugliano, Yuliya Lokhnygina, Robert A. Harrington, L. Kristin Newby, 1, Kurt Huber. Fasting Glucose, NT-proBNP, Treatment with Eptifibatide, and Outcomes in Non–ST-Segment Elevation Acute Coronary Syndromes: An Analysis from EARLY ACS. International Journal of Cardiology (2017). Author Affiliations a. 3rd Department of Internal Medicine, Cardiology, and […]

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4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation

Giuseppe Valacchi, Alessandra Pecorelli, Carlo Cervellati, Joussef Hayek. 4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation. Free Radical Biology and Medicine (2017). Author Affiliations a. Plants for Human Health Institute, Department of Animal Sciences, NC State University, NC Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA b. Department of Life Sciences and Biotechnology, […]

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Transcript Polymorphism Rates in Soybean Seed Tissue Are Increased in a Single Transformant of Glycine max

Kevin C. Lambirth, Adam M. Whaley, Jessica A. Schlueter, Kenneth J. Piller, and Kenneth L. Bost. Transcript Polymorphism Rates in Soybean Seed Tissue Are Increased in a Single Transformant of Glycine max. International Journal of Plant Genomics (2016). Author Affiliations 1. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, North Carolina Research […]

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Off-line mixed-mode liquid chromatography coupled with reversed phase high performance liquid chromatography-high resolution mass spectrometry to improve coverage in lipidomics analysis

Mónica Narváez-Rivas, Ngoc Vu, Guan-Yuan Chen, Qibin Zhang. Off-line mixed-mode liquid chromatography coupled with reversed phase high performance liquid chromatography-high resolution mass spectrometry to improve coverage in lipidomics analysis. Analytica Chimica Acta (2016). Author Affiliations a Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA […]

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Up-Regulation of Follistatin-Like 1 By the Androgen Receptor and Melanoma Antigen-A11 in Prostate Cancer

Shifeng Su, Amanda B. Parris, Gail Grossman, James L. Mohler, Zengjun Wang, Elizabeth M. Wilson. Up-Regulation of Follistatin-Like 1 By the Androgen Receptor and Melanoma Antigen-A11 in Prostate Cancer. The Prostate (2016). Author Affiliations Laboratories for Reproductive Biology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina State Key Laboratory of Reproductive Medicine, […]

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One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography

Mary H. Grace, Yin Qiang, Shengmin Sang, Mary Ann Lila. One-step isolation of carnosic acid and carnosol from rosemary by centrifugal partition chromatography. Journal of Separation Science (2016). Author Affiliations Plants for Human Health Institute, Food Bioprocessing and Nutrition Sciences Department, North Carolina State University, North Carolina Research Campus Center for Excellence in Post-Harvest Technologies, […]

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Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments

Mahendra Dia, Todd C Wehner, Penelope Perkins-Veazie, Richard Hassell, Daniel S Price, George E Boyhan, Stephen M Olson, Stephen R King, Angela R Davis, Gregory E Tolla, Jerome Bernier & Benito Juarez. Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments (2016). Horticulture Research 3, Article number: 16066. Author Affiliations Department […]

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IL-6 Linkage to Exercise-Induced Shifts in Lipid-Related Metabolites: A Metabolomics-Based Analysis

David C. Nieman, Wei Sha, and Kirk L Pappan. IL-6 Linkage to Exercise-Induced Shifts in Lipid-Related Metabolites: A Metabolomics-Based Analysis. Journal of Proteome Research (2016). Author Affiliations: Appalachian State University Human Performance Laboratory in Kannapolis, North Carolina Abstract: Metabolomics profiling and bioinformatics technologies were used to determine the relationship between exercise-induced increases in IL-6 and […]

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Genetic dissection of sorghum grain quality traits using diverse and segregating populations

Richard E. Boyles, Brian K. Pfeiffer, Elizabeth A. Cooper, Bradley L. Rauh, Kelsey J. Zielinski, Matthew T. Myers, Zachary Brenton, William L. Rooney, Stephen Kresovich. Genetic dissection of sorghum grain quality traits using diverse and segregating populations. Theoretical and Applied Genetics (2016). Author Affiliations 1. Department of Genetics and Biochemistry Clemson University Clemson, USA 2. […]

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Androgen receptor regulation by histone Methyltransferase suppressor of variegation 3-9 homolog 2 andMelanomaantigen-A11

Emily B. Askew, Suxia Bai, Amanda B. Parris, John T. Minges, Elizabeth M. Wilson. Androgen receptor regulation by histone Methyltransferase suppressor of variegation 3-9 homolog 2 andMelanomaantigen-A11. Molecular and Cellular Endocrinology 2016. Author Affiliations: Laboratories for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, and Department of Biochemistry and Biophysics, University of North Carolina, […]

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Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity

Chethan Sampath, Muhammed Raihan Rashid, Shengmin Sang, Mohamed Ahmedn. Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity. Biomedicine & Pharmacotherapy 2017:87(73-81). Author Affiliations: Department of Human Nutrition, College of HealthSciences, Qatar University, Doha, 2713, Qatar Laboratory for Functional Foods and Human […]

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Comparison of two models for gene-environment interactions: An example of simulated gene-medication interactions on systolic blood pressure

Fernandez-Rhodes L, Hodonsky CJ, Graff M, Love SM, Howard AG, Seyerle AA, Avery CL, Chittoor G, Franceschini N, Voruganti VS, Young KL, O’Connell JR, North KE, Justice AE. Comparison of two models for gene-environment interactions: An example of simulated gene-medication interactions on systolic blood pressure. BMC Proceedings. 10(Suppl 7):65. Author Affiliations 1.Department of Epidemiology University […]

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Genome-wide association of trajectories of systolic blood pressure change

Justice AE, Howard AG, Chittoor G (equal contribution as first author), Fernandez-Rhodes L, Graff M, Voruganti VS, Diao G, Love SM, Franceschini, N, O’Connell JR, Avery CL, Young KL, North KE. Genome-wide association of trajectories of systolic blood pressure change. BMC Proceedings. 10(Suppl 7):56. Author Affiliations 1. Department of Epidemiology University of North Carolina Chapel […]

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The Latino Eyelid: Anthropometric Analysis of a Spectrum of Findings

Fry CL, Naugle TC, Cole SA, Gelfond J, Chittoor G, Mariani AF, Goros MW, Haik BG, Voruganti VS. The Latino eyelid: anthropometric analysis of a spectrum of findings. Ophthal Plast Reconstr Surg. 2016 Nov 15. Author Affiliations Department of Ophthalmology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas Department of […]

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Characterization of the cytokinin-responsive transcriptome in rice

Tracy Raines, Ivory C. Blakley, Yu-Chang Tsai, Jennifer M. Worthen, José Manuel Franco-Zorrilla, Roberto Solano, G. Eric Schaller, Ann E. Loraine and Joseph J. Kieber (2016). Characterization of the cytokinin-responsive transcriptome in rice. BMC Plant Biology 16:260. Sequencing was done at the David H. Murdock Research Institute in Kannapolis. Author Affiliations Department of Biology, University […]

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Altered Transport and Metabolism of Phenolic Compounds in Obesity and Diabetes: Implications for Functional Food Development and Assessment

Benjamin W Redan, Kimberly K Buhman, Janet A Novotny, and Mario G Ferruzzi (2016). Altered Transport and Metabolism of Phenolic Compounds in Obesity and Diabetes: Implications for Functional Food Development and Assessment. Advances in Nutrition vol. 7: 1090-1104. Author Affiliations 3. Interdepartmental Nutrition Program, Department of Nutrition Science, and 4. Department of Food Science, Purdue […]

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Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner

Carol L. Cheatham, Itzel Vazquez-Vidal, Amanda Medlin and V. Saroja Voruganti (2016). Blueberry Consumption Affects Serum Uric Acid Concentrations in Older Adults in a Sex-Specific Manner. Antioxidants 2016, 5(4), 43; doi:10.3390/antiox5040043. Author Affiliations 1. Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 2. Nutrition Research Institute, […]

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Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress

Rita Canella, Marta Martini, Roberta Borriello, Carlotta Cavicchio, Ximena M Muresan, Mascia Benedusi, Franco Cervellati, Giuseppe Valacchi (2016). Modulation of Chloride Currents in Human Lung Epithelial Cells Exposed to Exogenous Oxidative Stress. Journal of Cellular Physiology doi: [10.1002/jcp.25705] Author Affiliations Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy Department of Animal Science, […]

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Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches

Yingdong Zhu, Pei Wang, Wei Sha & Shengmin Sang (2016). Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches. Scientific Reports 6. Author Affiliations Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC, […]

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Epigenetics: A tug of war for DNA methylation

Tzung-Fu Hsieh (2016). Epigenetics: A tug of war for DNA methylation. Nature Plants. Author Affiliation Plant and Microbial Biology Department and Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, North Carolina 28081, USA A new study uncovers thousands of RNA-directed DNA methylation target sites masked by […]

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Redox regulation of inflammatory processes

Giuseppe Valacchia, Carlo Cervellati, Pablo Evelson, Irfan Rahman (2016). Redox regulation of inflammatory processes. The International Journal of Biochemistry & Cell Biology. Author Affiliations Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy Department of Animal Science, NC State University, Plants for Human Health Institute, NC Research Campus, Kannapolis, NC, USA Department of […]

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Evaluating common data models for use with a longitudinal community registry

Maryam Garzaa, Guilherme Del Fiolb, Jessica Tenenbaumc, Anita Waldena, Meredith Zozusc (2016). Evaluating common data models for use with a longitudinal community registry. Journal of Biomedical Informatics. Author Affiliations Duke Translational Medicine Institute, Duke University, 2424 Erwin Road, Hock Plaza Box 3850, Durham, NC 27705, USA Department of Biomedical Informatics, University of Utah School of […]

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An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage

Makoto Inoue, Po-han Chen, Stephen Siecinski, Qi-jing Li, Chunlei Liu, Lawrence Steinman, Simon G. Gregory, Eric Benner, Mari L Shinohara (2016). An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage. Nature Neuroscience. Author Affiliations Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA. Department of Comparative Biosciences, College of Veterinary […]

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Evaluating common data models for use with a longitudinal community registry

Maryam Garza, Guilherme Del Fiol, Jessica Tenenbaum, Anita Walden, Meredith Zozus (2016). Evaluating common data models for use with a longitudinal community registry. Journal of Biomedical Informatics. Author Affiliations: a. Duke Translational Medicine Institute, Duke University, 2424 Erwin Road, Hock Plaza Box 3850, Durham, NC 27705, USA b. Department of Biomedical Informatics, University of Utah […]

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Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)

Katie A. Meyer; Thomas Z. Benton; Brian J. Bennett; David R. Jacobs Jr; Donald M. Lloyd‐Jones; Myron D. Gross; J. Jeffrey Carr; Penny Gordon‐Larsen; Steven H. Zeisel (2016). Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA). Journal of the American Heart Association. Author Affiliations: […]

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Event-related potential differences in children supplemented with long-chain polyunsaturated fatty acids during infancy

Ke Liao, Bruce D. McCandliss, Susan E. Carlson, John Colombo, D. Jill Shaddy, Elizabeth H. Kerling, Rebecca J. Lepping, Wichian Sittiprapaporn, Carol L. Cheatham, Kathleen M. Gustafson (2016). Event-related potential differences in children supplemented with long-chain polyunsaturated fatty acids during infancy. Developmental Science. Author Affiliations: Hoglund Brain Imaging Center, University of Kansas Medical Center, USA […]

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FIE, a nuclear PRC2 protein, forms cytoplasmic complexes in Arabidopsis thaliana

Moran Oliva, Yana Butenko, Tzung-Fu Hsieh, Ofir Hakim, Aviva Katz, Nechama I. Smorodinsky, Daphna Michaeli, Robert L. Fischer and Nir Ohad (2016). FIE, a nuclear PRC2 protein, forms cytoplasmic complexes in Arabidopsis thaliana. Journal of Experimental Biology, 67(19). Author Affiliations: 1 Department of Molecular Biology and Ecology of Plant, The George S. Wise Faculty of […]

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Variations in chlorogenic acid levels in an expanded gene pool of blueberries

Gad G. Yousef 1,3, Allan F. Brown 1,4, Ivette Guzman 1, James R. Ballington 2, and Mary A. Lila 3 (2016). Variations in chlorogenic acid levels in an expanded gene pool of blueberries. AIMS Agriculture and Food. Author Affiliations: 1. Plants for Human Health Institute, Department of Horticultural Science, NC State University, North Carolina Research […]

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Patient experiences with pharmacogenetic testing in a primary care setting

Susanne B Haga 1, Rachel Mills 1, Jivan Moaddeb 1, Nancy Allen Lapointe 2, Alex Cho 1 & Geoffrey S Ginsburg 1 (2016). Patient experiences with pharmacogenetic testing in a primary care setting. Pharmacogenomics. Author Affiliations: 1. Center for Applied Genomics & Precision Medicine, Duke University School of Medicine, 304 Research Drive, Durham, NC 27708, […]

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From “Personalized” to “Precision” Medicine: The Ethical and Social Implications of Rhetorical Reform in Genomic Medicine

Eric Juengst, Michelle L. McGowan, Jennifer R. Fishman, Richard A. Settersten Jr. (2016). From “Personalized” to “Precision” Medicine: The Ethical and Social Implications of Rhetorical Reform in Genomic Medicine. The Hastings Center Report, 46(5): 21-33. Author Affiliations UNC School of Medicine McGill University Oregon State University Pennsylvania State University Abstract: Since the late 1980s, the […]

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Muscle Glycogen Depletion Following 75-km of Cycling Is Not Linked to Increased Muscle IL-6, IL-8, and MCP-1 mRNA Expression and Protein Content

David C. Nieman 1, Kevin A. Zwetsloot 1, Dominic D. Lomiwes 2, Mary P. Meaney 1 and Roger D. Hurst 2 (2016). Muscle Glycogen Depletion Following 75-km of Cycling Is Not Linked to Increased Muscle IL-6, IL-8, and MCP-1 mRNA Expression and Protein Content. Frontiers in Physiology. Author Affiliations: 1. Appalachian State University, North Carolina […]

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Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function

Qian Suna, Wenliang Zhang, Wei Zhong, Xinguo Sun, Zhanxiang Zhou (2016). Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function. Biochemica et Biophysica General Subjects. Author Affiliations Department of Nutrition, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA 28081 Center for Translational […]

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Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection

Lina Zhanga, Giacomo Lanzoni, Matteo Battarra, Luca Inverardi, Qibin Zhang (2016). Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection. Journal of Proteomics, 150:149-169. Author Affiliations Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA Diabetes Research Institute, University of Miami, […]

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Performance of the Tobacco, Alcohol, Prescription Medication, and Other Substance Use (TAPS) Tool for Substance Use Screening in Primary Care Patients

Jennifer McNeely, MD, MS; Li-Tzy Wu, ScD, RN, MA; Geetha Subramaniam, MD; Gaurav Sharma, PhD; Lauretta A. Cathers, PhD; Dace Svikis, PhD; Luke Sleiter, MPH; Linnea Russell, BA; Courtney Nordeck, BA; Anjalee Sharma, MSW; Kevin E. O’Grady, PhD; Leah B. Bouk, CCRC; Carol Cushing, BBA, RN; Jacqueline King, MS; Aimee Wahle, MS; and Robert P. […]

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Patterns of Gene Flow between Crop and Wild Carrot, Daucus carota (Apiaceae) in the United States

Jennifer R. Mandel , Adam J. Ramsey, Massimo Iorizzo, Philipp W. Simon (2016). Patterns of Gene Flow between Crop and Wild Carrot, Daucus carota (Apiaceae) in the United States, PLOS One. Author Affiliations: Department of Biological Sciences, The University of Memphis, Memphis, Tennessee, United States of America, W. Harry Feinstone Center for Genomic Research, The […]

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Changes in phenolic content of commercial potato varieties through industrial processing and fresh preparation

Amber Furrer, Dennis P. Cladis, Anne Kurilich, Ramesh Manoharan, Mario G. Ferruzzi (2016). Changes in phenolic content of commercial potato varieties through industrial processing and fresh preparation. Food Chemistry, 218:47-55. Author Affiliations: Dept. of Food Science, Purdue University, 745 Agriculture Mall Dr., West Lafayette, IN 47907, United States Dept. of Nutrition Science, Purdue University, 700 […]

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Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity

R. Andrew Shanely, David C. Nieman, Penelope Perkins-Veazie, Dru A. Henson, Mary P. Meaney, Amy M. Knab, and Lynn Cialdell-Kam. 2016. Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity. Nutrients 2016, 8(8), 518. Author Affiliations: 1 Human Performance Laboratory, Appalachian State University, North Carolina Research […]

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In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents

Mary H. Grace, Debora Esposito, Michael A. Timmers, Jia Xiong, Gad Yousef, Slavko Komarnytsky and Mary Ann Lila. 2016. In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents. Food & Function. Author Affiliations: Plants for Human Health Institute, Food Bioprocessing and Nutrition Sciences Department, North Carolina State University, North Carolina […]

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Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice

Qian Sun, Wenliang Zhang, Wei Zhong, Xinguo Sun, Zhanxiang Zhou (2016). Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice. Alcoholism Clinical & Experimental Research. Author Affiliations: Department of Nutrition, University of North Carolina at Greensboro, Kannapolis, North Carolina Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina Abstract: […]

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Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer

Deepak Voora, MD, A. Koneti Rao, MD, Gauthami S. Jalagadugula, PhD, Rachel Myers, PhD, Emily Harris, Thomas L. Ortel, MD PhD, Geoffrey S. Ginsburg, MD PhD. 2016. Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer. EBioMedicine.. Author Affiliations a Duke Center for Applied Genomics & Precision Medicine, […]

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Central GIP signaling stimulates peripheral GIP release and promotes insulin and pancreatic polypeptide secretion in nonhuman primates.

Paul B. Higgins, Robert E. Shade, Iram P. Rodríguez-Sánchez, Magdalena Garcia-Forey, M. Elizabeth Tejero-Barrera, V. Saroja Voruganti, Shelley A. Cole, Anthony G Comuzzie, Franco Folli. 2016. Central GIP signaling stimulates peripheral GIP release and promotes insulin and pancreatic polypeptide secretion in nonhuman primates. American Journal of Physiology – Endocrinology and Metabolism. Author Affiliations 1. Texas […]

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Alcohol promotes migration and invasion of triple-negative breast cancer cells through activation of p38 MAPK and JNK†

Ming Zhao, Erin W. Howard, Amanda B. Parris, Zhiying Guo, Qingxia Zhao, Xiaohe Yang. 2016. Alcohol promotes migration and invasion of triple-negative breast cancer cells through activation of p38 MAPK and JNK. Molecular Carcinogenesis. Author Affiliations: Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, North Carolina Abstract: Although […]

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Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences

Delisha A. Stewart, Jason H. Winnike, Susan L. McRitchie, Robert F. Clark, Wimal W. Pathmasiri, and Susan J. Sumner, 2016. Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences. Journal of Proteome Research. Author Affiliations NIH Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, Research Triangle Park, North […]

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Outpatient Medications in Atrial Fibrillation

L. Kristin Newby, Sean D. Pokorney, (2016). Outpatient Medications in Atrial Fibrillation. Contemporary Cardiology, Short Stay Management of Atrial Fibrillation (195-217). Author Affiliations Division of Cardiology, Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center Abstract The three outpatient principles for managing patients with atrial fibrillation are (1) risk stratification and appropriate stroke […]

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Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure

Wynn G. Hunter, MD, MHSc; Jacob P. Kelly, MD; Robert W. McGarrah, III, MD; Michel G. Khouri, MD; Damian Craig, MS; Carol Haynes, BA; Olga Ilkayeva, PhD; Robert D. Stevens, PhD; James R. Bain, PhD; Michael J. Muehlbauer, PhD; Christopher B. Newgard, PhD; G. Michael Felker, MD, MHS; Adrian F. Hernandez, MD, MHS; Eric J. […]

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Lollipops in the Clinic: Information Dense Mutation Plots for Precision Medicine

Jeremy J. Jay , Cory Brouwer, 2016. Lollipops in the Clinic: Information Dense Mutation Plots for Precision Medicine. PLOS One. Author Affiliations Bioinformatics Services Division, North Carolina Research Campus, Kannapolis, North Carolina, United States of America, Bioinformatics and Genomics Department, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America Abstract Introduction […]

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Modeling the effects of microfluidization conditions on properties of corn bran

Fuli He, Tao Wang, Si Zhu, Guibing Chen. 2016. Modeling the effects of microfluidization conditions on properties of corn bran. Journal of Cereal Science, 71(86-92). Author Affiliations Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC, 28081, USA Abstract Corn bran was microfluidized […]

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FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPAR Agonist Rosiglitazone

Lance A. Stechschulte, Bin Qiu, Manya Warrier, Terry D. Hinds, Jr., Man Zhang, Hao Gu, Yuxue Xu, Saja S. Khuder, Lucia Russo, Sonia M. Najjar, Beata Lecka-Czernik, Weidong Yong, and Edwin R. Sanchez (2016). FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPAR Agonist Rosiglitazone. Endocrinology, 1-14. Author Affiliations Departments of Physiology & […]

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Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 20151,2,3

Jeffrey B Blumberg, Arpita Basu, Christian G Krueger, Mary Ann Lila, Catherine C Neto, Janet A Novotny, Jess D Reed, Ana Rodriguez-Mateos, and Cheryl D Toner. Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015. Advances In Nutrition, vol. 7: 759S-770S. Author Affiliations 4 Jean Mayer USDA […]

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Identification of a residue responsible for UDP-sugar donor selectivity of a dihydroxybenzoic acid glycosyltransferase from Arabidopsis natural accessions

Chen, H.-Y. and Li, X. (2016), Identification of a residue responsible for UDP-sugar donor selectivity of a dihydroxybenzoic acid glycosyltransferase from Arabidopsis natural accessions. The Plant Journal. Accepted Author Manuscript. doi:10.1111/tpj.13271 Author Affiliations Plants for Human Health Institute, North Carolina State University, Kannapolis, NC Department of Plant and Microbial Biology, North Carolina State University, Raleigh, […]

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Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction

Sean van Diepen, Wendimagegn G. Alemayehu, Yinggan Zheng, Pierre Theroux, L. Kristin Newby, Kenneth W. Mahaffey, Christopher B. Granger, Paul W. Armstrong (2016). Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction. Journal of Thrombosis and Thrombolysis: 1-10. Author Affiliations 1. Divisions of […]

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INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma

Bingying Zhou 1,2,3,12, Li Wang 1,4,12, Shu Zhang 5, Brian D. Bennett 6, Fan He 7, Yan Zhang 8, Chengliang Xiong 8, Leng Han 9, Lixia Diao 10, Pishun Li 4, David C. Fargo 6, Adrienne D. Cox 2,3,11 and Guang Hu 4, 2016. INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma. Genes […]

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Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction

Sean van Diepen , Wendimagegn G. Alemayehu, Yinggan Zheng, Pierre Theroux, L. Kristin Newby, Kenneth W. Mahaffey, Christopher B. Granger, Paul W. Armstrong, 2016. Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction. Journal of Thrombosis and Thrombolysis (1-10). Author Affiliations Divisions of […]

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Antioxidant Activity of Pomegranate Juice and Punicalagin

Akram Aloqbi 1, Ulfat Omar 2,3*, Marwa Yousr 2, Mary Grace 4, Mary Ann Lila 4, Nazlin Howell 2, 2016. Antioxidant Activity of Pomegranate Juice and Punicalagin. Natural Science, 8(235-246). Author Affiliations 1. Biology Department, Faculty of Sciences and Arts-Alkamel, University of Jeddah, Jeddah, KSA 2. Division of Nutrition and Metabolism, Faculty of Health and […]

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Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 – Ethics, Challenges and Endeavors of Precision Nutrition

Kohlmeier M., De Caterina R., Ferguson L.R., Görman U., Allayee H., Prasad C., Kang J.X., Nicoletti C.F., Martinez J.A, 2016. Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 – Ethics, Challenges and Endeavors of Precision Nutrition, 9(1). Author Affiliations Department of Nutrition, School of Public Health, School of Medicine, […]

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Oxidative products from alcohol metabolism differentially modulate pro-inflammatory cytokine expression in Kupffer cells and hepatocytes

Daoyin Dong, Wei Zhong, Qian Sun, Wenliang Zhang, Xinguo Sun, Zhanxiang Zhou, 2016. Oxidative products from alcohol metabolism differentially modulate pro-inflammatory cytokine expression in Kupffer cells and hepatocytes. Cytokine 85(109-119). Author Affiliations a Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA b Department of Nutrition, […]

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Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes

R. Ryanne Wu, Rachel A. Myers, Elizabeth R. Hauser, Allison Vorderstrasse, Alex Cho, Geoffrey S. Ginsburg, Lori A. Orlando, 2016. Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes. Journal of Genetic Counseling, pp. 1-8. Author Affiliations Center for Applied Genomics and Precision […]

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Fetal alcohol spectrum disorders and assessment of maxillary and mandibular arc measurements

Abell K, May W, May PA, Kalberg W, Hoyme HE, Robinson LK, Manning M, Jones KL, Abdul-Rahman O. 2016. Fetal alcohol spectrum disorders and assessment of maxillary and mandibular arc measurements. Am J Med Genet Part A 9999A:1–9. Author Affiliations 1. School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 2. School of Health […]

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Clinical implementation of genomic medicine: the importance of global collaboration

Teri A. Manolio, Robyn Ward & Geoffrey S. Ginsburg (2016): Clinical implementation of genomic medicine: the importance of global collaboration, Expert Review of Precision Medicine and Drug Development. Author Affiliations 1. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 2. University of Queensland, Australia 3. Center for Applied Genomics and Precision Medicine, […]

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Grapes and Gastrointestinal Health: Implications with Intestinal and Systemic Diseases

Brian Collins, Jessie Baldwin, Kristina Martinez, Mary Ann Lila, Michael McIntosh (2016). Grapes and Gastrointestinal Health: Implications with Intestinal and Systemic Diseases. Grapes and Health, pp 119-138. Author Affiliations Department of Nutrition, UNC-Greensboro, Greensboro, NC, 27402, USA Department of Medicine, University of Chicago, Chicago, IL, 60637, USA Plants for Human Health Institute, North Carolina State […]

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Relative Proportions of Individual Blueberry Anthocyanins Vacillate Within and Between Growing Seasons

Michael Anthony Timmers, Mary Grace, Gad Yousef and Mary Ann Lila (2016). Relative Proportions of Individual Blueberry Anthocyanins Vacillate Within and Between Growing Seasons. The FASEB Journal, 30(1). Author Affiliations College of Agriculture and Life Sciences, North Carolina State University, Kannapolis, NC Abstract Blueberries accumulate up to 18 different types of anthocyanins unlike most other berries, […]

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Zinc Deficiency Contributes to Alcohol Consumption-Induced Defect of Mitochondrial Electron Transport Chain and Overproduction of Reactive Oxygen Species in the Live of Rats

Qian Sun 1,2, Wei Zhong 2, Wenliang Zhang 2, Xinguo Sun 2 and Zhanxiang Zhou 1,2 (2016). Zinc Deficiency Contributes to Alcohol Consumption-Induced Defect of Mitochondrial Electron Transport Chain and Overproduction of Reactive Oxygen Species in the Live of Rats. The FASEB Journal, 30(1). Author Affiliations 1. Nutrition, UNCG, KANNAPOLIS, NC 2. Center for translational […]

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Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship

Dungan JR, Qin X, Horne BD, Carlquist JF, Singh A, Hurdle M, et al. (2016) Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. PLoS ONE 11(5): e0154856. Author Affiliations 1 Duke University School of Nursing, Durham, NC, United States of America 2 Duke University Department of Medicine, Durham, […]

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ABCA7 frameshift deletion associated with Alzheimer disease in African Americans

Holly N. Cukier, PhD*, Brian W. Kunkle, PhD, MPH*, Badri N. Vardarajan, PhD*, Sophie Rolati, MS, Kara L. Hamilton-Nelson, MPH, Martin A. Kohli, PhD, Patrice L. Whitehead, BS, Beth A. Dombroski, PhD, Derek Van Booven, BS, Rosalyn Lang, PhD, Derek M. Dykxhoorn, PhD, Lindsay A. Farrer, PhD, Michael L. Cuccaro, PhD, Jeffery M. Vance, MD, […]

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Supplementation with Choline Chloride in a Liquid Rodent Diet: Recipe Development for Differing Caloric Intake in a Fetal Alcohol Model

Thomas W Jackson 1, L Grant Canipe III 2 and Carol L Cheatham 1,2 (2016). Supplementation with Choline Chloride in a Liquid Rodent Diet: Recipe Development for Differing Caloric Intake in a Fetal Alcohol Model. The FASEB Journal, 30(1). Author Affiliations 1. Nutrition Research Insitute, University of North Carolina at Chapel Hill, Kannapolis, NC 2. […]

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Bioactive Components from Pistachios Reduce Adipogenesis and Suppress Inflammatory Gene Expression In Vitro

Mary H Grace 1, Debora Esposito 2, Jia Xiong 2, Michael Timmers 2, Slavko Komarnytsky 2 and Mary Ann Lila 2 (2016). Bioactive Components from Pistachios Reduce Adipogenesis and Suppress Inflammatory Gene Expression In Vitro. The FASEB Journal, 30(1). Author Affiliations 1. Plants for Human Health Institute, NCSU, Kannapolis, NC 2. Kannapolis, NC Abstract The […]

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RNA-Seq links AINTEGUMENTA and AINTEGUMENTA-LIKE6 to cell wall remodeling and plant defense pathways in Arabidopsis

Beth A. Krizek, Carlton J. Bequette, Kaimei Xu, Ivory C Blakley, Zheng Qing Fu, Johannes Stratmann and Ann E. Loraine (2016). RNA-Seq links AINTEGUMENTA and AINTEGUMENTA-LIKE6 to cell wall remodeling and plant defense pathways in Arabidopsis. Plant Physiology, 171(1). Author Affiliations University of South Carolina CITY: Columbia STATE: South Carolina POSTAL_CODE: 29208 United States Of […]

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The Total Phenolics Content of Fruit & Vegetable Extracts Does Not Correlate with Activation of the Anti-Oxidant Response in Human Cells

Stephen Joseph Orena 1, Jennifer Owen 1, Fuxia Jin 2, Morgan Fabian 2, Nicholas Gillitt 2 and Steven Zeisel 1 (2016). The Total Phenolics Content of Fruit & Vegetable Extracts Does Not Correlate with Activation of the Anti-Oxidant Response in Human Cells. The FASEB Journal, 30(1). Author Affiliations 1. Nutrition Research Institute, UNC Chapel Hill, […]

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Phytochemical Characterization and Anti-inflammatory Properties of Acacia mearnsii Leaves.

Xiong J, Graceb MH, Esposito D, Wang F, Lila MA. (2016). Phytochemical Characterization and Anti-inflammatory Properties of Acacia mearnsii Leaves. Nat Prod Commun, 11(5):649-53. Abstract: This study was performed to investigate potential bioactive secondary metabolites from the leaves of Acacia mearnsii, a forest waste product in China. The polyphenol constituents and bioactivity of crude extract […]

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Ingesting 25 g/day Milled Chia Seeds for Two Weeks Does Not Affect Exercise Performance

David Nieman and Mary Pat Meaney (2016). Ingesting 25 g/day Milled Chia Seeds for Two Weeks Does Not Affect Exercise Performance. The FASEB Journal, 30(1). Author Affiliations: Appalachian State University, North Carolina Research Campus, Kannapolis, NC Abstract:  Milled chia seed contains 4.4 grams of α-linolenic acid (ALA; 18:3n-3) per 25 gram serving; previous research in […]

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Novel Association Of Estimated Glomerular Filtration Rate With NKAIN2 Gene Variants In Hispanic Children

Geetha Chittoor 1, Karin Haack 2, Sandra Laston 3, Nitesh R Mehta 4, Shelley A Cole 2, Anthony G Comuzzie 2, Nancy F Butte 4 and V. Saroja Voruganti 1 (2016). Novel Association Of Estimated Glomerular Filtration Rate With NKAIN2 Gene Variants In Hispanic Children. The FASEB Journal, 30(1). Author Affiliations:  1. The University of […]

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Diverse bioenergetic profiles of M1/M2 macrophages exposed to anthocyanins and their phenolic metabolites

Slavko Komarnytsky 1,2, John Overall 1,3, Mickey Wilson 1 and Debora Esposito 1,2 (2016). Diverse bioenergetic profiles of M1/M2 macrophages exposed to anthocyanins and their phenolic metabolites. The FASEB Journal, 30(1). Author Affiliations 1 Plants for Human Health Institute, NC State University, Kannapolis, NC 2 Food, Bioprocessing and Nutrition Sciences, NC State University, Raleigh, NC […]

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A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women—A Randomized Controlled Trial

Lynn Cialdella-Kam, David C. Nieman, Amy M. Knab, R. Andrew Shanely, Mary Pat Meaney, Fuxia Jin, Wei Sha and Sujoy Ghosh (2016). A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women—A Randomized Controlled Trial. Nutrients, 8(5), 277. Author Affiliations Department of Nutrition, School of Medicine—WG 48, Case […]

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Targeting MicroRNA in Cancer Using Plant-Based Proanthocyanidins

Rishipal R. Bansode 1, Janak R. Khatiwada 1, Jack N. Losso 2 and Leonard L. Williams 1 (2016). Targeting MicroRNA in Cancer Using Plant-Based Proanthocyanidins. Diseases, 4(2). Author Affiliations 1. Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, North Carolina Agricultural and Technical State University, Kannapolis, NC 28081, USA 2. School of Nutrition & […]

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Mango Supplementation Prevents Gut Microbial Dysbiosis and Modulates Short Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High Fat Diet

Babajide Ojo 1, Guadalupe El-Rassi 2, Penelope Perkins-Veazie 3, Stephen Clarke 1, Brenda J Smith 1 and Edralin A Lucas 1 (2016). Mango Supplementation Prevents Gut Microbial Dysbiosis and Modulates Short Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High Fat Diet. The FASEB Journal, 30(1). Author Affiliations 1. […]

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The impact of choline oxidation pathway on liver methylation potential

Daniel S Lupu 1, Luz D. Orozco 2, Ying Wang 3 and Steven H Zeisel 1 (2016). The impact of choline oxidation pathway on liver methylation potential. The FASEB Journal, 30(1) Author Affiliations 1. Nutrition, University of North Carolina, Nutrition Research Institute, Kannapolis, NC 2. Cell and Developmental Biology, University of California, Los Angeles, CA […]

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DNA Methylation and microRNA Expression are Altered by Choline Deficiency During Mouse Brain Development

Isis Trujillo 1, Natalia Surzenko 1, Yanyan Wang 2 and Steven H Zeisel 1 (2016). DNA Methylation and microRNA Expression are Altered by Choline Deficiency During Mouse Brain Development. The FASEB Journal, 30(1). Author Affiliations 1. University of North Carolina at Chapel Hill, Kannapolis, NC 2. Medical Genetics, Third Military Medical University, Chonggin, China, People’s […]

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Nutrimetabolomics fingerprinting to identify biomarkers of whole grain wheat intake

Shengmin Sang 1, Yingdong Zhu 1, Wei Sha 2 and Pei Wang 1 (2016). Nutrimetabolomics fingerprinting to identify biomarkers of whole grain wheat intake. The FASEB Journal, 30(1). Author Affiliations 1. North Carolina A&T State University, Kannapolis, NC 2. University of North Carolina at Charlotte, Kannapolis, NC Abstract Increased whole grain (WG) consumption has been […]

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Exercise-induced muscle damage in healthy men with low choline intake

Martin Kohlmeier 1 and Olivia Dong 2 (2016). Exercise-induced muscle damage in healthy men with low choline intake. The FASEB Journal, 30(1). Author Affiliations 1 Nutrigenetics Laboratory, UNC Nutrition Research Institute, Kannapolis, NC 2 UNC Chapel Hill, Center for Pharmacogenetics and Individualized Therapy, Chapel Hill, NC Abstract Both very low choline intake and intense exercise […]

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Microbial-derived metabolites of oat avenanthramides

Aaron Yerke, Pei Wang and Shengmin Sang (2016). Microbial-derived metabolites of oat avenanthramides. The FASEB Journal, 30(1). Author Affiliations North Carolina A&T State University, Kannapolis, NC Abstract Oat is a multifunctional crop nutritionally superior to many other unfortified cereals. It is commonly consumed as whole grains and known to provide healthy nutrients to humans. Oats […]

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Low Intake of Choline During Pregnancy Leads to Aberrant Retinal Architecture and Poor Visual Function in the Offspring

Natalia Surzenko1 ,2, Isis Trujillo-González 1 and Steven H Zeisel 1,2 (2016). Low Intake of Choline During Pregnancy Leads to Aberrant Retinal Architecture and Poor Visual Function in the Offspring. The FASEB Journal, 30(1). Author Affiliations 1. Nutrition Research Institute, UNC Chapel Hill, Kannapolis, NC 2. Department of Nutrition, UNC Gillings School of Global Public […]

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Sex-specific and Obesity-specific Association of Serum Uric Acid with Cognitive Function in Older Adults

Carol L Cheatham 1,2, Itzel Vazquez-Vidal 2,3, Christa L Turski 2, Amanda Medlin 4, Grace Millsap 2 and V. Saroja Voruganti 2,3 (2016). Sex-specific and Obesity-specific Association of Serum Uric Acid with Cognitive Function in Older Adults. The FASEB Journal, 30(1). Author Affiliations 1 Psychology & Neuroscience, University of North Carolina at Chapel Hill, Kannapolis, […]

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The Hybrid Mouse Diversity Panel: A Resource for Systems Genetics Analyses of Metabolic and Cardiovascular Traits

Aldons J. Lusis 1,*, Marcus Seldin 2, Hooman Allayee 3, Brian J Bennett 4, Mete Civelek 5, Richard C. Davis 6, Eleazar Eskin 2, Charles Farber 5, Simon T Hui 2, Margarete Mehrabian 2, Frode Norheim 2, Calvin Pan 2, Brian Parks 7, Christoph Rau 2, Desmond J. Smith 2, Thomas Vallim 2, Yibin Wang […]

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Co-Substrating of Peanut Shells with Cornstalks Enhances Biodegradation by Pleurotus ostreatus

Anike FN, Yusuf M, and Isikhuemhen OS (2016). Co-Substrating of Peanut Shells with Cornstalks Enhances Biodegradation by Pleurotus ostreatus. Journal of Bioremediation and Biodegradation, 7(1). Author Affiliations Department of Natural Resources and Environmental Design, SAES North Carolina A&T State University, Greensboro, North Carolina, USA Abstract World consumption of peanuts has increased tremendously, resulting in abundance […]

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Anstifolines A and B, two dimeric furoquinoline alkaloids from the root bark of Dictamnus angustifolius

Jianbo Sun,*a; Neng Jiang, b; Mengying Lv, a; Benqin Tang, c; Pei Wang, d; Jingyu Liang, a; Li Chen,*a (2016). Anstifolines A and B, two dimeric furoquinoline alkaloids from the root bark of Dictamnus angustifolius. RSC Advances, 27(6). Author Affiliations * Corresponding authors a Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China […]

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A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice

Brian Collins a, 1, Jessie Hoffman a, 1, Kristina Martinez b, Mary Grace c, Mary Ann Lila c, Chase Cockrell b, Anuradha Nadimpalli b, Eugene Chang b, Chia-Chi Chuang d, Wei Zhong e, Jessica Mackert a, Wan Shen a, Paula Cooney a, Robin Hopkins a, Michael McIntosh a (2016). A polyphenol-rich fraction obtained from table […]

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Acute Bioavailability of (Poly)phenolic Content of Different Varieties of Vaccinium spp. in Ovariectomized Rats

Maria Maiz 1, Dennis P. Cladis 1, Pamela J. Lachcik 1, Elsa M. Janle 1, Mary Ann Lila 2, Mario G. Ferruzzi 1 and Connie M. Weaver 1 (2016). Acute Bioavailability of (Poly)phenolic Content of Different Varieties of Vaccinium spp. in Ovariectomized Rats. The FAESB Journal, 30(1). Author Affiliations 1. Nutrition Science, Purdue University, West […]

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Dietary quercetin inhibits methylglyoxal-induced advanced glycation end products formation in mice

Yantao Zhao, Pei Wang, Huadong Chen, and Shengmin Sang (2016). Dietary quercetin inhibits methylglyoxal-induced advanced glycation end products formation in mice. The FASEB Journal, 30 (4). doi:10.1096/fj.1530-6860 Author Affiliations: North Carolina A&T State University, Kannapolis, NC Abstract: Increasing evidence has identified the formation of advanced glycation end products (AGEs) as a major pathogenic link between […]

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Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts

Mary H. Grace, Debora Esposito, Michael A. Timmers, Jia Xiong, Gad Yousef, Slavko Komarnytsky, Mary Ann Lila (2016). Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts. Food Chemistry, 210:35-95. Author Affiliations: Plants for Human Health Institute, Food Bioprocessing and Nutrition Sciences Department, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, […]

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Mapping inflammation and cancer-modifying regions in broccoli genome

Weston Bussler, Jessica Alley, Holli Chandler, Claire Thetford, Gad Yousef, Allan Brown, Debora Esposito, Mary Ann Lila and Slavko Komarnytsky (2016). Mapping inflammation and cancer-modifying regions in broccoli genome. The FASEB Journal, 30(1). Author Affiliations: 1. Plants for Human Health Institute, NC State University, Kannapolis, NC 2. Food, Bioprocessing and Nutrition Sciences, NC State University, […]

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New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics

Lutz, M. W., Crenshaw, D., Welsh-Bohmer, K. A., Burns, D. K., & Roses, A. D. (2016). New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics. Current Neurology and Neuroscience Reports Curr Neurol Neurosci Rep, 16(5). doi:10.1007/s11910-016-0643-8 Author Affiliations 1. Joseph and Kathleen Bryan Alzheimer’s Disease Center, Department of Neurology, Duke University Medical Center, 2200 W […]

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Intravenous Beta-blockers for Cardioprotection in STEMI: The Saga Continues

Newby, L. K. (2016). Intravenous Beta-blockers for Cardioprotection in STEMI: The Saga Continues. Journal of the American College of Cardiology. doi:10.1016/j.jacc.2016.03.532. Author Affiliation: Division of Cardiology, Department of Medicine and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina

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Hepatic Peroxisome Proliferator-Activated Receptor Gamma Signaling Contributes to Alcohol-Induced Hepatic Steatosis and Inflammation in Mice

Zhang, W., Sun, Q., Zhong, W., Sun, X. and Zhou, Z. (2016), Hepatic Peroxisome Proliferator-Activated Receptor Gamma Signaling Contributes to Alcohol-Induced Hepatic Steatosis and Inflammation in Mice. Alcoholism: Clinical and Experimental Research. doi: 10.1111/acer.13049 Author Affiliations:  1. Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina 2. Department of Nutrition, […]

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Construction of a SNP and SSR linkage map in autotetraploid blueberry using genotyping by sequencing

Mccallum, S., Graham, J., Jorgensen, L., Rowland, L. J., Bassil, N. V., Hancock, J. F., Wheeler, E. J., Vining, K., Poland, J. A., Olmstead, J. W., Buck, E., Wiedow, C., Jackson, E., Brown, A., Hackett, C. A. (2016). Construction of a SNP and SSR linkage map in autotetraploid blueberry using genotyping by sequencing. Molecular Breeding, […]

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Synthesis, Evaluation, and Metabolism of Novel [6]-Shogaol Derivatives as Potent Nrf2 Activators

Synthesis, Evaluation, and Metabolism of Novel [6]-Shogaol Derivatives as Potent Nrf2 Activators. Free Radical Biology and Medicine, March 25, 2016. Yindong Zhu (a), Pei Wang (a), Yantao Zhao (a), Chun Yang (a,b), Anderson Clark (c), TinChung Leung (c), Xiaoxin Chen (d), Shengmin Sang (a). Author Affiliations a Laboratory for Functional Foods and Human Health, Center […]

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Engaging American Indian/Alaska Native (AI/AN) Students with Participatory Bioexploration Assays

Engaging American Indian/Alaska Native (AI/AN) Students with Participatory Bioexploration Assays. NACTA Journal, 2016. Joshua Kellogg (2), Nathalie J. Plundrich (2), Mary Ann Lila (2,5), D. Barry Croom (3), Rebecca F. Taylor (3), Brittany Graf (4), Ilya Raskin (4). Author Affiliations 2. North Carolina State University, Kannapolis, NC 3. North Carolina State University, Raleigh, NC 4. […]

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Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function

Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function. PLOS One, March 25, 2016. Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan McRitchie, Susan Sumner, Hilary J. Vernon. Author Affiliations Department of Chemistry, Cleveland State University, Cleveland, OH, United States of America Research Triangle International, […]

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9- and 13-hydroxy-octadecadienoic acids (9+13 HODE) are inversely related to granulocyte colony stimulating factor and IL-6 in runners after 2 h running

Nieman, D.C., Pat Meaney, M., John, C.S., Knagge, K.J., Chen, H., 9- and 13-hydroxy- octadecadienoic acids (9+13 HODE) are inversely related to granulocyte colony stimulating factor and IL-6 in runners after 2 h running, Brain, Behavior, and Immunity (2016), doi: http://dx.doi.org/10.1016/j.bbi.2016.03.020. Author Affiliations Appalachian State University, NC Research Campus, Kannapolis, NC Analytical Sciences, David H. […]

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Structure Calculation and Reconstruction of Discrete State Dynamics from Residual Dipolar Couplings

Structure Calculation and Reconstruction of Discrete State Dynamics from Residual Dipolar Couplings. Journal of Chemical Theory and Computation. March 16, 2016. Casey Anne Cole, Rishi Mukhopadhyay, Hanin Omar, Mirko Hennig, and Homayoun Valafar. Abstract Residual Dipolar Couplings (RDCs) acquired by Nuclear Magnetic Resonance (NMR) spectroscopy are an indispensable source of information in investigation of molecular […]

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Impact of a new postharvest disinfection method based on peracetic acid fogging on the phenolic profile of strawberries

Impact of a new postharvest disinfection method based on peracetic acid fogging on the phenolic profile of strawberries. Postharvest Biology and Technology. March 15, 2016. Franco Van de Velde a, b, Mary H. Grace c, María Élida Pirovani a, Mary Ann Lila c. Author Affiliations a Instituto de Tecnología de Alimentos, Facultad de Ingeniería Química, […]

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12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression

12-HETER1/GPR31, a high-affinity 12(S)-hydroxyeicosatetraenoic acid receptor, is significantly up-regulated in prostate cancer and plays a critical role in prostate cancer progression. The FASEB Journal, March 10, 2016. Kenneth V. Honn, Yande Guo, Yinlong Cai, Menq-Jer Lee, Gregory Dyson, Wenliang Zhang, and Stephanie C. Tucker. Author Affiliations Department of Pathology, Wayne State University, Detroit, Michigan Department […]

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Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment Elevation Acute Coronary Syndromes Clinical Trials

Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non-ST-Segment Elevation Acute Coronary Syndromes Clinical Trials. March 8, 2016. Circulation. Kristian Kragholm 1; Sarah A. Goldstein 1; Qinghong Yang 1; Renato D. Lopes 1; Phillip J. Schulte 1; Gwen M. Bernacki 1; Harvey D. White 2; Kenneth W. Mahaffey 3; Robert P. […]

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Clinical utility of a Web-enabled risk-assessment and clinical decision support program

Clinical utility of a Web-enabled risk-assessment and clinical decision support program. March 3, 2016. Genetics in Medicine. Lori A. Orlando MD, MHS, R. Ryanne Wu MD, Rachel A. Myers PhD, Adam H. Buchanan MS, MPH, Vincent C. Henrich PhD, Elizabeth R. Hauser PhD & Geoffrey S. Ginsburg MD, PhD. Author Affiliations Duke Center for Applied […]

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High purity galacto-oligosaccharides enhance specific Bifidobacterium species and their metabolic activity in the mouse gut microbiome

High purity galacto-oligosaccharides enhance specific Bifidobacterium species and their metabolic activity in the mouse gut microbiome. Beneficial Microbes, 2016. A. Monteagudo-Mera1, J.C. Arthur 2, C. Jobin 2,3, T. Keku 2, J.M. Bruno-Barcena 4 and M.A. Azcarate-Peril1, 5*. The derivates were analysed with gas chromatograph-mass spectrometer (GC-MS) analysis at UNCG Metabolomics Facility, Kannapolis, NC. Author Affiliations 1. Microbiome […]

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Comprehensive untargeted lipidomic analysis using core–shell C30 particle column and high field orbitrap mass spectrometer

Comprehensive untargeted lipidomic analysis using core–shell C30 particle column and high field orbitrap mass spectrometer. Journal of Chromatography A. February 22, 2016. Mónica Narváez-Rivas a, Qibin Zhang a, b. Author Affiliations a. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA b. Department of Chemistry […]

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Trapping of Methylglyoxal by Genistein and its Metabolites in Mice

Trapping of Methylglyoxal by Genistein and its Metabolites in Mice. Chemical Research in Toxicology. February 16, 2016. Pei Wang, Huadong Chen, and Shengmin Sang. Author Affiliations North Carolina Agricultural and Technical State University Center for Excellence in Post-Harvest Technologies Abstract Increasing evidence supports dicarbonyl stress such as methylglyoxal (MGO) as one of the major pathogenic […]

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Steroidal Saponins in Oat Bran

Steroidal Saponins in Oat Bran. Journal of Agricultural and Food Chemistry. February 7, 2016. Junli Yang, Pei Wang, Wenbin Wu, Yantao Zhao, Emmanuel Idehen, and Shengmin Sang. Author Affiliations Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate […]

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Assessment of cardiovascular disease risk factors in a genetically homogenous population of Parsi Zoroastrians in the United States: A pilot study

Assessment of cardiovascular disease risk factors in a genetically homogenous population of Parsi Zoroastrians in the United States: A pilot study. American Journal of Human Biology, January 28, 2016. Itzel Vazquez-Vidal 1, Geetha Chittoor 1, Sandra Laston 2, Sobha Puppala 3, Zeeba Kayani 4, Kaizeen Mody 5, Anthony G. Comuzzie 3, Shelley A. Cole 3 […]

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Formation of whey protein–polyphenol meso-structures as a natural means of creating functional particles

Margaret Schneider, Debora Esposito, Mary Ann Lila and E. Allen Foegeding (2016). Formation of whey protein–polyphenol meso-structures as a natural means of creating functional particles. Food and Function, 7, 1306-1318. Author Affiliations: North Carolina State University, Department of Food, Bioprocessing and Nutrition Sciences, 400 Dan Allen Dr., Raleigh, USA Plants for Human Health Institute, Department […]

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A novel association of neuropilin-1 and MUC1 in pancreatic ductal adenocarcinoma: role in induction of VEGF signaling and angiogenesis

A novel association of neuropilin-1 and MUC1 in pancreatic ductal adenocarcinoma: role in induction of VEGF signaling and angiogenesis.. Oncogene, January 25, 2016. R Zhou 1, JM Curry 1, LD Roy 1, P Grover 1, J Haider 2, LJ Moore 1, S-t Wu 1, A Kamesh 1, M Yazdanifar 1, WA Ahrens 3, T Leung […]

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Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina

Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina. Journal of Food Composition and Analysis, January 24, 2016. Franco Van de Velde a, b, Mary H. Grace c, Debora Esposito c, María Élida Pirovani a, Mary Ann Lila c. Author Affiliations a Instituto de Tecnología de Alimentos, Facultad de […]

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Do Stable Non-ST Segment Elevation Acute Coronary Syndromes Require Admission to Coronary Care Units?

Do Stable Non-ST Segment Elevation Acute Coronary Syndromes Require Admission to Coronary Care Units? American Heart Journal, January 23, 2016. Sean van Diepen, Meng Lin, Jeffrey A. Bakal, Finlay A. McAlister, Padma Kaul, Jason N. Katz, Christopher B. Fordyce, Danielle A. Southern, Michelle M. Graham, Stephen B. Wilton, L. Kristin Newby, Christopher B. Granger, Justin […]

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Host gene expression classifiers diagnose acute respiratory illness etiology

Host gene expression classifiers diagnose acute respiratory illness etiology. Science Translational Medicine, January 20, 2016. Ephraim L. Tsalik 1,2,3, Ricardo Henao 1,4, Marshall Nichols 1, Thomas Burke 1, Emily R. Ko 1,5, Micah T. McClain 1,3,6, Lori L. Hudson 1, Anna Mazur 1, Debra H. Freeman 1,3, Tim Veldman 1, Raymond J. Langley 7, Eugenia […]

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Opportunities for the Cardiovascular Community in the Precision Medicine Initiative

Opportunities for the Cardiovascular Community in the Precision Medicine Initiative. Circulation, 2016. Svati H. Shah, Donna Arnett, Steven R. Houser, Geoffrey S. Ginsburg, Calum MacRae, Seema Mital, Joseph Loscalzo, Jennifer L. Hall. Author Affiliations Division of Cardiology, Department of Medicine, Duke University, Durham, NC (S.H.S., G.S.G.); Duke Molecular Physiology Institute, Duke University, Durham, NC (S.H.S.); […]

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Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans

Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans. The Journal of Infectious Diseases, January 18, 2016. William E. Yang 1,2, Sunil Suchindran 2, Bradly P. Nicholson 2,3, Micah T. McClain 2,3,4, Thomas Burke 2, Geoffrey S. Ginsburg 2, Clayton D. Harro 5, Subhra Chakraborty 5, David A. […]

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A genetics-based biomarker risk algorithm for predicting risk of Alzheimer’s disease

A genetics-based biomarker risk algorithm for predicting risk of Alzheimer’s disease. Alzheimer’s & Dementia, January 13, 2016. Michael W. Lutz, Scott S. Sundseth, Daniel K. Burns, Ann M. Saunders, Kathleen M. Hayden, James R. Burke, Kathleen A. Welsh-Bohmer, Allen D. Roses. Author Affiliations a Joseph and Kathleen Bryan Alzheimer’s Disease Research Center, Duke University Medical […]

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Comparative Transcriptome Analysis of Close Wild Relatives of Sweet Potato Reveals Important Salt Adaptation Mechanisms for Crop Improvement

Comparative Transcriptome Analysis of Close Wild Relatives of Sweet Potato Reveals Important Salt Adaptation Mechanisms for Crop Improvement. Plant and Animal Genome XXIV Conference, January 2016. Daniella J. Freese 1, Robert Reid 1, Huazhong Shi 2, Hengyou Zhang 1, Ann Loraine 1, Bao-Hua Song 1. Author Affiliations 1 University of North Carolina at Charlotte, Charlotte, […]

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Association of Standard Clinical and Laboratory Variables with Red Blood Cell Distribution Width (RDW)

Association of Standard Clinical and Laboratory Variables with Red Blood Cell Distribution Width (RDW). American Heart Journal, January 12, 2016. Patrícia O. Guimarães, a; Jie-Lena Sun, a; Kristian Kragholm, a; Svati H. Shah, b, c; Karen S. Pieper, a; William E. Kraus, b, c; Elizabeth R. Hauser, b, c; Christopher B. Granger, a, c; L. […]

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The Carrot Genome: A Framework to Study Health-Promoting Metabolite Accumulation

The Carrot Genome: A Framework to Study Health-Promoting Metabolite Accumulation. Plant and Animal Genome XXIV Conference, 2016. Massimo Iorizzo (1), Shelby Ellison (2), Douglas Senalik (3, 4), Pim Satapoomin (2), Allen Van Deynze (5), Philipp W. Simon (3, 4). Author Affiliations 1 Plants for Human Health Institute, Department of Horticultural Science, North Carolina State University, […]

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Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells

Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells. Phytomedicine, January 5, 2016. Chethan Sampath a, Yingdong Zhu b, Shengmin Sang b, Mohamed Ahmedna a. Author Affiliations a Department of Health Sciences, College of Arts & Sciences, Qatar University, Doha 2713, Qatar b Center for […]

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Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents

Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents. The Official Journal of the Federation of American Societies for Experimental Biology, January 4, 2016. Torbjörn K. Nilsson*,1, Anita Hurtig-Wennlöf †, Michael Sjöström ‡, Wolfgang Herrmann §, Rima Obeid §, Jennifer R. Owen ¶ and Steven Zeisel ¶,‖. Author Affiliations * Department of Medical Biosciences/Clinical Chemistry, […]

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The continuum of fetal alcohol spectrum disorders in four rural communities in south africa: Prevalence and characteristics

The continuum of fetal alcohol spectrum disorders in four rural communities in South Africa: Prevalence and characteristics. Drug and Alcohol Dependence, December 31, 2015. Philip A. May, a, b, Marlene M. de Vries, b, Anna-Susan Marais, b, Wendy O. Kalberg, c, Colleen M. Adnams, d, Julie M. Hasken, a, Barbara Tabachnick, e, Luther K. Robinson, […]

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Vitamin D heritability and effect of pregnancy status in Vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation.

Vitamin D heritability and effect of pregnancy status in Vervet monkeys (Chlorocebus aethiops sabaeus) under conditions of modest and high dietary supplementation. American Journal of Physical Anthropology, 2015. Geetha Chittoor, 1, 2, †, Nicholas M. Pajewski, 3, † , V. Saroja Voruganti, 1, 2, Anthony G. Comuzzie, 4, 5, Thomas B. Clarkson, 6, Matthew Nudy, […]

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Indicated Prevention of Fetal Alcohol Spectrum Disorders in South Africa: Effectiveness of Case Management

Indicated Prevention of Fetal Alcohol Spectrum Disorders in South Africa: Effectiveness of Case Management. International Journal of Environmental Research and Public Health, December 23, 2015. Marlene M. de Vries 1, Belinda Joubert 1, Marise Cloete 1, Sumien Roux 1, Beth A. Baca 2, Julie M. Hasken 3, Ronel Barnard 1, David Buckley 2, Wendy O. […]

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Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring

Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring. The Journal of the Federation of American Societies for Experimental Biology, December 23, 2015. Yanyan Wang*,†, Natalia Surzenko*,‡, Walter B. Friday* and Steven H. Zeisel*,‡. Author Affiliations *Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North […]

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Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients

Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. Annals of the American Thoracic Society, December 23, 2015. Ephraim L Tsalik, Yanhong Li, Lori L Hudson, Vivian H Chu, Tiffany Himmel, Alex T Limkakeng, Jason N Katz, Seth W Glickman, Micah T McClain, Karen E Welty-Wolf, Vance G Fowler, Geoffrey S Ginsburg, […]

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Combined Use of Molecular Markers and High-Resolution Melting (HRM) to Assess Chromosome Dosage in Potato Hybrids

Combined Use of Molecular Markers and High-Resolution Melting (HRM) to Assess Chromosome Dosage in Potato Hybrids, Journal of Heredity, December 10, 2015. Clizia Villano, Valeria Miraglia, Massimo Iorizzo, Riccardo Aversano and Domenico Carputo. From the Department of Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Italy (Villano, Miraglia, Aversano, and Carputo); andPlants for Human Health Institute, Department […]

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Chemopreventative Effect of Phytochemimcals against Colon Cancer

Chemopreventative Effect of Phytochemimcals against Colon Cancer, Medicinal and Aromatic Plants, December 2015. Williams LL, Khatiwada J and Davis S. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, North Carolina Research Campus, Kannapolis, NC. Editorial Currently, the incidence of colorectal cancer (CRC) has been declining, even though it remains a major public […]

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Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes

Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes, Arteriosclerosis, Thrombosis and Vascular Biology, December 10, 2015. David A. Zidar, Joseph C. Mudd, Steven Juchnowski, Joao P. Lopes, Sara Sparks,Samantha S. Park, Masakazu Ishikawa, Robyn Osborne, Jeffrey B. Washam, Cliburn Chan, Nicholas T. Funderburg, Adeyinka Owoyele, Mohamad A. Alaiti, Myttle Mayuga, Carl Orringer, Marco […]

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Maternal Nutritional Status as a Contributing Factor for the Risk of Fetal Alcohol Spectrum Disorders

Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders, Reproductive Toxicology. December 3, 2015. Philip A. Maya, b, Kari J. Hamrickc, Karen D. Corbind, Julie M. Haskena, Anna-Susan Maraise, f, Jason Blankenshipb, H.Eugene Hoymeg, J.Phillip Gossageb a University of North Carolina at Chapel Hill, Nutrition Research Institute, Gillings School of Global Public Health, USA b The University of New Mexico Center on […]

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Strategies for transporting nanoparticles across the blood–brain barrier

Strategies for transporting nanoparticles across the blood–brain barrier, Biomaterials Science. 2015. Tian-Tian Zhang (a); Wen Li (B); Guanmin Meng (C); Pei Wang (D); Wenzhen Liao (A). Author Affiliations A. Department of Food Science and Technology, South China University of Technology B. IHRC, Inc. C. Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province D. Center […]

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Revascularization versus Optimal Medical Therapy for Patients With Prior Coronary Artery Bypass Surgery: An Analysis From the Duke Databank for Cardiovascular Disease

Revascularization versus Optimal Medical Therapy for Patients With Prior Coronary Artery Bypass Surgery: An Analysis From the Duke Databank for Cardiovascular Disease, Circulation. 2015. Ralf E Harskamp; Karen Chiswell; Sharif Halim; Jennifer Rymer; Linda Shaw; L Kristin Newby. Author Affiliations Cardiology, Duke Clinical Research Institute, Durham, NC Abstract Objectives: To describe treatment strategies of patients with […]

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Metabolism of dictamnine in liver microsomes from mouse, rat, dog, monkey, and human

Metabolism of dictamnine in liver microsomes from mouse, rat, dog, monkey, and human, Journal of Pharmaceutical and Biomedical Analysis. November 18, 2015. Pei Wang (A,B), Yunli Zhao (A), Yingdong Zhu (B), Jianbo Sun (C), Aaron Yerke (B), Shengmin Sang (B), Zhiguo Yu (A). Author Affiliations A School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China […]

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Characterization of Phenolic Compounds and Antioxidant and Anti-inflammatory Activity from Mamuyo (Styrax ramirezii Greenm) Fruit

Characterization of Phenolic Compounds and Antioxidant and Anti-inflammatory Activity from Mamuyo (Styrax ramirezii Greenm) Fruit. Journal of Agricultural and Food Chemistry. November 17, 2015. Michael A. Timmers (A), Jorge L. Guerrero-Medina (A,B), Debora Esposito(A), Mary H. Grace(A), Octavio Paredes-López(C), Pedro A. García-Saucedo(B), and Mary Ann Lila (A). Author Affiliations A Plants for Human Health Institute, […]

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Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery

Metabolomics-Based Analysis of Banana and Pear Ingestion on Exercise Performance and Recovery, Journal of Proteome Research, November 12, 2015. David C. Nieman,*,† Nicholas D. Gillitt,‡ Wei Sha,§ Mary Pat Meaney,† Casey John,† Kirk L. Pappan,# and Jason M. Kinchen# †Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, North Carolina 28081, United States […]

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Maize Homologs of Hydroxycinnamoyltransferase, a Key Enzyme in Lignin Biosynthesis, Bind the Nucleotide Binding Leucine-Rich Repeat Rp1 Proteins to Modulate the Defense Response

Maize Homologs of Hydroxycinnamoyltransferase, a Key Enzyme in Lignin Biosynthesis, Bind the Nucleotide Binding Leucine-Rich Repeat Rp1 Proteins to Modulate the Defense Response, Plant Physiology, November 2015. Guan-Feng Wang, Yijian He, Renee Strauch, Bode A. Olukolu, Dahlia Nielsen, Xu Li and Peter J. Balint-Kurti. Author Affiliations Departments of Plant Pathology, Plant and Microbial Biology, and Biological Sciences , North Carolina […]

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Does This Patient With Chest Pain Have Acute Coronary Syndrome?

Does This Patient With Chest Pain Have Acute Coronary Syndrome? The Rational Clinical Examination Systematic Review, The Journal of the American Medical Association. Alexander C. Fanaroff, MD1,2; Jennifer A. Rymer, MD, MBA1,2; Sarah A. Goldstein, MD2; David L. Simel, MD, MHS3; L. Kristin Newby, MD, MHS1,2,4 Author Affiliations 1Division of Cardiology, Duke University, Durham, North Carolina 2Department of Medicine, Duke University, Durham, North Carolina 3Durham Veterans […]

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Cultural Adaptation of the TOMMORROW Cognitive Battery in Russia, Switzerland, and Italy

Cultural Adaptation of the TOMMORROW Cognitive Battery in Russia, Switzerland, and Italy, Clinical Trials on Alzheimer’s Disease, November 6, 2015. Alexandra S. Atkins (1); Adam W. Vaughan (1); Nicole M. Turcotte (1); Oksana A. Makeeva (2); Andreas U. Monsch (3); Giovanni B. Frisoni (4,10); Maura Parapini (4,10); Irina Zhukova (2); Zara Melikyan (11); Shyama Brewster […]

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Frequency, clinical and angiographic characteristics, and outcomes of high-risk Non–ST-segment elevation acute coronary syndromes patients with left circumflex culprit lesions

Frequency, clinical and angiographic characteristics, and outcomes of high-risk Non–ST-segment elevation acute coronary syndromes patients with left circumflex culprit lesions, International Journal of Cardiology, Sharif A. Halim, Robert M. Clare, L. Kristin Newby, Yuliya Lokhnygina, Marc J. Schweiger, Arnoud W. Hof, Judith S. Hochman, Stefan K. James, Harvey D. White, Petr Widimsky, Amadeo Betriu, Christoph Bode, Robert P. Giugliano, Robert A. Harrington, Uwe Zeymer. Author Affiliations Division of Cardiology […]

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Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study

Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study, Nutrients, November 3, 2015. Carol L. Cheatham and Kelly Will Sheppard. Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA and Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, […]

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Phytochemicals: Natural Remedies for Emerging Viral Infection

Phytochemicals: Natural Remedies for Emerging Viral Infection, Medicinal and Aromatic Plants. 2015. Lloghalu U (1), Khatiwada P (2), Khatiwada J (1), Williams LL (1). Author Affiliations 1. North Carolina Agricultural & Technical State University, Center for Excellence in Post-Harvest Technologies 2. The University of North Carolina at Chapel Hill, Department of Biological Sciencesf Abstract Noroviruses […]

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Procedural and Clinical Outcomes after Use of the Glycoprotein IIb/IIIa inhibitor Abciximab for Saphenous Vein Graft Interventions

Procedural and Clinical Outcomes after Use of the Glycoprotein IIb/IIIa inhibitor Abciximab for Saphenous Vein Graft Interventions, 30 oct, 2015, Cardiovascular Revascularization Medicine, Ralf E. Harskamp, Niels Hoedemaker, L. Kristin Newby, Pier Woudstra, Maik J. Grundeken, Marcel A. Beijk, Jan J. Piek, Jan G. Tijssen, Rajendra H. Mehta, Robbert J. de Winter Academic Medical Center – University of Amsterdam, Amsterdam, The Netherlands,VU University Medical Center, […]

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Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge

Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge, Clin Exp Immunol. 2015 Oct 28, McClain MT1,2,3, Henao R1,4, Williams J2, Nicholson B2, Veldman T1, Hudson L1, Tsalik EL1,2,3, Lambkin-Williams R5, Gilbert A5, Mann A5, Ginsburg GS1,Woods CW1,2,3. 1Center for Applied Genomics and Precision Medicine, , Duke University, Durham, NC. […]

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Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus, Cell Rep. 2015 Oct 27, Mou Z1, Hyde TM2, Lipska BK3, Martinowich K4, Wei P5, Ong CJ5, Hunter LA5, Palaguachi GI5, Morgun E1, Teng R6, Lai C5, Condarco TA7, Demidowich AP7,Krause AJ7, Marshall LJ8, Haack K9, Voruganti VS10, Cole SA9, Butte NF11, Comuzzie AG9, […]

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Lessons learned from metabolomics in cystic fibrosis

Lessons learned from metabolomics in cystic fibrosis, Molecular and Cellular Pediatrics 2015, Marianne S. Muhlebach1* and Wei Sha2 1Department Pediatrics, Division Pulmonology, UNC Chapel Hill 430 MacNider, CB 7217, Chapel Hill 27599-7217, NC, USA 2Bioinformatics Services Division, University of North Carolina at Charlotte, Kannapolis 28081, NC, USA Abstract Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory […]

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An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation

An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation, JNB,  15 Oct 2015, Jing Xue, Folami Y. Ideraabdullah, UNC Chapel Hill Abstract In recent years, the etiology of human disease has greatly improved with the inclusion of epigenetic mechanisms, in particular as a common link between environment and disease. However, for […]

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Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats

Preventing Gut Leakiness and Endotoxemia Contributes to the Protective Effect of Zinc on Alcohol-Induced Steatohepatitis in Rats, J Nutr. 2015 Oct 14, Zhong W1, Li Q1, Sun Q2, Zhang W1, Zhang J3, Sun X1, Yin X3, Zhang X3, Zhou Z4. 1Center for Translational Biomedical Research and. 2Center for Translational Biomedical Research and Department of Nutrition, University of […]

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Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial

Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial, Am J Clin Nutr. 2015 Oct 7, Wozniak JR1, Fuglestad AJ2, Eckerle JK3, Fink BA2, Hoecker HL4, Boys CJ3, Radke JP5, Kroupina MG3, Miller NC3, Brearley AM6, Zeisel SH7, Georgieff MK3. 1Department of Psychiatry, jwozniak@umn.edu. 2Department of Psychiatry. 3Department of Pediatrics, and. 4School […]

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A Comparison of transgenic and wild type soybean seeds: analysis of transcriptome profiles using RNA-Seq

A Comparison of transgenic and wild type soybean seeds: analysis of transcriptome profiles using RNA-Seq, BMC Biotechnol, 2015 Oct 1, Lambirth KC1, Whaley AM2, Blakley IC3, Schlueter JA4, Bost KL5, Loraine AE6, Piller KJ7. 1Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA. kclambirth@uncc.edu. 2Department of Bioinformatics and Genomics, University of North Carolina […]

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CAP [mdash] advancing the evaluation of preclinical Alzheimer disease treatments

CAP [mdash] advancing the evaluation of preclinical Alzheimer disease treatments, Nat Rev Neurol. 2015 Sep 29, Reiman EM1, Langbaum JB1, Tariot PN1, Lopera F2, Bateman RJ3, Morris JC3, Sperling RA4, Aisen PS5, Roses AD6, Welsh-Bohmer KA6, Carrillo MC7,Weninger S8. 1Banner Alzheimer‘s Institute, 901 E. Willetta Street, Phoenix, AZ 85006, USA. 2Grupo de Neurosciencias, Universidad de Antioquia, Calle […]

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Shelf life and changes in phenolic compounds of organically grown blackberries during refrigerated storage

Shelf life and changes in phenolic compounds of organically grown blackberries during refrigerated storage, Postharvest Biology and Technology. Moo Jung Kima, Penelope Perkins-Veaziea, , Guoying Maa, Gina Fernandezb, a Plants for Human Health Institute, NC Research Campus, North Carolina State University, Kannapolis, NC 28081, United States b Department of Horticultural Science, North Carolina State University, Raleigh NC 27695, United States Abstract […]

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Nutrition and the science of disease prevention: a systems approach to support metabolic health

Nutrition and the science of disease prevention: a systems approach to support metabolic health, Ann N Y Acad Sci. 2015 Sep, Bennett BJ1, Hall KD2, Hu FB3, McCartney AL4, Roberto C5. 1Departments of Genetics and Nutrition, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina. 2Integrative Physiology Section, National Institute of Diabetes […]

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Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance

Genetic and epigenetic transgenerational implications related to omega-3 fatty acids. Part II: Maternal FADS2 rs174575 genotype and DNA methylation predict toddler cognitive performance, Nutrition Research, September 10, 2015, Carol L. Cheatham, Daniel S. Lupu, Mihai D. Niculescu UNC Chapel Hill Abstract Maternal transfer of fatty acids is important to fetal brain development. The prenatal environment may differentially affect the substrates supporting […]

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Genome‐wide association links candidate genes to resistance to Plum Pox Virus in apricot (Prunus armeniaca)

Genome‐wide association links candidate genes to resistance to Plum Pox Virus in apricot (Prunus armeniaca), New Phytol. 2015 Sep 10, Mariette S1,2,3, Wong Jun Tai F1,4, Roch G5,6, Barre A4, Chague A1, Decroocq S1, Groppi A4, Laizet Y2,3, Lambert P5, Tricon D1, Nikolski M4, Audergon JM5,Abbott AG1,7, Decroocq V1. 1UMR 1332 Biologie du Fruit et Pathologie, Equipe […]

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Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice

Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice,2 Sep 2015 The Journal of Nutritional Biotechnology, Jessie Baldwin1, Brian Collins1, Patricia G. Wolf, Kristina Martinez, Wan Shen, Chia-Chi Chuang, Wei Zhong, Paula Cooney, Chase Cockrell, Eugene Chang, H. Rex Gaskins, Michael K. McIntosh. Author Afiliations Department of Nutrition, University of North Carolina at Greensboro (UNCG), Greensboro, NC Carl […]

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Discovery of a novel amino acid racemase through exploration of natural variation in Arabidopsis thaliana

Discovery of a novel amino acid race mase through exploration of natural variation in Arabidopsis thaliana, Proc Natl Acad Sci U S A. 2015 Aug 31, Strauch RC1, Svedin E2, Dilkes B2, Chapple C3, Li X4. Author information 1Plants for Human Health Institute, North Carolina State University, Kannapolis, NC 28081; Department of Plant and Microbial Biology, North […]

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Lessons learned from pre-implementation activities to integrate a web-based personalized health risk assessment program in diverse primary care settings

Lessons learned from pre-implementation activities to integrate a web-based personalized health risk assessment program in diverse primary care settings, Implementation Science 2015, Lori A Orlando, R Ryanne Wu, Nina Sperber, Geoffrey S Ginsburg and Corrine Voils. 1Department of Medicine, Duke University, Durham, NC 27705, USA 2Center for Applied Genomics and Precision Medicine, Duke University, Durham, NC 27705, […]

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Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes

Genotype, B-vitamin status, and androgens affect space flight–induced ophthalmic changes. FASEB J. 2015 Aug 27, Zwart SR1, Gregory JF1, Zeisel SH1, Gibson CR1, Mader TH2, Kinchen JM1, Ueland PM1, Ploutz-Snyder R1, Heer MA1, Smith SM2. Author Affiliations 1*Division of Space Life Sciences, Universities Space Research Association, Houston, Texas, USA; Food Science and Human Nutrition, Institute of Food […]

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Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA expression

Post-exercise skeletal muscle glycogen related to plasma cytokines and muscle IL-6 protein content, but not muscle cytokine mRNA expression, Frontiers in Nutrition, 26 Aug 2015, David C. Nieman1* 1Appalachian State University, USA Abstract Objectives: The purpose of this study was to correlate post-exercise muscle glycogen levels with changes in plasma cytokine, and muscle mRNA cytokine […]

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Development of a high-density cranberry SSR linkage map for comparative genetic analysis and trait detection

Development of a high-density cranberry SSR linkage map for comparative genetic analysis and trait detection, Molecular Breeding,August 2015, Brandon Schlautman, Giovanny Covarrubias-Pazaran, Luis A. Diaz-Garcia, Jennifer Johnson-Cicalese, Massimo Iorrizo, Lorraine Rodriguez-Bonilla, Tierney Bougie, Tiffany Bougie, Eric Wiesman, Shawn Steffan, James Polashock, Nicholi Vorsa, Juan Zalapa 1. Department of Horticulture, University of Wisconsin, Madison, Madison, WI, USA 2. Instituto Nacional de Investigaciones Forestales, Agricolas, y Pecuarias, Campo Experimental Pabellon, Aguascalientes, […]

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Fatty acids linked to cardiovascular mortality are associated with risk factors

Fatty acids linked to cardiovascular mortality are associated with risk factors, International Journal of Circumpolar Health, Aug 2015, Sven O. E. Ebbesson1,2*, Venkata S. Voruganti3, Paul B. Higgins4, Richard R. Fabsitz5, Lars O. Ebbesson6, Sandra Laston7, William S. Harris8,9, John Kennish10, Benjamin D. Umans11, Hong Wang12, Richard B. Devereux13, Peter M. Okin13, Neil J. Weissman12, Jean W. MacCluer7, Jason G. Umans12 and Barbara V. Howard12,14 1Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA; 2Norton Sound Health Corporation, Nome, AK, USA; 3Department of Nutrition and UNC Nutrition Research Institute, […]

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Dynamics and thermodynamic properties of CXCL7 chemokine

Dynamics and thermodynamic properties of CXCL7 chemokine, Proteins. 2015 Aug 22, Herring CA1, Singer CM1, Ermakova EA2, Khairutdinov BI2, Zuev YF2, Jacobs DJ1,3, Nesmelova IV1,3. 1Department of Physics and Optical Science, University of North Carolina, Charlotte, NC, 28223, USA. 2Kazan Institute of Biochemistry and Biophysics, Kazan, 40111, Russia. 3Center for Biomedical Engineering, University of North Carolina, Charlotte, […]

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New functionally-enhanced soy proteins as food ingredients with anti-viral activity

New functionally-enhanced soy proteins as food ingredients with anti-viral activity, VirusDisease, 15 Aug 2015,  Aizhan Sabirzhanovna Turmagambetova, Nadezhda Sergeevna Sokolova, Andrey Pavlinovich Bogoyavlenskiy, Vladimir Eleazarovich Berezin, Mary Ann Lila, Diana M. Cheng, Vyacheslav Dushenkov Author Affiliations 1. Institute of Microbiology and Virology, 103, Bogenbai Batyr Street, Almaty, 050010, Kazakhstan 2. Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, […]

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A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience

A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience, J Cardiovasc Transl Res. 2015 Aug 14, Kraus WE1, Granger CB, Sketch MH Jr, Donahue MP, Ginsburg GS, Hauser ER, Haynes C, Newby LK, Hurdle M, Dowdy ZE, Shah SH. Author information 1Division of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA, […]

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Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City

Prevalence and Characteristics of Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome in a Rocky Mountain Region City. Drug and Alcohol Dependence, 14 Aug 2015, Philip A. May, Carol Keaster, Rosemary Bozeman, Joelene Goodover, Jason Blankenship, Wendy O. Kalberg, David Buckley, Marita Brooks, Julie Hasken, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, H. Eugene Hoyme Nutrition Research Institute, University of North Carolina at Chapel Hill, Gillings School […]

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Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal

Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal, Chem Res Toxicol. 2015 Aug 13, Zhu Y1, Zhao Y1, Wang P1, Ahmedna M, Sang S1. 1†Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina 28081, United States. Abstract Considerable evidence suggests […]

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Comparison of Tomato Genotypes Grown Under Conventional and Organic Production System for Nutrient Composition

Comparison of Tomato Genotypes Grown Under Conventional and Organic Production System for Nutrient Composition, Aug 2015, Dilip R. Panthee, Department of Horticultural Science, North Carolina State University, Mountain Horticultural Crops Research and Extension Center, 455 Research Drive, Mills River, NC 28759. Penelope Perkins-Veazie, Plants for Human Health Institute, Department of Horticultural Science, North Carolina State University, […]

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Rhodiola rosea Exerts Antiviral Activity in Athletes Following a Competitive Marathon Race

Rhodiola rosea Exerts Antiviral Activity in Athletes Following a Competitive Marathon Race, Front. Nutr., 31 July 2015, Maryam Ahmed1*, Dru A. Henson1, Matthew C. Sanderson1, David C. Nieman2, Jose M. Zubeldia3 and R. Andrew Shanely4 1Department of Biology, Appalachian State University, Boone, NC, USA 2Human Performance Laboratory, Appalachian State University, Kannapolis, NC, USA 3PoliNat SL, Las Palmas, […]

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Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells

Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells, J Nutr. 2015 Jul 29, Orena S1, Owen J1, Jin F2, Fabian M2, Gillitt ND2, Zeisel SH3. 1University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NC; 2Dole Nutrition Research Laboratory, Kannapolis, NC; and. 3University of North Carolina at Chapel Hill Nutrition […]

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p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells, Biochem Biophys Res Commun. 2015 Jul 28, Li P1, Zhao M2, Parris AB2, Feng X3, Yang X4. 1JLC Biomedical/Biotechnology Research Institute, Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA; Department of Oncology, Cancer Institute, First Affiliated Hospital of Henan University […]

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A high-throughput, simultaneous analysis of carotenoids, chlorophylls and tocopherol using sub two micron core shell technology columns

A high-throughput, simultaneous analysis of carotenoids, chlorophylls and tocopherol using sub two micron core shell technology columns, ScienceDirect, 26 July 2015,  Kranthi K. Chebrolua, , , Gad G. Yousefa, Ryan Parka, Yoshinori Tanimurab, Allan F. Browna a Department of Horticultural Science, Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Suite 1329, Kannapolis, North Carolina-28081, United States b […]

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Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity

Novel Resveratrol-based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity, J Med Chem. 2015 J Zhu Y, Fu J, Shurlknight K, Soroka D, Hu Y, Chen XL, Sang S. Abstract Regular aspirin use has been convincingly shown to reduce the risk of colorectal cancer. However, long-term use of aspirin leads to gastrotoxicity. Herein, we designed and synthesized […]

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Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study

Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study, Toxicol Sci. 2015 Jul 23, Gribble MO1, Voruganti VS2, Cole SA3, Haack K3, Balakrishnan P4, Laston SL5, Tellez-Plaza M6, Francesconi KA7, Goessler W7, Umans JG8, Thomas DC9,Gilliland F9, North KE10, Franceschini N10, Navas-Acien A11. 1* Department of Preventive Medicine; University of Southern California; […]

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Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer

Activity of the anti-estrogenic cajanin stilbene acid towards breast cancer, July 22, 2015, In Press Accepted Manuscript, Yujie Fu, Onat Kadioglu, Benjamin Wiench, Zuofu Wei, Wei Wang, Meng Luo, Xiaohe Yang, Chengbo Gu, Yuangang Zu, Thomas Efferth NC Central University <style>.requiresJS{display:none}.dartAd{display:block !important}</style> Abstract Anti-estrogenic therapy is a mainstay for estrogen receptor (ERα)-positive breast cancer. Due to the development of resistance to established anti-hormones such as tamoxifen, novel […]

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Making Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable

Making Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable, Ann Fam Med. 2015 Jul;13, David SP1, Johnson SG2, Berger AC3, Feero WG4, Terry SF5, Green LA6, Phillips RL Jr7, Ginsburg GS8. 1Department of Medicine, Stanford University School […]

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H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1

H, 15 N and 13 C backbone resonance assignments of the N-terminal, tandem KH domains of human hnRNP E1, 5Jul2015, Biomolecular NMR Assignments, Yang Li, Mirko Hennig UNC Chapel Hill Abstract Heterogeneous nuclear ribonucleoproteins (hnRNPs) can be divided into subgroups based on their RNA-binding characteristics. One subgroup in mammalian cells are the Poly(C)-binding proteins (PCBPs) comprised of […]

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What was old is new again: using the host response to diagnose infectious disease

What was old is new again: using the host response to diagnose infectious disease, Expert Rev Mol Diagn. 2015 Jul 4, Ko ER1, Yang WE, McClain MT, Woods CW, Ginsburg GS, Tsalik EL. 1Department of Medicine Center for Applied Genomics & Precision Medicine, Duke University, Durham, NC 27708, USA. Abstract A century of advances in infectious disease […]

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19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR

19 F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR, Methods in Enzymology, 19Jun2015, Lincoln G. Scott*, Mirko Hennig†, , * Cassia LLC, San Diego, California, USA † Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA Abstract Naturally occurring RNA lacks fluorine-19 (19F), thus, their specifically fluorinated counterparts are particularly well suited […]

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Gene Expression Signatures and the Spectrum of Coronary Artery Disease.

Gene Expression Signatures and the Spectrum of Coronary Artery Disease. J Cardiovasc Transl Res. 2015 Jun 19,Friede KA1, Ginsburg GS, Voora D. Department of Medicine, Duke University, Durham, NC, USA. Abstract Over the past 10-15 years, developments in gene expression profiling have opened new arenas for the discovery of important factors in the pathogenesis of numerous disease […]

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Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency, Mol Genet Metab. 2015 Jun 18, Strauss KA1, Ferreira C2, Bottiglieri T3, Zhao X4, Arning E3, Zhang S4, Zeisel SH4, Escolar ML5, Presnick N6, Puffenberger EG7, Vugrek O8, Kovacevic L8,Wagner C9, Mazariegos GV10, Mudd SH11, Soltys K10. Author information 1Clinic for Special Children, Strasburg, PA, USA; Franklin […]

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Distribution and biomarker of carbon‐14 labeled fullerene C60 ([14C (U)] C60) in pregnant and lactating rats and their offspring after maternal intravenous exposure

Distribution and biomarker of carbon‐14 labeled fullerene C60 ([14C (U)] C60) in pregnant and lactating rats and their offspring after maternal intravenous exposure,J Appl Toxicol. 2015 Jun 17, Snyder RW1, Fennell TR1, Wingard CJ2, Mortensen NP1, Holland NA2, Shannahan JH2, Pathmasiri W1, Lewin AH1, Sumner SC1. Note: The David H. Murdock Research Institute at the NC […]

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Global metabolomic profiling targeting childhood obesity in the Hispanic population

Global metabolomic profiling targeting childhood obesity in the Hispanic population, Am J Clin Nutr. 2015 Jun 17, Butte NF1, Liu Y2, Zakeri IF3, Mohney RP4, Mehta N2, Voruganti VS5, Göring H6, Cole SA6, Comuzzie AG6. 1USDA/Agricultural Research Service Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX; nbutte@bcm.edu. 2USDA/Agricultural Research Service Children’s Nutrition […]

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A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine

A rapid LC‐MRM/MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N‐oxide and creatinine in human plasma and urine, Electrophoresis. 2015 Jun 17, Zhao X1, Zeisel S1,2, Zhang S3. Author information 1Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, 28081, USA. 2Department of Nutrition, School of Public Health and School of Medicine, […]

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Blackcurrant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

Blackcurrant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome, J Agric Food Chem. 2015 Jun 12., Esposito D, Damsud T, Wilson M, Grace MH, Strauch R, Li X, Lila MA, Komarnytsky S. Abstract Blackcurrant (Ribes nigrum L) is a rich source of anthocyanins, however the relationship […]

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Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non–ST-Segment Elevation Acute Coronary Syndrome Patients

Sex-Stratified Trends in Enrollment, Patient Characteristics, Treatment, and Outcomes Among Non–ST-Segment Elevation Acute Coronary Syndrome Patients , June 8, 2015, American Heart Association, Inc, Kristian Kragholm, MD*, Sharif A. Halim, MD, MHS*, Qinghong Yang, MSc, Phillip J. Schulte, MSc, PhD, Judith S. Hochman, MD, Chiara Melloni, MD, Kenneth W. Mahaffey, MD, David J. Moliterno, MD, Robert A. Harrington, MD, Harvey D. White, DSc, Paul W. Armstrong, MD, E. Magnus Ohman, […]

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RNA-seq analysis reveals genetic response and tolerance mechanisms to ozone exposure in soybean

RNA-seq analysis reveals genetic response and tolerance mechanisms to Ozone exposure in soybean, BMC Genomics. 2015 Jun 4, Whaley A1, Sheridan J2, Safari S3, Burton A4, Burkey K5, Schlueter J6. Author information 1Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC, 28223, USA. awhaley9@uncc.edu. 2Department of Bioinformatics and Genomics, University of […]

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The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice

The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice, 2015 Jun 3, Stem Cell Reports. Zhou X1, Crow AL2, Hartiala J2, Spindler TJ1, Ghazalpour A3, Barsky LW1, Bennett BB4, Parks BW3, Eskin E5, Jain R6, Epstein JA6, Lusis AJ3, Adams GB7,Allayee H8. Author information 1Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at […]

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Numerical solution of a microbial growth model applied to dynamic environments.

Numerical solution of a microbial growth model applied to dynamic environments, 2015 May, J Microbiol Methods,  Zhu S1, Chen G2. 1Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA. 2Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research […]

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Serum Proteome Profiles in Stricturing Crohn’s Disease: A Pilot Study

Serum Proteome Profiles in Stricturing Crohn’s Disease: A Pilot Study, 19 May 2015, Crohn’s & Colitis Foundation of America, Inc, Townsend, Peter MD; Zhang, Qibin PhD; Shapiro, Jason MD; Webb-Robertson, Bobbie-Jo PhD; Bramer, Lisa PhD; Schepmoes, Athena A. BS; Weitz, Karl K. BS; Mallette, Meaghan BS, MS; Moniz, Heather BS; Bright, Renee MS; Kamphaus, Tania PhD; Shah, […]

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Stability and immunogenicity of hypoallergenic peanut protein–polyphenol complexes during in vitro pepsin digestion

Stability and immunogenicity of hypoallergenic peanut protein-polyphenol complexes during in vitro pepsin digestion, Food & Function, May 2015.Nathalie J. Plundrich, Brittany L. White,  Lisa L. Deanb, Jack P. Davis, E. Allen Foegeding, Mary Ann Lila Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, North Carolina Research Campus, 600 Laureate […]

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No Positive Influence of Ingesting Chia Seed Oil on Human Running Performance

No Positive Influence of Ingesting Chia Seed Oil on Human Running Performance, 15 May 2015,  Nutrients , David C. Nieman 1,*, Nicholas D. Gillitt 2, Mary Pat Meaney 1 and Dustin A. Dew Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA; E-Mails: meaneymp@appstate.edu (M.P.M.); dustindew@gmail.com (D.A.D.) Dole Nutrition Research Laboratory, […]

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Perceptions of personalized medicine in an academic health system: Educational findings

Perceptions of personalized medicine in an academic health system: Educational findings, 13 May 2015,  Journal of Contemporary Medical Education, Allison Vorderstrasse, Sara Huston Katsanis, Mollie A Minear, Nancy Yang, Tejinder Rakhra-Burris, Jason W Reeves, Robert Cook-Deegan, Geoffrey S Ginsburg, Leigh Ann Simmons. Abstract Objective: Prior reports demonstrate that personalized medicine implementation in clinical care is […]

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Application of 1H NMR Profiling To Assess Seed Metabolomic Diversity. A Case Study on a Soybean Era Population

Application of 1H NMR Profiling To Assess Seed Metabolomic Diversity. A Case Study on a Soybean Era Population, 2015 May 5, J Agric Food Chem., Harrigan GG1, Skogerson K1, MacIsaac S2, Bickel A1, Perez T1, Li X1. 1†Monsanto Company, 800 North Lindbergh Boulevard, St. Louis, Missouri 63167, United States. 2§150 North Research Campus Drive, Kannapolis, North Carolina 28081, […]

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Genetic analysis of glucosinolate variability in broccoli florets using genome-anchored single nucleotide polymorphisms

Genetic analysis of glucosinlates variability in broccoli florets using genome-anchored single nucleotide polymorphisms, 2015 May 1, Theor Appl Genet., Brown AF1, Yousef GG, Reid RW, Chebrolu KK, Thomas A, Krueger C, Jeffery E, Jackson E, Juvik JA. 1Department of Horticultural Science, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, 28081, USA, afbrown2@ncsu.edu. Abstract KEY MESSAGE: […]

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Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.

Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. 2015 Apr 28, FASEB J., Silver MJ1, Corbin KD1, Hellenthal G1, da Costa KA1, Dominguez-Salas P1, Moore SE1, Owen J1, Prentice AM1, Hennig BJ1, Zeisel SH2. 1*Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United […]

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Species authentication and geographical origin discrimination of herbal medicines by near infrared spectroscopy: A review

Species authentication and geographical origin discrimination of herbal medicines by near infrared spectroscopy: A review, 23 April 2015,  Journal of Pharmaceutical Analysis, Pei Wanga, b, Zhiguo Yua School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China b Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, […]

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Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib

Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib, Journal of Cancer Research, April 22, 2015, Ming Zhao, Amanda Blackwelder, Harry Lee, and Xiaohe Yang Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC. Abstract 3557: Cancerous inhibitor of PP2A is a novel molecular target and resistance factor of Lapatinib Abstract […]

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Anthocyanin, Carotenoid, Tocopherol, and Ellagitannin Content of Red Raspberry Cultivars Grown under Field or High Tunnel Cultivation in the Southeastern United States

Anthocyanin, Carotenoid, Tocopherol, and Ellagitannin Content of Red Raspberry Cultivars Grown under Field or High Tunnel Cultivation in the Southeastern United States, Apr 2015, Journal of the American Society for Horticultural Science, Christine M. Bradish1, Gad G. Yousef, Guoying Ma, Penelope Perkins-Veazie, Gina E. Fernandez Department of Horticultural Science, North Carolina State University, Campus Box 7609, Raleigh, NC 27695 Plants for […]

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Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content

Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content, 2015 Apr 18, BMC Sports Sci Med Rehabil. Nieman DC1, Shanely RA2, Zwetsloot KA2, Meaney MP1, Farris GE3. 1Appalachian State University, Human Performance Lab, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081 USA. 2Department of Health and Exercise Science, Appalachian State University, Boone, NC USA. 3Department […]

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Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans.

Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans. 2015 Apr 16, J Gen Intern Med., Voils CI1, Coffman CJ, Grubber JM, Edelman D, Sadeghpour A, Maciejewski ML, Bolton J, Cho A, Ginsburg GS, Yancy WS Jr. 1Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical […]

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SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization

SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization, 2015 Apr 16, Pharmacogenomics. Li JH1, Suchindran S, Shah SH, Kraus WE, Ginsburg GS, Voora D. 1Duke Center for Applied Genomics & Precision Medicine, Duke University, 101 Science Drive, Durham, NC 27705, USA. Abstract AIM: SLCO1B1 variants are associated with intermediate outcomes […]

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Novel value-added uses for sweet potato juice and flour in polyphenol- and protein-enriched functional food ingredients

Mary H. Grace, An N. Truong, Van-Den Truong, Ilya Raskin, Mary Ann Lila (2015). Novel value-added uses for sweet potato juice and flour in polyphenol- and protein-enriched functional food ingredients. Food Science & Nutrition, 3: 415–424. Author Affiliations: Department of Food, Bioprocessing and Nutrition Sciences, Plants for Human Health Institute, North Carolina State University, North […]

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Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes

Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes, 14 Apr 2015, Journal of Functional Foods. Joshua Kellogg, Debora Esposito, Mary H. Grace, Slavko Komarnytsky, Mary Ann Lila NC State University Abstract Chronic inflammation is characterized by macrophage accumulation in adipose tissue, which subsequently up-regulates pro-inflammatory cytokines and promotes the dysregulation of lipid metabolism, […]

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Community-Based Research as a Mechanism to Reduce Environmental Health Disparities in American Indian and Alaska Native Communities

Community-Based Research as a Mechanism to Reduce Environmental Health Disparities in American Indian and Alaska native communities , 2015 Apr 13, Int J Environ Res Public Health. McOliver CA1, Camper AK2, Doyle JT3, Eggers MJ4, Ford TE5, Lila MA6, Berner J7, Campbell L8, Donatuto J9. Office of Research and Development, National Center for Environmental Research, United States Environmental Protection […]

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The plant parasite Pratylenchus coffeae carries a minimal nematode genome

The plant parasite Pratylenchus coffeae carries a minimal nematode genome,  11 Apr 2015, Nematology, Mark BURKE 1,2,3, Elizabeth H. SCHOLL 4, DavidMcK. BIRD 1,4, Jennifer E. SCHAFF 5, Steve COLEMAN 2, Randy CROWELL 6, Stephen DIENER 3, Oksana GORDON 6, Steven GRAHAM 3, Xinguo WANG 6, EricWINDHAM 3, Garron M. WRIGHT 3 and Charles H. OPPERMAN 4, 1 Bioinformatics […]

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Phytochemical Characterization, Anti-inflammatory and Lipolytic Activities of Pistachio Hulls, Skins, and Kernels

Phytochemical Characterization, Anti-inflammatory and Lipolytic Activities of Pistachio Hulls, Skins, and Kernels, Apr 2015, The FASEB Journal, Mary Grace Dr1, Debora Esposito1, Michael Timmers1 and Mary Ann Lila1 1Food Bioprocessing and Nutrition Sciences Plants for Human Health Institute, NCSU Kannapolis NC United States Abstract Anti-inflammatory, antioxidant, and lipolytic properties of pistachio hull, skin, and kernel extracts were evaluated here. All […]

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Diverse Classes of Bitter Phytochemicals Modulate Carbohydrate Metabolism and Immune Responses through Gastrointestinal Bitter Taste Receptors

Diverse Classes of Bitter Phytochemicals Modulate Carbohydrate Metabolism and Immune Responses through Gastrointestinal Bitter Taste Receptors, Apr 2015, The FASEB Journal, Kimberly Palatini1,2, Mickey Wilson1,2, Jessica Alley1,3, Debora Esposito1,2 and Slavko Komarnytsky1,2 1Plants for Human Health Institute North Carolina State University Kannapolis NC United States 2Food, Bioprocessing, and Nutrition Sciences North Carolina State University Raleigh NC United States 3Health and Exercise […]

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Effects of Mthfd1 Gene on Mouse Behavior

Effects of Mthfd1 Gene on Mouse Behavior, Apr 2015,The FASEB Journal,  Eneda Pjetri1 and Steven Zeisel1 1Nutrition Research Institute UNC Chapel Hill Kannapolis NC United States Abstract Methylenetetrahydrofolate dehydrogenase 1 (Mthfd1) gene encodes the trifunctional C1 tetrahydrofolate (C1THF) enzyme that plays an important role in the folate-mediated one-carbon metabolism. A polymorphism of this gene (1958G>A; rs2236225) has […]

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California Table Grape Consumption Reduces Adiposity, Hepatic Triglycerides, Lipogenic Gene Expression, and Abundance of Sulfidogenic Bacteria in Mice

California Table Grape Consumption Reduces Adiposity, Hepatic Triglycerides, Lipogenic Gene Expression, and Abundance of Sulfidogenic Bacteria in Mice, Apr 2015, The FASEB Journal, Jessie Baldwin1, Brian Collins1, Patricia Wolfe2, Wan Shen1, Chia-Chi Chuang3, Wei Zhong4, Paula Cooney1, H Rex Gaskins2 and Michael McIntosh1 1Nutrition UNC-Greensboro NC United States 2Animal Science University of Illinois IL United States 3Pathology Wake Forest School of Medicine Winston Salem NC […]

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Phytochemical Characterization And Anti-inflammatory Activity Of The Mexican Fruit Styrax ramirezii Greenm

Phytochemical Characterization And Anti-inflammatory Activity Of The Mexican Fruit Styrax ramirezii Greenm, Apr 2015, The FASEB Journal, Jorge Guerrero-Medina2 and Mary Ann Lila1, Michael Timmers Dr1, 1PHHI, Department of Food, Bioprocessing and Nutrition Sciences North Carolina State University Kannapolis North Caolina United States 2Agrobiologia Department Universidad Michoacana de San Nicolás de Hidalgo Uruapan Michoacán Mexico Abstract With an increasing […]

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Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer

Synergistic Effects of Fiber and Phytochemicals in Wheat Bran on Colon Cancer, Apr 2015, The FASEB Journal, Jennifer McBride1, Yingdong Zhu1, Pei Wang1 and Shengmin Sang1 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Colorectal cancer (CRC) is a leading cause of cancer related deaths in the United States. Epidemiological […]

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In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice

In Utero Exposure to Low-Dose Alcohol Induces Reprogramming of Mammary Development and Tumor Risk in MMTV-erbB-2 Transgenic Mice, 2015 Apr 7, Int J Mol Sci, Ma Z1, Blackwelder AJ2, Lee H3, Zhao M4, Yang X5. 1Julius L. Chambers Biomedical/Biotechnology Research Institute and Department of Biology, North Carolina Central University, Kannapolis, NC 28081, USA. mzhao@nccu.edu. 2Julius L. Chambers Biomedical/Biotechnology […]

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Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice

Carnosic Acid as the Major Bioactive Component in Rosemary Extract Ameliorates High-fat Diet-induced Obesity and Metabolic Syndrome in Mice, Apr 2015, The FASEB Journal, Yantao Zhao1, Rashin Sedighi1, Pei Wang1, Huadong Chen1, Yingdong Zhu1 and Shengmin Sang1 –1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States Abstract Rosemary has been used as a natural […]

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Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells

Oat Avenanthramides Induce Heme Oxygengase-1 Expression via Nrf2-mediated Signaling in HK-2 Cells, Apr 2015, The FASEB Journal, Shengmin Sang1, Junsheng Fu1, Yingdong Zhu1, Aaron Yerke1, Mitchell Wise2, Jodee Johnson3 and YiFang Chu3 1Center for Excellence in Post-Harvest Technologies North Carolina Agricultural and Technical State University Kannapolis NC United States 2Cereal Crops Research Unit USDA Madison WI United States 3Quaker Oats Center of Excellence […]

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Adiposity, Aerobic and Anaerobic Fitness in Middle School Aged Children

Adiposity, Aerobic and Anaerobic Fitness in Middle School Aged Children,  Apr 2015 ,The FASEB Journal, David Nieman1, Dustin Dew1 and Pamela Krasen1 1North Carolina Research Campus Appalachian State University Kannapolis NC United States Abstract National data suggest that aerobic fitness and adiposity are negatively correlated in children, but this relationship was established using submaximal exercise tests and skinfold […]

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Patient Beliefs and Behaviors About Genomic Risk for Type 2 Diabetes: Implications for Prevention

Patient Beliefs and Behaviors About Genomic Risk for Type 2 Diabetes: Implications for Prevention, 2015 Apr 6, J Health Commun, Gallagher P1, King HA, Haga SB, Orlando LA, Joy SV, Trujillo GM, Scott WM, Bembe M, Creighton DL, Cho AH, Ginsburg GS, Vorderstrasse A. Altisource, Inc. , Winston-Salem , North Carolina , USA. Abstract Type 2 diabetes is […]

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Chia Seed Oil Supplementation Has No Influence on Running Performance

Chia Seed Oil Supplementation Has No Influence on Running Performance, The FASEB Journal, April 2015, David Nieman1, Nicholas Gillitt2, Mary Pat Meaney1, Dustin Dew1 and Fuxia Jin2 1NCRC Appalachian State University United States 2Dole Nutrition Research Laboratory Dole Foods United States Chia Seed Oil Supplementation Has No Influence on Running Performance Abstract Plasma ALA levels peak about 2 h after ingestion, […]

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Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats

Kupffer cell depletion protects against the steatosis, but not the liver damage, 1 induced by marginal copper, high fructose diet in male rats, 2015 Mar 26, Am J Physiol Gastrointest Liver Physiol., Song M1, Schuschke DA2, Zhou Z3, Zhong W3, Zhang J2, Zhang X2, Wang Y2, McClain CJ2. 1University of Louisville m0song03@louisville.edu. 2University of Louisville. 3University of North […]

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Analysis and Visualization of RNA-Seq Expression Data Using RStudio, Bioconductor, and Integrated Genome Browser

Analysis and Visualization of RNA-Seq Expression Data Using RStudio, Bioconductor, and Integrated Genome Browser, Methods Mol Biol. 2015 Mar, Loraine AE1, Blakley IC, Jagadeesan S, Harper J, Miller G, Firon N. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, North Carolina Research Campus, Charlotte, NC, USA, aloraine@uncc.edu. Abstract Sequencing costs are falling, but the […]

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A novel Alzheimer disease locus located near the gene encoding tau protein

A novel Alzheimer disease locus located near the gene encoding tau protein, Mol Psychiatry. 2015 Mar 17, Jun G1, Ibrahim-Verbaas CA2, Vronskaya M3, Lambert JC4, Chung J5, Naj AC6, Kunkle BW7, Wang LS6, Bis JC8, Bellenguez C4, Harold D9, Lunetta KL10,Destefano AL10, Grenier-Boley B4, Sims R3, Beecham GW11, Smith AV12, Chouraki V13, Hamilton-Nelson KL7, Ikram MA14, Fievet […]

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Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease

Subcellular Zinc Deficiency Links with ER and Mitochondria Cell Death Signaling in Alcoholic Liver Disease, 2015 Mar 12, Am J Physiol Gastrointest Liver Physiol. Sun Q1, Zhong W2, Zhang W2, Li Q2, Sun X2, Tan X2, Sun X2, Dong D2, Zhou Z3. UNC greensboro. 2University of North Carolina at Greensboro. 3University of North Carolina at Greensboro z_zhou@uncg.edu. Abstract […]

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Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells, Phytomedicine, 11 March 2015,  Yujie Fua, b, 1, Onat Kadiogluc, 1, Benjamin Wienchc, Zuofu Weia, b, Chang Gaod, Meng Luoa, b, Xiaohe Yange, Chengbo Gua, b, Yuangang Zua, b, Thomas Efferth Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer […]

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Genetics of CD33 in Alzheimer’s Disease and Acute Myeloid Leukemia.

Genetics of CD33 in Alzheimer’s Disease and Acute Myeloid Leukemia. Hum Mol Genet. 2015 Mar 11, Malik M, Chiles J 3rd, Xi HS, Medway C, Simpson J, Potluri S, Howard D, Liang Y, Paumi CM, Mukherjee S, Crane P, Younkin S, Fardo DW, Estus S. Abstract The CD33 single nucleotide polymorphism (SNP) rs3865444 has been associated with the risk of Alzheimer’s disease (AD). Rs3865444 is in […]

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Implementation of Management Strategies for Diabetes and Hypertension: From Local to Global Health in Cardiovascular Diseases

Implementation of Management Strategies for Diabetes and Hypertension: From Local to Global Health in Cardiovascular Diseases, Glob Heart. 2015 Mar, Bloomfield GS1, Wang TY1, Boulware LE1, Califf RM1, Hernandez AF1, Velazquez EJ1, Peterson ED1, Li JS2. Duke University Medical Center and Duke Clinical Research Institute, Durham, NC. 2Duke University Medical Center and Duke Clinical Research Institute, Durham, […]

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Explicit modeling of microbial growth under nonisothermal conditions.

Explicit modeling of microbial growth under nonisothermal conditions. J Microbiol Methods. 2015 Mar 10, Zhu S1, Chen G2. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA. 2Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, The North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA. […]

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Analysis of Nutrition Education in Osteopathic Medical Schools

Analysis of Nutrition Education in Osteopathic Medical Schools, 4 Mar 2015, Journal of Biomedical Education, Kathaleen Briggs Early,1 Kelly M. Adams,2 and Martin Kohlmeier2,3 1College of Osteopathic Medicine, Pacific Northwest University of Health Sciences, 200 University Pkwy, Yakima, WA 98901, USA 2Department of Nutrition, School of Medicine and Gillings School of Global Public Health, University of North Carolina at […]

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Comparison of GC-MS and GC× GC-MS in the Analysis of Human Serum Samples for Biomarker Discovery

Comparison of GC-MS and GC× GC-MS in the Analysis of Human Serum Samples for Biomarker Discovery, J Proteome Res. 2015 Mar 4, Winnike JH, Wei X, Knagge KJ, Colman SD, Gregory SG, Zhang X, David H. Murdock Research Institute. Abstract We compared the performance of gas chromatography time-of-flight mass spectrometry (GC-MS) and comprehensive two-dimensional gas chromatography time-of-flight […]

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COBRA-LIKE2, a Member of the Glycosylphosphatidylinositol-Anchored COBRA-LIKE Family, Plays a Role in Cellulose Deposition in Arabidopsis Seed Coat Mucilage Secretory Cells.

COBRA-LIKE2, a Member of the Glycosylphosphatidylinositol-Anchored COBRA-LIKE Family, Plays a Role in Cellulose Deposition in Arabidopsis Seed Coat Mucilage Secretory Cells. Plant Physiol. 2015 Mar, Ben-Tov D1, Abraham Y1, Stav S1, Thompson K1, Loraine A1, Elbaum R1, de Souza A1, Pauly M1, Kieber JJ1, Harpaz-Saad S2. 1Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, […]

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Prognostic Implications of Low Level Cardiac Troponin Elevation Using High‐Sensitivity Cardiac Troponin T

Prognostic Implications of Low Level Cardiac Troponin Elevation Using High‐Sensitivity Cardiac Troponin T, Clin Cardiol. 2015 Mar 3, Grinstein J1, Bonaca MP, Jarolim P, Conrad MJ, Bohula-May E, Deenadayalu N, Braunwald E, Giugliano RP, Newby LK, Sabatine MS, Morrow DA. Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts. Abstract BACKGROUND: High-sensitivity cardiac troponin T (hsTnT) is […]

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Volume changes and brain‐behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure

Volume changes and brain‐behavior relationships in white matter and subcortical gray matter in children with prenatal alcohol exposure, Hum Brain Mapp. 2015 Feb 25, Gautam P1, Lebel C, Narr KL, Mattson SN, May PA, Adnams CM, Riley EP, Jones KL, Kan EC, Sowell ER. 1Department of Pediatrics, Developmental Cognitive Neuroimaging Laboratory, Keck School of Medicine, USC/Children‘s Hospital […]

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Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects

Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects, Queensland University, Feb 2015, Jonathan M. Peake1, Paul Della Gatta2, Katsuhiko Suzuki3, David C. Nieman4 Affiliations: 1 School of Biomedical Sciences and Institute of Health and Biomedical Sciences, Queensland University of Technology, Brisbane, Australia 2 Centre for Physical Activity and Nutrition, School of Exercise and […]

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Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde

Visceral White Adipose Tissue is Susceptible to Alcohol‐Induced Lipodystrophy in Rats: Role of Acetaldehyde, Alcohol Clin Exp Res. 2015 Feb 19, Zhang W1, Zhong W, Sun X, Sun Q, Tan X, Li Q, Sun X, Zhou Z. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina. Abstract BACKGROUND: Chronic alcohol exposure causes […]

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Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice

Interactions Between Nuclear receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice, Gastroenterology. 2015 Feb 18, Tsuchiya H1, Costa KA2, Lee S3, Renga B4, Jaeschke H5, Yang Z6, Orena SJ2, Goedken MJ7, Zhang Y5, Bo K8, Lebofsky M5, Rudraiah S3, Smalling R1, Guo G8, Fiorucci S4, Zeisel SH2, Wang L9. Department of Medicine, University of Utah […]

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Control of Paternally Expressed Imprinted UPWARD CURLY LEAF1, a Gene Encoding an F-Box Protein That Regulates CURLY LEAF Polycomb Protein, in the Arabidopsis Endosperm

Control of Paternally Expressed Imprinted UPWARD CURLY LEAF1, a Gene Encoding an F-Box Protein That Regulates CURLY LEAF Polycomb Protein, in the Arabidopsis Endosperm, PLoS One. 2015 Feb 17, Jeong CW1, Park GT1, Yun H1, Hsieh TF2, Choi YD3, Choi Y1, Lee JS1. School of Biological Sciences, Seoul National University, Seoul, Korea. 2Plants for Human Health Institute […]

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Identification of Aortic Arch-Specific Quantitative Trait Loci for Atherosclerosis by an Intercross of DBA/2J and 129S6 Apolipoprotein E-Deficient Mice.

Identification of Aortic Arch-Specific Quantitative Trait Loci for Atherosclerosis by an Intercross of DBA/2J and 129S6 Apolipoprotein E-Deficient Mice. PLoS One. 2015 Feb 17, Kayashima Y1, Makhanova NA1, Matsuki K1, Tomita H1, Bennett BJ2, Maeda N1. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. […]

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Behavior of a modified Dissociation element in barley: a tool for genetic studies and for breeding transgenic barley

Behavior of a modified Dissociation element in barley: a tool for genetic studies and for breeding transgenic barley, Molecular Breeding, 17 Feb 2015,  Ryan H. Brown, Jaswinder Singh, Surinder Singh, Lynn S. Dahleen, Peggy G. Lemaux, Nils Stein, Martin Mascher, Phil Bregitzer General Mills Abstract Maize-derived sequences from the transposable elements Activator (Ac) and Dissociation (Ds) have enabled studies of gene function via transposon […]

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RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage-specific alternative splicing

Vikas Gupta, April D Estrada, Ivory Blakley, Rob Reid, Ketan Patel, Mason D Meyer, Stig Uggerhøj Andersen, Allan F Brown, Mary Ann Lila and Ann E Loraine (2016). RNA-Seq analysis and annotation of a draft blueberry genome assembly identifies candidate genes involved in fruit ripening, biosynthesis of bioactive compounds, and stage-specific alternative splicing. GigaScience, 4:5. […]

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Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review

Preventive and Protective Properties of Rosemary (Rosmarinus Officinalis L.) in Obesity and Diabetes Mellitus of Metabolic Disorders: A Brief Review, Current Opinion in Food Science, 10 February 2015,  Rashin Sedighi, Yantao Zhao, Aaron Yerke, Shengmin Sang Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, North Carolina […]

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Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practices™ systematic review.

Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practices™ systematic review. Clin Biochem. 2015 Feb 7, Layfield C1, Rose J2, Alford A2, Snyder SR3, Apple FS4, Chowdhury FM5, Kontos MC6, Newby LK7, Storrow AB8, Tanasijevic M9, Leibach E5, Shaw C5, Liebow EB10, Christenson […]

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Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation

Oxyphytosterols as Active Ingredients in Wheat Bran Suppress Human Colon Cancer Cell Growth: Identification, Chemical Synthesis and Biological Evaluation, J Agric Food Chem. 2015 Feb 6, Zhu Y, Soroka D, Sang S. NC A&T University Abstract Consumption of whole grains has been reported to be associated with a lower risk of several lifestyle-related diseases such as colorectal […]

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Proteinuria in Cynomolgus macaques (Macaca fascicularis) with Spontaneously Developed Metabolic Disorder and Diabetes: Transcriptome Analysis of Biopsy Kidney

Proteinuria in Cynomolgus macaques (Macaca fascicularis) with Spontaneously Developed Metabolic Disorder and Diabetes: Transcriptome Analysis of Biopsy Kidney ,  Journal of Diabetes and Metabolism. Sheng Guo1, Wubin Qian1, Fenglai Du1, Bingdi Wang1, Xiaoli Wang1, Yupeng Fang1, Xuan Chen1, Michael Benzinou1, Francine M. Gregoire2, Michael, Staup2, Keefe Chng2, Yaxiong Chen1, Yong-Fu Xiao1, Yi-Xin (Jim) Wang1,2* 1Cardiovascular and Metabolic […]

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Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study

Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study, The American Journal of Clinical Nutrition,  V Saroja Voruganti, Sandra Laston, Karin Haack, Nitesh R Mehta, Shelley A Cole, Nancy F Butte, and Anthony G Comuzzie From the Department of Nutrition (VSV) and UNC Nutrition Research Institute (VSV), University of North Carolina at Chapel Hill, Kannapolis, NC; […]

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Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin

Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin, American Heart Association, 28 Jan 2015,Jonathan C. Schisler, PhD; Trisha J. Grevengoed, BS; Florencia Pascual, PhD; Daniel E. Cooper, BS; Jessica M. Ellis, PhD; David S. Paul, PhD; Monte S. Willis, MD, PhD; Cam Patterson, MD; Wei Jia, PhD; Rosalind A. Coleman, MD 1Division […]

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Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease

Allergenicity of Roasted Peanuts Treated with a Non-Human Digestive Protease, Food Research International, 16Jan2015,  Jianmei Yua, , ,Michelle Hernandezd,Hao Lib, e,Ipek Goktepec,Carole Robinetted,Amy Auerbachd,David Pedend,Mohamed Ahmednac a Department of Family and Consumer Sciences, North Carolina A&T State University, Greensboro, NC 27411 b Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, Kannapolis, NC 28081, USA c […]

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Nutrition Competencies in Health Professionals’ Education and Training: A New Paradigm

Nutrition Competencies in Health Professionals’ Education and Training: A New Paradigm Adv Nutr. 2015 Jan 15, Kris-Etherton PM1, Akabas SR2, Douglas P3, Kohlmeier M4, Laur C5, Lenders CM6, Levy MD7, Nowson C8, Ray S5, Pratt CA9, Seidner DL10, Saltzman E11. Penn State University, University Park, PA; pmk3@psu.edu. 2Columbia University, New York, NY; 3University of Ulster, Londonderry, Northern […]

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Methods and initial findings from the Durham Diabetes Coalition: Integrating geospatial health technology and community interventions to reduce death and disability

Methods and initial findings from the Durham Diabetes Coalition: Integrating geospatial health technology and community interventions to reduce death and disability 14 January 2015, Journal of Clinical & Translational Endocrinology. Susan E. Spratta, , ,Bryan C. Batcha,Lisa P. Davisb, c,Ashley A. Dunhamb, c,Michele Easterlingd,Mark N. Feinglosa,Bradi B. Grangere,Gayle Harrisd,Michelle J. Lynf,Pamela J. axsong,Bimal R. Shahc,Benjamin Straussg,Tainayah Thomasd,Robert […]

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Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites

Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human Microbiota into Bioactive Metabolites,2015 American Society for Nutrition Dec 2014, Pei Wang4, Huadong Chen4, Yingdong Zhu, Jennifer McBride, Junsheng Fu, and Shengmin Sang* Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, Kannapolis, NC Oat Avenanthramide-C (2c) Is Biotransformed by Mice and the Human […]

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Aldehyde dehydrogenase homologous folate enzymes: evolutionary switch between cytoplasmic and mitochondrial localization.

Aldehyde dehydrogenase homologous folate enzymes: evolutionary switch between cytoplasmic andmitochondrial localization. Chem Biol Interact. 2014 Dec 27, Krupenko NI1, Holmes RS2, Tsybovsky Y3, Krupenko SA4. Department of Nutrition, UNC-Chapel Hill, UNC Nutrition Research Institute, Kannapolis, NC 28081, United States. 2The Eskitis Institute for Drug Discovery and School of Natural Sciences, Griffith University, Nathan 4111 Brisbane, Queensland, Australia. 3Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, […]

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Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosisand cell death in mice.  J Hepatol. 2014 Dec 24, Zhong W1, Zhang W1, Li Q1, Xie G2, Sun Q3, Sun X1, Tan X1, Sun X1, Jia W2, Zhou Z4. 1Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC, USA 28081. 2University of Hawaii Cancer Center, Honolulu, Hawaii, USA 96813. 3Center for Translational […]

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Medicinal Plants of Israel: A Model Approach to Enable an Efficient, Extensive, and Comprehensive Field Survey

Medicinal Plants of Israel: A Model Approach to Enable an Efficient, Extensive, and Comprehensive Field Survey Joseph et al., J Biodivers Biopros Dev 2014 , Gili Joseph1*, Mina Faran1, Ilya Raskin2, Mary Ann Lila3 and Bertold Fridlender1 1Department of Biotechnology, Hadassah Academic College, Jerusalem, Israel 2Department of Plant Biology and Pathology Rutgers University, New Brunswick, NJ 08901, […]

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Comparisons of computational methods for differential alternative splicing detection using RNA-seq in plant systems

Comparisons of computational methods for differential alternative splicing detection using RNA-seq in plantsystems. BMC Bioinformatics. 2014 Dec 16, Liu R, Loraine AE, Dickerson JA. UNC Charlotte Abstract BackgroundAlternative Splicing (AS) as a post-transcription regulation mechanism is an important application of RNA-seq studies in eukaryotes. A number of software and computational methods have been developed for detecting AS. Most of the methods, however, are designed and tested on animal data, […]

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Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species

Compounds leached from quinoa seeds inhibit matrix metalloproteinase activity and intracellular reactive oxygen species,  International Journal of Cosmetic Science – Wiley Online Library, Dec 2014,Brittany L. Graf1, Diana M. Cheng1, Debora Esposito2, Tara Shertel1, Alexander Poulev1, Nathalie Plundrich2, David Itenberg1, Nava Dayan3, Mary Ann Lila2 and Ilya Raskin1,* Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA2 Plants […]

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Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid.

Tea Flavanols Block Advanced Glycation of Lens Crystallins Induced by Dehydroascorbic Acid. Chem Res Toxicol. 2014 Dec 1, Zhu Y, Zhao Y, Wang P, Ahmedna M, Ho CT, Sang S. NC A&T University Abstract Growing evidence has shown that ascorbic acid (ASA) can contribute to protein glycation and the formation of advanced glycation end products (AGEs), especially in the lens. The mechanism by which ascorbic acid can cause […]

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Mechanisms and correlates of a healthy brain: a commentary.

Mechanisms and correlates of a healthy brain: a commentary. Monogr Soc Res Child Dev. 2014 Dec, Cheatham CL. Abstract In this monograph, the message is that early inactivity and obesity lead to later chronic disease, and, as such, physical inactivity should be recognized as a public health crisis. Sedentary behavior, to some extent, serves a purpose in […]

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Simultaneous Consideration of Multiple Candidate Protein Biomarkers for Long-Term Risk for Cardiovascular Events

Simultaneous Consideration of Multiple Candidate Protein Biomarkers for Long-Term Risk for Cardiovascular Events, Circ Cardiovasc Genet. 2014 Nov 24, Halim SA1, Neely ML2, Pieper KS2, Shah SH3, Kraus WE4, Hauser ER5, Califf RM6, Granger CB1, Newby LK7. 1Division of Cardiology & Duke Clinical Research Institute, Duke University Medical Center, Durham, NC. 2Duke Clinical Research Institute, Duke University […]

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Variation of Carotenoids and Polyphenolics in Peach and Implications on Breeding for Modified Phytochemical Profiles

Variation of Carotenoids and Polyphenolics in Peach and Implications on Breeding for Modified Phytochemical Profiles, Journal of the American Society for Horticultural Science, 2014, Allan F. Brown1, Gad G. Yousef, Ivette Guzman and Kranthi K. Chebrolu Plants for Human Health Institute, Department of Horticultural Science, North Carolina Research Campus, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, Dennis J. Werner and Mike […]

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Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal

Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal. J Agric Food Chem. 2014 Nov 20, Li X, Zheng T, Sang S, Lv L. NC A&T University Abstract Methylglyoxal (MGO) and glyoxal (GO) are not only endogenous metabolites, but also exist in exogenous resources, such as food, beverages, urban atmosphere, and cigarette smoke. They […]

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Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians

Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians. J Clin Endocrinol Metab. 2014 Nov 20, Tsai CW1, North KE, Tin A, Haack K, Franceschini N, Saroja Voruganti V (UNC Nutrition Research Institute), Laston S, Zhang Y, Best LG, MacCluer JW, Beaty TH, Navas-Acien A, Linda Kao WH,Howard BV. Department […]

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Venous Thromboembolism and Cardiovascular Risk: Results from the NAVIGATOR Trial

Venous Thromboembolism and Cardiovascular Risk: Results from the NAVIGATOR Trial   The American Journal of Medicine, 20 November 2014,  Marcelo Katz, MDa, b, Robert M. Califf, MDc, Jie-Lena Sun, MSd, John J.V. McMurray, MDe, Laine Thomas, PhDd, Renato D. Lopes, MD, PhD, MHSd, Brazilian Clinical Research Institute, Sao Paulo, Brazil b Hospital Israelita Albert Einstein, Sao Paulo, Brazil c Duke Translational Medicine Institute, Duke […]

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Influence of Pistachios on Performance and Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, and Metabolite Shifts in Cyclists: A Randomized, Crossover Trial.

Influence of Pistachios on Performance and Exercise-Induced Inflammation, Oxidative Stress, Immune Dysfunction, and Metabolite Shifts in Cyclists: A Randomized, Crossover Trial. PLoS One. 2014 Nov 19, Nieman DC1, Scherr J2, Luo B3, Meaney MP1, Dréau D4, Sha W5, Dew DA1, Henson DA6, Pappan KL7. Appalachian State University, Human Performance Lab, North Carolina Research Campus, Kannapolis, NC, United States of America. 2Department of Prevention and […]

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In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk

In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk.  Molecular Cancer Research. Nov 2014, Zhikun Ma, Amanda Blackwelder, and Xiaohe Yang North Carolina Central Unversity, Kannapolis, NC. Abstract A09: In utero exposure to estrogen promotes mammary tumor risk in MMTV-erbB-2 transgenic mice through induction of ER-erbB-2 crosstalk Abstract The mammary […]

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Grafting Extends Field Storage Life of Seedless Watermelon

Grafting Extends Field Storage Life of Seedless Watermelon, Cucerbitaceae 2014 Proceedings, RichArd hAssell* Coastal REC, Clemson University, Charleston, SC 29414, USA, PeneloPe Perkins-veAZie, Plants for Human Health Institute, Department of Horticultural Sciences, North Carolina State University, Kannapolis, NC 28081, USA, lisA deAn, USDA-ARS, Market Quality and Handling Research, Raleigh, NC 27695, USA AbstrAct. Quality of watermelon fruit is a combination of firmness, […]

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Yield and Quality Response of Spaghetti Squash (Cucurbita pepo) Cultivars Grown in the Southeastern United States

Yield and Quality Response of  Spaghetti Squash (Cucurbita pepo) Cultivars Grown in the Southeastern United States. Cucerbitaceae 2014 Proceedings., Jonathan r. Schultheis1*, Travis E. Birdsell2, And Penelooe Perkins-veazie3, 1Department of Horticultural Science, North Carolina State University, 2721 Founders Drive, Raleigh, NC 27695-7609, USA, 2134 Ashe County Center, Government Circle, Suite 202, Jefferson, NC 28640, USA, 3Plants for Human Health Institute, Department […]

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Analysis of Changes in Diversity and Abundance of the Microbial Community in a Cystic Fibrosis Patient Over a Multi-Year Period.

Analysis of Changes in Diversity and Abundance of the Microbial Community in a Cystic Fibrosis Patient Over a Multi-Year Period. J Clin Microbiol. 2014 Nov 12, Stokell JR1, Gharaibeh RZ2, Hamp TJ3, Zapata MJ3, Fodor AA3, Steck TR4 Department of Biological Sciences, Univ. of North Carolina at Charlotte, Charlotte, NC 28223, USA. 2Bioinformatics Services Division, Department of […]

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Analysis of Changes in Diversity and Abundance of the Microbial Community in a Cystic Fibrosis Patient Over aMulti-Year Period.

Analysis of Changes in Diversity and Abundance of the Microbial Community in a Cystic Fibrosis Patient Over aMulti-Year Period. J Clin Microbiol. 2014 Nov 12, Stokell JR1, Gharaibeh RZ2, Hamp TJ3, Zapata MJ3, Fodor AA3, Steck TR4 1Department of Biological Sciences, Univ. of North Carolina at Charlotte, Charlotte, NC 28223, USA. 2Bioinformatics Services Division, Department of Bioinformatics and Genomics, Univ. of North Carolina at Charlotte, Kannapolis, NC 28081, USA. 3Department of Bioinformatics and […]

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Translation of acute coronary syndrome therapies: From evidence to routine clinical practice

Translation of acute coronary syndrome therapies: From evidence to routine clinical practice  12 November 2014, American Heart Journal, Martin Putera, MDa, Robin Roark, MD, MBAb, Renato D. Lopes, MD, PhDb, Krishna Udayakumar, MD, MBAa, b, c, Eric D. Peterson, MD, MPHb, Robert M. Califf, MDb, c, Bimal R. Shah, MD, MBAb, d Translation of acute coronary syndrome therapies: From evidence to routine clinical practice […]

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Comparative Assessment of Short-term Adverse Events in Acute Heart Failure With Cystatin C and Other Estimates of Renal Function : Results From the ASCEND-HF Trial

Comparative Assessment of Short-term Adverse Events in Acute Heart Failure With Cystatin C and Other Estimates of Renal Function  : Results From the ASCEND-HF Trial, Science Direct  11 November 2014   W.H. Wilson Tang, MD∗, , , Matthias Dupont, MD†, Adrian F. Hernandez, MD‡, Adriaan A. Voors, MD§, Amy P. Hsu, MS∗, G. Michael Felker, MD‡, Javed Butler, MD‖, Marco Metra, MD¶, Stefan D.  nker, MD, […]

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Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism, FASEB J. 2014 Nov 10, Martínez-Vega R1, Garrido F2, Partearroyo T3, Cediel R4, Zeisel SH5, Martínez-Álvarez C6, Varela-Moreiras G3, Varela-Nieto I7, Pajares MA8. 1Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain; Unidad 761, Centro de Investigación Biomédica en […]

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The Correlation of Patient Reported versus Observed Medication Adherence in Type 2 Diabetes (T2DM)

The Correlation of Patient Reported versus Observed Medication Adherence in Type 2 Diabetes (T2DM) American Heart Association 2014, Katherine Kelly1; Maria Grau-Sepulveda2; Leoncio Flavio Rojas3; Bryan C Batch4; Melodie Staton5; Anne Wolfley2; Vicki Hatfield6; Monica Murphy7; Ellen Jones8; Bradi Granger 2Duke Clinical Rsch Institute, Duke Univ, Durham, NC 3Duke Transational Medicine Institute, Duke Univ, Durham, NC 4Medicine – Endocrinology and Metabolism, Duke Univ Sch of Medicine, Durham, […]

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The Folding of the Specific DNA Recognition Subdomain of the Sleeping Beauty Transposase Is Temperature-Dependent and Is Required for Its Binding to the Transposon DNA

The Folding of the Specific DNA Recognition Subdomain of the Sleeping Beauty Transposase Is Temperature-Dependent and Is Required for Its Binding to the Transposon DNA, PLoS One. 2014 Nov 6, Leighton GO1, Konnova TA2, Idiyatullin B3, Hurr SH1, Zuev YF3, Nesmelova IV4. The NMR experiments for this study were carried out at the David H. Murdock Research […]

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Analysis of pollen-specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR

Analysis of pollen-specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR, PeerJ PrePrints, 2014 Nov 6,  April D Estrada, Nowlan H Freese, Ann E Loraine​ Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Kannapolis, NC. Abstract  Alternative splicing enables a single gene to produce multiple mRNA isoforms by varying splice site selection. In animals, […]

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Acute Decompensated Heart Failure Patients Admitted to Critical Care Units: Insights from ASCEND-HF

Acute Decompensated Heart Failure Patients Admitted to Critical Care Units: Insights from ASCEND-HF, International Journal of Cardiology, Nov 3, 2014, Sean van Diepen, Divisions of Critical Care and Cardiology, University of Alberta, Edmonton, Alberta, Canada, Mohua Podder,  Vigour Center, Edmonton, Alberta, Canada, Adrian F. Hernandez, Clinical Research Institute, Duke University Medical Center, Durham, NC, USA, Cynthia M. Westerhout,  Vigour Center Alberta, Canada, Paul W. […]

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Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein- rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives

Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein- rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives. Plant Foods Hum Nutr. 2014 Oct 31, Grace MH1, Yousef GG, Esposito D, Raskin I, Lila MA 1Department of Food Bioprocessing and Nutrition Sciences, Plants for Human Health Institute, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC, 28081, USA. Abstract Well-known health-protective phytochemicals from muscadine grape and […]

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Concentrating Immunoprotective Phytoactive Compounds from Fruits and Vegetables into Shelf-stable Protein-rich Ingredients.

Concentrating Immunoprotective Phytoactive Compounds from Fruits and Vegetables into Shelf-stable Protein-rich Ingredients. Plant Foods Hum Nutr. 2014 Oct 29, Yousef GG1, Grace MH, Medina JL, Neff S, Guzman I, Brown AF, Raskin I, Lila MA. 1Department of Food Bioprocessing and Nutrition Sciences, Plants for Human Health Institute, North Carolina Research Campus, North Carolina State University, 600 Laureate Way, Kannapolis, NC, 28081, USA. Abstract Co-delivery of edible proteins with […]

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Check It, Change It: A Community-Based, Multifaceted Intervention to Improve Blood Pressure Control.

Check It, Change It: A Community-Based, Multifaceted Intervention to Improve Blood Pressure Control. Circ Cardiovasc Qual Outcomes. 2014 Oct 28, Thomas KL1, Shah BR2, Elliot-Bynum S2, Thomas KD2, Damon K2, Allen LaPointe NM2, Calhoun S2, Thomas L2, Breathett K2, Mathews R2, Anderson M2,Califf RM2, Peterson ED2. 1From the Department of Medicine, Duke University, Durham, NC (K.L.T., B.R.S., […]

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Prevalence and characteristics of fetal alcohol spectrum disorders

Prevalence and characteristics of fetal alcohol spectrum disorders Pediatrics. 2014 Oct 27, May PA1, Baete A2, Russo J2, Elliott AJ3, Blankenship J4, Kalberg WO4, Buckley D4, Brooks M4, Hasken J5, Abdul-Rahman O6, Adam MP7, Robinson LK8,Manning M9, Hoyme HE3. 1Department of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel […]

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The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes.

The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes.  2014 Oct 24Proc Natl Acad Sci U S A. Mérai Z1, Chumak N1, García-Aguilar M1, Hsieh TF2, Nishimura T3, Schoft VK1, Bindics J1, Slusarz L1, Arnoux S1, Opravil S4, Mechtler K4, Zilberman D5,Fischer RL5, Tamaru H6. Gregor Mendel Institute, Austrian Academy […]

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High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis

High-Resolution Genetic Mapping in the Diversity Outbred Mouse Population Identifies Apobec1 as a Candidate Gene for Atherosclerosis G3 (Bethesda). 2014 Oct 23, Smallwood TL1, Gatti DM2, Quizon P3, Weinstock GM4, Jung KC1, Zhao L1, Hua K1, Pomp D1, Bennett BJ5. University of North Carolina at Chapel Hill; 2The Jackson Laboratory; 3University of North Carolina Nutrition Research Institute; […]

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Long-term Clinical and Angiographic Outcomes in Patients with Diabetes Undergoing Coronary Artery Bypass Graft Surgery: Results from the PREVENT IV Trial

Long-term Clinical and Angiographic Outcomes in Patients with Diabetes Undergoing Coronary Artery Bypass Graft Surgery: Results from the PREVENT IV Trial, Published Online: October 23, 2014 ,  American Heart Journal<style>.requiresJS{display:none}.dartAd{display:block !important}</style> Masaya Koshizaka, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, Renato D. Lopes, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, Eric M. Reyes, Rose-Hulman Institute […]

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Phlorotannins from alaskan seaweed inhibit carbolytic enzyme activity.

Phlorotannins from alaskan seaweed inhibit carbolytic enzyme activity. Mar Drugs. 2014 Oct 22,  Kellogg J1, Grace MH2, Lila MA3. 1Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA. jjkellog@ncsu.edu. 2Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North […]

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Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion

Plasma Cholesterol-Lowering Activity of Gingerol- and Shogaol-Enriched Extract Is Mediated by Increasing Sterol Excretion. Journal of Agricultural and Food Chemistry. October 7, 2014. Lin Lei †, Yuwei Liu †, Xiaobo Wang †, Rui Jiao ‡,Ka Ying Ma †, Yuk Man Li †, Lijun Wang †, Sun Wa Man †, Shengmin Sang §, Yu Huang #, and Zhen-Yu Chen *† Author Affiliations † Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, […]

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Hypotension During Hospitalization for Acute Heart Failure Is Independently Associated With 30-Day Mortality

Hypotension During Hospitalization for Acute Heart Failure Is Independently Associated With 30-Day Mortality: Findings from ASCEND-HF. Circulation: Heart Failure, 2014. October 3, 2014. Priyesh A. Patel1,  Gretchen Heizer1, Christopher M. O’Connor2, Phillip J. Schulte1, Kenneth Dickstein3, Justin A. Ezekowitz4,Paul W. Armstrong4, Vic Hasselblad1, Roger M. Mills5, John J. McMurray6,Randall C. Starling7, W. H. Wilson Tang7, Robert M. Califf2 and Adrian F. Hernandez2 Author Affiliations […]

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A major quantitative trait locus conferring adult plant partial resistance to crown rust in oat.

A major quantitative trait locus conferring adult plant partial resistance to crown rust in oat. BMC Plant Biol. 2014 Sep 27, Lin Y, Gnanesh BN, Chong J, Chen G, Beattie AD, Mitchell Fetch JW, Kutcher H, Eckstein PE, Menzies JG, Jackson EW, McCartney CA. Abstract BackgroundCrown rust, caused by Puccinia coronata f. sp. avenae, is the most important disease of oat worldwide. Adult plant resistance (APR), based upon partial resistance, has proven to be a durable rust management strategy in other […]

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Novel strategies for capturing health-protective mango phytochemicals in shelf stable food matrices

Ivette Guzman, Mary H. Grace, Gad G. Yousef, Ilya Raskin & Mary Ann Lila. 2014. Novel strategies for capturing health-protective mango phytochemicals in shelf stable food matrices. International Journal of Food Sciences and Nutrition, 66(175-185). Abstract: Cost-effective methods for concentration and stabilization of otherwise perishable mango fruit phytoactives into shelf stable high protein ingredients were […]

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Pilot study of pharmacist-assisted delivery of pharmacogenetic testing in a primary care setting.

Pilot study of pharmacist-assisted delivery of pharmacogenetic testing in a primary care setting. Pharmacogenomics. 2014 Sep;15, Haga SB1, Allen LaPointe NM, Cho A, Reed SD, Mills R, Moaddeb J, Ginsburg GS. 1Duke University Center for Applied Genomics & Precision Medicine, 304 Research Drive, Box 90141 Durham, NC 27708, USA. Abstract AIM: To describe the rationale and design […]

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Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique JoVE Clinical and Translational Medicine, Sept 10, 2014, R. Andrew Shanely1,2, Kevin A. Zwetsloot2, N. Travis Triplett2, Mary Pat Meaney1,2, Gerard E. Farris3, David C. Nieman Human Performance Laboratory, North Carolina Research Campus, Appalacian State University, 2College of Health Sciences, Appalachian State University, 3Department of Emergency Medicine, […]

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The current epidemiology and clinical decisions surrounding acute respiratory infections

The current epidemiology and clinical decisions surrounding acute respiratory infections Trends Mol Med. 2014 Sep 5, Zaas AK1, Garner BH2, Tsalik EL3, Burke T2, Woods CW3, Ginsburg GS2. Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address: aimee.zaas@duke.edu. 2Center for Applied Genomics and Precision […]

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Bioavailability and Hypolipidemic Effects of Peanut Skin Polyphenols

Bioavailability and Hypolipidemic Effects of Peanut Skin Polyphenols J Med Food. 2014 Sep 3, Bansode RR1, Randolph P, Ahmedna M, Williams LL, Yu J.  Center for Excellence in Post Harvest Technologies, North Carolina Agricultural and Technical State University , North Carolina Research Campus, Kannapolis, North Carolina, USA . Abstract Abstract Peanut skin is a rich source of polyphenols, such as proanthocyanidins. Peanut skin proanthocyanidins mainly consist of a subgroup […]

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Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway.

Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway. PLoS One. 2014 Sep 1, Zha L1, Chen J2, Sun S2, Mao L2, Chu X2, Deng H2, Cai J3, Li X4, Liu Z5, Cao W6. 1Department of Nutrition and Food Hygiene, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China; Nutrition Research Institute at Kannapolis, Department of Nutrition, Gillings School […]

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Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics.

Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics. Mamm Genome. 2014 Aug 27, O’Connor A1, Quizon PM, Albright JE, Lin FT, Bennett BJ. UNC Chapel Hill Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081, USA. Abstract Intestinal microbial community structure is driven by host genetics in addition to environmental factors such as diet. In comparison with environmental influences, the effect of host genetics on intestinal microbiota, […]

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Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo.

Ginger Compound [6]-Shogaol and Its Cysteine-conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo. Chem Res Toxicol. 2014 Aug 22, Chen H, Fu J, Chen H, Hu Y, Soroka DN, Prigge J, Schmidt EE, Yan F, Major MB, Chen XL, Sang S. Abstract In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in […]

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Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial.

Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial. Eur Heart J. 2014 Aug 22, Breithardt G1, Baumgartner H2, Berkowitz SD3, Hellkamp AS4, Piccini JP4, Stevens SR4, Lokhnygina Y4, Patel MR4, Halperin JL5, Singer DE6, Hankey GJ7,Hacke W8, Becker RC4, Nessel CC9, Mahaffey KW10, Fox KA11, Califf RM12; for the ROCKET AF Steering Committee & […]

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The Metabolite Profiles of the Obese Population Are Gender-Dependent

The Metabolite Profiles of the Obese Population Are Gender-Dependent J Proteome Res. 2014 Aug 17, Xie G, Ma X, Zhao A, Wang C, Zhang Y, Nieman D, Nicholson JK, Jia W, Bao Y, Jia W. Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China. Appalachian State University Human Performance Laboratory Abstract Recent studies have […]

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Use of a Patient-Entered Family Health History Tool with Decision Support in Primary Care: Impact of Identification of Increased Risk Patients on Genetic Counseling Attendance.

Use of a Patient-Entered Family Health History Tool with Decision Support in Primary Care: Impact of Identification of Increased Risk Patients on Genetic Counseling Attendance. J Genet Couns. 2014 Aug 15, Buchanan AH1, Christianson CA, Himmel T, Powell KP, Agbaje A, Ginsburg GS, Henrich VC, Orlando LA. Duke Cancer Institute, Duke University, DUMC 2715 2424 Erwin Rd., Suite 602, Durham, NC, 27705, USA, adam.buchanan@duke.edu. Abstract […]

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Quantitative trait loci from two genotypes of oat (Avena sativa L.) conditioning resistance to Puccinia coronata

Quantitative trait loci from two genotypes of oat (Avena sativa L.) conditioning resistance to Puccinia coronata,  Phytopathology. 2014 Aug 14, Babiker EM1, Gordon T, Jackson E, Chao S, Harrison S, Carson M, Obert D, Bonman JM. USDA-ARS , 1691 S 2700 W , Aberdeen, Idaho General Mills Inc., Kannapolis, NC USDA-ARS, Fargo, North Dakota Louisiana State University, Baton Rouge, Louisiana USDA-ARS, St. Paul, Minnesota Limagrain […]

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High-density single nucleotide polymorphism (SNP) array mapping in Brassica oleracea: identification of QTL associated with carotenoid variation in broccoli florets

High-density single nucleotide polymorphism (SNP) array mapping inBrassica oleracea: identification of QTL associated with carotenoid variation in broccoli florets Theoretical and Applied Genetics 14 Aug 2014 Allan F. Brown, Gad G. Yousef, Kranthi K. Chebrolu, Robert W. Byrd, Koyt W. Everhart, Robert W. Reid, Isobel A. P. Parkin, Andrew G. Sharpe, Rebekah Oliver, Ivette Guzman, Eric W. Jackson Department of Horticultural Science, Plants for Human Health Institute, North Carolina […]

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Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery

Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery BMC Med Genomics. 2014 Aug 12, Albright J, Quizon PM, Lusis AJ, Bennett BJ. Department of Genetics, Nutrition Research Institute, University of North, Carolina, Chapel Hill, 500 Laureate Way, Suite 2303, Kannapolis, NC 28081, USA Abstract BACKGROUND: Atherosclerosis, the underlying cause of cardiovascular disease, results from both genetic and environmental factors. METHODS: […]

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A Registry-Based Randomized Trial Comparing Radial and Femoral Approaches in Women Undergoing Percutaneous Coronary Intervention

A Registry-Based Randomized Trial Comparing Radial and Femoral Approaches in Women Undergoing Percutaneous Coronary Intervention J Am Coll Cardiol Intv. Aug 2014, Sunil V. Rao, MD∗; Connie N. Hess, MD, MHS∗; Britt Barham, BA∗; Laura H. Aberle, BSPH∗; Kevin J. Anstrom, PhD∗; Tejan B. Patel, MD†; Jesse P. Jorgensen, MD‡; Ernest L. Mazzaferri, MD§; Sanjit S. Jolly, […]

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Chronic Obstructive Pulmonary Disease and Cardiovascular Risk: Insights from the NAVIGATOR Trial

Chronic Obstructive Pulmonary Disease and Cardiovascular Risk: Insights from the NAVIGATOR Trial International Journal of Cardiology Aug 11, 2014, Pedro Barros e Silvaa, Robert M. Califfb, Jie-Lena Sunc, John J.V. McMurrayd, Rury Holmane, Steven Haffnerf, Laine Thomasc, Renato D. Lopesc Brazilian Clinical Research Institute, Sao Paulo, Brazil,  Duke Translational Medicine Institute, Duke University Medical Center, Durham, NC, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC,  BHF […]

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Construction of a genetic linkage map of an interspecific diploid blueberry population and identification of QTL for chilling requirement and cold hardiness

Construction of a genetic linkage map of an interspecific diploid blueberry population and identification of QTL for chilling requirement and cold hardiness Molecular Breeding, 10 Aug 2014, Lisa J. Rowland, Elizabeth L. Ogden, Nahla Bassil, Emily J. Buck, Susan McCallum, Julie Graham, Allan Brown, Claudia Wiedow, A. Malcolm Campbell, Kathleen G. Haynes, Bryan T. Vinyard Beltsville Agricultural Research Center-West, United States Department of Agriculture, Agricultural Research Service, Bldg. 010A, 10300 Baltimore […]

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A need for a transdisciplinary environment: the Plant Pathways Elucidation Project.

A need for a transdisciplinary environment: the Plant Pathways Elucidation Project. Trends Plant Sci. 2014 Aug, Reid RW1, Brouwer CR1, Jackson EW2, Lila MA3. Department of Bioinformatics and Genomics, 150 Research Campus Drive, Suite 3333, Kannapolis, NC 28081, USA. 2General Mills, North Carolina Research Campus, Kannapolis, NC 28081, USA. 3Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC […]

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Loading and Release Mechanism of Red Clover Necrotic Mosaic Virus Derived Plant Viral Nanoparticles for Drug Delivery of Doxorubicin

Loading and Release Mechanism of Red Clover Necrotic Mosaic Virus Derived Plant Viral Nanoparticles for Drug Delivery of Doxorubicin Small. 2014 Aug 5 Cao J1, Guenther RH, Sit TL, Opperman CH, Lommel SA, Willoughby JA. Department of Textile Engineering, Chemistry and Science, North Carolina State University, 2401 Research Drive, Raleigh, NC, 27695, USA Abstract Loading and release mechanisms of Red clover necrotic mosaicvirus (RCNMV) derived plant viral nanoparticle (PVN) are shown for controlled deliveryof the […]

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he genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains

The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains. Eur J Pharmacol. 2014 Aug 5 de Mooij-van Malsen A1, Pjetri E2, Kas MJ3. 1Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Institute of Physiology, CAU Kiel, Germany. 2Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, the […]

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Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study

Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study Cereb Cortex. 2014 Aug  Gautam P1, Nuñez SC1, Narr KL2, Mattson SN3, May PA4, Adnams CM5, Riley EP3, Jones KL6, Kan EC1, Sowell ER1. Developmental Cognitive Neuroimaging Laboratory, Department of Pediatrics, Keck School of Medicine at USC/Children’s Hospital of Los Angeles, Los Angeles, CA, USA. 2Department of Neurology, University of California at […]

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The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection

The Protective Effects of a Polyphenol-Enriched Protein Powder on Exercise-Induced Susceptibility to Virus Infection Phytother Res. 2014 Aug 2, Ahmed M1, Henson DA, Sanderson MC, Nieman DC, Gillitt ND, Lila MA. Department of Biology, Appalachian State University, Boone, NC, 28608, USA. Abstract Prolonged and intensive exercise induces transient immunosuppression and is associated with an increased risk and severity of infections. The goal of […]

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Nesiritide, Renal Function, and Associated Outcomes During Hospitalization for Acute Decompensated Heart Failure: Results From ASCEND-HF

  Nesiritide, Renal Function, and Associated Outcomes During Hospitalization for Acute Decompensated Heart Failure: Results From ASCEND-HF. Circulation. July 29, 2014. van Deursen VM1, Hernandez AF2, Stebbins A2, Hasselblad V2, Ezekowitz JA3, Califf RM4, Gottlieb SS5, O’Connor CM2, Starling RC2, Tang WH6, McMurray JJ7, Dickstein K8, Voors AA9. 1University Medical Center Groningen, University of Groningen, The Netherlands. […]

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A Small Amount of Dietary Carbohydrate Can Promote the HFD-Induced Insulin Resistance to a Maximal Level

A Small Amount of Dietary Carbohydrate Can Promote the HFD-Induced Insulin Resistance to a Maximal Level. PlosOne, July 23, 2014. Shuang Mei equal contributor; Xuefeng Yang equal contributor; Huailan Guo; Haihua Gu; Longying Zha; Junwei Cai; Xuefeng Li; Zhenqi Liu; Brian J. Bennett; Ling He; Wenhong Cao.  Author Affiliations: Nutrition Research Institute at Kannapolis, Department of Nutrition, Gillings School […]

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A comparison of neuropsychological performance between US and Russia: Preparing for a global clinical trial

A comparison of neuropsychological performance between US and Russia: Preparing for a global clinical trial. Alzheimer’s & Dementia, July 22, 2014. Kathleen M. Hayden, Oksana A. Makeeva, L. Kristin Newby, Brenda L. Plassman, Valentina V. Markova, Ashley Dunham, Heather R. Romero, Zarui A. Melikyan, Cassandra M. Germain, Kathleen A. Welsh-Bohmer, Allen D. Roses,  on the […]

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Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the ―Dop‖ System among Farm Workers in the Western Cape Province, South Africa: Hope Despite High Levels of Risky Drinking

Alcohol Use, Working Conditions, Job Benefits, and the Legacy of the ―Dop‖ System among Farm Workers in the Western Cape Province, South Africa: Hope Despite High Levels of Risky Drinking International Journal of Environmental Research and Public Health Jul 21, 2014 J. Phillip Gossage 1, Cudore L. Snell 2, Charles D. H. Parry 3,4, Anna-Susan Marais 4, Ronel […]

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Improving population representation through geographic health information systems: mapping the MURDOCK study

Improving population representation through geographic health information systems: mapping the MURDOCK study. American Journal of  Translational Research. July 2014. Ben W Strauss1, Ellis M Valentiner1, Sayanti Bhattacharya2,3, Michelle M Smerek2, Ashley A Dunham2, L Kristin Newby4,5, Marie Lynn Miranda1,6,7 Author Affiliations: 1National Center for Geospatial Medicine, School of Natural Resources and Environment, University of Michigan, Ann Arbor, MI, USA; […]

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The Clinical Utility and Specificity of Parent Report of Executive Function among Children with Prenatal Alcohol Exposure.

The Clinical Utility and Specificity of Parent Report of Executive Function among Children with Prenatal Alcohol Exposure. Jul 17,2014 Journal of the International Neuropsychological Society. Nguyen TT1, Glass L1, Coles CD2, Kable JA2, May PA3, Kalberg WO4, Sowell ER5, Jones KL6, Riley EP1, Mattson SN1; the CIFASD. 11Center for Behavioral Teratology,Department of Psychology,San Diego State University,San […]

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Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Molecular Biosystems

Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Molecular Biosystems.  July 2014. Baxter SS, Dibble CF, Byrd WC, Carlson J, Mack CR, Saldarriaga I, Bencharit S. David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA. David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA. Abstract Three genetic mutations […]

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Comparing reference-based RNA-Seq mapping methods for non-human primate data

Comparing reference-based RNA-Seq mapping methods for non-human primate data.Jul 11,2014  BMC Genomics. Ashlee M Benjamin1; Marshall Nichols1; Thomas W Burke1; Geoffrey S Ginsburg1; Joseph E Lucas2; 1Center for Applied Genomics, Department of Medicine, Duke University, Durham, North Carolina, USA 2Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA. Author details: 1Center for Applied Genomics, Department of Medicine, Duke University,Durham, North Carolina, USA. 2Department […]

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Practice patterns and clinical outcomes among non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients presenting to primary and tertiary hospitals: Insights from the EARLY glycoprotein IIb/IIIa inhibition in NSTE-ACS (EARLY-ACS) trial

Practice patterns and clinical outcomes among non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients presenting to primary and tertiary hospitals: Insights from the EARLY glycoprotein IIb/IIIa inhibition in NSTE-ACS (EARLY-ACS) trial. Catheterization Cardiovascular Interventions. July 2014. Olga Toleva MD1, Cynthia M. Westerhout PhD1, Manohara P.J. Senaratne MBBS, PhD2, Christoph Bode MD3, Magnus Lindroos MD, PhD4, Vitaly A. Sulimov MD, PhD5, Gilles Montalescot MD6, L. Kristin […]

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Tissue specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region

Tissue specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Jun 30, 2014 Human Molecular Genetics. July 2014. Folami Y. Ideraabdullah1,2,3; Joanne L. Thorvaldsen1; Jennifer A. Myers1; Marisa S. Bartolomei1 1Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, 9-123 SCTR, 3400 Civic Center Blvd, Philadelphia, PA 19104 USA Current address: […]

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Copia autorizada por CDR

Copia autorizada por CDR Circulation, Jun 30 2014, Vincent M. van Deursen, Adrian F. Hernandez, Amanda Stebbins, Vic Hasselblad, Justin A. Ezekowitz, Robert M. Califf, Stephen S. Gottlieb, Christopher M. O’Connor, Randall C. Starling, W.H. Wilson Tang, John J. McMurray, Kenneth Dickstein, Adriaan A. Voors,  From the Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands (V.M.v.D., A.A.V.); Duke Clinical Research Institute, Duke University Medical Center, Durham, […]

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Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus.

Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus. Jun 30,2014 Al-Sinani S1, Hassan MO2, Zadjali F2, Al-Yahyaee S2, Albarwani S2, Rizvi S2, Jaju D2, Comuzzie A3, Voruganti VS4, Bayoumi R2. 1College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: Sawsan.alsinani@gmail.com. 2College of Medicine & Health Sciences, […]

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Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study. Jun 26, 2014 The American Journal of Clinical Nutrition. August 2014. Carolyn A Miller, Karen D Corbin, Kerry-Ann da Costa, Shucha Zhang, Xueqing Zhao, Joseph A Galanko, Tondra Blevins, Brian J Bennett, Annalouise O’Connor, and Steven H Zeisel. The Nutrition Research Institute, University of North Carolina at Chapel Hill, […]

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Distinguishing Vaccinium Species by Chemical Fingerprinting Based on NMR Spectra, Validated with Spectra Collected in Different Laboratories

Distinguishing Vaccinium Species by Chemical Fingerprinting Based on NMR Spectra, Validated with Spectra Collected in Different Laboratories. Planta Medica. June 2014. Epub Jun 25, 2014.  Markus MA1, Ferrier J2, Luchsinger SM1, Yuk J1, Cuerrier A3, Balick MJ4, Hicks JM1, Killday KB1, Kirby CW5, Berrue F6, Kerr RG6, Knagge K7, Gödecke T8,Ramirez BE8, Lankin DC8, Pauli GF8, Burton I9, Karakach TK9, Arnason JT2, Colson KL1. 1Bruker BioSpin Corporation, Billerica, MA, USA.; 2University of Ottawa, Ottawa, […]

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Long-term quercetin dietary enrichment decreases muscle injury in mdx mice

Long-term quercetin dietary enrichment decreases muscle injury in mdx mice. Clinical Nutrition, June 21, 2014. Katrin Hollinger a; R. Andrew Shanely b, c; John C. Quindry d; Joshua T. Selsby a. a Department of Animal Science, Iowa State University; b. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus; Appalachian State University, College of Health […]

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Unraveling Genomic Complexity at a Quantitative Disease Resistance Locus in Maize

Unraveling Genomic Complexity at a Quantitative Disease Resistance Locus in Maize Jun 19,2014 Tiffany M. Jamann1, Jesse A. Poland2, Judith M. Kolkman1,Laurie G. Smith3 and Rebecca J. Nelson1,* –Author Affiliations  Cornell University; 2 Kansas State University; 3 University of California, San Diego Abstract Multiple disease resistance has important implications for plant fitness, given the selection pressure that many pathogens exert directly on natural plant populations […]

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Vein Graft Preservation Solutions, Patency, and Outcomes After Coronary Artery Bypass Graft Surgery

Vein Graft Preservation Solutions, Patency, and Outcomes After Coronary Artery Bypass. JAMA Surgery. June 2014. Ralf E. Harskamp, MD1,2; John H. Alexander, MD, MHS1; Phillip J. Schulte, PhD1; Colleen M. Brophy, MD3; Michael J. Mack, MD4; Eric D. Peterson, MD, MPH1; Judson B. Williams, MD, MHS1; C. Michael Gibson, MD, MS5; Robert M. Califf, MD6; Nicholas T. Kouchoukos, MD7; Robert A. Harrington, MD8; T. Bruce Ferguson Jr, MD9; Renato D. Lopes, MD, PhD1 1Department of Medicine, Duke Clinical Research Institute, Duke University, […]

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Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial. The Lancet. June 12, 2014. Prof L Kristin Newby, MDa; Prof Michael S Marber, MBBSc; Chiara Melloni, MDa; Lea Sarov-Blat,PhDd; Laura H Aberle, BSPHa; Prof Philip E Aylward, BM BChe; Gengqian Cai, PhDd; Prof Robbert J de Winter, MDf; Prof Christian W Hamm, MDg; John F Heitner, MDh; Prof Raymond Kim, MDb; Amir Lerman,MDi; Manesh […]

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Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes

Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes The Lancet, June 2014. RR Holman, H Sourij, RM CaliffDiabetes Trials Unit, University of Oxford, Oxford, UK; Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA 1Diabetes Trials Unit, University of Oxford, […]

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Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis

Role of Salivary and Candidal Proteins in Denture Stomatitis; an exploratory proteomic analysis. Molecular Biosystem. June 11, 2014.  Warren C Byrd,  Sarah Schwartz Baxter,  James Carlson,  Silvana Barros,  Steven Offenbacher and Sompop Bencharit. 1Department of Prosthodontics, School of Dentistry, Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; 2David H. Murdock […]

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Effect of microfluidisation on antioxidant properties of corn bran

Effect of microfluidisation on antioxidant properties of corn bran. Food Chemistry. June 1, 2014 Wang T, Zhu Y, Sun X, Raddatz J, Zhou Z, Chen G. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, NC Research Campus; School of Food Science & Technology, Dalian Polytechnic University, Dalian, China; Center for Translational & Biomedical Research, The University of North […]

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A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease Risk: A Randomized Clinical Trial

A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease Risk: A Randomized Clinical Trial. JAMA: Journal of Internal Medicine. May 26, 2014. [Epub ahead of print] Keyserling TC1, Sheridan SL2, Draeger LB3, Finkelstein EA4, Gizlice Z3, Kruger E4, Johnston LF3, Sloane PD5, Samuel-Hodge C6, Evenson KR7, Gross MD8,Donahue KE5, Pignone MP9, Vu MB3, Steinbacher EA10, Weiner BJ11, Bangdiwala SI12, Ammerman AS13. 1Division of General […]

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A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease RiskA Randomized Clinical Trial

A Comparison of Live Counseling With a Web-Based Lifestyle and Medication Intervention to Reduce Coronary Heart Disease RiskA Randomized Clinical Trial. JAMA Internal Medicine. Published online May 26, 2014 Thomas C. Keyserling, MD, MPH1,2; Stacey L. Sheridan, MD, MPH1,2,3; Lindy B. Draeger, MPH2; Eric A. Finkelstein, PhD, MA, MHA4; Ziya Gizlice, PhD2; Eliza Kruger, MHE4; Larry F. Johnston, MA2; Philip D. Sloane, MD3,5; Carmen Samuel-Hodge, PhD, RD2,6; Kelly R. Evenson, PhD, MS7; Myron D. Gross, PhD8; Katrina E. Donahue, MD, […]

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Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring

Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring. International Journal of developmental neuroscience.  May 24, 2014.[Epub ahead of print] He F1, Lupu DS2, Niculescu MD3. 1Department of Nutrition and Nutrition Research Institute, University of North Carolina at […]

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Multiplex detection of disease biomarkers using SERS molecular sentinel-on-chip.

Multiplex detection of disease biomarkers using SERS molecular sentinel-on-chip. Anal Bioanal Chem. 2014 May, Ngo HT1, Wang HN, Burke T, Ginsburg GS, Vo-Dinh T. 1Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA. Abstract Developing techniques for multiplex detection of disease biomarkers is important for clinical diagnosis. In this work, we have demonstrated for the first […]

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Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties

Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties. Food Chemistry. November 15, 2014. Brittany L. Grafa, Alexander Pouleva, Peter Kuhna, Mary H. Graceb, Mary Ann Lilab, Ilya Raskina, A Department of Plant Biology & Pathology, Rutgers University, 59 Dudley Rd, New Brunswick, NJ 08901, USA; Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, […]

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Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS

Efficient preparative isolation and identification of walnut bioactive components using high-speed counter-current chromatography and LC-ESI-IT-TOF-MS. Food Chemistry. Sep 1, 2014 Epub Mar 1, 2014. Grace MH1, Warlick CW1, Neff SA1, Lila MA2. 1Plants for Human Health Institute, Food Bioprocessing and Nutritional Sciences, North Carolina State University, North Carolina Research Campus, Kannapolis, NC 28081, USA.; 2Plants for Human Health Institute, Food […]

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Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats

Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats. Alcoholism Clinical and Experimental Research. May 21, 2014. Qiong Li1, Guoxiang Xie2, Wenliang Zhang1, Wei Zhong1, Xiuhua Sun1, Xiaobing Tan1, Xinguo Sun1, Wei Jia2,3and Zhanxiang Zhou1,4,* 1 Center for Translational Biomedical Research, University of North Carolina at Greensboro, Kannapolis, North Carolina; 2 University of Hawaii Cancer Center, Honolulu, Hawaii; 3 Center for Translational […]

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Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells

Cysteine-Conjugated Metabolites of Ginger Components, Shogaols, Induce Apoptosis through Oxidative Stress-Mediated p53 Pathway in Human Colon Cancer Cells. Journal of Agricultural Food Chemistry. May 21, 2014; Epub 2014 May 12. Fu J1, Chen H, Soroka DN, Warin RF, Sang S. 1Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus , 500 Laureate […]

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Novel Strategy To Create Hypoallergenic Peanut Protein-Polyphenol Edible Matrices for OralImmunotherapy.

Novel Strategy To Create Hypoallergenic Peanut Protein-Polyphenol Edible Matrices for OralImmunotherapy. Journal of Agricultural and Food Chemistry. May 2, 2014. [Epub ahead of print] Plundrich NJ, Kulis M, White BL, Grace MH, Guo R, Burks AW, Davis JP, Lila MA. Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State […]

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An improved UHPLC-UV method for separation and quantification of carotenoids in vegetable crops.

An improved UHPLC-UV method for separation and quantification of carotenoids in vegetable crops. Food Chemistry. May 17, 2014. Megan M. Maurer, Jonathan R. Mein, Swapan K. Chaudhuri, Howard L. Constant Monsanto Center for Food and Nutrition Research, North Carolina Research Campus, 150 N. Research Campus Dr. Ste 3700, Kannapolis, NC 28081, USA Abstract Carotenoid identification and quantitation is […]

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Intestinal and Systemic Inflammatory Responses Are Positively Associated with Sulfidogenic Bacteria Abundance in High-Fat–Fed Male C57BL/6J Mice

Intestinal and Systemic Inflammatory Responses Are Positively Associated with Sulfidogenic Bacteria Abundance in High-Fat–Fed Male C57BL/6J Mice, The Journal of Nutrition, June 11, 2014. Wan Shen, Patricia G. Wolf, Franck Carbonero, Wei Zhong, Tanya Reid, H. Rex Gaskins, Michael K. McIntosh. Department of Nutrition, University of North Carolina, Greensboro, NC; Institute of Genomic Biology, University of Illinois, Urbana-Champaign, IL; Department of Food Science, […]

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Reduction in CD4 Central Memory T-cell subset in Co-Stimulation Modulator Abatacept-Treated Patients with Recent-Onset Type 1 Diabetes is Associated with Slower C-Peptide Decline

Reduction in CD4 Central Memory T-cell subset in Co-Stimulation Modulator Abatacept-Treated Patients with Recent-Onset Type 1 Diabetes is Associated with Slower C-Peptide Decline. Diabetes. May 16, 2014. [Epub ahead of print] Orban T1, Beam CA2, Xu P2, Moore K3, Jiang Q3, Deng J3, Muller S2, Gottlieb P4, Spain L5, Peakman M6; The Type 1 Diabetes TrialNet Abatacept Study Group. 1Joslin Diabetes Center, Boston, MA; 2Division of […]

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Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration

Activation of pattern recognition receptors in brown adipocytes induces inflammation and suppresses uncoupling protein 1 expression and mitochondrial respiration. American Journal of Physiology.  Cell Physiology. May 15, 2014. Epub 2014 Mar 13. Bae J1, Ricciardi CJ1, Esposito D2, Komarnytsky S2, Hu P1, Curry BJ1, Brown PL1, Gao Z3, Biggerstaff JP4, Chen J5, Zhao L6. 1Department of Nutrition, University of Tennessee, Knoxville, Tennessee; 2Plants for Human Health […]

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A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration.

A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration. May 15, 2014 Gruber HE1, Sha W2, Brouwer CR2, Steuerwald N3, Hoelscher GL1, Hanley EN1. Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, N.C.; 2. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, N.C.; 3. Bioinformatics Services Division, North Carolina Research Campus, Kannapolis, N.C.; 4. […]

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Comparative Systems Biology Reveals Allelic Variation Modulating Tocochromanol Profiles in Barley (Hordeum vulgare L.)

Comparative Systems Biology Reveals Allelic Variation Modulating Tocochromanol Profiles in Barley (Hordeum vulgare L.) PLoS One. May 12,2014; eCollection 2014. Oliver RE1, Islamovic E2, Obert DE3, Wise ML4, Herrin LL4, Hang A2, Harrison SA5, Ibrahim A6, Marshall JM7, Miclaus KJ8, Lazo GR9, Hu G2, Jackson EW10. 1Department of Plant Sciences, North Dakota State University, Fargo, North Dakota, United States of America, formerly USDA-ARS, Small Grains and Potato Germplasm […]

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Comparison of Culture and Molecular Techniques for Microbial Community Characterization in Infected Necrotizing Pancreatitis

Comparison of Culture and Molecular Techniques for Microbial Community Characterization in Infected Necrotizing Pancreatitis. Journal of Surgical Research. May 9, 2014. Erin M. Hanna, MD1, Timothy J. Hamp, MS2, Iain H. McKillop, PhD1,Farah Bahrani-Mougeot,PhD3, John B. Martinie, MD1, James M. Horton, MD4, David Sindram, MD, PhD1, Raad Z. Gharaibeh,PhD2, 5, Anthony A. Fodor, PhD2, David A. Iannitti, MD1 1Department of Surgery, Carolinas Medical Center, Charlotte, NC; 2Department of Bioinformatics and Genomics, UNC […]

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Residency and specialties training in nutrition: a call for action

Residency and specialties training in nutrition: a call for action. American Journal of Clinical Nutrition. May 2014; Epub 2014 Mar 19. Lenders CM1, Deen DD, Bistrian B, Edwards MS, Seidner DL, McMahon MM, Kohlmeier M, Krebs NF. 1Division of Pediatric Nutrition, Boston Medical Center, and Department of Pediatrics, Boston University School of Medicine, Boston, MA (CML); the Department of Community Health and […]

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Nutrition education in medical school: a time of opportunity.

Nutrition education in medical school: a time of opportunity. American Journal of Clinical Nutrition. May 2014; Epub 2014 Mar 19. Kushner RF1, Van Horn L, Rock CL, Edwards MS, Bales CW, Kohlmeier M, Akabas SR. 1Feinberg School of Medicine, Northwestern University, Chicago, IL (RFK); the Department of Preventive Medicine, Northwestern University, Chicago, IL (LVH); the Department of Family and Preventive Medicine, University […]

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Maternal nutrition at conception modulates DNA methylation of human metastable epialleles.

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications. April 29,2014; Dominguez-Salas P1, Moore SE1, Baker MS2, Bergen AW3, Cox SE1, Dyer RA4, Fulford AJ1, Guan Y5, Laritsky E2, Silver MJ1, Swan GE6, Zeisel SH7, Innis SM4, Waterland RA5, Prentice AM1, Hennig BJ1. 1MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street, London WC1E 7HT, UK.; […]

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Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat

Early endothelial damage detected by circulating particles in baboons fed a diet high in simple carbohydrates in conjunction with saturated or unsaturated fat Am J Cardiovasc Dis 2014;4, Qiang Shi1,2, Vida Hodara1,3, Qinghe Meng4, V Saroja Voruganti5, Karen Rice1, Joel E Michalek6, Anthony G Comuzzie1,2, John L VandeBerg1,2 1Southwest National Primate Research Center, Texas Biomedical Research Institute, […]

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Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis.

Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis. Molecular Biosystems. Apr 25,2014. [Epub ahead of print] Baxter SS1, Dibble CF, Byrd WC, Carlson J, Mack CR, Saldarriaga I, Bencharit S. 1David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA. Abstract Three genetic mutations were found to cause cerebral cavernous malformation (CCM), a vascular anomaly […]

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Production and characterization of biochars from agricultural by-products for use in soil quality enhancement

Production and characterization of biochars from agricultural by-products for use in soil quality enhancement Apr 24, 2014 D. Rehraha, M.R. Reddyb, J.M. Novakc, R.R. Bansodeb, K.A. Schimmelb, J. Yub, D.W. Wattsc, M. Ahmednaa,    Department of Health Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar b Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and […]

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Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 23. [Epub ahead of print] Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. Nieman DC, Shanely RA, Luo B, Meaney MP, Dew DA, Pappan KL. Appalachian State University Human Performance Laboratory, NC Research Campus. Abstract Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- […]

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Sulforaphane attenuates inflammation by decreasing Toll-like receptor 2 and 4 expression and activity in human monocytes and peripheral blood mononuclear cells

Sulforaphane attenuates inflammation by decreasing Toll-like receptor 2 and 4 expression and activity in human monocytes and peripheral blood mononuclear cells. FASEB Journal. Jonathan Mein4, Fu-Zhang Wang2, Qi Jiang2, Don James3, Sekhar Boddupalli3; Sridevi Devaraj1,5 1Baylor College of Medicine Houston TX United States; 2David H. Murdock Research Institute Kannapolis NC United States; 3Monsanto Company Woodland CA United States; […]

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Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease.

Towards nutrigenomics: studies to identify gene-diet interactions affecting susceptibility to cardiovascular disease. The FASEB Journal, April 2014; Brian Bennett1,3; Karen Corbin2,; Tangi Smallwood3,; Annalouise o’Connor2; Steven Zeisel1,4. 1UNC Nutrition Research Institute Kannapolis NC United States; 2UNC Nutrition Research Institute Kannapolis NC United States; 3Department of Genetics University of North Carolina Chapel Hill NC United States; 4 Department of […]

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Priming of the antiviral immune transcriptome by a mixed flavonoid-fish oil supplement in adult overweight women

Priming of the antiviral immune transcriptome by a mixed flavonoid-fish oil supplement in adult overweight women. The FASEB Journal. April 2014. Lynn Cialdella-Kam2, David Nieman1, Amy Knab5, R. Andrew Shanely1,Mary Pat Meaney1, Fuxia Jin3, Wei Sha6 and Sujoy Ghosh4. 1Appalachian State University Kannapolis NC United States; 2Case Western University Cleveland OH United States; 3Dole Nutrition Research Laboratory Kannapolis NC United States; 4Duke-NUS […]

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Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet

Excess exposure to insulin (glargine) induces type 2 diabetes mellitus in mice on chow diet. The Journal of Endocrinology. Apr 16, 2014 [Epub ahead of print] Yang X1, Mei S, Gu H, Guo H, Zha L, Cai J, Li X, Liu Z, Cao W. 1X Yang, Nutrition, UNC at Chapel Hill, Kannapolis, United States. Abstract We have previously shown that insulin plays an essential role […]

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Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro.

Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry. 2014 Apr 11. pii: S0031-9422(14)00147-2. doi: 10.1016/j.phytochem.2014.03.028. [Epub ahead of print]Waterman C, Cheng DM, Rojas-Silva P, Poulev A, Dreifus J, Lila MA, Raskin I. Department of Plant Biology & Pathology, Rutgers, The State University of New Jersey; Plants for Human Health Institute, North Carolina […]

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The Imperative of Overcoming Barriers to the Conduct of Large, Simple Trials

The imperative of overcoming barriers to the conduct of large, simple trials Apr 9, 2014 Eapen ZJ1, Lauer MS2, Temple RJ3. Duke Clinical Research Institute, Durham, North Carolina. 2Office of the Director of the Division of Cardiovascular Sciences of the National Heart, Lung, and Blood Institute, Bethesda, Maryland. 3Center for Drug Evaluation and Research, US Food and Drug Administration, […]

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Use of RxNorm and NDF-RT to normalize and characterize participant-reported medications in an i2b2-based research repository

Use of RxNorm and NDF-RT to normalize and characterize participant-reported medications in an i2b2-based research repository, AMIA Jt Summits Transl Sci Proc. 2014 Apr 7, Blach C1, Del Fiol G2, Dundee C1, Frund J1, Richesson R1, Smerek M1, Walden A1, Tenenbaum JD1. 1Duke University, Durham, NC. 2Univerity of Utah, Salt Lake City, UT. Abstract The MURDOCK Study […]

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IRAK4 and breast cancer cell migration in culture and zebrafish xenografts

IRAK4 and breast cancer cell migration in culture and zebrafish xenografts AACR Annual Meeting 2014; April 5-9, 2014, K. Sean Kimbro, Karine Ferri-Lagneau, Jamil Haider, Susan Yeyeodu, Xiaohe Yang, and TinChung Leung North Carolina Central University, Durham, NC. Abstract Growing evidence indicates that incongruities in the inflammatory and immune response pathways contribute to tumorigenesis. We seek to explore the underlying biological mechanisms […]

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MUC1 enhances neuropilin-1 signaling in pancreatic ductal adenocarcinoma

MUC1 enhances neuropilin-1 signaling in pancreatic ductal adenocarcinoma AACR Annual Meeting 2014; April 5-9, 2014, Ru Zhou1, Jennifer Curry1, Priyanka Grover1, Lopamudra Das  Roy1, TinChung Leung2, and Pinku Mukherjee1 1University of North Carolina, Charlotte, NC; 2Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Kannapolis, NC. Abstract 26: MUC1 enhances neuropilin-1 signaling in pancreatic ductal adenocarcinoma Abstract Pancreatic ductal adenocarcinoma (PDA) […]

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Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal

Essential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal. Journal of Agricultural and Food Chemistry. April 1, 2014. [Epub ahead of print] Shao X, Chen H, Zhu Y, Sedighi R, Ho CT, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University , North Carolina Research Campus. Abstract Reactive dicarbonyl species, such as […]

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Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In Vitro

Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In Vitro. PlosOne, April 1, 2014. Helena Morales Johansson, Donna R. Newman, Philip L. Sannes. Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United […]

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Patterns of simple sequence repeats in cultivated blueberries (Vaccinium sectionCyanococcus spp.) and their use in revealing genetic diversity and population structure

Patterns of simple sequence repeats in cultivated blueberries (Vaccinium sectionCyanococcus spp.) and their use in revealing genetic diversity and population structure. Molecular Breeding. March 2014. Yang Bian, James Ballington, Archana Raja, Cory Brouwer, Robert Reid, Mark Burke, Xinguo Wang, Lisa J. Rowland, Nahla Bassil,  Allan Brown 1. Department of Horticultural Science, North Carolina State University, 2721 Founders Dr., Raleigh, NC, 27695, USA; 2. Plants for Human […]

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Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and L-Carnitine.

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N-Oxide, a Proatherogenic Metabolite of Choline and L-Carnitine. Arteriosclerosis, thrombosis, and vascular biology. Mar 27, 2014. [Epub ahead of print] Hartiala J1, Bennett BJ, Tang WH, Wang Z, Stewart AF, Roberts R, McPherson R; CARDIoGRAM Consortium, Lusis AJ, Hazen SL, Allayee H. From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., […]

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Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. March 26, 2014. FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. da Costa KA, Corbin KD, Niculescu MD, Galanko JA, Zeisel SH. Department of Nutrition, School of Public Health, School of Medicine, […]

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Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Brain Research. February 2014. Epub ahead of print. Katherine E. Strathearn, Gad G. Yousef, Mary H. Grace, Susan L. Roy, Mitali A. Tambe, Mario G. Ferruzzi, Qing-Li Wu, James E. Simon, Mary Ann Lila and Jean-Christophe Rochet. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University; Departments of Food Science […]

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A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential

A Distinct Metabolic Signature of Human Colorectal Cancer with Prognostic Potential. Clinical Cancer Research: An Official Journal of the American Association of Cancer Research. March 25, 2014. Qiu Y, Cai G, Zhou B, Li D, Zhao A, Xie G, Li H, Cai S, Xie D, Huang C, Ge W, Zhou Z, Xu LX, Jia W, Zheng S, Yen Y, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth […]

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Impact of Interspecific Introgression on Anthocyanin Profiles of Southern Highbush Blueberry

Impact of Interspecific Introgression on Anthocyanin Profiles of Southern Highbush Blueberry. Journal of the American Society for Horticultural Science. March 2014. Gad G. Yousef1, Mary Ann Lila2, Ivette Guzman3, James R. Ballington4; Allan F. Brown1 1Plants for Human Health Institute, Department of Horticultural Science and Department of Food Bioprocessing and Nutrition Sciences, North Carolina Research […]

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Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1- phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut- Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity

Discovery of N-Benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1- phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an Orally Active, Gut- Selective CCK1 Receptor Agonist for the Potential Treatment of Obesity Bioorg. and Med. Chem. Let. 20:6797- 6801 Mar, 2014  Richard L. Elliott, Kimberly O. Cameron, Janice E. Chin, Jeremy A. Bartlett, Elena E. Beretta, Yue Chen, Paul Da Silva Jardine, Jeffrey S. Dubins, Melissa L. Gillaspy, Diane […]

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Genomics of Cold Hardiness in Woody Plants

Genomics of Cold Hardiness in Woody Plants. Critical Reviews in Plant Sciences. March 7, 2014.  Michael Wisniewskia*, Annette Nassuth b, Chantal Teulières c, Christiane Marque c, Jeannine Rowland d, Phi Bang Caoc & Allan Brown a U.S. Department of Agriculture, Agricultural Research Service, Kearneysville, West Virginia; b Department of Molecular and Cellular Biology, University of Guelph, Ontario, Canada; […]

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Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists

Effects of a freeze-dried juice blend powder on exercise-induced inflammation, oxidative stress, and immune function in cyclists.  Applied Physiology, Nutrition and Metabolism. March 2014. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson D, Sha W, Meaney MP. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus; Dole Nutrition Research Laboratory, NC Research Campus; UNC Charlotte Bioinformatics Services Division, […]

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Microfluidization of Brans and Uses Thereof

Microfluidization of Brans and Uses Thereof FPO 28 Feb 2014, Chen, Guibing (Concord, NC, US) ,Raddatz, Julia (Cornelius, NC, US), Wang, Tao (Kannapolis, NC, US) Abstract The present application generally relates to the development of palatable fiber-enriched foodstuffs, including but not limited to soups, salad dressings, dips, sauces, baked goods and beverages, through modifying various dietary fiber ingredients using […]

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Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa.

Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa. Reproductibe Toxicology. February 22. 2014. [Epub ahead of print] May PA, Hamrick KJ, Corbin KD, Hasken JM, Marais AS, Brooke LE, Blankenship J, Hoyme HE, Gossage JP. University of North Carolina at Chapel Hill, Nutrition Research Institute, NC Research […]

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Quantitative Trait Loci Affecting Atherosclerosis at the Aortic Root Identified in an Intercross between DBA2J and 129S6 Apolipoprotein E-Null Mice.

Quantitative Trait Loci Affecting Atherosclerosis at the Aortic Root Identified in an Intercross between DBA2J and 129S6 Apolipoprotein E-Null Mice. PloS One, February 20, 2014. Kayashima Y, Tomita H, Zhilicheva S, Kim S, Kim HS, Bennett BJ, Maeda N. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill,  Department of Genetics, University of North Carolina at Chapel […]

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Phytochemical changes in phenolics, anthocyanins, ascorbic acid, and carotenoids associated with sweetpotato storage and impacts on bioactive properties

Phytochemical changes in phenolics, anthocyanins, ascorbic acid, and carotenoids associated with sweetpotato storage and impacts on bioactive properties. Food Chemistry. February 15, 2014. [Epub September 5, 2013] Grace MH, Yousef GG, Gustafson SJ, Truong VD, Yencho GC, Lila MA. Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, NC State University, USDA-ARS, SAA Food Science Research Unit, […]

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Induction of Lung Cancer Cell Apoptosis through a p53 Pathway by [6]-Shogaol and Its Cysteine-Conjugated Metabolite M2

Induction of Lung Cancer Cell Apoptosis through a p53 Pathway by [6]-Shogaol and Its Cysteine-Conjugated Metabolite M2. Journal of Agricultural Food Chemistry. January 30, 2014. Epub ahead of print. Warin RF, Chen H, Soroka DN, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus Abstract Dietary chemoprevention of […]

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Identification and Pharmacokinetics of Novel Alkylresorcinol Metabolites in Human Urine, New Candidate Biomarkers for Whole-Grain Wheat and Rye Intake.

Identification and Pharmacokinetics of Novel Alkylresorcinol Metabolites in Human Urine, New Candidate Biomarkers for Whole-Grain Wheat and Rye Intake. The Journal of Nutrition. November 20, 2013. [Epub ahead of print] Zhu Y, Shurlknight KL, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, Kannapolis, NC. Abstract Biomarkers of dietary intake […]

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Cabarrus health alliance: experiences with state and national accreditation

Cabarrus health alliance: experiences with state and national accreditation. Journal of Public Health Management and Practice. January-February 2014. Walker C. Cabarrus Health Alliance, Kannapolis, North Carolina Cabarrus Health Alliance, Kannapolis, North Carolina. Correspondence: Cindy Walker, MPH, Cabarrus Health Alliance, 300 Mooresville Rd, Kannapolis, NC 28081 ( ncwalkington@gmail.com). Cabarrus Health Alliance received a grant from the NACCHO (National […]

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Biotransformation of tea polyphenols by gut microbiota

Biotransformation of tea polyphenols by gut microbiota. Journal of Functional Foods. February 2014. Huadong Chen, Shengmin Sang. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract Tea is one of the most widely consumed beverages worldwide and has received increasing attention from researchers and food industries […]

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Chemically induced conditional rescue of the reduced epidermal fluorescence8 mutant of Arabidopsisreveals rapid restoration of growth and selective turnover of secondary metabolite pools.

Chemically induced conditional rescue of the reduced epidermal fluorescence8 mutant of Arabidopsisreveals rapid restoration of growth and selective turnover of secondary metabolite pools. Plant Physiology. February 2014. Kim JI, Ciesielski PN, Donohoe BS, Chapple C, Li X (NC State University Plants for Human Health Institute). Department of Biochemistry, Purdue University, West Lafayette, Indiana. Abstract The phenylpropanoid pathway is responsible for […]

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Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro

Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro. Journal of Agricultural and Food Chemistry. Jan 17, 2014. [Epub ahead of print] Esposito D, Chen A, Grace MH, Komarnytsky S, Lila MA. Plants for Human Health Institute, North Carolina State University , Kannapolis, North Carolina. Abstract Wild lowbush blueberries ( Vaccinium […]

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High-intensity interval training induces a modest systemic inflammatory response in active, young men.

High-intensity interval training induces a modest systemic inflammatory response in active, young men. Journal of Inflammation Research. January, 9, 2014. eCollection. Zwetsloot KA, John CS, Lawrence MM, Battista RA, Shanely RA. Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC; Human Performance Laboratory, North Carolina Research Campus, Appalachian State University. Abstract THE […]

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Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). Food Chemistry. E-pub January 2014. David M. Ribnicky, Diana E. Roopchand, Andrew Oren, Mary Grace, Alexander Poulev, Mary Ann Lila, Robert Havenaar and Ilya Raskin. School of Environmental and Biological Sciences, Rutgers the […]

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Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.

Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Frontiers in Genetics. Dec 16, 2013. Voruganti VS, Kent JW Jr, Debnath S, Cole SA, Haack K, Göring HH, Carless MA, Curran JE, Johnson MP, Almasy L, Dyer TD, Maccluer JW,Moses EK, Abboud HE, Mahaney MC, Blangero J, Comuzzie AG. Department of Genetics, Texas Biomedical Research Institute San Antonio, TX; Department of Nutrition, […]

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Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols.

Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols. Food Chemistry. December 15, 2013. Diana E. Roopchand, Christian G. Krueger, Kristin Moskal, Bertold Fridlender, Mary Ann Lila, Ilya Raskin. Rutgers, The State University of New Jersey, School of Environmental and Biological Sciences; Complete Phytochemical Solutions, LLC, Cambridge, WI; University of Wisconsin-Madison, Reed […]

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Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models

Metformin Selectively Targets Tumor Initiating Cells in erbB-2 Overexpressing Breast Cancer Models. Cancer Prevention Research (Philadephia, PA). December 9, 2013. [Epub ahead of print] Zhu P, Davis M, Blackwelder A, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Julius L. Chambers Biomedical Biotechnology Research Institute, Julius L. Chambers Biomedical Biotechnology Research Institute/NC Central University Nutrition Research Program, NC Research […]

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Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice.

Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice. American Journal of Physiology. Gatrointestinal and liver physiology. December 2013. [Epub Oct 10, 2013]. Sun X, Luo W, Tan X, Li Q, Zhao Y, Zhong W, Sun X, Brouwer C, Zhou Z. Center for Translational & Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis. Abstract […]

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Vitamin D2 Supplementation Amplifies Eccentric Exercise-Induced Muscle Damage in NASCAR Pit Crew Athlete

Vitamin D2 Supplementation Amplifies Eccentric Exercise-Induced Muscle Damage in NASCAR Pit Crew Athletes. Nutrients 2014. December 2013. David C. Nieman, Nicholas D. Gillitt, R. Andrew Shanely, Dustin Dew, Mary Pat Meaney and Beibei Luo. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis; Dole Nutrition Research Laboratory, North Carolina Research Campus, Kannapolis; Key […]

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Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians.

Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. European Journal of Human Genetics. December 2013 [Epub ahead of print] Voruganti VS, Franceschini N, Haack K, Laston S, Maccluer JW, Umans JG, Comuzzie AG, North KE, Cole SA. Department of Nutrition and Nutrition Research Institute, University of North […]

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The Effects of Moderate Exercise on Chronic Stress-Induced Intestinal Barrier Dysfunction and Antimicrobial Defense.

The Effects of Moderate Exercise on Chronic Stress-Induced Intestinal Barrier Dysfunction and Antimicrobial Defense. Brain, Behavior, and Immunity. Nov 27, 2013. [Epub ahead of print] Luo B, Xiang D, Nieman DC (ASU Human Performance Lab at the NC Research Campus), Chen P. Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University […]

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A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.

A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutrition Journal. November 25, 2013. David C Nieman, R Andrew Shanely, Beibei Luo, Dustin Dew, Mary Pat Meaney, and Wei Sha. Appalachian State University, Human Performance Lab, North Carolina Research Campus; Key Laboratory of Exercise and Health Sciences of Ministry […]

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Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries.

Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries. Journal of Agriculture Food Chemistry. November 19, 2013 [Epub ahead of print] Grace MH, Esposito D, Dunlap KL, Lila MA. Plants for Human Health Institute, Food Bioprocessing and Nutrition Sciences Department, North Carolina State University, North Carolina Research […]

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Chemical and in Vitro Assessment of Alaskan Coastal Vegetation Antioxidant Capacity.

Chemical and in Vitro Assessment of Alaskan Coastal Vegetation Antioxidant Capacity. Journal of Agricultural and Food Chemistry. November 2013. [Epub ahead of print] Kellogg J, Lila MA. Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 600 Laureate Way, Kannapolis, NC. Abstract Alaska Native (AN) communities have utilized […]

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Students’ perspective on genomics: from sample to sequence using the case study of blueberry.

Students’ perspective on genomics: from sample to sequence using the case study of blueberry. Frontiers in Genetics. November 2013. Mudd AB, White EJ, Bolloskis MP, Kapur NP, Everhart KW, Lin YC, Bussler WW, Reid RW, Brown RH. Plants for Human Health Institute, North Carolina State University, Kannapolis. Abstract Advances in genomic sequencing technologies in the […]

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Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors.

Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. PlosOne. Oct 14, 2013. Zhong W, Zhao Y, Sun X, Song Z, McClain CJ, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract Clinical studies have demonstrated that alcoholics have a […]

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Bioavailability of polyphenols from peanut skin extract associated with plasma lipid lowering function

Bioavailability of polyphenols from peanut skin extract associated with plasma lipid lowering function. Food Chemistry. October 2013. R.R. Bansode, P. Randolph, M. Ahmedna, S. Hurley, T. Hanner, S. Baxter, T. Johnston, M. Su, B. Holmes, J. Yu, L.L. Williams. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus; Department of Health Sciences, Qatar University, P.O. Box […]

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Conceptual shifts needed to understand the dynamic interactions of genes, environment, epigenetics, social processes, and behavioral choices

Conceptual shifts needed to understand the dynamic interactions of genes, environment, epigenetics, social processes, and behavioral choices. American Journal of Public Health. October 2013. Jackson FL, Niculescu MD, University of North Carolina at Chapel Hill;  Jackson RT, University of Maryland at College Park. Abstract Social and behavioral research in public health is often intimately tied […]

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Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway.

Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. Cell Death & Disease. October 2013. Li H, Zhou Y, Zhao A, Qiu Y, Xie G, Jiang Q, Zheng X, Zhong W, Sun X, Zhou Z, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University, Affiliated Sixth People’s Hospital, Shanghai, […]

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Influence of vitamin D mushroom powder supplementation on exercise-induced muscle damage in vitamin D insufficient high school athletes

Influence of vitamin D mushroom powder supplementation on exercise-induced muscle damage in vitamin D insufficient high school athletes. Journal of Sports Sciences. October 2013. Shanely RA, Nieman DC, Knab AM, Gillitt ND, Meaney MP, Jin F, Sha W, Cialdella-Kam L. Human Performance Laboratory, Appalachian State University, NC Research Campus, Kannapolis , NC. Abstract Abstract Incidence of vitamin D deficiency is increasing worldwide. The purpose […]

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Interface between Pharmacotherapy and Genes in Human Obesity

Interface between Pharmacotherapy and Genes in Human Obesity. Human Heredity. September 27, 2013. O’Connor A, Swick AG. UNC Chapel Hill Nutrition Research Institute, Kannapolis, NC. Abstract Obesity is a polygenic chronic condition, and dysregulation in multiple underlying energy balance processes drives the obese phenotype. Lifestyle changes can be difficult to sustain long term, and anti-obesity drugs can […]

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The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide

The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide. PLoS One.  September 20, 2013. Sha W, Martins AM, Laubenbacher R, Mendes P, Shulaev V. Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia; Bioinformatics Research Division, University of North Carolina at Charlotte, Kannapolis, NC. Abstract Oxidative stress is a well-known biological process that occurs in all […]

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Immune and inflammation responses to a 3-day period of intensified running versus cycling.

Immune and inflammation responses to a 3-day period of intensified running versus cycling.  Brain, Behavior and Immunity. September 19, 2013. Nieman DC, Luo B, Dréau D, Henson DA, Shanely RA, Dew D, Meaney MP. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC. Abstract Functional overreaching has been linked to alterations in immunity and host pathogen defense, but […]

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Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon

Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain, Behavior and Immunity. September 18, 2013. Shanely RA, Nieman DC, Zwetsloot KA, Knab AM, Imagita H, Luo B, Davis B, Zubeldia JM. Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC; Appalachian State University, […]

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Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners

Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners. Journal of Proteome Research. 2013 Sep 13 [Epub ahead of print]. Nieman DC, Shanely RA, Gillitt ND, Pappan KL, Lila MA. Human Performance Laboratory, Appalachian State University, Dole Nutrition Research Laboratory and NC State University Plants for […]

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Phytochemical Changes in Phenolics, Anthocyanins, Ascorbic Acid, and Carotenoids Associated with Sweetpotato Storage and Impacts on Bioactive Properties.

Phytochemical Changes in Phenolics, Anthocyanins, Ascorbic Acid, and Carotenoids Associated with Sweetpotato Storage and Impacts on Bioactive Properties. Food Chemistry. E-Pub September 5, 2013. Mary H. Grace , Gad Yousef, Sally J. Gustafson, Van-Den Truong, G. Craig Yencho , Mary Ann Lila. Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North […]

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A new genetic linkage map of barley (Hordeum vulgare L.) facilitates genetic dissection of height and spike length and angle

A new genetic linkage map of barley (Hordeum vulgare L.) facilitates genetic dissection of height and spike length and angle. Field Crop Research. August 23, 2013. Emir Islamovic, Donald E. Obert, Rebekah E. Oliver, Juliet M. Marshall, Kelci J. Miclaus, An Hang, Shiaoman Chao, Gerard R. Lazo, Stephen A. Harrison, Amir Ibrahim, Eric N. Jellen, […]

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Effects of microfluidization on antioxidant properties of wheat bran.

Effects of microfluidization on antioxidant properties of wheat bran. Journal of Cereal Science. August 22, 2013. Tao Wang, Julia Raddatz, Guibing Chen. Center for Excellence in Post-Harvest Technologies, North Carolina A&T State University, NC Research Campus; College of Food Science and Engineering, Dalian Ocean University. Abstract Phenolic compounds present in native wheat bran are majorly […]

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Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach

Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach. PlosOne, August 15, 2013. David C. Nieman, Appalachian State University (ASU) Human Performance Laboratory at the NC Research Campus, Kannapolis, NC (NCRC); Nicholas D. Gillitt, Dole Nutrition Research Laboratory at the NCRC; Amy M. […]

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Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990-1998) and Education Research (1997-2007) Databases.

Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990-1998) and Education Research (1997-2007) Databases. JAMA Pediatrics, August 12, 2013. Simon G. Gregory, PhD; Rebecca Anthopolos, MA; Claire E. Osgood, BS; Chad A. Grotegut, MD; Marie Lynn Miranda, PhD. Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, […]

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Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): Quantity, frequency, and timing of drinking

Maternal alcohol consumption producing fetal alcohol spectrum disorders (FASD): Quantity, frequency, and timing of drinking. Drug Alcohol Dependence. Aug 8, 2013 [Epub ahead of print]. May PA, Blankenship J, Marais AS, Gossage JP, Kalberg WO, Joubert B, Cloete M, Barnard R, De Vries M, Hasken J, Robinson LK, Adnams CM, Buckley D, Manning M, Parry […]

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Biosynthesis of highly enriched 13C-lycopene for human metabolic studies using repeated batch tomato cell culturing with13C-glucose.

Biosynthesis of highly enriched 13C-lycopene for human metabolic studies using repeated batch tomato cell culturing with13C-glucose. Food Chemistry, August 2013. Nancy Engelmann Moran, Randy B. Rogers, Chi-Hua Lue, Lauren E. Conlon, Mary Ann Lila, Steven K. Clinton, John W. Erdman Jr. Division of Medical Oncology, Department of Internal Medicine, and the Comprehensive Cancer Center, The Ohio State […]

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Effects of microfluidization on microstructure and physicochemical properties of corn bran

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Omega-6 to omega-3 fatty acid ratio and higher-order cognitive functions in 7- to 9-y-olds: a cross-sectional study

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Aspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events

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Stable Binding of Alternative Protein-Enriched Food Matrices with Concentrated Cranberry Bioflavonoids for Functional Food Applications

Stable Binding of Alternative Protein-Enriched Food Matrices with Concentrated Cranberry Bioflavonoids for Functional Food Applications. Journal of Agricultural and Food Chemistry. July 1, 2013, [Epub ahead of print] Grace MH, Guzman I, Roopchand DE, Moskal K, Cheng DM, Pogrebnyak N, Raskin I, Howell A, Lila MA. Plants for Human Health Institute, Food, Bioprocessing, and Nutrition […]

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A 6-week diet and exercise intervention alters metabolic syndrome risk factors in obese Chinese children aged 11–13 years

A 6-week diet and exercise intervention alters metabolic syndrome risk factors in obese Chinese children aged 11–13 years. Journal of Sport and Health Science. E-pub June 28, 2013. Beibei Luoa, Yang Yang, David C. Nieman, Yajun Zhang, Jie Wang, Ru Wang, Peijie Chen. Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai […]

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Spectral Deconvolution for Gas Chromatography Mass Spectrometry-Based Metabolomics: Current Status and Future Perspectives

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Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols

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Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes

Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes. Electrophoresis. Jun 17, 2013. [Epub ahead of print]. Xie G, Zhang S, Zheng X, Jia W. Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 200233, China; Center for Translational Biomedical Research, University of North Carolina at Greensboro, North […]

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Chronic Ethanol Consumption Alters Mammalian Gastrointestinal Content Metabolites

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RNA-Seq of Arabidopsis Pollen Uncovers Novel Transcription and Alternative Splicing

RNA-Seq of Arabidopsis Pollen Uncovers Novel Transcription and Alternative Splicing. Plant Physiology. June 2013. Loraine AE, McCormick S, Estrada A, Patel K, Qin P. Department of Bioinformatics and Genomics, University of North Carolina, Kannapolis. Abstract Pollen grains of Arabidopsis (Arabidopsis thaliana) contain two haploid sperm cells enclosed in a haploid vegetative cell. Upon germination, the […]

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Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults

Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults. The British Journal of Nutrition. June 2013. Appalachian State University Human Performance Laboratory, North Carolina Research Campus. Abstract Quercetin, a flavonol in fruits and vegetables, has been demonstrated to have antioxidant, anti-inflammatory and immunomodulating influences. The purpose of the present […]

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Pathview: an R/Bioconductor package for pathway based data integration and visualization

Pathview: an R/Bioconductor package for pathway based data integration and visualization. Bioinformatics. Epub June 4, 2013. Luo W, Brouwer C. Department of Bioinformatics and Genomics, UNC Charlotte and NC Research Campus. Abstract SUMMARY: Pathview is a novel tool set for pathway-based data integration and visualization. It maps and renders user data on relevant pathway graphs. […]

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[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos.

[10]-Gingerdiols as the Major Metabolites of [10]-Gingerol in Zebrafish Embryos and in Humans and Their Hematopoietic Effects in Zebrafish Embryos. Journal of Agricultural and Food Chemistry.  Epub May 23, 2013. Chen H, Soroka DN, Haider J, Ferri-Lagneau KF, Leung T (NC Central University Nutrition Research Program), Sang S. Center for Excellence in Post-Harvest Technologies, North […]

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Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice

Cysteine-Conjugated Metabolite of Ginger Component [6]-Shogaol Serves as a Carrier of [6]-Shogaol in Cancer Cells and in Mice. Chemical Research in Toxicology.  Epub May 15, 2013.  Chen H, Soroka DN, Zhu Y, Hu Y, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University , North Carolina Research […]

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Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption

Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB: Official Publication of the Federation of American Societies for Experimental Biology.  Epub May 14, 2013. Xie G, Zhong W, Li H, Li Q, Qiu Y, Zheng X, Chen H, Zhao X, Zhang S, Zhou Z, Zeisel SH, Jia W. Center for […]

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Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries ( Vaccinium spp.).

Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries ( Vaccinium spp.). Journal of Agricultural Food Chemistry. Epub May 13, 2013. Yousef GG, Brown AF, Funakoshi Y, Mbeunkui F, Grace MH, Ballington JR, Loraine A, Lila MA. Department of Horticultural Science and Department of Food Bioprocessing and […]

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Novel molecular marker associated with Tm2a gene conferring resistance to tomato mosaic virus in tomato

Novel molecular marker associated with Tm2a gene conferring resistance to tomato mosaic virus in tomato. Plant Breeding. May 2013 Dilip R. Panthee, Allan F. Brown, Gad G. Yousef, Ragy Ibrahem, Candice Anderson. NC State University Plants for Human Health Institute, NC Research Campus. Abstract Tomato mosaic virus (ToMV) is an important Tobamovirus that causes significant […]

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Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro.

Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. Journal of Ethnopharmacology. Epub May 2, 2013.  Esposito D, Munafo JP, Lucibello T, Baldeon M, Komarnytsky S, Gianfagna TJ. Department of Plant Biology and Pathology, Rutgers-The State University of New Jersey; North Carolina State University Plants for Human […]

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Gender difference in the acute influence of a 2-hour run on arterial stiffness in trained runners.

Gender difference in the acute influence of a 2-hour run on arterial stiffness in trained runners.  Res Sports Med. Apr 2013, Nieman D1, Dew D, Krasen P.  Appalachian State University, Boone, North Carolina 28608, USA. niemandc@appstate.edu Abstract Arterial stiffness scores over a 5-h period following a 2-h run were measured in trained males (N = 8, age 39.3 ± […]

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Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass

Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Metabolism.  Aug 2013, Swick AG1, Orena S, O’Connor A. UNC Nutrition Research Institute, University of North Carolina Chapel Hill, North Carolina Research Campus, Kannapolis, North Carolina, USA. andrew_swick@unc.edu Abstract Objective Obesity is a result of chronic overconsumption of […]

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Validity of COSMED’s Quark CPET Mixing Chamber System in Evaluating Energy Metabolism During Aerobic Exercise in Healthy Male Adults

Validity of COSMED’s Quark CPET Mixing Chamber System in Evaluating Energy Metabolism During Aerobic Exercise in Healthy Male Adults. Research in Sports Medicine. April 2013. Nieman DC, Austin MD, Dew D, Utter AC. Department of Health, Leisure, and Exercise Science, Human Performance Lab, Appalachian State University. Abstract This study validated the accuracy of COSMED’s Quark […]

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Bioactive Polyphenols from Muscadine Grape and Blackcurrant Stably Concentrated onto Protein-rich Matrices for Topical Applications.

Bioactive Polyphenols from Muscadine Grape and Blackcurrant Stably Concentrated onto Protein-rich Matrices for Topical Applications. International Journal of Cosmetic Science. April 2013. Plundrich N, Grace MH, Raskin I, Lila MA. Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC, […]

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Nutrition in pregnancy: the argument for including a source of choline

Nutrition in pregnancy: the argument for including a source of choline April 2013. International Journal of Women’s Health. April 2013. Zeisel, SH. Nutrition Research Institute at Kannapolis, Department of Nutrition, University of North Carolina at Chapel Hill. Abstract Women, during pregnancy and lactation, should eat foods that contain adequate amounts of choline. A mother delivers […]

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High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways

High Fat Diet Feeding Exaggerates Perfluorooctanoic Acid-Induced Liver Injury in Mice via Modulating Multiple Metabolic Pathways. PLoS One. April 2013.  Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus. Abstract High […]

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Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis.

Identification of cytokinin-responsive genes using microarray meta-analysis and RNA-Seq in Arabidopsis. Plant Physiology. May 2013. Epub Mar 22, 2013. Bhargava A, Clabaugh I, To JP, Maxwell BB, Chiang YH, Schaller GE, Loraine A (UNC Charlotte at the NC Research Campus), Kieber JJ. Department of Biology, University of North Carolina, Chapel Hill, North Carolina. Abstract Cytokinins […]

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SNP discovery and chromosome anchoring provide the first physically-anchored hexaploid oat map and reveal synteny with model species

SNP discovery and chromosome anchoring provide the first physically-anchored hexaploid oat map and reveal synteny with model species. PloS One. March 22, 2013. Oliver RE, Tinker NA, Lazo GR, Chao S, Jellen EN, Carson ML, Rines HW, Obert DE, Lutz JD, Shackelford I, Korol AB, Wight CP, Gardner KM, Hattori J, Beattie AD, Bjørnstad A, […]

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New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering.

New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering.  Archives of Virology. March 13, 2013. Martin SL, He L, Meilleur F, Guenther RH, Sit TL, Lommel SA (Plants for Human Health Institute and DHMRI, NC Research Campus) and D, Heller WT. […]

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Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms

Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms. Current Opinion in Clinical Nutrition and Metabolomic Care. March 13, 2013. Mehedint, MG, Zeisel SH. Nutrition Research Institute at the NC Research Campus, Kannapolis, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Abstract PURPOSE OF REVIEW: Humans eating diets low in […]

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A randomized, controlled trial to assess short-term black pepper consumption on 24-hour energy expenditure and substrate utilization

A randomized, controlled trial to assess short-term black pepper consumption on 24-hour energy expenditure and substrate utilization Functional Foods in Health and Disease 2013, Annalouise O’Connor1 , Karen D. Corbin,1 David C. Nieman2 , Andrew G. Swick1* 1UNC Nutrition Research Institute, University of North Carolina Chapel Hill, North Carolina Research Campus, Kannapolis, North Carolina, USA; 2Human Performance Laboratory, Appalachian State […]

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Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment

Reduction of major peanut allergens Ara h 1 and Ara h 2, in roasted peanuts by ultrasound assisted enzymatic treatment. Food Chemistry. March 2013. Hao Lia, Jianmei Yub, Mohamed Ahmednaa, Ipek Goktepeb. Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus; Department of Family and Consumer Sciences, North Carolina A&T State University; College of […]

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Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill.

Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill. Phytochemistry.   Science Direct March 2013. Rocky Graziosea, Mary H. Grace, Thirumurugan Rathinasabapathyd, Patricio Rojas-Silva, Carmen Dekock, Alexander Pouleva, Mary Ann Lila, Peter Smith, Ilya Raskina. Department of Plant Biology and Pathology, SEBS, Rutgers, The State University of New Jersey; Plants for Human Health Institute, North […]

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Rapid emergence of a ceftazidime-resistant Burkholderia multivorans strain in a Cystic Fibrosis patient.

Rapid emergence of a ceftazidime-resistant Burkholderia multivorans strain in a Cystic Fibrosis patient. Journal of Cystic Fibrosis. March 2013. Joshua R. Stokell, Raad Z. Gharaibehb, Todd R. Steck. Department of Biology, University of North Carolina at Charlotte, Bioinformatics Services Division, Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Kannapolis. Abstract Background Burkholderia multivorans […]

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Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Carcinogenesis. March 4 2013. Chiou YS, Sang S (NC A&T Center for Excellence in Post Harvest Technologies at the NC Research Campus), Cheng KH, Ho CT, Wang YJ, Pan MH. Department of Seafood Science, […]

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Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model

Effects of pregnane glycosides on food intake depend on stimulation of the melanocortin pathway and BDNF in an animal model. Journal of Agricultural and Food Chemistry. February 27, 2013. Komarnytsky S, Esposito D, Rathinasabapathy T, Poulev A, Raskin I. NC State University Plants for Human Health Institute, NC Research Campus. Abstract Pregnane glycosides appear to modulate food […]

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Melamine-induced renal toxicity is mediated by the gut microbiota

Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. February 13, 2013. Zheng X,Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Luther M, Su M, Nicholson JK, Jia W. Shanghai Key Laboratory of Diabestes Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated […]

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Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice.

Blueberry polyphenol-enriched soybean flour reduces hyperglycemia, body weight gain and serum cholesterol in mice. Pharmacological Research. February 2013. Roopchand DE, Kuhn P, Rojo LE, Lila MA, Raskin I. Rutgers, The State University of New Jersey, School of Environmental and Biological Sciences; Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC […]

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Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB Journal. February 1, 2013. Corbin KD, Abdelmalek MF, Spencer MD, da Costa KA, Galanko JA, Sha W, Suzuki A, Guy CD, Cardona DM, Torquati A, Diehl AM, Zeisel SH. University of North Carolina at Chapel Hill Nutrition Research Institute, Abstract […]

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Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness. Metabolism: Clinical and Experimental. January 31, 2013. Batch BC, Shah SH, Newgard CB, Turer CB, Haynes C, Bain JR, Muehlbauer M, Patel MJ, Stevens RD, Appel LJ, Newby LK, Svetkey LP. Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, […]

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Structure Elucidation and Chemical Profile of Sphingolipids in Wheat Bran and Their Cytotoxic Effects against Human Colon Cancer Cells.

Structure Elucidation and Chemical Profile of Sphingolipids in Wheat Bran and Their Cytotoxic Effects against Human Colon Cancer Cells. Journal of Agricultural and Food Chemistry. January 30, 2013. Zhu Y, Soroka DN, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract Sphingolipids are known to have […]

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Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation

Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation. PloS One, January 30, 2013. Zhu Y, Warin RF, Soroka DN, Chen H, Sang S.  Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. – Abstract Our previous study found that […]

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Continuous infusion of 20-hydroxyecdysone increased mass of triceps brachii in C57BL/6 mice.

Continuous infusion of 20-hydroxyecdysone increased mass of triceps brachii in C57BL/6 mice.Phytotherapy Research. January 27, 2013. Cheng DM, Kutzler LW, Boler DD, Drnevich J, Killefer J, Lila MA (NC State Plants for Human Health Institute). Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801. Abstract Phytoecdysteroids have been attributed with numerous […]

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A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study

A metabolomics-based strategy for the quality control of traditional chinese medicine: shengmai injection as a case study. Evidence-based Complementary and Alternative Medicine. January 20, 2013. Li X, Chen H, Jia W, Xie G. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian China; Center for Translational Biomedical Research, University of North Carolina at […]

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Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics

Polymeric Systems Incorporating Plant Viral Nanoparticles for Tailored Release of Therapeutics. Advanced Healthcare Materials. January 20, 2013. Honarbakhsh S, Guenther RH, Willoughby JA, Lommel SA (Plants for Human Health Institute and DHMRI, NC Research Campus), Pourdeyhimi B.  The Nonwovens Institute, North Carolina State University, 2401 Research Drive, Raleigh, North Carolina, 27695 USA. Abstract Therapeutic polylactide […]

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Genetic dissection of grain beta-glucan and amylose content in barley (Hordeum vulgare L.)

Genetic dissection of grain beta-glucan and amylose content in barley (Hordeum vulgare L.) Emir Islamovic, Donald E. Obert,  Rebekah E. Oliver, Stephen A. Harrison, Amir Ibrahim, Juliet M. Marshall, Kelci J. Miclaus, Gongshe Hu, Eric W. Jackson Abstract High beta-glucan (BG) barleys (Hordeum vulgare L.) have major potential as food ingredients due to their well-known health benefits. Quantitative trait loci (QTL) associated with BG […]

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Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.

Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.  Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka D, Zhu Y, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract SCOPE: There are limited data on the metabolism of [6]-shogaol (6S), […]

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Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol

Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.  Molecular Nutrition and Food Research. January 16, 2013. Chen H, Soroka DN, Hu Y, Chen X, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract […]

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A 6-week diet and exercise intervention alters metabolic syndrome risk factors in obese Chinese children aged 11–13 years

A 6-week diet and exercise intervention alters metabolic syndrome risk factors in obese Chinese children aged 11–13 years Beibei Luo, Yang Yang, David C. Nieman, Yajun Zhang, Jie Wang, Ru Wang,Peijie Chen Journal of Sport and Health Science 01/2013; ABSTRACT Purpose A randomized, controlled trial was conducted to determine whether a 6-week low calorie diet and aerobic exercise intervention could alter […]

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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.

Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.  Cell Metabolism. January 8, 2013. Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Department of Medicine, University of California, Los […]

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Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.

Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metabolism. January 8, 2013. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, […]

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The heterodimerization of platelet-derived chemokines

The heterodimerization of platelet-derived chemokines. Biochimica et Biophysica Acta (BBA)- Proteins and Proteomics. January 2013. James Carlson, Sarah A. Baxter, Didier Dréau, Irina V. Nesmelova. Analytical Sciences Laboratory, David H. Murdock Research Institute and the Department of Biology,  Department of Physics and Optical Science and the Center for Biomedical Engineering and Science, University of North […]

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Elicited Imitation Performance at 20 Months Predicts Memory Abilities in School-Age Children

Elicited Imitation Performance at 20 Months Predicts Memory Abilities in School-Age Children. Journal of Cognition and Developmental: official journal of the Cognitive Development Society. January 1, 2013 Riggins T, Cheatham CL, Stark E, Bauer PJ. University of Maryland, College Park; University of North Carolina, Chapel Hill Nutrition Research Institute, NC Research Campus; Minnesota State University, Mankato; Emory […]

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Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet

Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet. Food Chemistry. December 2012. Bansode RR, Randolph P, Hurley S, Ahmedna M. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract The effect of water soluble polyphenolic extract of peanut skin (PE) was investigated for its hypolipidemic properties […]

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The microbiota is essential for the generation of black tea theaflavins-derived metabolites

The microbiota is essential for the generation of black tea theaflavins-derived metabolites. PLoS One. December 2012. Chen H, Hayek S, Rivera Guzman J, Gillitt ND, Ibrahim SA, Jobin C, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University and Dole Foods Nutrition Research Institute Abstract BACKGROUND: Theaflavins including theaflavin […]

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Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study.

Approaching the Prevalence of the Full Spectrum of Fetal Alcohol Spectrum Disorders in a South African Population-Based Study. Alcoholism, Clinical and Experimental Research. December 2012. May PA, Blankenship J, Marais AS, Gossage JP, Kalberg WO, Barnard R, De Vries M, Robinson LK, Adnams CM, Buckley D, Manning M, Jones KL, Parry C, Hoyme HE, Seedat […]

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Perinatal epigenetic determinants of cognitive and metabolic disorders

Perinatal epigenetic determinants of cognitive and metabolic disorders Aging and Disease.Aging and Disease. December 2012. Lupo, DS, Tint D, Niculescu MD. UNC Chaple Hill Nutrition Research Institute. Abstract Multiple cues from the environment of our indirect and immediate ancestors, which often persist throughout the prenatal period and adulthood, are shaping our phenotypes through either direct, […]

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Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach.

Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach. Plants for Human Nutrition. November 2012. Nieman DC, Cialdella-Kam L, Knab AM, Shanely RA. Appalachian State University Human Performance Lab. Abstract Red pepper spice (RP) and turmeric (TM) are used as flavorings in foods and for […]

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Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults

Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults. The British Journal of Nutrition. November 2012. Cialdella-Kam L, Nieman DC, Sha W,Meaney MP, Knab AM, Shanely RA. Appalachian State University Human Performance Laboratory. Abstract Quercetin, a flavonol in fruits and vegetables, has been demonstrated to have antioxidant, anti-inflammatory and […]

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A Brief History of Choline

A Brief History of Choline. Annals of Nutrition and Metabolism. Epub November 2012. Zeisel SH. UNC Nutrition Research Institute. Abstract In 1850, Theodore Gobley, working in Paris, described a substance, ‘lecithine’, which he named after the Greek ‘lekithos’ for egg yolk. Adolph Strecker noted in 1862 that when lecithin from bile was heated, it generated […]

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6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cell.

6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cell. Jounral of Agricultural and Food Chemistry. November 2012. Lv L, Chen H, Soroka D, Chen X, Leung T, Sang S. (NC A&T Center for Excellence in Post Harvest Technologies). Department of Food Science and […]

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Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol

Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol.  Nutrition and Cancer. November 2012. Chen X, Zhang X, Lu Y, Shim JY, Sang S (NC A&T Center for Excellence in Post Harvest Technologies), Sun Z, Chen X. School of Pharmaceutical & Life Sciences, Changzhou University, Jiangsu, China. Abstract Our previous studies […]

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Elucidating role of salivary proteins in denture stomatitis using a proteomic approach.

Elucidating role of salivary proteins in denture stomatitis using a proteomic approach. Mol Biosyst. 2012 Oct 30, Bencharit S1, Altarawneh SK, Baxter SS, Carlson J, Ross GF, Border MB, Mack CR, Byrd WC, Dibble CF, Barros S, Loewy Z, Offenbacher S. 1Department of Prosthodontics, School of Dentistry, University of North Carolina, CB#7450, Chapel Hill, NC 27599, USA. Sompop_Bencharit@dentistry.unc.edu […]

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Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells

Pregnane glycosides interfere with steroidogenic enzymes to down-regulate corticosteroid production in human adrenocortical H295R cells. Journal of Cellular Physiology. October 2012. Komarnytsky S, Esposito D, Poulev A, Raskin I. Rutgers University and NC State University Plants for Human Health Institute. Abstract A group of bioactive steroidal glycosides (pregnanes) with anorectic activity in animals was isolated […]

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Effects of a Flavonoid-rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics Based Approach.

Effects of a Flavonoid-rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics Based Approach. International Journal of  Sport Nutrition and Exercise Metabolism. October 2012. Knab AM, Nieman DC, Gillitt ND, Shanely RA, Cialdella-Kam L, Henson DA, Sha W. Appalachian State University Human Performance Laboratory, Dole Nutrition Research Laboratory and UNC Charlotte […]

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The Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) Study Community Registry and Biorepository.

The Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) Study Community Registry and Biorepository.  October 2012. American Journal of Translational Research. Bhattacharya S, Dunham AA, Cornish MA, Christian VA, Ginsburg GS, Tenenbaum JD, Nahm ML, Miranda ML, Califf RM, Dolor RJ, Newby LK. Duke Translational Research Institute/MURDOCK Study. Abstract Current understanding of chronic diseases […]

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Antiplasmodial activity of the ethnobotanical plant Cassia fistula.

Antiplasmodial activity of the ethnobotanical plant Cassia fistula. National Product Communications.  October 2012. Grace MH, Lategan C, Graziose R, Smith PJ, Raskin I, Lila MA. NC State University Plants for Human Health Institute. Abstract In our ongoing investigation of new compounds with activity against malaria parasites, we tested the in vitro antiplasmodial activity of fractions […]

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Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages

Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell. October 2012. Orozco LD, Bennett BJ (UNC Chapel Hill Nutrition Research Institute), Farber CR, Ghazalpour A, Pan C, Che N, Wen P, Qi HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, Lusis AJ. Department of Human […]

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Hypoglycemic effects of brassinosteroid in diet-induced obese mice

Hypoglycemic effects of brassinosteroid in diet-induced obese mice. Amerian Journal of Physiology, Endriconology and Metabolism. September 2012. Esposito D, Kizelsztein P, Komarnytsky S, Raskin I. North Carolina State University Plants for Human Health Institute. Abstract The prevalence of obesity is increasing globally, and obesity is a major risk factor for metabolic diseases such as type […]

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Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.

Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. Journal of Chromatography, September 2012. Chen H, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University. Abstract Ginger is frequently consumed as a spice and has numerous medicinal properties. Extensive research […]

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The heterodimerization of platelet-derived chemokines

The heterodimerization of platelet-derived chemokines. Biochemica et Biophysica acta. September 2012. Carlson J, Baxter SA, Dréau D, Nesmelova IV. Analytical Sciences Laboratory, David H. Murdock Research Institute. Abstract Chemokines encompass a large family of proteins that act as chemoattractants and are involved in many biological processes. In particular, chemokines guide the migration of leukocytes during […]

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Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols

Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols. Journal of Agricultural and Food Chemistry. September 2012. Zhu Y, Soroka DN, Sang S. Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus. Abstract We have identified alkylresorcinols (ARs) as the major active components […]

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High-resolution association mapping of atherosclerosis loci in mice.

High-resolution association mapping of atherosclerosis loci in mice. Artiosclerosis, Thrombosis, and Vascular Biology, August 2012. Bennett BJ, Orozco L, Kostem E, Erbilgin A, Dallinga M, Neuhaus I, Guan B, Wang X, Eskin E, Lusis AJ. UNC Chapel Hill Nutrition Research Institute. Abstract OBJECTIVE: The purpose of this study was to fine map previously identified quantitative […]

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Simultaneous extraction and quantitation of carotenoids, chlorophylls, and tocopherols in brassica vegetables.

Simultaneous extraction and quantitation of carotenoids, chlorophylls, and tocopherols in brassica vegetables.  Journal of Agricultural and Food Chemistry, July 2012. Guzman I, Yousef GG, Brown AF. NC State University Plants for Human Health Institute. Abstract Brassica oleracea vegetables, such as broccoli (B. oleracea L. var. italica) and cauliflower (B. oleracea L. var. botrytis), are known […]

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ADAP-GC 2.0: Deconvolution of Coeluting Metabolites from GC/TOF-MS Data for Metabolomics Studies.

ADAP-GC 2.0: Deconvolution of Coeluting Metabolites from GC/TOF-MS Data for Metabolomics Studies. Analytical Chemistry, July 2012. Ni Y, Qiu Y, Jiang W, Suttlemyre K, Su M, Zhang W, Jia W, Du X. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, North Carolina Research Campus. Abstract ADAP-GC 2.0 has been developed to deconvolute […]

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Comparison of Health-Relevant Flavonoids in Commonly Consumed Cranberry Products.

Comparison of Health-Relevant Flavonoids in Commonly Consumed Cranberry Products. Journal of Food Science, July 2012. Mbeunkui F, Grace MH, Yousef GG, Ann Lila M. NC State University Plants for Human Health Institute. Abstract The human health benefits from consumption of cranberry products have been associated with the fruits’ unique flavonoid composition, including a complex profile […]

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Ginger Stimulates Hematopoiesis via Bmp Pathway in Zebrafish.

Ginger Stimulates Hematopoiesis via Bmp Pathway in Zebrafish. PLoS One. July 2012. Epub June 2012. Ferri-Lagneau KF, Moshal KS, Grimes M, Zahora B, Lv L, Sang S, Leung T. North Carolina Central University Nutrition Research Program. Abstract BACKGROUND: Anemia is a hematologic disorder with decreased number of erythrocytes. Erythropoiesis, the process by which red blood […]

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Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation.

Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. Journal of Alternate Complementary Medicine. July 2012. Nieman DC, Gillitt N, Jin F, Henson DA, Kennerly K, Shanely RA, Ore B, Su M, Schwartz S. Appalachian State University Human Performance Lab, Dole Nutrition Research Laboratory and DHMRI. Abstract OBJECTIVE/SETTING: This study assessed […]

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Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice.

Leptin Deficiency Contributes to Pathogenesis of Fatty Liver Disease in Mice. The Journal of American Pathology, July 2012. Xiaobing Tan, Xiuhua Sun, Qiong Li, Yantao Zhao, Wei Zhong, Xinguo Sun, Wei Jia, Craig J. McClain, Zhanxiang Zhou. UNC Greensboro Center for Translational Biomedical Research. Abstract White adipose tissue (WAT) secretes adipokines, which critically regulate lipid […]

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Isolation and characterization of flavonols from blackcurrant by high-performance counter-current chromatography and electrospray ionization tandem mass spectrometry.

Isolation and characterization of flavonols from blackcurrant by high-performance counter-current chromatography and electrospray ionization tandem mass spectrometry.  Journal of Separation Science, July 2012. Mbeunkui F, Grace MH, Yousef GG, Ann Lila M. NC State University Plants for Human Health Institute. Abstract Blackcurrant is considered as a natural high-value food raw material and possesses a variety […]

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Grafting Effects on Vegetable Quality

Grafting Effects on Vegetable Quality HortScience June 2012, Angela R. Davis1 and Penelope Perkins-Veazie U.S. Department of Agriculture, Agricultural Research Service, South Central Agricultural Research Laboratory, P.O. Box 159, Highway 3 West, Lane, OK 74555,  Richard Hassell Clemson University, CREC, 2700 Savannah, Highway, Charleston, SC 29414, Amnon Levi U.S. Vegetable Laboratory, USDA, ARS, 2700 Savannah Highway, Charleston, SC 29414, Stephen R. King Vegetable Fruit […]

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Therapeutic Modulation of Microbiota-Host Metabolic Interactions.

Therapeutic Modulation of Microbiota-Host Metabolic Interactions. Science Translational Medicine, June 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for R Abstract The complex metabolic relationships between the host and its microbiota change throughout life and vary extensively between  individuals, affecting disease risk factors […]

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Clinical implications of exercise immunology

Clinical implications of exercise immunology Journal of Sports and Health, May 1012, David C. Nieman Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA Abstract Maintaining leanness and a physically active lifestyle during adulthood reduces systemic inflammation, an underlying factor in multiple chronic diseases. The anti-inflammatory influence of near-daily physical activity in lowering […]

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Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.

Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.  Annals of Nutrition Metabolism, May 2012. Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract One of the underlying mechanisms for metabolic individuality is genetic variation. Single nucleotide polymorphisms (SNPs) in genes of metabolic pathways can create […]

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Bananas as an Energy Source during Exercise: A Metabolomics Approach

Bananas as an Energy Source during Exercise: A Metabolomics Approach. PLoS One, May 2012. Nieman DC, Gillitt ND, Henson DA, Sha W, Shanely RA, Knab AM, Cialdella-Kam L, Jin F. Appalachian State University Human Performance Lab and Dole Nutrition Research Lab. Abstract This study compared the acute effect of ingesting bananas (BAN) versus a 6% […]

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Urine metabolite profiling offers potential early diagnosis of oral cancer

Urine metabolite profiling offers potential early diagnosis of oral cancer Metabolomics, April 2012, Guo X. Xie, Tian L. Chen, Yun P. Qiu, Peng Shi, Xiao J. Zheng, Ming M. Su, Ai H. Zhao, Zeng T. Zhou, Wei Jia Abstract Oral cancer is the sixth most common human cancer, with a high morbidity rate and an overall 5-year survival rate of less than 50%. It is often […]

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An alternative paradigm for the role of antimalarial plants in Africa.

An alternative paradigm for the role of antimalarial plants in Africa. Scientific World Journal. April 2012. Maranz S. David H. Murdock Research Institute. Abstract Most investigations into the antimalarial activity of African plants are centered on finding an indigenous equivalent to artemisinin, the compound from which current frontline antimalarial drugs are synthesized. As a consequence, […]

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Metabonomic Variations Associated with AOM-induced Precancerous Colorectal Lesions and Resveratrol Treatment.

Metabonomic Variations Associated with AOM-induced Precancerous Colorectal Lesions and Resveratrol Treatment. Journal of Proteome Research, April 2012. Liao W, Wei H, Wang X, Qiu Y, Gou X, Zhang X, Zhou M, Wu J, Wu T, Kou F, Zhang Y, Bian Z, Xie G, Jia W. UNC Greensboro Center for Research Excellence in Bioactive Food Components. […]

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Metabolism of [6]-shogaol in mice and in cancer cells.

Metabolism of [6]-shogaol in mice and in cancer cells. Drug Metablism and Disposition: The Biological Fate of Chemicals, April 2012. Chen H, Lv L, Soroka D, Warin RF, Parks TA, Hu Y, Zhu Y, Chen X, Sang S. North Carolina Agricultural and Technical State University Center for Excellence in Post-Harvest Technologies. Abstract Ginger has received […]

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Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice.

Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. Journal of Agricultural and Food Chemistry. April 2012. Chiou YS, Ma NJ, Sang S (NC A&T Center for Excellence in Post Harvest Technology), Ho CT, Wang YJ, Pan MH. Department of Seafood Science, National Kaohsiung Marine University, Nanzih District, Kaohsiung, Taiwan. […]

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Supplementation of Milled Chia Seeds Increases Plasma ALA and EPA in Postmenopausal Women

Supplementation of Milled Chia Seeds Increases Plasma ALA and EPA in Postmenopausal Women. Plant Foods for Human Nutrition, April 2012. Jin F, Nieman DC, Sha W, Xie G, Qiu Y, Jia W, Fuxia, J. Appalachian State University Human Performance Lab and Dole Nutrition Research Lab. Abstract Ten postmenopausal women (age 55.6 ± 0.8 years, BMI 24.6 ± 1.1 kg/m²) […]

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Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function.

Choline Dehydrogenase Polymorphism rs12676 Is a Functional Variation and Is Associated with Changes in Human Sperm Cell Function. PLoS One, April 2012. Corbin KD, Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract Approximately 15% of couples are affected by infertility and up to half of these cases arise from male factor infertility. Unidentified genetic […]

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Exploring salivary proteomes in edentulous patients with type 2 diabetes

Exploring salivary proteomes in edentulous patients with type 2 diabetes. Mol Biosyst. April 2012, Border MB, Schwartz S, Carlson J, Dibble CF, Kohltfarber H, Offenbacher S, Buse JB, Bencharit S. Molecular Biosystems. David H. Murdock Research Institute. Abstract Type 2 diabetes and tooth loss are linked both epidemiologically and pathophysiologically. We applied label-free differential protein expression analysis […]

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Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.Current Opinion Gastroenterology, March 2012. Corbin KD, Zeisel SH. UNC Chapel Hill Nutrition Research Institute. Abstract PURPOSE OF REVIEW: Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans […]

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Human gouty arthritis is associated with a distinct serum trace elemental profile

Human gouty arthritis is associated with a distinct serum trace elemental profile. Metallomics, March 2012. Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, and Jeremy K. Nicholson. UNC Greensboro Center for Research Excellence in BioActive Food Components and David H. Murdock Research Institute. Abstract Homeostatic imbalance of essential trace elements […]

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Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors.

Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. Neurotoxicology Teratology, January-February 2012. Fordahl S, Cooney P, Qiu Y, Xie G, Jia W, Erikson KM. UNC Greensboro Department of Nutrition, Center for Research Excellence in Bioactive Food Components. Abstract Overexposure to waterborne manganese (Mn) is linked with cognitive impairment […]

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Mining Arabidopsis thaliana RNA-seq data with Integrated Genome Browser reveals stress-induced alternative splicing of the putative splicing regulator SR45a.

Mining Arabidopsis thaliana RNA-seq data with Integrated Genome Browser reveals stress-induced alternative splicing of the putative splicing regulator SR45a. American Journal of Botany, February 2012. Gulledge AA, Roberts AD, Vora H, Patel K, Loraine AE. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, North Carolina Research Campus. Abstract PREMISE OF THE STUDY: […]

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Isolation and structural elucidation of indole alkaloids from Geissospermum vellosii by mass spectrometry.

Isolation and structural elucidation of indole alkaloids from Geissospermum vellosii by mass spectrometry. Journal of Chromatology, February 2012. Mbeunkui F, Grace MH, Lila MA. NC State University Plants for Human Health Institute. Abstract Alkaloids from the stem bark of Geissospermum vellosii possess a variety of therapeutic properties including antimalarial activities, activity as a sexual stimulant […]

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Distinct urinary metabolic profile of human colorectal cancer.

Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012 Feb 3, Cheng Y1, Xie G, Chen T, Qiu Y, Zou X, Zheng M, Tan B, Feng B, Dong T, He P, Zhao L, Zhao A, Xu LX, Zhang Y, Jia W. Department of Chemistry, East China Normal University, Shanghai 200062, China. Abstract A full spectrum […]

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Urinary metabolite markers of precocious puberty

Urinary metabolite markers of precocious puberty Mol Cell Proteomics. 2012 Jan;11, Qi Y1, Li P, Zhang Y, Cui L, Guo Z, Xie G, Su M, Li X, Zheng X, Qiu Y, Liu Y, Zhao A, Jia W, Jia W. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Abstract The incidence of precocious puberty (PP, the appearance of […]

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Exercise Frequency Is Related to Psychopathology but not Neurocognitive Function.

Exercise Frequency Is Related to Psychopathology but not Neurocognitive Function. Medicine and Science in Sports Exercise, January 2012.Knab AM, Nieman DC, Broman-Fulks JJ, Canu WH, Sha W. Appalachian State University Human Performance Laboratory; Appalachian State University Department of Psychology, NC; and Bioinformatics Services Division, University of North Carolina at Charlotte, North Carolina Research Campus. Abstract […]

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Variance in the acute inflammatory response to prolonged cycling is linked to exercise intensity

Variance in the acute inflammatory response to prolonged cycling is linked to exercise intensity. Journal of  Interferon and Cytokine Research, January 2012. Nieman DC, Konrad M, Henson DA, Kennerly K, Shanely RA, Wallner-Liebmann SJ. Appalachian State University Human Performance Lab. Abstract This study investigated the influence of age, body composition, physical fitness, training volume and […]

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Combined fruit and vegetable intake is correlated with improved inflammatory and oxidant status from a cross-sectional study in a community setting.

Combined fruit and vegetable intake is correlated with improved inflammatory and oxidant status from a cross-sectional study in a community setting. Nutrients. January 2012. Root MM, McGinn MC, Nieman DC, Henson DA, Heinz SA, Shanely RA, Knab AM, Jin F. Appalachian State University Department of Nutrition and Health Care Management, Boone, NC; Human Performance Lab, […]

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Antimicrobial susceptibility testing of Shiga toxin-producing Escherichia coli from various samples by using a spiral gradient endpoint technique.

Antimicrobial susceptibility testing of Shiga toxin-producing Escherichia coli from various samples by using a spiral gradient endpoint technique. Foodborne Pathogens and Disease, January 2012. Khatiwada J, Fullerton M, Davis S, Williams LL. North Carolina A&T State University Center for Excellence in Post-Harvest Technologies. Abstract Shiga toxin-producing Escherichia coli (STEC) remains a major public health concern. […]

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In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii

In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii. Journal of Ethnopharmacology, January 2012. Mbeunkui F, Grace MH, Lategan C, Smith PJ, Raskin I, Lila MA. North Carolina State University Plants for Human Health Institute. Abstract ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Geissospermum vellosii has been traditionally used by the […]

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Protein Modification by Deamidation Indicates Variations in Joint Extracellular Martrix Turnover.

Catterall JB, Hsueh MF, Stabler TV, Feng S, McCudden CF, Bolognesi M, Zuru R, Jordan JM, Renner JB, Kraus VB. Protein Modification by Deamidation Indicates Variations in Joint Extracellular Martrix Turnover. JBiolChem.2012 Feb 10;287(7):4640-51. Epub 2011 Dec 16. Abstract As extracellular proteins age, they undergo and accumulate nonenzymatic post-translational modifications that cannot be repaired. We […]

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Mannan structural complexity is decreased when Candida albicans is cultivated in blood or serum at physiological temperature.

Mannan structural complexity is decreased when Candida albicans is cultivated in blood or serum at physiological temperature. Lowman DW1, Ensley HE, Greene RR, Knagge KJ, Williams DL, Kruppa MD Abstract The Candida albicans cell wall provides an architecture that allows for the organism to survive environmental stress as well as interaction with host tissues. Previous […]

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Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice

Metabolomic evaluation of di-n-butyl phthalate-induced teratogenesis in mice Hongfei Xia, Yi Chi, Xin Qi, Mingming Su, Yu Cao, Peipei Song, Xin Li, Tianlu Chen, Aihua Zhao, Yinan Zhang Abstract Di-n-butyl phthalate (DBP) has been linked to the neural, reproductive and developmental toxicity. We present here a metabolomic study that characterized the metabolic variations associated with the DBP-induced teratogenesis in maternal and fetal mice. DBP […]

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Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action.

Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. Xuan J1, Pan G, Qiu Y, Yang L, Su M, Liu Y, Chen J, Feng G, Fang Y, Jia W, Xing Q, He L. Abstract Despite recent advances in understanding the pathophysiology of schizophrenia and the mechanisms of antipsychotic drug action, the development […]

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Metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice

Metabonomic phenotyping reveals an embryotoxicity of deca-brominated diphenyl ether in mice Chi Y1, Xia H, Su M, Song P, Qi X, Cui Y, Cao Y, Chen T, Qiu Y, Zhao A, Ma X, Zheng X, Jia W. Abstract Recent studies have demonstrated that polybrominated diphenyl ethers (PBDEs), a group of industrial chemicals, could disrupt thyroid […]

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Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats.

Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. Khatiwada J1, Verghese M, Davis S, Williams LL. Abstract Experimental as well as epidemiologic studies in human populations provide evidence that consumption of phytochemicals reduces the incidence of degenerative diseases. Green tea (GT) catechins are known for their […]

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Use of Mutant-Assisted Gene Identification and Characterization (MAGIC) to identify novel genetic loci that modify the maize hypersensitive response.

Use of Mutant-Assisted Gene Identification and Characterization (MAGIC) to identify novel genetic loci that modify the maize hypersensitive response. Chaikam V1, Negeri A, Dhawan R, Puchaka B, Ji J, Chintamanani S, Gachomo EW, Zillmer A, Doran T, Weil C, Balint-Kurti P, Johal G. Abstract The partially dominant, autoactive maize disease resistance gene Rp1-D21 causes hypersensitive response (HR) lesions to form spontaneously on leaves and stems in […]

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Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing.

Lee EJ,Pei L,Srivastava G,Joshi T,Kushwaha G,Choi JH,Robertson KD,Wang X,Colbourne JK,Zhang L,Schroth GP, Xu D,Zhang K,Shi H.Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing. NucleicAcidsRes.2011 Oct;39(19):e127. Epub 2011 Jul 23. Abstract We applied a solution hybrid selection approach to the enrichment of CpG islands (CGIs) and promoter sequences from the human genome for […]

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Metabolic signature of pregnant women with neural tube defects in offspring.

Metabolic signature of pregnant women with neural tube defects in offspring. Zheng X1, Su M, Pei L, Zhang T, Ma X, Qiu Y, Xia H, Wang F, Zheng X, Gu X, Song X, Li X, Qi X, Chen G, Bao Y, Chen T, Chi Y, Zhao A, Jia W. Abstract Neural tube defects (NTDs) are […]

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A 45-minute vigorous exercise bout increases metabolic rate for 14 hours.

A 45-minute vigorous exercise bout increases metabolic rate for 14 hours. Knab AM1, Shanely RA, Corbin KD, Jin F, Sha W, Nieman DC. Abstract INTRODUCTION: The magnitude and duration of the elevation in resting energy expenditure after vigorous exercise have not been measured in a metabolic chamber. This study investigated the effects of inserting a 45-min vigorous cycling bout into […]

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Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity.

Nieman DC,Konrad M,Henson DA,Kennerly K,Shanely RA,Wallner-Liebmann SJ. Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity. 1 Human Performance Laboratory, Appalachian State University Kannapolis, North Carolina. J Interferon Cytokine Res.2011 Sep 14. [Epub ahead of print] Abstract This study investigated the influence of age, body composition, physical fitness, training volume […]

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HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance

Huang X,Wang S,Lee CK,Yang X,Liu B. HDAC inhibitor SNDX-275 enhances efficacy of trastuzumab in erbB2- overexpressing breast cancer cells and exhibits potential to overcome trastuzumab resistance. Cancer Letters.2011 Aug 1;307(1):72-9. doi: 10.1016/j.canlet.2011.03.019. Epub 2011 Apr 16. Abstract Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with […]

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The Acute Effect of Ingesting a Quercetin-Based Supplement on Exercise-Induced Inflammation and Immune Changes in Runners

The Acute Effect of Ingesting a Quercetin-Based Supplement on Exercise-Induced Inflammation and Immune Changes in Runners Konrad M1, Nieman DC, Henson DA, Kennerly KM, Jin F, Wallner-Liebmann SJ. Abstract This study tested the acute anti-inflammatory and immune-modulating influence of a quercetin-based supplement consumed by endurance athletes 15 min before an intense 2-hr run. In this randomized, crossover study, 20 runners (11 men, 9 women, age 38.4 ± 2.1 yr) completed […]

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5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth

5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth Yingdong Zhu, Dawn R. Conklin, Huadong Chen, Liyan Wang, Shengmin Sang Abstract We and others have found that wheat bran oil is the active constituent in wheat bran for colon cancer prevention. However, the active components in wheat bran oil are still unknown. Using […]

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Serum apolipoprotein C-III is independently associated with chronic hepatitis C infection and advanced fibrosis.

Rowell J, Thompson A, Guyton JR, Qian LX, McHutchison JG, McCarthy JJ and Patel K. Serum apolipoprotein C-III is independently associated with chronic hepatitis C infection and advanced fibrosis. Hepatol Int 2011 Jul 7. Abstract BACKGROUND: The hepatitis C virus (HCV) is known to disrupt lipid metabolism, making serum lipoprotein levels good candidates to explore […]

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Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C

Characterization of Serum Proteins Associated with IL28B Genotype among Patients with Chronic Hepatitis C Derek D. Cyr,  Joseph E. Lucas, J. Will Thompson, Keyur Patel, Paul J. Clark, Alexander Thompson, Hans L. Tillmann, John G. McHutchison, Jeanette J. McCarthy Abstract Introduction Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous clearance and treatment response to pegIFN/RBV in chronic hepatitis […]

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Prospects for Commercialisation of an Alaska Native Wild Resource as a Commodity Crop

Prospects for Commercialisation of an Alaska Native Wild Resource as a Commodity Crop Joshua Kellogg, Clyde Higgs and Mary Ann Lila The emerging research evidence regarding functional food health benefits, coupled with the modern rise in degenerative and lifestyle-related health conditions, has created a growing market in the United States: the super-fruit. Wild berries, which […]

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Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects

Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects Lv L1, Chen H, Ho CT, Sang S. Abstract Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were […]

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Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride

Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride Xiaoyan Wang, Jingchao Lin, Tianlu Chen, Mingmei Zhou, Mingming Su, Wei Jia Abstract Diammonium glycyrrhizinate (DG), a constitutent of Glycyrrhiza uralensis, has a protective effect on hepatic injury, hepatisis and cirrhosis. To date, the mechanism has been poorly understood, especially at the metabolic level. A […]

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Non-Alcoholic Beer Reduces Inflammation and Incidence of Respiratory Tract Illness.

Scherr J,Nieman DC,Schuster T,Habermann J,Rank M,Braun S,Pressler A,Wolfarth B,Halle M. Non-Alcoholic Beer Reduces Inflammation and Incidence of Respiratory Tract Illness. Med Sci Sports Exerc.2011 Jun 8. [Epub ahead of print] Abstract PURPOSE: Strenuous exercise significantly increases the incidence of upper respiratory tract illness (URTI) caused by transient immune dysfunction. Naturally occurring polyphenolic compounds present in […]

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Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide.

Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide. Bansode RR1, Ahmedna M, Svoboda KR, Losso JN. Abstract The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined. The […]

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Genistein inhibits advanced glycation end product formation by trapping methylglyoxal.

Genistein inhibits advanced glycation end product formation by trapping methylglyoxal. Lv L1, Shao X, Chen H, Ho CT, Sang S. Abstract Methylglyoxal (MGO) is a highly reactive endogenous metabolite derived from several nonenzymatic and enzymatic reactions, and identified as a well-known precursor of advanced glycation end products (AGEs). In the present study, genistein, a naturally occurring isoflavone derived from […]

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Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma.

Chen, Tianlu, Xie, Guoxiang, Wang, Xiaoying, Fan, Jia, Qiu, Yunping, Zheng, Xiaojiao, Qi, Xin, Cao, Yu, Su, Mingming, Wang, Xiaoyan, Xu, Lisa X. Yen, Yun, Liu, Ping, Jia, Wei (2011). Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma. . Molecular and Cellular Proteomics, 2011July;10(7):M110.004945. Epub 2011 Apr 25. Abstract Hepatocellular carcinoma (HCC) […]

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Influence of quercetin supplementation on disease risk factors in community-dwelling adults

KnabAM,Shanely RA,Henson DA,Jin F,Heinz SA,Austin MD,Nieman DC. Influence of quercetin supplementation on disease risk factors in community-dwelling adults.AppalachianStateUniversity, Kannapolis, NC, USA. J Am Diet Assoc.2011 Apr;111(4):542-9. Abstract BACKGROUND: In vitro data indicate quercetin has antioxidative and anti-inflammatory functions with the potential to lower disease risk factors, but data in human beings are limited. OBJECTIVE: The […]

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Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.

Shi Y,Yang S,Troup S,Lu X,Callaghan S,Park DS,Xing Y,Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.Oncology Reports.2011 Jun;25(6):1713-9. doi: 10.3892/or.2011.1248. Epub 2011 Apr 6. Abstract Resveratrol is a natural polyphenolic compound with cancer chemopreventive activity. However, our understanding of the molecular mechanism responsible for resveratrol-induced apoptosis is still very limited. […]

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What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders

Zeisel, S.H.(2011)What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. Molecular Neurobiology. doi 10.1007/s12035-011-8165-5. Abstract The consequences of fetal exposure to alcohol are very diverse and the likely molecular mechanisms involved must be able to explain how so many developmental processes could go awry. If pregnant rat dams are […]

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Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment

Tint, D.,Anghel, M., Lupu, D. S., Fischer, L. M., and Niculescu, M. D. (2011)Low dose Flaxseed Oil Supplementation Alters the Fatty Acids Profile and the Progression of Metabolic Syndrome in Men without Adequate Medical Treatment .J Nutrition Disorder TherS7, 1 Abstract Many studies indicated that increased intakes of ω-3 fatty acids could positively impact the progression […]

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Discovery of microsomal triglyceride transfer protein (MTP) inhibitorswith potential for decreased active metabolite load compared to dirlotapide

Ralph P. Robinson , Jeremy A. Bartlett, Peter Bertinato, Andrew J. Bessire, Judith Cosgrove, Patrick M. Foley, Tara B. Manion, Martha L. Minich, Brenda Ramos, Matthew R. Reese, Theodore J. Schmahai, Andrew G. Swick , David A. Tess, Alfin Vaz, Angela Wolford(2011)Discovery of microsomal triglyceride transfer protein (MTP) inhibitorswith potential for decreased active metabolite load […]

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Prevalence of Children with Fetal Alcohol Spectrum Disorders in Communities Near Rome, Italy: Rates Are Substantially Higher Than Previous Estimates

Philip A. May, Daniela Fiorentino, Giovana Coraile, Wendy O. Kalberg, H. Eugene Hoyme, Alfredo S. Aragon, David Buckley, Chandra Stellavato, J. Phillip Gossage, Luther K. Robinson, Melanie Manning, and Mauro Ceccanti.(2011)Prevalence of Children with Fetal Alcohol Spectrum Disorders in Communities Near Rome, Italy: Rates Are Substantially Higher Than Previous Estimates. International Journal of Environmental Research […]

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Maternal Risk Factors Predicting Child Physical Characteristics and Dysmorphology in Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome

Philip A. May, Barbara G. Tabachnick, Luther K. Robinson, H. Eugene Hoyme, and J. Phillip Gossage (2011)Maternal Risk Factors Predicting Child Physical Characteristics and Dysmorphology in Fetal Alcohol Syndrome and Partial Fetal Alcohol Syndrome. Drug and Alcohol Dependencedoi:10,1016/j.drugaldep.2011.05.009 Abstract BACKGROUND: Previous research in South Africa revealed very high rates of fetal alcohol syndrome (FAS), of 46-89 […]

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Maternal Risk Factors for Fetal Alcohol Spectrum Disorders: Not as Simple as it Might Seem

Philip A. May and J. Phillip Gossage(2011)Maternal Risk Factors for Fetal Alcohol Spectrum Disorders: Not as Simple as it Might Seem.Alcohol Research and Health34(1):15-26 Abstract Gathering information about drinking during pregnancy is one of the most difficult aspects of studying fetal alcohol spectrum disorders (FASD). This information is critical to linking specific risk factors to […]

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Nutritional influence on epigenetics and effects on longevity

Niculescu, M.D. & Lupu, D.S.(2011)Nutritional influence on epigenetics and effects on longevity. Curr Opin Clin Nutr Metab CareJan;14(1):35-40 Abstract PURPOSE OF REVIEW: This review synthesizes recently published information regarding nutrition and its impact upon epigenetically mediated mechanisms involved in longevity and aging. RECENT FINDINGS: Recent studies enriched considerably our understanding of the relationship between aging […]

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Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring.

Niculescu, M. D., Lupu, D. S., and Craciunescu, C. N. (2011)Maternal alpha-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. Int J Dev Neurosci29, 795-802 Abstract The availability of ω-3 polyunsaturated fatty acids is essential for perinatal brain development. While the roles of docosahexaenoic acid (the most abundant […]

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Epigenetic transgenerational inheritance: Should obesity-prevention policies be reconsidered

Niculescu M.D.(2011)Epigenetic transgenerational inheritance: Should obesity-prevention policies be reconsidered?SynesisJ, 2, G18-26. Studies have shown that the nutrition of one generation can alter the epigenetics of DNA in subsequent generations. The increase in the obesity epidemic, especially in the US requires significant health care-related expenditures and negatively impacts the quality of life for many Americans. Obesity […]

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A 45-min Vigorous Exercise Bout Increases Metabolic Rate for 14 hours

Knab, AM, Shanely, RA, Corbin, KD, Jin, F, Nieman, DC. (2011)A 45-min Vigorous Exercise Bout Increases Metabolic Rate for14 hours. Med Sci Sports Exerc.43(9):1643-1648. PMID:2131136 Abstract INTRODUCTION: The magnitude and duration of the elevation in resting energy expenditure after vigorous exercise have not been measured in a metabolic chamber. This study investigated the effects of […]

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A Field Trial of Alcohol Server Training for Prevention of Fetal Alcohol Spectrum Disorders

Jack Dresser, Randall Starling, W. Gill Woodall, Paula Stanghetta, and Philip A. May (2011)A Field Trial of Alcohol Server Training for Prevention of Fetal Alcohol Spectrum Disorders Journal of Studies on Alcohol and Drugs 72(3): 490-496 Abstract OBJECTIVE: An alcohol-server training program to prevent fetal alcohol syndrome was developed, implemented, and evaluated in a comparison […]

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LCPUFA supplementation in infancy reduces heart rate and affects distribution of attention

Colombo, J., Carlson, S.E., Cheatham, C.L., Fitzgerald-Gustafson, K.M., Kepler, A., Schmeidler, T. (2011)LCPUFA supplementation in infancy reduces heart rate and affects distribution of attention. Pediatric Research,70, 1-5. Abstract A double-blind, randomized, controlled, parallel-group prospective trial was conducted to determine whether a dose-response existed for four different levels of docosahexaenoic acid (DHA) supplementation on the cognitive […]

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Leptin potentiates the anti-obesity effects of rimonabant European

C.M. Boustany-Kari, M.V. Jackson, C.P. Gibbons, A.G. Swick (2011)Leptin potentiates the anti-obesity effects of rimonabant European Journal of Pharmacology Volume 658, Issues 2-3,11: 270-276 Abstract We hypothesized that a combination of low doses of rimonabant and leptin would markedly reduce body weight through the modulation of neuronal activity within the hypothalamus. To this end, high […]

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Antimalarial activity of aporphine alkaloids and sesquiterpene lactones fromLiriodendrontulipiferaL

Graziose, Rocky, Thirumurugan Rathinasabapathy, Carmen Lategan, Alexander Poulev, Peter J. Smith, Mary H. Grace, Mary Ann Lila and Ilya Raskin. 2011. Antimalarial activity of aporphine alkaloids and sesquiterpene lactones from LiriodendrontulipiferaL. J. Ethnopharmacology 133: 26-30. Abstract AIM OF THE STUDY: The objective of this study was to isolate and characterize the active constituents of the […]

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The Metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems

Barnes, Stephen, Jeevan Prasain, Tracy D’Alessandro, Ali Arabshahi, Nigel Botting, Mary Ann Lila, George Jackson, Elsa Janle and Connie Weaver. 2011. The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. Food and Function: In Press. Abstract Polyphenols in dietary and botanical matrices are usually present as simple and complex […]

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High Predictive Accuracy of an Unbiased Proteomic Profile for Sustained Virologic Response in Chronic Hepatitis C Patients

Patel K, Lucas J, Thompson JW, Dubois LG, Tillmann H, Thompson A, Uzarski D, Califf RM, Moseley MA, Ginsburg GS, McHutchison JG, McCarthy JJ. High Predictive Accuracy of an Unbiased Proteomic Profile for Sustained Virologic Response in Chronic Hepatitis C Patients. Hepatology 2011; 53(6):1809-18. Abstract Chronic hepatitis C (CHC) infection is a leading cause of […]

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The chemistry and biotransformation of tea constituents

Sang S, Lambert JD, Ho CT, Yang CS. The chemistry and biotransformation of tea constituents. Pharmacological Research2011 Aug;64(2):87-99. Epub 2011 Mar 1. Abstract Tea (Camellia sinensis, Theaceae) is one of the most widely consumed beverages in the world. The three major types of tea, green tea, oolong tea, and black tea, differ in terms of […]

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Model SNP development for complex genomes based on hexaploid oat using high-throughput 454 sequencing technology.

OliverRE,LazoGR,LutzJD,RubenfieldMJ,TinkerNA,AndersonJM,WisniewskiMoreheadNH,AdhikaryD,Jellen EN,MaughanPJ,BrownGuediraGL,ChaoS,BeattieAD,CarsonML,RinesHW,ObertDE,BonmanJM,JacksonEW. Model SNP development for complex genomes based on hexaploid oat using high-throughput 454 sequencing technology.. BMC Genomics. January 2011. Abstract BACKGROUND: Genetic markers are pivotal to modern genomics research; however, discovery and genotyping of molecular markers in oat has been hindered by the size and complexity of the genome, and by a scarcity […]

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Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection

ShaoX,LvL,ParksT,WuH,HoCT,SangS.Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. Journal of Agricultural and Food Chemistry. 2010 Dec 22;58(24):12608-14. Epub 2010 Nov 23. Abstract For the first time, a sensitive reversed-phase HPLC electrochemical array method has been developed for the quantitative analysis of 8 major ginger components ([6]-, [8]-, and […]

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Impact of Bioflavonoids from Berryfruits on Biomarkers of Metabolic Syndrome

Impact of Bioflavonoids from Berryfruits on Biomarkers of Metabolic Syndrome Mary Ann Lila , Plants for Human Health Institute, North Carolina State University, 600 Laureate Way, Kannapolis, NC 28081, USA Abstract The phytochemical constituents which comprise many edible berry fruits have increasingly been linked to modulation of biomarkers associated with conditions of diabetes, overweight/obesity, and cardiovascular […]

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Salivary metabolite signatures of oral cancer and leukoplakia

Wei, Jie, Xie, Guoxiang, Zhoul, Zengtong, Shi, Peng, Qiu, Yunping, Zheng, Xiaojiao, Chen, Tianlu, Su, Mingming, Zhao, Aihua, Jia, Wei (December, 2010).  Salivary metabolite signatures of oral cancer and leukoplakia. International Journal of Cancer 10.1002/ijc.25881 NA. Abstract Oral cancer, one of the six most common human cancers with an overall 5-year survival rate of <50%, is […]

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Upper respiratory tract infection is reduced in physically fit and active adults.

Nieman DC,Henson DA,Austin MD,Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Human Performance Laboratory, AppalachianStateUniversity, North Carolina Research Campus, Kannapolis, North Carolina, USA.Br J Sports Med.2010 Nov 1. [Epub ahead of print] Abstract OBJECTIVE: Limited data imply an inverse relationship between physical activity or fitness level and the rates of […]

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Wound-healing properties of nut oil from Pouteria lucuma.

Wound-healing properties of nut oil from Pouteria lucuma. Rojo LE1, Villano CM, Joseph G, Schmidt B, Shulaev V, Shuman JL, Lila MA, Raskin I. Abstract BACKGROUND: Cell migration, angiogenesis, inflammation, and extracellular matrix remodeling are key events in wound healing. Natural products, including fatty acids (FAs), can accelerate wound healing by modulating the aforementioned events. AIMS: This study aims to evaluate the […]

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Reclassification of Cardiovascular Risk Using Integrated Clinical and Molecular Biosignatures: Design and Rationale of the MURDOCK Horizon 1 Cardiovascular Disease Study

Shah SH, Granger CB, Hauser ER, Kraus WE, Sun JL, Pieper K, Nelson CL, DeLong ER, Califf RM, Newby LK, for the MURDOCK Horizon 1 Cardiovascular Disease Investigators. Reclassification of Cardiovascular Risk Using Integrated Clinical and Molecular Biosignatures: Design and Rationale of the MURDOCK Horizon 1 Cardiovascular Disease Study. Am Heart J 2010 Sep;160(3):371-379.e2. Abstract […]

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An automated data analysis pipeline for GC-TOF-MS metabonomics studies

Jiang W,Qiu Y,Ni Y,Su M,Jia W,Du X.An automated data analysis pipeline for GC-TOF-MS metabonomics studies. Also in partnership with UNC Greensboro. Department ofBioinformatics & Genomics, University of North Carolina at Charlotte, Kannapolis, NC 28081, USA. JournalofProteomeResearch.2010 Nov 5;9(11):5974-81. Epub 2010 Sep 29. Abstract Recent technological advances have made it possible to carry out high-throughput metabonomics […]

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Effect of n-3 fatty acids and antioxidants on oxidative stress after exercise.

McAnulty SR, Nieman DC, Fox-Rabinovich M, Duran V, McAnulty LS, Henson DA, Jin F, Landram MJ. Effect of n-3 fatty acids and antioxidants on oxidative stress after exercise. Department of Health, Leisure, and Exercise Science, AppalachianStateUniversity, Boone, NC 28608, USA. Med Sci Sports Exerc. 2010 Sep;42(9):1704-11. Abstract PURPOSE: n-3 fatty acids are known to exert […]

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Simplifying informed consent for biorepositories: stakeholder perspectives.

Beskow LM, Friedman J, Hardy C, Lin L, Weinfurt KP. Simplifying informed consent for biorepositories: stakeholder perspectives. Genetics in Medicine; 2010 Aug 6. Abstract PURPOSE: Complex and sometimes controversial information must be conveyed during the consent process for participation in biorepositories, and studies suggest that consent documents in general are growing in length and complexity. […]

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Blueberries: Genotype-dependent variation in antioxidant, free-radical scavenging, and prebiotic activities

Blueberries: Genotype-dependent variation in antioxidant, free-radical scavenging, and prebiotic activities A.L. Molan1*, M. A. Lila2 and G. Ravindran 1 Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand * Corresponding author: Tel: +64-6-350 4799; Fax: +64-6-350 5446; E-mail address: A.L.Molan@massey.ac.nz 2College of Agriculture, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, […]

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Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandemmassspectrometry.

Shao X,Chen X,Badmaev V,Ho CT,Sang S. Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandemmassspectrometry. Rapid Communications in Mass Spectrometry.2010 Jun 30;24(12):1770-8. Abstract Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the […]

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Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin.

Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin. McCarthy JJ1, Li JH, Thompson A, Suchindran S, Lao XQ, Patel K, Tillmann HL, Muir AJ, McHutchison JG. Abstract BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infections are treated with pegylated interferon and ribavirin (PEG-IFN/RBV), which is effective in less than 50% of those infected with HCV genotype 1. Genome-wide association […]

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Interferon-lambda Genotype and Low Serum Low- Density Lipoprotein Cholesterol Levels in Patients with Chronic Hepatitis C Infection

Interferon-lambda Genotype and Low Serum Low-Density Lipoprotein Cholesterol Levels in Patients with Chronic Hepatitis C Infection Li JH1, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG, McCarthy JJ. Abstract Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment ofhepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with […]

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Serum Proteomic Profiles Associated with IL28B Genotype among CHC Patients

McCarthy JJ, Cyr D, Lucas J, Thompson JW, Patel K, Thompson A, Tillmann H, Clark PJ, Moseley MA and McHutchison JG. Serum Proteomic Profiles Associated with IL28B Genotype among CHC Patients. Hepatology 2010 (52): 4 (suppl):727A Abstract INTRODUCTION: Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous […]

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Zebrafish model:worth considering indefining tumor angiogenesis

MoshalKS,Ferri-LagneauKF,LeungT. Zebrafish model:worth considering indefining tumor angiogenesis. Trends in Cardiovascular Medicine. 2010 May;20(4):114-9. Abstract The process of angiogenesis is essential for tumor progression and metastasis; however, antiangiogenesis therapy-induced hypoxia and inflammation are perhaps the driving force for tumor escape and metastasis formation, thereby compromising its efficacy. This warrants the complete understanding of the molecular and […]

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Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation

Yang X,Yang S,McKimmey C,Liu B,Edgerton SM,Bales W,Archer LT,Thor AD. Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation.Carcinogenesis.2010 Apr;31(4):695-702. Epub 2010 Jan 12. Abstract Genistein is a major isoflavone with known hormonal and tyrosine kinase-modulating activities. Genistein has been shown to promote the growth of estrogen receptor positive […]

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Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins.

ZhongW, Zhao Y, McClain CJ, Kang YJ, Zhou Z. Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins. Am J Physiol.2010; 299:G643-G651 Abstract Chronic alcohol exposure has been shown to increase the gut permeability in the distal intestine, in part, through induction of zinc deficiency. The present study evaluated the molecular […]

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The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction.

Zhong W, McClain CJ, Cave M, Kang YJ, Zhou Z. The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol.2010; G625-633. Abstract Disruption of the intestinal barrier is a causal factor in the development of alcoholic endotoxemia and hepatitis. This study was undertaken to determine whether zinc deficiency is related to the deleterious […]

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Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins.

Zhong W, Zhao Y, McClain CJ, Kang YJ, Zhou Z. Inactivation of hepatocyte nuclear factor-4a mediates alcohol- induced down-regulation of intestinal tight junction proteins. Am J Physiol.2010; 299:G643-G651 Abstract Chronic alcohol exposure has been shown to increase the gut permeability in the distal intestine, in part, through induction of zinc deficiency. The present study evaluated […]

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A regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunity.

Humphry A, Pednarek P, Kemmerling B, Koh S, Stein M, Gobel U, Stuber K, Pislewska-Bednarek M, Loraine A, Schulze-Lefert P, Somerville S, Panstruga R. A regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunity. PNAS 2010, 107(50):21896-901. Abstract BACKGROUND: Around 14% of protein-coding genes of Arabidopsis thaliana genes from […]

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Prevalence of alternative splicing choices in Arabidopsis

English A, Patel K, Loraine AE. Prevalence of alternative splicing choices in Arabidopsis. BMC Plant Biology. BMC Plant Biology 2010, 10:102.PubMed.ArabiTag-alternative splicing data-mining tool. Abstract BACKGROUND: Around 14% of protein-coding genes of Arabidopsis thaliana genes from the TAIR9 genome release are annotated as producing multiple transcript variants through alternative splicing. However, for most alternatively spliced […]

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Alteration of PTGS2 promoter methylation in chronic periodontitis

Zhang, S., Barros, S. P., Niculescu, M. D., Moretti, A. J., Preisser, J. S., and Offenbacher, S. (2010)Alteration of PTGS2 promoter methylation in chronic periodontitis.J Dent Res89, 133-137 Abstract   Levels of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in actively progressing periodontal lesions, but decrease in chronic disease. We hypothesized that […]

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A Grand Challenge for Nutrigenomics

Zeisel, S.H.(2010)A Grand Challenge for Nutrigenomics. Frontiers in Nutrigenomics.1(2): 1-3.

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Nutritional Genomics Defining the dietary requirement and effects of choline

Zeisel, S.H.(2010)Nutritional Genomics Defining the dietary requirement and effects of choline. The Journal of Nutrition. 531-534. Abstract As it becomes evident that single nucleotide polymorphisms (SNPs) in humans can create metabolic inefficiencies, it is reasonable to ask if such SNPs influence dietary requirements. Epidemiologic studies that examine SNPs relative to risks for diseases are common, […]

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Choline: An essential nutrient for public health

Zeisel, S.H.(2010)Choline: An essential nutrient for public health. SCAN’S PULSE29(3): 4–7. Abstract Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998. There is significant variation in the dietary requirement for choline that can be explained by common genetic polymorphisms. Because of its wide-ranging roles in human metabolism, from […]

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Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency.

Spencer, M.D., Hamp, T.J., Reid, R.W., Fischer, L.M., Zeisel, S.H., Fodor, A.A. (2010)Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology. doi:10.1053/j.gastro.2010.11.049. Abstract BACKGROUND & AIMS: Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood. […]

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Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

Resseguie, M.,da Costa, K-A, Galanko, J., Davis, I.J., Zeisel, S.H. (2010)Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. Journal of Biological Chemistry.286(2): 1649-58. PMCID: PMC3020773. Abstract When dietary choline is restricted, most men and postmenopausal women develop multiorgan dysfunction marked by hepatic steatosis (choline deficiency syndrome (CDS)). However, a significant subset of […]

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Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus.

Mehedint, M.G., Craciunescu, C.N., Zeisel, S.H. (2010)Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus. Proceedings of the National Academy of Sciences USA. 107(29): 12834-39. PMCID: PMC2919920. Abstract We examined whether maternal dietary choline modulates angiogenesis in fetal brain. Pregnant C57BL/6 mice were fed either a choline-deficient (CD), control (CT), or choline-supplemented diet (CS) from […]

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Choline intake and genetic polymorphisms influence cholinemetabolite concentrations in human breast milk and plasma.

Fischer, L.M., daCosta, K-A, Galanko, J., Sha, W., Stephenson, B., Vick, J., Zeisel, S.H. (2010)Choline intake and genetic polymorphisms influence cholinemetabolite concentrations in human breast milk and plasma. American Journal of Clinical Nutrition.92(2): 336-346. PMCID: PMC2904035. Abstract BACKGROUND: Choline is essential for infant nutrition, and breast milk is a rich source of this nutrient. Common […]

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Dietary choline requirements of women: effects of estrogen and genetic variation

Fischer, L.M., da Costa, K-A, Kwock, L., Galanko, J., Zeisel, S.H. (2010)Dietary choline requirements of women: effects of estrogen and genetic variation. American Journal of Clinical Nutrition.92(5):1113-19. PMCID: PMC2954445. Abstract BACKGROUND: Choline is obtained from the diet and from the biosynthesis of phosphatidylcholine. Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by […]

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Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain

Craciunescu, C.N., Johnson, A.R., Zeisel, S.H. (2010)Dietary choline reverses some, but not all effects of folate deficiency on neurogenesis and apoptosis in the fetal mouse brain.The Journal of Nutrition. 140:1162-6. PMCID: PMC2869500. Abstract In mice, maternal dietary folate, a cofactor in 1-carbon metabolism, modulates neurogenesis and apoptosis in the fetal brain. Similarly, maternal dietary choline, […]

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Declarative memory in abused and neglected infants

Cheatham, C.L., Larkina, M., Bauer, P.J., Toth, S., Cicchetti, D. (2010)Declarative memory in abused and neglected infants.Advances in Child Development and Behavior, Volume 38 -Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy (pp. 161-182). London, U.K.: Elsevier. Abstract To summarize, all children interacted with the experimenter and actively participated in […]

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The development of declarative memory in infants born preterm

Cheatham, C. L., Sesma, H. W., & Georgieff, M. K. (2010)The development of declarative memory in infants born preterm.In P.J. Bauer (Ed.), Advances in Child Development and Behavior, Volume 38 -Varieties of Early Experience: Implications for the Development of Declarative Memory in Infancy(pp. 111-135). London, U.K.: Elsevier.

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Adiponectin lowers glucose production by increasing SOGA

Bryan, R.P., Asmar, M.M., Alderman, J.M., Alderman, E.A., Garland, A.L., Busby, W.H., Bodnar, W.M., Rusyn, I., Medoff, B., Tisch, R., Swenberg, J.A., Zeisel, S.H., Combs, T.P. (2010)Adiponectin lowers glucose production by increasing SOGA. American Journal of Pathology. 177(40): 1936-1945. PMCID: PMC2947288. Abstract Adiponectin is a hormone that lowers glucose production by increasing liver insulin sensitivity. […]

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Nutrition in Medicine: Nutrition education for medical students and residents

Adams, K.M., Kohlmeier, M., Powell, M., Zeisel, S.H. (2010)Nutrition in Medicine: Nutrition education for medical students and residents. Nutrition in Clinical Practice.25(5):471-80. Abstract Proper nutrition plays a key role in disease prevention and treatment. Many patients understand this link and look to physicians for guidance diet and physical activity. Actual physician practice, however, is often […]

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Method for evaluating the potential of 14C labeled plant polyphenols to cross the blood-brain barrier using accelerator mass spectrometry. Nuclear Instruments and Methods in Physics Research

Janle, Elsa M., Mary Ann Lila, Michael Grannan, Lauren Wood, Aine Higgins, Gad G. Yousef, Randy B. Rogers, Helen Kim, George S. Jackson, Connie M. Weaver. 2010. Method for evaluating the potential of 14C labeled plant polyphenols to cross the blood-brain barrier using accelerator mass spectrometry. Nuclear Instruments and Methods in Physics Research. B. Beam […]

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Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.

Graziose, Rocky, Mary Ann Lila and Ilya Raskin. 2010. Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods. Current Drug Discovery Technologies 7: 2-12. Abstract Traditional Chinese Medicines (TCM) are rapidly gaining attention in the West as sources of new drugs, dietary supplements and functional foods. However, lack […]

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Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration

Janle, Elsa M., Mary Ann Lila, Michael Grannan, Lauren Wood, Aine Higgins, Gad. G. Yousef, Randy B. Rogers, Helen Kim, George S. Jackson, Lap Ho and Connie Weaver. 2010. Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration. Journal of Medicinal Food 13: 1-8. Abstract […]

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Alaskan wild berry resources and human health under the cloud of climate change.

Kellogg, Joshua, Jinzhi Wang, Courtney Flint, David Ribnicky, Peter Kuhn, Elvira González De Mejia, Ilya Raskin and Mary Ann Lila. 2010. Alaskan wild berry resources and human health under the cloud of climate change. Journal of Agricultural and Food Chemistry 58: 3884-3900. Abstract Wild berries are integral dietary components for Alaska Native people and a […]

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Berries from South America a Comprehensive Review on: Chemistry, Health Implications and Commercialization.

Schrenkinger, Maria Elisa, Jennifer Lotton, Mary Ann Lila and Elvira Gonzalez de Mejia. 2010. Berries from South America a Comprehensive Review on: Chemistry, Health Implications and Commercialization. Journal of Medicinal Food 13(2): 233-246. Abstract Dietary intake of berry fruits has been demonstrated to positively impact human health. Interest in exploring new and exotic types of […]

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Wound healing properties of fatty acids fromPouterialucumae.

Rojo, Leonel, Caren Villano, G. Joseph, B. Schmidt, V. Shulaev, Mary Ann Lila and Ilya Raskin. 2010. Wound healing properties of fatty acids fromPouterialucumae. Journal of Cosmetic Dermatology 9: 185-195. Abstract BACKGROUND: Cell migration, angiogenesis, inflammation, and extracellular matrix remodeling are key events in wound healing. Natural products, including fatty acids (FAs), can accelerate wound […]

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Characterization of anthocyanins and proanthocyanidins in wild and domesticated Mexican blackberries (Rubus spp.).

Cuevas-Rodríguez, Edith O., Gad G. Yousef, Pedro A. García-Saucedo, José López-Medina, Octavio Paredes-López and Mary Ann Lila. 2010. Characterization of anthocyanins and proanthocyanidins in wild and domesticated Mexican blackberries (Rubus spp.). Journal of Agricultural and Food Chemistry 58: 7458-7464. Abstract This study was designed to characterize and compare wild, commercial, and noncommercial cultivated blackberry genotypes […]

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Comparative invitro activities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells.

Newell, Amanda M.B., Gad G. Yousef, Mary Ann Lila, Marco Vinicio Ramirez-Mares and Elvira Gonzalez de Mejia. 2010. Comparative invitro activities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells. Journal of Ethnopharmacology 130: 536-544. Abstract AIM OF THE STUDY: Ardisia species, notably A. compressa, are used […]

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Tracking deposition of a 14C-radiolabeled hairy root-derived isoflavone-rich fraction into bone

Mun, Jonathan G, Michael D. Grannan, Pamela J. Lachcik, Randy B. Rogers, Gad G. Yousef, Mary H. Grace, Elsa M. Janle, Qing Li Wu, James E. Simon, Connie M. Weaver and Mary Ann Lila. Tracking deposition of a 14C-radiolabeled hairy root-derived isoflavone-rich fraction into bone. Experimental Biology and Medicine 235: 1224-1235. Abstract Hairy roots were […]

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Antioxidant capacity and in vitro inhibition of adipogenesis and inflammation by phenolic extracts of VacciniumfloribundumandAristotelia chilensis.

Schrenckinger, Maria Elisa, J. Wang, G. Yousef, M.A. Lila and E. de Mejia. 2010. Antioxidant capacity and in vitro inhibition of adipogenesis and inflammation by phenolic extracts of VacciniumfloribundumandAristotelia chilensis. Journal of Agricultural and Food Chemistry 58: 8966-8976. Abstract Interest in berries from South America has increased due to their potential health benefits. The objective […]

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Screening and selection of high carotenoid producing in vitro tomato cell culture lines for [13C]-carotenoid production.

Engelmann, Nancy, J. Campbell, S. Rupassara, R. Rogers, P. Garlick, M.A. Lila and J. W. Erdman, Jr. 2010. Screening and selection of high carotenoid producing in vitro tomato cell culture lines for [13C]-carotenoid production. Journal of Agricultural and Food Chemistry 58: 9979-9987. Abstract Isotopically labeled tomato carotenoids, phytoene, phytofluene, and lycopene, are needed for mammalian […]

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Inhibition of pro-inflammatory responses and antioxidant capacity of Mexican blackberry (Rubusspp.) extracts

Cuevas-Rodrigues, Edith, V. Dia, G. Yousef, P. Garcia-Saucedo, J. Lopez-Medina, O. Paredes-Lopez, E. de Mejia and M.A. Lila. 2010. Inhibition of pro-inflammatory responses and antioxidant capacity of Mexican blackberry (Rubusspp.) extracts. Journal of Agricultural and Food Chemistry 58: 9542-9548. Abstract Total polyphenolic and anthocyanin- and proanthocyanidin-rich fractions from wild blackberry genotypes (WB-3, WB-7, WB-10, and […]

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Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canellawinterana.

Grace, Mary H., Carmen Lategan, Flaubert Mbeunkui, Rocky Graziose, Peter J. Smith, Ilya Raskin and Mary Ann Lila. 2010. Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canellawinterana. Journal of Natural Product Communications 5: 1869-1872. Abstract The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of […]

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Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection.

Li JH, Lao XQ, Tillmann HL, Rowell J, Patel K, Thompson A, Suchindran S, Muir AJ, Guyton JR, Gardner SD, McHutchison JG and  McCarthy JJ.  Interferon lambda genotype and low serum LDL cholesterol levels in patients with chronic hepatitis C infection. Hepatology 2010;51(6): 1904-11.  PMID: 20235331. Abstract Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda […]

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Developing a Simplified Consent Form for Biobanking

Beskow LM, Friedman JY, Hardy NC, Lin L, Weinfurt KP (2010) Developing a Simplified Consent Form for Biobanking. PLoS ONE 5(10): e13302. doi:10.1371/journal.pone.0013302 Abstract BACKGROUND: Consent forms have lengthened over time and become harder for participants to understand. We sought to demonstrate the feasibility of creating a simplified consent form for biobanking that comprises the […]

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An optimized procedure for metabonomic analysis of rat liver tissue using gas chromatography/time-of-flight mass spectrometry

Pan, Li, Qiu, Yunping, Chen, Tianlu, Lin, Jinchao, Chi, Yi, Su, Mingming, Zhao, Aihua, Jia, Wei (2010). An optimized procedure for metabonomic analysis of rat liver tissue using gas chromatography/time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 52(4) 589-596. Abstract In this paper, we present a tissue metabonomic method with an optimized extraction procedure […]

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Urinary metabonomic study on colorectal cancer

Qiu, Yunping, Cai, Guoxiang, Su, Mingming, Chen, Tianlu, Liu, Yumin, Xu, Ye, Ni, Yan, Zhao, Aihua, Cai, Sanjun, Xu, Lisa X., Jia, Wei (2010).  Urinary metabonomic study on colorectal cancer .Journal of Proteome Research 9(3) 1627- 1634. Abstract After our serum metabonomic study of colorectal cancer (CRC) patients recently published in J. Proteome Res., we profiled […]

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Quercetin supplementation does not alter antioxidant status in humans.

Shanely RA,Knab AM,Nieman DC,Jin F,McAnulty SR,Landram MJ. Quercetin supplementation does not alter antioxidant status in humans. North Carolina Research Campus, AppalachianStateUniversity, Human Performance Laboratory, Plants for Human Health Building, 600 Laureate Way, Kannapolis, NC 28081, USA. Free Radic Res.2010 Feb; 44(2):224-31. Abstract This study measured the influence of ingesting quercetin on plasma measures for oxidative stress […]

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Quercetin’s influence on exercise performance and muscle mitochondrial biogenesis.

Nieman DC,Williams AS,Shanely RA,Jin F,McAnulty SR,Triplett NT,Austin MD,Henson DA.Quercetin’s influence on exercise performance and muscle mitochondrial biogenesis. Department of Health, Leisure, and Exercise Science, AppalachianStateUniversity, Boone, NC 28608, USA.Med Sci Sports Exerc.2010 Feb;42(2):338-45. Abstract PURPOSE: To determine the influence of 2 wk of quercetin (Q; 1000 mg x d(-1)) compared with placebo (P) supplementation on […]

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Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin

Huang X,Gao L,Wang S,McManaman JL,Thor AD,Yang X,Esteva FJ,Liu B. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. CancerRes.2010Feb 1;70(3):1204-14. Epub 2010 Jan 26. Abstract Primary and acquired resistance to the breast cancer drug trastuzumab (Herceptin) is a significant clinical problem. Here, we report […]

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Phytochemical Characterization of an Adaptogenic Preparation from Rhodiola heterodonta

Phytochemical Characterization of an Adaptogenic Preparation from Rhodiola heterodonta Mary H. Grace,a Gad G. Yousef,a Anvar G. Kurmukov,b Ilya Raskin,c and Mary Ann Lila Abstract The phytochemical constituents of a biologically active, standardized, 80% ethanol extract of Rhodiola heterodonta were characterized. The extract was fractionated over a Sephadex LH-20 column to afford two main fractions […]

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In vitro and in vivo evaluation of the prebiotic activity of water-soluble blueberry extracts

In vitro and in vivo evaluation of the prebiotic activity of water-soluble blueberry extracts Abdul Lateef Molan, Mary Ann Lila, John Mawson, Shampa De Abstract The prebiotic effects of water extracts of two blueberry (BBE) cultivars (‘Centurion’ and ‘Maru’) were studied using pure and mixed cultures of human faecal bacteria. The results demonstrated for the first time that […]

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Postharvest Challenges for Organically Grown Orchard Fruit

Postharvest Challenges for Organically Grown Orchard Fruit Penelope Perkins-Veazie Abstract Switching from conventional to organic production requires a philosophical shift and recognition of different production system inputs plus postharvest handling challenges. First, and most obvious, is the replacement of common and readily available manufactured chemical inputs with approved “natural” or “nature-made compounds” (i.e., organic) for […]

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Interactions Between Flavonoids that Benefit Human Health

Interactions Between Flavonoids that Benefit Human Health Mary Ann Lila Abstract Interactions between anthocyanin pigments and other flavonoids or other phytochemicals accumulating within a plant contribute significantly to the ability of natural plant extracts (ingested as food or pharmaceutical product) to protect human health or mitigate disease damage. Interactions are the rule, rather than the […]

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ENVIRONMENTAL EFFECT ON ANTIOXIDANT CONTENT OF TEN RASPBERRY CULTIVARS

ENVIRONMENTAL EFFECT ON ANTIOXIDANT CONTENT OF TEN RASPBERRY CULTIVARS P.P. Moore, P. Perkins-Veazie, C.A. Weber, L. Howard Abstract: Ten red raspberry cultivars grown in New York and Washington were harvested in 2002 and 2003 and analyzed for fruit composition and antioxidant content. The contributions of production environment and year were compared to genetic variability. Fruit […]

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Enhancement of Tomato Fruit Lycopene by Potassium Is Cultivar Dependent

Enhancement of Tomato Fruit Lycopene by Potassium Is Cultivar Dependent Henry Taber Department of Horticulture, Iowa State University, Ames, IA 50011,  Penelope Perkins-Veazie USDA-Agricultural Research Service, Lane, OK 74555, Shanshan Lil and Wendy White Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, Steven Rodermel and Yang Xu Abstract The purpose of this experiment was to determine […]

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Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4a and peroxisome proliferators activated receptor-a

Kang X, Zhong W, Liu J, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4a and peroxisome proliferators activated receptor-a. Hepatology2009; 50:1241-1250. Abstract Alcoholic steatosis is a fundamental metabolic disorder in the progression of alcoholic liver disease. Zinc deficiency is one of the most […]

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A rapid ultra-performance liquid chromatography–electrospray ionization mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng,

Dan, M., Xie, G., Gao, X., Long, X., Su, M., Zhao, A., Zhao, T., Zhou, M., Qiu, Y., Jia, W.*A rapid ultra-performance liquid chromatography–electrospray ionization mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng, Phytochemical Analysis, 20 (1), 68-76, 2009. Abstract INTRODUCTION: Saponins are bioactive compounds employed in the […]

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Paeonol attenuates high-fat-induced atherosclerosis in rabbits by anti-inflammatory activity

Li, H., Dai, M.,Jia, W. Paeonol attenuates high-fat-induced atherosclerosis in rabbits by anti-inflammatory activity, Planta Medica, 75(1), 7-11, 2009. Abstract Cortex Moutan (Paeonia suffruticosa Andrews, Ranunculaceae) has several uses in traditional medicine, such as analgesic, antipyretic, and anti-inflammatory applications and use in the prevention of thromboembolic diseases. Paeonol, a main active component in Cortex Moutan, […]

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Nephro-protective effect of Kangqianling decociton on chronic renal failure rats

He, L., Shen, P., Fu, Q.,Li, J., Dan, M., Wang, X.,Jia, W.*Nephro-protective effect of Kangqianling decociton on chronic renal failure rats, Journal of Ethnopharmacology, 122, 367-373, 2009. Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Kangqianling decoction (KQL), the modified formulation of a classical Chinese prescription named Taohongsiwu decoction, was clinically employed to treat renal fibrosis in chronic renal failure. […]

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Characterization of Pu-erh tea using chemical and metabolic profiling approaches

Xie, G., Ye, M., Wang, Y., Ni, Y., Su, M., Huang, H., Qiu, M., Zhao, A., Zheng, X., Chen, T., Jia, W.*Characterization of Pu-erh tea using chemical and metabolic profiling approaches, Journal of Agricultural and Food Chemistry, 57, 3046-3054, 2009. Abstract In this study, the chemical constituents of pu-erh tea, black tea, and green tea, […]

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Metabonomics approach to understanding acute and chronic stress in rat models

Wang, X., Zhao, T., Qiu, Y., Su, M., Jiang, T., Zhou, M., Zhao, A., Jia, W.*Metabonomics approach to understanding acute and chronic stress in rat models, Journal of Proteome Research,8(5), 2511-2518, 2009. Abstract The effects of acute and chronic stress on the production of systemic metabolites were investigated in male Sprague-Dawley (SD) rats. Metabolites excreted […]

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Trace element profiling using inductively coupled plasma mass spectrometry and its application in an osteoarthritis study

Zhao, T., Chen, T., Qiu, Y., Zou, X., Li, X., Su, M., Yan, C., Zhao, A., Jia, W.*Trace element profiling using inductively coupled plasma mass spectrometry and its application in an osteoarthritis study, Analytical Chemistry(IF = 5.287), 81(9), 3683-3692, 2009. Abstract In this study, a novel method of quantitatively measuring serum trace elements using inductively […]

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Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers

Bao, Y., Zhao, T., Wang, X., Qiu, Y., Su, M., Jia, W.*Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers, Journal of Proteome Research(IF = 5.675), 8(4), 1623-1630, 2009. Abstract The pathological development and the drug intervention of type 2 diabetes mellitus (T2DM) involve altered expression of downstream low molecular weight […]

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Metabonomic evaluation of Melamine-induced acute renal toxicity in rats.

Xie, G., Zheng, X., Qi, X., Cao, Y., Chi, Y., Su, M., Ni, Y., Qiu, Y., Liu, Y., Li, H., Zhao, A., Jia, W.*Metabonomic evaluation of Melamine-induced acute renal toxicity in rats. Journal of Proteome Research(IF = 5.675), Epubahead of print (DOI: 10.1021/pr900333h), 2009. Abstract The recent outbreak of renal failure in infants in China […]

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Consistency analysis of redundant probe sets on Affymetrix three-prime expression arrays and applications to differential mRNA processing

Cui X, Loraine AE. 2009. Consistency analysis of redundant probe sets on Affymetrix three-prime expression arrays and applications to differential mRNA processing. PLoSOne. 2009;4(1):e4229. Epub 2009 Jan 23. PubMed Abstract Affymetrix three-prime expression microarrays contain thousands of redundant probe sets that interrogate different regions of the same gene. Differential expression analysis methods rarely consider probe […]

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Co-expression Analysis of Metabolic Pathways in Plants

Loraine, A. Co-expression Analysis of Metabolic Pathways in Plants. Methods Mol Biol. 2009; 553:247-64.PubMed Abstract Co-expression analysis allows experimenters to re-use archived expression microarray data to uncover previously unknown functional relationships between genes. An observation that a group of genes are co-expressed across diverse experimental conditions suggests they may play similar roles in the cell. […]

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The Integrated Genome Browser: Free software for distribution and exploration of genome-scale data sets.

Nicol JW, Helt GA, Blanchard SG, Raja A, Loraine AE. The Integrated Genome Browser: Free software for distribution and exploration of genome-scale data sets. Bioinformatics. 2009 October 15; 25(20):27302. Article Abstract Experimental techniques that survey an entire genome demand flexible, highly interactive visualization tools that can display new data alongside foundation datasets, such as reference […]

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The Genoviz Software Development Kit: A Java toolkitfor building genomics visualization applications.

Helt GA, Nicol JW, Blossom E, Blanchard S, Chervitz SA, Harmon C, LoraineAE. The Genoviz Software Development Kit: A Java toolkitfor building genomics visualization applications. BMC Bioinformatics. 2009, 10:266. Abstract BACKGROUND: Visualization software can expose previously undiscovered patterns in genomic data and advance biological science. RESULTS: The Genoviz Software Development Kit (SDK) is an open […]

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Assembly of an interactive network for the Arabidopsis genome using a novel heuristic clustering algorithm. Plant Physiol

Mutwil M, Usadel B, Schutte M, Loraine A, Ebenhoh O, Persson S. Assembly of an interactive network for the Arabidopsis genome using a novel heuristic clustering algorithm. Plant Physiol. 2010 Jan;152(1):29-43. Epub 2009 Nov 4.PubMed Abstract A vital quest in biology is comprehensible visualization and interpretation of correlation relationships on a genome scale. Such relationships […]

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Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery.

Barnes M R, Harland L, Foord S M, Hall M D, Dix I, Thomas S, Williams-Jones B I, Brouwer C R. (2009) Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery. Nat Rev Drug Discov. 8:701-708. Abstract Pharmaceutical research and development is facing substantial challenges that have prompted the industry to shift funding from early- […]

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Visualizing the drug target landscape.

Campbell S A, Gaulton A, Marshall J, Bichko D, Martin S, Brouwer C and Harland L. (2009) Visualizing the drug target landscape. Drug Disc Today. 15:3-15. Abstract Generating new therapeutic hypotheses for human disease requires the analysis and interpretation of many different experimental datasets. Assembling a holistic picture of the current landscape of drug discovery […]

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Cardiac involvement in trichinellosis: a case of left ventricular thrombosis

Tint, D., Cocuz, M. E., Ortan, O. F., Niculescu, M. D., and Radoi, M. (2009)Cardiac involvement in trichinellosis: a case of left ventricular thrombosis. Am J Trop Med Hyg81, 313-316. Abstract We report the case of a 42-year-old woman who was admitted to the hospital for fever, chills, nausea, vomiting, fatigue, myalgia, and general muscle […]

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High fat diet-induced maternal obesity alters fetal hippocampal development

Niculescu, M. D., and Lupu, D. S.(2009)High fat diet-induced maternal obesity alters fetal hippocampal development. Int J Dev Neurosci27, 627-633 Abstract The importance of maternal nutrition for fetal brain development is increasingly recognized. Previous studies have suggested that maternal obesity or maternal exposure to obesogenic diets may permanently alter brain structure and function in the […]

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Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans

Craciunescu, C. N., Niculescu, M. D., Guo, Z., Johnson, A. R., Fischer, L., and Zeisel, S. H. (2009)Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans.Toxicol Sci107, 220-226 Abstract Diethanolamine (DEA) is a common ingredient of personal care products. Dermal administration of DEA diminishes hepatic stores […]

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Herbicide treatments alter carotenoid profiles for 14C tracer production from tomato (Lycopersiconesculentum) cell cultures.

Engelmann, Nancy J., Randy Rogers, Mary Ann Lila and John Erdman, Jr. 2009. Herbicide treatments alter carotenoid profiles for 14C tracer production from tomato (Lycopersiconesculentum) cell cultures. Journal of Agricultural and Food Chemistry 57: 4614-4619. Abstract Progress in learning about underlying carotenoid bioactivity mechanisms has been limited because of the lack of commercially available radiolabeled […]

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Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifoliumAiton.

Grace, M., David M. Ribnicky, Peter Kuhn, Alex Poulev, Sithes Logendra, Gad G. Yousef, Ilya Raskin and Mary Ann Lila. 2009. Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifoliumAiton. Phytomedicine 16: 406-415. Abstract Blueberry fruits are known as a rich source of anthocyanin components. In this study we demonstrate that anthocyanins […]

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In vitro production of radiolabeled red clover (Trifoliumpratense) isoflavones.

Engelmann, Nancy J., Adam Reppert, Gad Yousef, Randy Rogers and Mary Ann Lila. 2009. In vitro production of radiolabeled red clover (Trifoliumpratense) isoflavones. Plant Cell Tissue & Organ Culture 98: 147-156. Abstract Red clover isoflavones are increasingly used in dietary supplements for their purported estrogenic effects. However, little is known about their metabolism in animals […]

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In vivo metabolic tracking of 14C-labeled isoflavones in kudzu and red clover extracts

Mun, J., Michael Grannan, Pamela Lachcik, Adam Reppert, Gad G. Yousef, Randy B. Rogers, Elsa M. Janle, Connie M. Weaver and Mary Ann Lila. 2009. In vivo metabolic tracking of 14C-labeled isoflavones in kudzu and red clover extracts. British Journal of Nutrition 102: 1523–1530. Abstract Absorption, distribution and elimination of 14C-labelled isoflavone-containing extracts from kudzu […]

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Research highlights from the Purdue-UAB Botanicals Research Center for Age-related Diseases

Weaver, Connie M., Steve Barnes, James M. Wyss, Helen Kim, D. M. Morre, D.J. Morre, James E. Simon, Mary Ann Lila, Elsa Janle and Mario Ferruzzi. 2009. Research highlights from the Purdue-UAB Botanicals Research Center for Age-related Diseases. Pharmceutical Biology 47: 768-773. PMID: 19890436. Abstract The Purdue-UAB Botanicals Research Center for Age Related Disease uses […]

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Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC- QTOFMS

Qiu, Yunping, Cai, Guoxiang, Su, Mingming, Chen, Tianlu, Zheng, Xiaojiao, Xu, Ye, Ni, Yan, Zhao, Aihua, Xu, Lisa X., Cai, Sanjun, Jia, Wei (2009).  Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC- QTOFMS.  Journal of Proteome Research 8(10) 4844-4850. Abstract Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with […]

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Theorphan G protein-coupled receptor 161is required for left–right patterning

TinChung Leung, Jasper E. Humbert, Anna M. Stauffer, Kathryn E. Giger, Hui Chen, Huai-Jen Tsai, Chuan Wang, Tooraj Mirshahi and Janet D. Robishaw. Theorphan G protein-coupled receptor 161is required for left–right patterning. DevelopmentBiology.2008 Nov 1;323(1):31-40. Epub 2008 Aug 7. Abstract Gpr161 (also known as RE2) is an orphan G protein-coupled receptor (GPCR) that is expressed […]

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Isolation and linkage mapping of NBS-LRR resistance gene analogs in red raspberry (Rubus idaeus L.) and classification among 270 Rosaceae NBS-LRR genes

Isolation and linkage mapping of NBS-LRR resistance gene analogs in red raspberry (Rubus idaeus L.) and classification among 270 Rosaceae NBS-LRR genes Suren K. Samuelian, Angela M. Baldo, Jeremy A. Pattison, Courtney A. Weber Abstract Plant R genes confer resistance to pathogens in a gene-for-gene mode. Seventy-five putative resistance gene analogs (RGAs) containing conserved domains were cloned from […]

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Genetic diversity in the USDA Limnanthes germplasm collection assessed by simple sequence repeats

Genetic diversity in the USDA Limnanthes germplasm collection assessed by simple sequence repeats Linda M. Donnellya1a2 p1, Maria M. Jendereka1 p2 c1, James P. Princea2, Patrick A. Reevesa3, Allan Browna1 and Richard M. Hannana4   a1 National Arid Land Plant Genetic Research Unit, USDA-ARS, Parlier, CA 93648, USA a2 Department of Biology, California State University Fresno, Fresno, CA […]

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Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease.

Song Z, Zhou Z, Deaciuc I, Chen T, McClain CJ. Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease. Hepatology 2008; 47:867-879. Abstract Although recent evidence suggests that down-regulation of production of the adipocyte hormone adiponectin has pathophysiological consequences for the development of alcoholic liver disease (ALD), the underlying mechanisms are […]

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Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4ain mice subjected to a long-term ethanol administration

Kang X, Song Z, McClain CJ, Kang YJ, Zhou Z. Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4ain mice subjected to a long-term ethanol administration. Am J Pathol.2008; 172:916- 925. Abstract Alcoholic liver disease is associated with sustained liver damage and impaired regeneration, as well as significant zinc deficiency. This study was undertaken […]

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The anti-diabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats

Xu, Z., Wang, X., Liu, J.,Jia, W.*The anti-diabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats, Phytotherapy Research, Vol 22, 97-101, 2008. Abstract The antidiabetic activity of the total lignan from the plant Fructus Arctii, used in China for the control of diabetes, was investigated in models of alloxan-induced […]

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Simultaneous analysisof nine saponins in flower buds of Panax notoginseng using high performance liquid chromatography

Gao, X., Dan, M., Zhao, A., Xie, G., Jia, W.*Simultaneous analysisof nine saponins in flower buds of Panax notoginseng using high performance liquid chromatography, Biomedical Chromatography, 22: 244-249, 2008. Abstract The flower buds of Panax notoginseng have been commonly used for the treatment of hypertension, vertigo, tinnitus and acute faucitis in China. The amount of […]

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Metabolite profiling ofPanax notoginsengusing UPLC-ESI-MS

Dan, M., Su, M., Gao, X., Zhao, T., Zhao, A., Xie, G., Qiu, Y., Zhou, M., Liu, Z., Jia, W.*Metabolite profiling of Panax notoginsengusing UPLC-ESI-MS, Phytochemistry, 69, 2237-2244, 2008. Abstract The metabolite profiling of different parts of Panax notoginseng was carried out using rapid ultra-performance liquid chromatography-electrospray ionization mass spectrometry (UPLC-ESI-MS) and multivariate statistical analysis. […]

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Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs

Xie, G., Ni, Y., Su, M., Zhang, Y., Zhao, A., Gao, X., Liu, Z., Long, X., Jia, W.*Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs, Metabolomics, 4: 248-260, 2008. Abstract The morphological appearance and some ingredients of Panax ginseng, Panax notoginseng and Panax                               japonicus of the Panax genus […]

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Mass Spectrometry-based Metabolic Profiling of Rat Urine Associated with General Toxicity Induced by Multiglycoside of Tripterygium Wilfordii Hook

Chen, M.,Ni, Y., Duan, H., Qiu, Y., Guo, C., Jiao, Y., Shi, H., Su, M., Jia, W.*Mass Spectrometry-based Metabolic Profiling of Rat Urine Associated with General Toxicity Induced by Multiglycoside of Tripterygium Wilfordii Hook. F.,Chemical Research in Toxicology, 21: 288-294, 2008. Abstract We propose here a combined gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry […]

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GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia

Tao, X., Liu, Y., Qiu, Y., Lin, J., Zhao, A., Su, M., Jia, W.*GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia, Analytical and Bioanalytical Chemistry, 391: 2881-288, 2008.  

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Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research

Xie, G., Plumb, R., Su, M., Xu, Z., Zhao, A., Qiu, Q., Long, X., Liu, Z. Jia, W.*Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research, Journal of Separation Science, 31, 1015-1026, 2008. Abstract In this study, metabolite profiling of five medicinal Panax herbs including Panax ginseng (Chinese ginseng), Panax notoginseng (Sanchi), Panax […]

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Symbiotic gut microbes modulate human metabolic phenotypes

Li, M., Wang, B., Zhang, M., Rantlainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., Wei , H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia,W., Xiao, C., Smith, L., Holmes, E., Tang, H., Zhao, G., Yang, S., Nicholson, J. K., Li, L., Zhao, L., Symbiotic gut […]

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Metabolic profiling reveals disorder of amino acid metabolism in various brain regions from a rat model of chronic unpredictable mild stress

Ni, N., Su, M., Lin, J., Wang, X., Qiu, Y., Zhao, A., Chen, T., Jia, W.*Metabolic profiling reveals disorder of amino acid metabolism in various brain regions from a rat model of chronic unpredictable mild stress, FEBS Letters, Vol. 582 (17), 2627-2636, 2008. Abstract Chronic stress is closely linked to clinical depression, which could be […]

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Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats

Shen, Q., Li, X., Qiu, Y., Su, M., Liu, Y., Li, H., Wang, X., Zou, X., Yan, C., Yu, L., Li, S., Wan, C., He, L., Jia, W.*Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats, Journal of Proteome Research, 7(5), 2151-2157, 2008. Abstract Epidemiology and studies in animal models have revealed […]

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Gut microbiota: a potential new territory for drug targeting

Jia, W.,*Li, H., Zhao, L., Nicholson, J., Gut microbiota: a potential new territory for drug targeting, Nature Reviews Drug Discovery(IF = 23.31),Vol 7, 123-131, 2008. Abstract The significant involvement of the gut microbiota in human health and disease suggests that manipulation of commensal microbial composition through combinations of antibiotics, probiotics and prebiotics could be a […]

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Transcriptomic and metabonomic profiling of obesity-Prone and obesity-resistant rats under high fat diet

Li, H., Xie, Z., Lin, J., Song, H., Wang, Q., Wang, K., Su, M., Qiu, Y., Zhao, T., Song, K., Wang, X., Zhou, M., Liu, P., Zhao, G., Zhang, Q.,Jia, W.* Transcriptomic and metabonomic profiling of obesity-Prone and obesity-resistant rats under high fat diet, Journal of Proteome Research, 7(11), 4775-4783, 2008. Abstract Rodents respond to […]

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Large-Scale Transposon Mutagenesis of Mycoplasma pulmonis

French CT, Lao P, Loraine AE, Matthews BT, Yu H, Dybvig K. Large-Scale Transposon Mutagenesis of Mycoplasma pulmonis. Mol Microbiol. Mol Microbiol. 2008 Jul;69(1):67-76. Epub 2008 Apr 28. Abstract To obtain mutants for the study of the basic biology and pathogenic mechanisms of mycoplasmas, the insertion site of transposon Tn4001T was determined for 1700 members […]

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Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient.

Yao J, Chang C, Salmi ML, Hung YS, Loraine A, Roux SJ. Genome-scale cluster analysis of replicated microarrays using shrinkage correlation coefficient. BMC Bioinformatics. 2008 Jun 18;9:288. Abstract BACKGROUND: Currently, clustering with some form of correlation coefficient as the gene similarity metric has become a popular method for profiling genomic data. The Pearson correlation coefficient […]

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The Genome of Mycoplasma arthritidis

Dybvig K, Zuhua C, Lao P, Jordan DS, French CT, Tu AH, Loraine AE. The Genome of Mycoplasma arthritidis. Infect Immun. 2008 Jun 23. Abstract The genomes of several species of mycoplasma have been sequenced. Most of these species rely on the glycolytic pathway for energy production, with the one exception of Ureaplasma, a species […]

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CressExpress: A tool for large-scale mining of expression data from Arabidopsis thaliana.

Srinivasasainagendra V, Page G, Mehta T, Coulibaly I, Loraine AE. CressExpress: A tool for large-scale mining of expression data from Arabidopsis thaliana. Plant Physiology. 2008 Jul;147(3):1004-16. Abstract CressExpress is a user-friendly, online, coexpression analysis tool for Arabidopsis (Arabidopsis thaliana) microarray expression data that computes patterns of correlated expression between user-entered query genes and the rest […]

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Simultaneous determination of saponins in flower buds of Panax notoginseng using high performance liquid chromatography

Simultaneous determination of saponins in flower buds of Panax notoginseng using high performance liquid chromatography Xianfu Gao, Mo Dan, Aihua Zhao, Guoxiang Xie and Wei Jia* Abstract The flower buds of Panax notoginseng have been commonly used for the treatment of hypertension, vertigo, tinnitus and acute faucitis in China. The amount of total saponins in the flower buds is […]

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Plant extracts from Central Asia showing anti-inflammatory activities in gene expression assays

Dey, Moul, C. Ripoll, R. Pouleva, R. Dorn, I. Aranovich, D Zaurov, A Kurmukov, M. Eliseyeva, I. Belolipov, A. Akimaliev, I. Sodombekov, D. Akimaliev, M.A. Lila and I. Raskin. 2008. Plant extracts from Central Asia showing anti-inflammatory activities in gene expression assays. Phytotherapy Research 22: 929-934. Abstract Plant natural products remain a good resource for […]

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Phytochemical composition and metabolic performance enhancing activity of dietary berries traditionally used by native North Americans

Kraft, Tristan F. Burns, David M. Ribnicky, Randy B. Rogers, Moul Dey, Will Cefalu, David M. Gipp, Ilya Raskin and Mary Ann Lila. 2008. Phytochemical composition and metabolic performance enhancing activity of dietary berries traditionally used by native North Americans. Journal of Agricultural & Food Chemistry 56: 654-600. Abstract Four wild berry species, Amelanchier alnifolia, […]

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Antiradical capacity and induction of apoptosis in HeLa cells by a Phaseolus vulgarisextract

Aparicio-Fernández, Xochitl, Rosalia Reynoso-Camacho, Eduardo Castaño-Tostado, Teresa García-Gasca, Elvira González de Mejía, Horacio Guzmán-Maldonado, Guillermo Elizondo, Gad Gabra Yousef, Mary Ann Lila and Guadalupe Loarca-Pina. 2008. Antiradical capacity and induction of apoptosis in HeLa cells by a Phaseolus vulgarisextract. Plant Foods for Human Nutrition 63: 35-40. Abstract Jamapa bean is a black Phaseolus vulgaris variety […]

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Botanicals for age related diseases: from field to practice

Weaver, Connie M., Stephen Barnes, J. Michael Wyss, Helen Kim, Dorothy M. Morré, D. James Morré, James E. Simon, Mary Ann Lila, Elsa M. Janle and Mario G. Ferruzzi. 2008. Botanicals for age related diseases: from field to practice. American Journal of Clinical Nutrition 87: 493S-497S. Abstract The Purdue-University of Alabama Botanicals Research Center for […]

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The influence of alternative liquid chromatography techniques on chemical complexity and bioactivity of separated proanthocyanidin mixtures.

Alwerdt, Jessica, D.S. Seigler, Elvira Gonzalez de Mejia, Gad G. Yousef and Mary Ann Lila. 2008. The influence of alternative liquid chromatography techniques on chemical complexity and bioactivity of separated proanthocyanidin mixtures. Journal of Agricultural & Food Chemistry 56: 1896-1906. Abstract Extracts rich in proanthocyanidins, which are implicated in multiple human health benefits, were comparatively […]

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Phytoecdysteroids increase protein synthesis in skeletal muscle cells

Gorelick-Feldman, Jonathan, David MacLean, Nebojsa Ilic, Alexander Poulev, Mary Ann Lila, Diana Cheng and Ilya Raskin. 2008. Phytoecdysteroids increase protein synthesis in skeletal muscle cells. Journal of Agricultural & Food Chemistry 56: 3532-3537. Abstract Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth […]

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Neo-Clerodane diterpenes from Ajugaturkestanica

Grace, Mary, Diana Cheng, Ilya Raskin and Mary Ann Lila. 2008. Neo-Clerodane diterpenes from Ajugaturkestanica. Phytochemistry Letters 1: 81-84. Abstract The ethyl acetate extract of the aerial parts of Ajuga turkestanica afforded 6 neo-clerodane diterpenes, including two novel compounds, 14, 15-dihydroajugachin B (1) and 14-hydro-15-methoxyajugachin B (2), in addition to the known diterpenoids chamaepitin (3), […]

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Isolation of biolabeled isoflavones from kudzu (Puerarialobata) root cultures.

Reppert, Adam, Gad G. Yousef, Randy B. Rogers and Mary Ann Lila. 2008. Isolation of biolabeled isoflavones from kudzu (Puerarialobata) root cultures. Journal of Agricultural and Food Chemistry 56: 7860-7865. Abstract Isoflavones have potential for preventing and treating several chronic health conditions, such as osteoporosis, cardiovascular disease, and cancer. In this study, radiolabeled isoflavones were […]

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Optimization of lycopene extraction from tomato cell suspension culture by response surface methodology.

Lu, Chi-Hua, Nancy J. Engelmann, Mary Ann Lila and John W. Erdman, Jr. 2008. Optimization of lycopene extraction from tomato cell suspension culture by response surface methodology. Journal of Agricultural and Food Chemistry 56: 7710-7714. Abstract Radioisotope-labeled lycopene is an important tool for biomedical research but currently is not commercially available. A tomato cell suspension […]

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Clarifying the Source of Black Shank Resistance in Flue-cured Tobacco

Clarifying the Source of Black Shank Resistance in Flue-cured Tobacco Charles S. Johnson, Professor, Jeremy A. Pattison, Assistant Professor, and Elizabeth M. Clevinger, Research Specialist Senior, Southern Piedmont Agricultural Research and Extension Center, Virginia Polytechnic Institute and State University, Blackstone 23824; Thomas A. Melton, Assistant Director and Associate State Program Leader ANR/CRD, North Carolina Cooperative Extension, North Carolina State University, Raleigh 27695; Bruce A. Fortnum,Professor, Clemson University, Pee Dee Research and Education Center, Florence, […]

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