The Metabolite Profiles of the Obese Population Are Gender-Dependent J Proteome Res. 2014 Aug 17, Xie G, Ma X, Zhao A, Wang C, Zhang Y, Nieman D, Nicholson JK, Jia W, Bao Y, Jia W.
Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China.
Appalachian State University Human Performance Laboratory
Recent studies have identified that several amino acids, in particular, branched-chain amino acids (BCAAs), increased significantly in obesecompared with lean individuals. Additionally, these metabolites were strongly associated with future diabetes, rendering them prognostic markers suitable for obese populations. Here we report a metabonomic study that reveals new findings on the role of these amino acid markers, particularly BCAAs, in a Chinese cohort including 106 healthy obese and 105 healthy lean participants. We found that the BCAAs were correlated with insulin resistance and differentially expressed in obese men, but not in obese women. The results were verified with two independent groups of participants (Chinese, n=105 and American, n=72), demonstrating that the serum metabolite profiles of the obese population are gender-dependent. The study supports the previous findings of a panel of several key metabolites as prognostic markers of obese population, and highlights the need to take into account gender differences when using these markers for risk assessment.
25132568[PubMed – as supplied by publisher]