Journal Articles

The continuum of fetal alcohol spectrum disorders in four rural communities in south africa: Prevalence and characteristics

December 31, 2015

The continuum of fetal alcohol spectrum disorders in four rural communities in South Africa: Prevalence and characteristics. Drug and Alcohol Dependence, December 31, 2015. Philip A. May, a, b, Marlene M. de Vries, b, Anna-Susan Marais, b, Wendy O. Kalberg, c, Colleen M. Adnams, d, Julie M. Hasken, a, Barbara Tabachnick, e, Luther K. Robinson, f, Melanie A. Manning, g, Kenneth Lyons Jones, h, Derek Hoyme, i, Soraya Seedat, j, Charles D.H. Parry, b, j, H. Eugene Hoyme, k.

Author Affiliations
a The University of North Carolina at Chapel Hill, Nutrition Research Institute, United States
b Stellenbosch University, Faculty of Medicine and Health Sciences, United States
c The University of New Mexico, Center on Alcoholism, Substance Abuse and Addictions, United States
d University of Cape Town, Department of Psychiatry and Mental Health, United States
e California State University, Northridge, United States
f State University of New York, Buffalo, Department of Pediatrics, United States
g Stanford University School of Medicine, Departments of Pathology and Pediatrics, United States
h University of California San Diego School of Medicine, Department of Pediatrics, United States
i University of Iowa, Department of Pediatrics, United States
j South African Medical Research Council, United States
k Sanford Research, University of South Dakota Sanford School of Medicine, Department of Pediatrics, United States



Prevalence and characteristics of the continuum of diagnoses within fetal alcohol spectrum disorders (FASD) were researched in previously unstudied rural, agricultural, lower socioeconomic populations in South Africa (ZA).


Using an active case ascertainment approach among first grade learners, 1354 (72.6%) were consented into the study via: height, weight, and/or head circumference ≤25th centile and/or random selection as normal control candidates. Final diagnoses were made following: examination by pediatric dysmorphologists/geneticists, cognitive/behavioral testing, and maternal risk factor interviews.


FASD children were significantly growth deficient and dysmorphic: physical measurements, cardinal facial features of FAS, and total dysmorphology scores clearly differentiated diagnostic categories from severe to mild to normal in a consistent, linear fashion. Neurodevelopmental delays were also significantly worse for each of the FASD diagnostic categories, although not as consistently linear across groups. Alcohol use is well documented as the proximal maternal risk factor for each diagnostic group. Significant distal maternal risk factors in this population are: low body weight, body mass, education, and income; and high gravidity, parity, and age at birth of the index child. In this low SES, highly rural region, FAS occurs in 93–128 per 1,000 children, PFAS in 58–86, and, ARND in 32–46 per 1,000. Total FASD affect 182–259 per 1,000 children or 18–26%.


Very high rates of FASD exist in these rural areas and isolated towns where entrenched practices of regular binge drinking co-exist with challenging conditions for childbearing and child development.

Comments are closed.

Connect With Us