Journal Articles

Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction

July 14, 2016

Sean van Diepen, Wendimagegn G. Alemayehu, Yinggan Zheng, Pierre Theroux, L. Kristin Newby, Kenneth W. Mahaffey, Christopher B. Granger, Paul W. Armstrong (2016). Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction. Journal of Thrombosis and Thrombolysis: 1-10.

Author Affiliations

1. Divisions of Critical Care and Cardiology, University of Alberta, Edmonton, AB, Canada
2. Canadian VIGOUR Centre, University of Alberta, Edmonton, AB, Canada
7. 2C2 Cardiology Walter MacKenzie Center, University of Alberta Hospital, 8440-11 St., Edmonton, AB, T6G 2B7, Canada
3. Institut de Cardiologie de Montréal, Université de Montréal, Québec, Canada
4. Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
6. Stanford University Medical Center, Stanford University School of Medicine, Stanford, CA, USA
5. Division of Cardiology, University of Alberta, Edmonton, AB, Canada

Abstract

Coronary plaque rupture mediating acute ST segment elevation myocardial infarction (STEMI) is associated with a systemic inflammatory response. Whether early temporal changes in inflammatory biomarkers are associated with angiographic and electrocardiographic markers of reperfusion and subsequent clinical outcomes is unclear. In the APEX-AMI biomarker substudy, 376 patients with STEMI had inflammatory biomarkers measured at the time of hospital presentation and 24 h later. The primary outcome was the 90-day composite of death, shock, or heart failure. Secondary reperfusion outcomes were (1) worst least residual ST segment elevation (ST-E:

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