Vazquez-Vidal I1,2, Voruganti VS2, Hannon BA3, Andrade FCD4, Aradillas-García C5, Nakamura MT1,3, Terán-García M1,3,6. Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study. Lifestyle Genom. 2018 May 30:1-9. doi: 10.1159/000488085. [Epub ahead of print]
1 Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
2 Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
3 Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
4 Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
5 Coordination for the Innovation and Application of Science and Technology, Autonomous University of San Luis Potosí, San Luis Potosí, Mexico.
6 Department of Human Development and Family Studies, Cooperative Extension, Family Resiliency Center, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Recent genome-wide association studies in the Mexican population have identified several genetic loci associated with blood lipid levels in adults. However, studies focusing on the fatty acid desaturase (FADS) gene cluster have been understudied in this population, even though it seems associated with lipid profiles in other ethnicities. The aim of this study was to test associations between single nucleotide polymorphisms (SNPs) in the FADS cluster (rs174546, rs1535, rs174548, rs174550, rs174450, and rs174618) and serum lipid profiles in young Mexicans.
Anthropometrics, serum lipid profiles, and FADS SNPs were measured in 998 subjects in the UP-AMIGOS cohort study. Genotype-phenotype (total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and very-low-density lipoprotein [VLDL]) associations were assessed using PLINK adjusted for sex, age, and body mass index (BMI).
Among 6 FADS SNPs, we found that carriers of the C-allele of the FADS1-rs174546 showed a significant association with lower TG concentrations (β = -12.6 mg/dL, p = 0.009) and lower VLDL concentrations (β = -2.52 mg/dL, p = 0.005). We found that rs174546, rs1535, and rs174550 were in high linkage disequilibrium (r2 > 0.80). There were no significant associations between rs174550, rs174548, and rs174618 and lipid profiles.
A genetic variant in the FADS1 (rs174546) gene is a major contributor of plasma TG and VLDL concentrations in healthy young Mexicans.
© 2018 S. Karger AG, Basel.
Blood lipid; FADS genotype; Young healthy Mexicans