Veronica Sanda Chedea, Simona Ioana Vicas, Claudia Sticozzi, Federica Pessina, Maria Frosini, Emanuela Maioli and Giuseppe Valacchi (2017). Resveratrol from diet to topical usage. Food & Function.
The stilbene derivative Resveratrol (3,5,4’-trihydroxy-stilbene; RESV) has become the subject of interest of many researchers and pharmaceutical industries due to its well-claimed biological beneficial activities. Although earlier research tended to focus on the effects of RESV on cardiovascular disorders, many others studies have described the beneficial effects of RESV in the area of cancer chemoprevention, inflammation and the interest of researchers on this compound is still increasing. It is now well accepted that the effect of RESV is not just due to its so call “antioxidant” activity but mainly (if not only) to the ability of this compound to trigger cell signaling pathways and gene expression involved in cellular defense systems. Many “in vitro” studies on RESV did not take into account that although its oral absorption is about 75% its goes through a very rapid metabolism and the concentration in the blood stream is almost undetectable. For this reason the interest of the topical usage of RESV by cosmaceutical skin care brands has exponentially raised in the last decade years reporting in general a very promising results on its beneficial effect in protecting the skin from outdoor insults, but there is still some controversy on its topical usage mainly determined by the concentration used. Therefore, more basic research on the topical application of RESV should be performed to better understand its way to prevent cutaenous damage and whether it could be recommended as a preventive skin aging agent for all skin insults.