Journal Articles

Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice

July 27, 2017

Emily A.K. Prieur , Eneda Pjetri, Steven H. Zeisel, Nafisa M Jadavji (2017). Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Applied Physiology, Nutrition, and Metabolism.

Abstract

Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain MRI volume, as well as impaired reference and short- term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.

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