Prevalence and characteristics of fetal alcohol spectrum disorders Pediatrics. 2014 Oct 27, May PA1, Baete A2, Russo J2, Elliott AJ3, Blankenship J4, Kalberg WO4, Buckley D4, Brooks M4, Hasken J5, Abdul-Rahman O6, Adam MP7, Robinson LK8,Manning M9, Hoyme HE3.
- 1Department of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center on Alcoholism, Substance Abuse and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico; Department of Pediatrics, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota firstname.lastname@example.org.
- 2Sanford Research, Sioux Falls, South Dakota;
- 3Sanford Research, Sioux Falls, South Dakota; Department of Pediatrics, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota.
- 4Center on Alcoholism, Substance Abuse and Addictions (CASAA), The University of New Mexico, Albuquerque, New Mexico;
- 5Department of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;
- 6Department of Pediatrics, University of Mississippi, Jackson, Mississippi;
- 7Department of Pediatrics, University of Washington, Seattle, Washington;
- 8Dysmorphology and Clinical Genetics, State University of New York at Buffalo, Buffalo, New York;
- 9Departments of Pathology and Pediatrics, Stanford University, Stanford, California; and.
To determine the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) among first grade students (6- to 7-year-olds) in a representative Midwestern US community.
From a consented sample of 70.5% of all first graders enrolled in public and private schools, an oversample of small children (≤25th percentile on height, weight, and head circumference) and randomly selected control candidates were examined for physical growth, development, dysmorphology, cognition, and behavior. The children’s mothers were interviewed for maternal risk.
Total dysmorphology scores differentiate significantly fetal alcohol syndrome (FAS) and partial FAS (PFAS) from one another and from unexposed controls. Alcohol-related neurodevelopmental disorder (ARND) is not as clearly differentiated from controls. Children who had FASD performed, on average, significantly worse on 7 cognitive and behavioral tests and measures. The most predictive maternal risk variables in this community are late recognition of pregnancy, quantity of alcoholic drinks consumed 3 months before pregnancy, and quantity of drinking reported for the index child’s father. From the final multidisciplinary case findings, 3 techniques were used to estimate prevalence. FAS in this community likely ranges from 6 to 9 per 1000 children (midpoint, 7.5), PFAS from 11 to 17 per 1000 children (midpoint, 14), and the total rate of FASD is estimated at 24 to 48 per 1000 children, or 2.4% to 4.8% (midpoint, 3.6%).
Children who have FASD are more prevalent among first graders in this Midwestern city than predicted by previous, popular estimates.