Journal Articles

Nephro-protective effect of Kangqianling decociton on chronic renal failure rats

March 19, 2009

He, L., Shen, P., Fu, Q.,Li, J., Dan, M., Wang, X.,Jia, W.*Nephro-protective effect of Kangqianling decociton on chronic renal failure rats, Journal of Ethnopharmacology, 122, 367-373, 2009.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Kangqianling decoction (KQL), the modified formulation of a classical Chinese prescription named Taohongsiwu decoction, was clinically employed to treat renal fibrosis in chronic renal failure.

AIM OF THE STUDY:

The present study was designed to examine whether KQL has a protective effect on renal function in association with transforming growth factor-beta (TGF-beta), angiotensin II (Ang II), tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappaB (NF-kappaB) in rats with 5/6 renal ablation (Nx)-induced chronic renal failure.

RESULTS:

In renal function deterioration progression, the high expression of serum creatinine (Scr), 24-h urine protein and systolic blood pressure were markedly (P<0.05 or P<0.01) restored by KQL, respectively, at 4 and 8 weeks. The increasing expressions of renal Ang II (P<0.05), angiotensin II1-receptor (AT1R) (P<0.05), TNF-alpha (P<0.05), NF-kappaB (P<0.001) and urine TGF-beta1 (P<0.05) were reduced by the treatment of KQL. Immunohistochemical study further confirmed the nephro-protective activity of KQL as compared to the control and Sham group.

CONCLUSIONS:

The results indicate that KQL is able to protect renal function via ameliorating experimental rat renal failure as found in these renal functional parameters.

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