Journal Articles

Neo-Clerodane diterpenes from Ajugaturkestanica

March 14, 2008

Grace, Mary, Diana Cheng, Ilya Raskin and Mary Ann Lila. 2008. Neo-Clerodane diterpenes from Ajugaturkestanica. Phytochemistry Letters 1: 81-84.


The ethyl acetate extract of the aerial parts of Ajuga turkestanica afforded 6 neo-clerodane diterpenes, including two novel compounds, 14, 15-dihydroajugachin B (1) and 14-hydro-15-methoxyajugachin B (2), in addition to the known diterpenoids chamaepitin (3), ajugachin B (4), ajugapitin (5) and lupulin A (6). Structures were established through exhaustive NMR spectroscopic analysis and chemical transformation in the case of 1. The full (1)H and (13)C NMR assignment of the C-15 R and S configurations of 14-hydro-15-methoxyajugachin B and chamaepitin were elucidated.

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