Nilton C. Ribeiro, Antonio J. Demuner, Marcelo H. dos Santos, Célia R. A. Maltha, Elson A. de Alvarenga, Slavko Komarnytsky (2018). Metals Complexes Formed with Oleanolic Acid. International Journal of Organic Chemistry, 8(1).
Chemistry Department, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n Campus Universitário, Viçosa, Minas Gerais, Brazil.
IFMT, Rondonópolis, Brazil.
North Carolina State University, Research Campus, Kannapolis, NC, USA.
The oleanolic acid possesses diverse pharmacological properties, it is considered as a good starting material for creating new compounds. The oleanolic acid isolated of Plumeria obtusa leaves was used as raw material to obtained calcium, magnesium, zinc, nickel and copper complexes. The structures of complexes were confirmed by HRMS, 1H NMR, and 13C NMR. Five new compounds were synthesized to promote increased biological activity of oleanolic acid and PCR assays for the different type of cancer.