Journal Articles

Making Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable

July 13, 2015

Making Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics Roundtable Personalized Health Care Even More Personalized: Insights From Activities of the IOM Genomics RoundtableAnn Fam Med. 2015 Jul;13, David SP1, Johnson SG2, Berger AC3, Feero WG4, Terry SF5, Green LA6, Phillips RL Jr7, Ginsburg GS8.

  • 1Department of Medicine, Stanford University School of Medicine, Palo Alto, California Roundtable on Translating Genomic-Based Research forHealth, Institute of Medicine (IOM) of the National Academies spdavid@stanford.edu.
  • 2Roundtable on Translating Genomic-Based Research for Health, Institute of Medicine (IOM) of the National Academies Applied Pharmacogenomics, Kaiser-Permanente Colorado, Aurora, Colorado Department of Clinical Pharmacy, University of Colorado, Denver, Colorado.
  • 3Applied Pharmacogenomics, Kaiser-Permanente Colorado, Aurora, Colorado.
  • 4Applied Pharmacogenomics, Kaiser-Permanente Colorado, Aurora, Colorado Maine-Dartmouth Family Medicine Residency Program, Augusta, Maine.
  • 5Roundtable on Translating Genomic-Based Research for Health, Institute of Medicine (IOM) of the National Academies Genetic Alliance, Washington, DC.
  • 6Department of Family Medicine, University of Colorado, Denver, Colorado.
  • 7American Board of Family Medicine, Lexington, Kentucky.
  • 8Roundtable on Translating Genomic-Based Research for Health, Institute of Medicine (IOM) of the National Academies Center for AppliedGenomics and Precision Medicine, Duke University School of Medicine, Durham, North Carolina.

Abstract

Genomic research has generated much new knowledge into mechanisms of human disease, with the potential to catalyze novel drug discovery and development, prenatal and neonatal screening, clinical pharmacogenomics, more sensitive risk prediction, and enhanced diagnostics. Genomic medicine, however, has been limited by critical evidence gaps, especially those related to clinical utility and applicability to diverse populations. Genomic medicine may have the greatest impact on health care if it is integrated into primary care, where most health care is received and where evidence supports the value of personalized medicine grounded in continuous healing relationships. Redesigned primary care is the most relevant setting for clinically useful genomic medicine research. Taking insights gained from the activities of the Institute of Medicine (IOM) Roundtable on Translating Genomic-Based Research for Health, we apply lessons learned from the patient-centered medical home national experience to implement genomic medicine in a patient-centered, learning health care system.

© 2015 Annals of Family Medicine, Inc.

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