Journal Articles

Influence of quercetin supplementation on disease risk factors in community-dwelling adults

April 11, 2011

KnabAM,Shanely RA,Henson DA,Jin F,Heinz SA,Austin MD,Nieman DC. Influence of quercetin supplementation on disease risk factors in community-dwelling adults.AppalachianStateUniversity, Kannapolis, NC, USA. J Am Diet Assoc.2011 Apr;111(4):542-9.

Abstract

BACKGROUND:

In vitro data indicate quercetin has antioxidative and anti-inflammatory functions with the potential to lower disease risk factors, but data in human beings are limited.

OBJECTIVE:

The objective of this study was to investigate the effect of quercetin, vitamin C, and niacin supplements (500 mg quercetin, 125 mg vitamin C, and 5 mg niacin [Q-500]; 1,000 mg quercetin, 250 mg vitamin C, and 10 mg niacin [Q-1,000]), on disease risk factors in a large group of community adults (n=1,002, 60% women) varying widely in age and body mass index.

DESIGN:

Subjects were randomized into one of three groups (placebo, Q-500, or Q-1,000) and ingested supplements for 12 weeks. Blood samples were taken pre- and postsupplementation, and plasma quercetin, inflammatory markers (ie, C-reactive protein and five cytokines), diagnostic blood chemistries, blood pressure, and blood lipid profiles were measured.

RESULTS:

Plasma quercetin increased in the Q-500 and Q-1,000 groups. No differences in blood chemistries were found except for a small decrease in serum creatinine and increase in glomerular filtration rate in Q-500 and Q-1,000 groups. A small decrease in mean arterial blood pressure was measured for Q-500 and Q-1,000 groups compared to placebo. A difference in serum total cholesterol was measured between Q-500 and placebo groups, and there was small decrease in high-density lipoprotein cholesterol levels in the Q-1,000 group. Change in inflammatory measures did not differ between groups except for a slight decrease in interleukin-6 for the Q-1,000 group.

CONCLUSIONS:

Q-500 or Q-1,000 supplementation for 12 weeks had a negligible influence on disease risk factors.

Copyright © 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved.

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