David C. Nieman, Courtney L. Goodman, Christopher R. Capps, Zack L. Shue, Robert Arnot (2017). Influence of 2-Weeks Ingestion of High Chlorogenic Acid Coffee On Mood State, Performance, and Post-Exercise Inflammation and Oxidative Stress: A Randomized, Placebo Controlled Trial. Sport Nutrition and Exercise Metabolism, pp. 1-26.
Appalachian State University, Human Performance Lab, North Carolina Research Campus, Kannapolis, NC
Academic Neutriceuticals LLC, Cheyenne, WY
This study measured the influence of 2-weeks ingestion of high chlorogenic acid (CQA) coffee on post-exercise inflammation and oxidative stress, with secondary outcomes including performance and mood state. Cyclists (N=15) were randomized to CQA coffee or placebo (300 ml/day) for 2 weeks, participated in a 50-km cycling time trial, and then crossed over to the opposite condition with a 2-week washout period. Blood samples were collected pre- and post-supplementation, and immediately post-exercise. CQA coffee was prepared using the Turkish method with 30 g lightly roasted, highly ground Hambela coffee beans in 300 ml boiling water, and provided 1,066 mg CQA and 474 mg caffeine versus 187 mg CQA and 33 mg caffeine for placebo. Plasma caffeine was higher with CQA coffee versus placebo after 2-weeks (3.3-fold) and post-exercise (21.0-fold) (interaction effect, P<0.001). Higher ferric reducing ability of plasma (FRAP) levels were measured after exercise with CQA coffee versus placebo (P=0.010). No differences between CQA coffee and placebo were found for post-exercise increases in plasma IL-6 (P=0.737) and hydroxyoctadecadienoic acids (9+13 HODEs) (P=0.992). Total mood disturbance (TMD) scores were lower with CQA coffee versus placebo (P=0.041). 50-km cycling time performance and power did not differ between trials, with heart rate and ventilation higher with CQA coffee, especially after 30-minutes. In summary, despite more favorable TMD scores with CQA coffee, these data do not support the chronic use of coffee highly concentrated with chlorogenic acids and caffeine in mitigating post-exercise inflammation or oxidative stress or improving 50-km cycling performance.