Journal Articles

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

July 19, 2017

Ramos-Lopez, O.; Milagro F.I.; Allayee H.; Chmurzynska A.; Choi M.S.; Curi R.; De Caterina R.; Ferguson L.R.; Goni L.; Kang J.X.; Kohlmeier M.; Marti A.; Moreno L.A.; Pérusse L.; Prasad C.; Qi L.; Reifen R.; Riezu-Boj J.I.; San-Cristobal R.; Santos J.L.; Martínez J.A (2017). Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity. Journal of Nutrigenetics and Nutrigenomics 10(1-2).

Author Affiliations:

a. Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde” and Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico;
b. Department of Nutrition, Food Science and Physiology, University of Navarra, and Center for Nutrition Research, University of Navarra, Pamplona
c. CIBERobn, Physiopathology of Obesity, Carlos III Institute, Madrid, Spain;
d. Institute for Genetic Medicine and Department of Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA, USA;
e. Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland;
f. Center for Food & Nutritional Genomics, Department of Food Science & Nutrition, Kyungpook National University, Daegu, Korea;
g. Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Butantan, São Paulo, Brazil;
hInstitute of Cardiology “G. d’Annunzio” University and Center of Excellence on Aging, Chieti, Italy;
i. Discipline of Nutrition and Auckland Cancer Society Research Centre, FM & HS, and Nutrigenomics New Zealand, University of Auckland, Auckland, New Zealand;
j. Laboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA
k. Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;
l. GENUD (Growth, Exercise, Nutrition and Development) Research Group, Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain;
m. Department of Kinesiology and Institute of Nutrition and Functional Foods, Université Laval, Québec City, QC, Canada;
n. Department of Nutrition and Food Sciences, Texas Woman’s University, Denton, TX
o. Department of Medicine, Section of Endocrinology, LSU Health Sciences Center
p. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, and qDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;
r. Department of Biochemistry and Food Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Jerusalem, Israel;
s. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain;
t. Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile;
u. Madrid Institute of Advanced Studies (IMDEA Food), Madrid, Spain


Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention and management. Precision nutrition is an emerging therapeutic approach that takes into account an individual’s genetic and epigenetic information, as well as age, gender, or particular physiopathological status. Advances in genomic sciences are contributing to a better understanding of the role of genetic variants and epigenetic signatures as well as gene expression patterns in the development of diverse chronic conditions, and how they may modify therapeutic responses. This knowledge has led to the search for genetic and epigenetic biomarkers to predict the risk of developing chronic diseases and personalizing their prevention and treatment. Additionally, original nutritional interventions based on nutrients and bioactive dietary compounds that can modify epigenetic marks and gene expression have been implemented. Although caution must be exercised, these scientific insights are paving the way for the design of innovative strategies for the control of chronic diseases accompanying obesity. This document provides a number of examples of the huge potential of understanding nutrigenetic, nutrigenomic, and nutriepigenetic roles in precision nutrition.

Comments are closed.

Connect With Us