Bioavailability of polyphenols from peanut skin extract associated with plasma lipid lowering function. Food Chemistry. October 2013. R.R. Bansode, P. Randolph, M. Ahmedna, S. Hurley, T. Hanner, S. Baxter, T. Johnston, M. Su, B. Holmes, J. Yu, L.L. Williams.
Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus; Department of Health Sciences, Qatar University, P.O. Box 2713, Doha, Qatar. Department of Animal Sciences; North Carolina Agricultural and Technical State University, Web Hall, East Market Street, Greensboro, North Carolina; David H. Murdoch Research Institute, North Carolina Research Campus; Department of Family and Consumer Sciences, North Carolina Agricultural and Technical State University, Carver Hall, Greensboro, North Carolina.
Peanut skin is a rich source of polyphenols including procyanidins and is shown to have hypolipidemic properties. This study investigated the bioavailability of peanut skin polyphenols using a rat model. First, the bioavailability of peanut skin polyphenols in rat plasma was evaluated. Our results showed procyanidin A2 levels in plasma peaked within 30 min of ingestion. The results of a second study show that peanut skin extract supplemented in addition to oil gavage resulted in significant decrease in plasma triglyceride and VLDL within 5 h. In the third study, rats were given a Western type diet for 5 weeks with peanut skin extract at a dose of 150 and 300 mg/kg body weight. The main effects observed were lowering of total blood lipid and reduction of the plasma fatty acids profile. Our results suggest that procyanidin A may impart a key role of hypolipidemic effect seen in peanut skin polyphenols.
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