Journal Articles

Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canellawinterana.

March 12, 2010

Grace, Mary H., Carmen Lategan, Flaubert Mbeunkui, Rocky Graziose, Peter J. Smith, Ilya Raskin and Mary Ann Lila. 2010. Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canellawinterana. Journal of Natural Product Communications 5: 1869-1872.

Abstract

The hexane extract from the leaves of Canella winterana exhibited strong activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10) in vitro (IC50 2.53 microg/mL). Bioassay guided fractionation of this extract has led to the isolation of 5 drimane-type sesquiterpenoids: 9-epideoxymuzigadial, 9-deoxymuzigadial, muzigadial, 3-beta-acetoxypolygodial and the newly isolated hemiacetal, named muzigodiol, with IC50-values of 1.01, 2.19, 0.31, 2.77 and 7.43 microg/mL, respectively. The first four compounds were tested for their cytotoxicity using Chinese Hamster Ovarian (CHO) cells, where they showed IC50-values of 1.82, 33.69, 1.18, and 58.31 microg/mL, respectively. A structure-activity relationship is discussed.

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