Journal Articles

Acute intravenous exposure to silver nanoparticles during pregnancy induces particle size and vehicle dependent changes in vascular tissue contractility in Sprague Dawley rats

November 30, 2017

A.K. Vidanapathirana, L.C. Thompson, M. Herco, J. Odom, S.J. Sumner, T.R. Fennell, J.M. Brown, C.J.Wingard (2017). Acute intravenous exposure to silver nanoparticles during pregnancy induces particle size and vehicle dependent changes in vascular tissue contractility in Sprague Dawley rats. Reproductive Toxicology 76, 10-22.

Author Affiliations

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA
Discovery Sciences, RTI International, Research Triangle Park, NC, 27709, USA
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, CO, 80045, USA
Department of Nutrition School of Public Health University of North Carolina at Chapel Hill, Kannapolis, NC, 28081, USA
Department of Physical Therapy, Bellarmine University, Louisville, KY, 40205, USA

Abstract

The use of silver nanoparticles (AgNP) raises safety concerns during susceptible life stages such as pregnancy. We hypothesized that acute intravenous exposure to AgNP during late stages of pregnancy will increase vascular tissue contractility, potentially contributing to alterations in fetal growth. Sprague Dawley rats were exposed to a single dose of PVP or Citrate stabilized 20 or 110 nm AgNP (700 μg/kg). Differential vascular responses and EC50 values were observed in myographic studies in uterine, mesenteric arteries and thoracic aortic segments, 24 h post-exposure. Reciprocal responses were observed in aortic and uterine vessels following PVP stabilized AgNP with an increased force of contraction in uterine artery and increased relaxation responses in aorta. Citrate stabilized AgNP exposure increased contractile force in both uterine and aortic vessels. Intravenous AgNP exposure during pregnancy displayed particle size and vehicle dependent moderate changes in vascular tissue contractility, potentially influencing fetal blood supply.

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